TNFAIP8L3 (TNF alpha induced protein 8 like 3)

2005-11-01  

Identity

HGNC
TNFAIP8L3
LOCATION
15q21.2
LOCUSID
388121
ALIAS
TIPE3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 388121
MIM: 616438
HGNC: 20620
Ensembl: ENSG00000183578

Variants:

dbSNP: 388121
ClinVar: 388121
TCGA: ENSG00000183578
COSMIC: TNFAIP8L3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183578ENST00000327536Q5GJ75
ENSG00000183578ENST00000637513A0A1B0GTK8
ENSG00000183578ENST00000649177A0A494C051

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
PI MetabolismREACTOMER-HSA-1483255

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
277832292016Molecular insights into the binding of phosphoinositides to the TH domain region of TIPE proteins.5
294227692018A genome-wide association study of corneal astigmatism: The CREAM Consortium.2
252420442014TIPE3 is the transfer protein of lipid second messengers that promote cancer.0
254797912015Identical expression profiling of human and murine TIPE3 protein reveals links to its functions.0
283885802017TIPE3 protein promotes breast cancer metastasis through activating AKT and NF-κB signaling pathways.0
295106882018TIPE3 differentially modulates proliferation and migration of human non-small-cell lung cancer cells via distinct subcellular location.0
302172242018TIPE3 hypermethylation correlates with worse prognosis and promotes tumor progression in nasopharyngeal carcinoma.0
306395322019TIPE3 is a regulator of cell apoptosis in glioblastoma.0
311400502019miR-9-5p Suppresses Malignant Biological Behaviors of Human Gastric Cancer Cells by Negative Regulation of TNFAIP8L3.0

Citation

Dessen P

TNFAIP8L3 (TNF alpha induced protein 8 like 3)

Atlas Genet Cytogenet Oncol Haematol. 2005-11-01

Online version: http://atlasgeneticsoncology.org/gene/43044/tnfaip8l3