Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TNFRSF10A (TNF receptor superfamily member 10a)

Identity

Alias_namestumor necrosis factor receptor superfamily, member 10a
Alias_symbol (synonym)DR4
Apo2
TRAILR-1
CD261
TRAILR1
Other aliasAPO2
HGNC (Hugo) TNFRSF10A
LocusID (NCBI) 8797
Atlas_Id 42605
Location 8p21.3  [Link to chromosome band 8p21]
Location_base_pair Starts at 23191457 and ends at 23225167 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TNFRSF10A (8p21.3) / DMTN (8p21.3)TNFRSF10A 8p21.3 EPB49

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]

Solid Tumors TT_t0808p21p21ID108059

External links

Nomenclature
HGNC (Hugo)TNFRSF10A   11904
Cards
Entrez_Gene (NCBI)TNFRSF10A  8797  TNF receptor superfamily member 10a
AliasesAPO2; CD261; DR4; TRAILR-1; 
TRAILR1
GeneCards (Weizmann)TNFRSF10A
Ensembl hg19 (Hinxton)ENSG00000104689 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104689 [Gene_View]  ENSG00000104689 [Sequence]  chr8:23191457-23225167 [Contig_View]  TNFRSF10A [Vega]
ICGC DataPortalENSG00000104689
TCGA cBioPortalTNFRSF10A
AceView (NCBI)TNFRSF10A
Genatlas (Paris)TNFRSF10A
WikiGenes8797
SOURCE (Princeton)TNFRSF10A
Genetics Home Reference (NIH)TNFRSF10A
Genomic and cartography
GoldenPath hg38 (UCSC)TNFRSF10A  -     chr8:23191457-23225167 -  8p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFRSF10A  -     8p21.3   [Description]    (hg19-Feb_2009)
GoldenPathTNFRSF10A - 8p21.3 [CytoView hg19]  TNFRSF10A - 8p21.3 [CytoView hg38]
ImmunoBaseENSG00000104689
Mapping of homologs : NCBITNFRSF10A [Mapview hg19]  TNFRSF10A [Mapview hg38]
OMIM603611   
Gene and transcription
Genbank (Entrez)AK291299 BC012866 BT006906 CN423254 DB101031
RefSeq transcript (Entrez)NM_003844
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNFRSF10A
Cluster EST : UnigeneHs.591834 [ NCBI ]
CGAP (NCI)Hs.591834
Alternative Splicing GalleryENSG00000104689
Gene ExpressionTNFRSF10A [ NCBI-GEO ]   TNFRSF10A [ EBI - ARRAY_EXPRESS ]   TNFRSF10A [ SEEK ]   TNFRSF10A [ MEM ]
Gene Expression Viewer (FireBrowse)TNFRSF10A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8797
GTEX Portal (Tissue expression)TNFRSF10A
Human Protein AtlasENSG00000104689-TNFRSF10A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00220   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00220  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00220
Splice isoforms : SwissVarO00220
PhosPhoSitePlusO00220
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)DEATH-like_dom_sf    Death_domain    TNFR/NGFR_Cys_rich_reg    TNFR_10    TNFRSF10_N    TNFRSF10A/B_death   
Domain families : Pfam (Sanger)Death (PF00531)    TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00531    pfam00020   
Domain families : Smart (EMBL)DEATH (SM00005)  TNFR (SM00208)  
Conserved Domain (NCBI)TNFRSF10A
DMDM Disease mutations8797
Blocks (Seattle)TNFRSF10A
PDB (RSDB)5CIR   
PDB Europe5CIR   
PDB (PDBSum)5CIR   
PDB (IMB)5CIR   
Structural Biology KnowledgeBase5CIR   
SCOP (Structural Classification of Proteins)5CIR   
CATH (Classification of proteins structures)5CIR   
SuperfamilyO00220
Human Protein Atlas [tissue]ENSG00000104689-TNFRSF10A [tissue]
Peptide AtlasO00220
HPRD04679
IPIIPI00021975   IPI00978848   
Protein Interaction databases
DIP (DOE-UCLA)O00220
IntAct (EBI)O00220
FunCoupENSG00000104689
BioGRIDTNFRSF10A
STRING (EMBL)TNFRSF10A
ZODIACTNFRSF10A
Ontologies - Pathways
QuickGOO00220
Ontology : AmiGOprotease binding  death receptor activity  protein binding  plasma membrane  plasma membrane  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  signal transduction  cell surface receptor signaling pathway  activation of NF-kappaB-inducing kinase activity  transcription factor binding  extrinsic apoptotic signaling pathway via death domain receptors  cell surface  cell surface  integral component of membrane  TRAIL-activated apoptotic signaling pathway  TRAIL-activated apoptotic signaling pathway  signaling receptor activity  regulation of apoptotic process  positive regulation of apoptotic process  TRAIL binding  leukocyte migration  cellular response to mechanical stimulus  extrinsic apoptotic signaling pathway  regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
Ontology : EGO-EBIprotease binding  death receptor activity  protein binding  plasma membrane  plasma membrane  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  signal transduction  cell surface receptor signaling pathway  activation of NF-kappaB-inducing kinase activity  transcription factor binding  extrinsic apoptotic signaling pathway via death domain receptors  cell surface  cell surface  integral component of membrane  TRAIL-activated apoptotic signaling pathway  TRAIL-activated apoptotic signaling pathway  signaling receptor activity  regulation of apoptotic process  positive regulation of apoptotic process  TRAIL binding  leukocyte migration  cellular response to mechanical stimulus  extrinsic apoptotic signaling pathway  regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
Pathways : KEGGCytokine-cytokine receptor interaction    Apoptosis    Natural killer cell mediated cytotoxicity    Measles    Influenza A   
NDEx NetworkTNFRSF10A
Atlas of Cancer Signalling NetworkTNFRSF10A
Wikipedia pathwaysTNFRSF10A
Orthology - Evolution
OrthoDB8797
GeneTree (enSembl)ENSG00000104689
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF10A
HOGENOMO00220
Homologs : HomoloGeneTNFRSF10A
Homology/Alignments : Family Browser (UCSC)TNFRSF10A
Gene fusions - Rearrangements
Fusion : MitelmanTNFRSF10A/DMTN [8p21.3/8p21.3]  
Fusion PortalTNFRSF10A 8p21.3 EPB49 BLCA
Fusion : QuiverTNFRSF10A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFRSF10A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFRSF10A
dbVarTNFRSF10A
ClinVarTNFRSF10A
1000_GenomesTNFRSF10A 
Exome Variant ServerTNFRSF10A
ExAC (Exome Aggregation Consortium)ENSG00000104689
GNOMAD BrowserENSG00000104689
Varsome BrowserTNFRSF10A
Genetic variants : HAPMAP8797
Genomic Variants (DGV)TNFRSF10A [DGVbeta]
DECIPHERTNFRSF10A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFRSF10A 
Mutations
ICGC Data PortalTNFRSF10A 
TCGA Data PortalTNFRSF10A 
Broad Tumor PortalTNFRSF10A
OASIS PortalTNFRSF10A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFRSF10A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNFRSF10A
Mutations and Diseases : HGMDTNFRSF10A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFRSF10A
DgiDB (Drug Gene Interaction Database)TNFRSF10A
DoCM (Curated mutations)TNFRSF10A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF10A (select a term)
intoGenTNFRSF10A
Cancer3DTNFRSF10A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603611   
Orphanet
DisGeNETTNFRSF10A
MedgenTNFRSF10A
Genetic Testing Registry TNFRSF10A
NextProtO00220 [Medical]
TSGene8797
GENETestsTNFRSF10A
Target ValidationTNFRSF10A
Huge Navigator TNFRSF10A [HugePedia]
snp3D : Map Gene to Disease8797
BioCentury BCIQTNFRSF10A
ClinGenTNFRSF10A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8797
Chemical/Pharm GKB GenePA36597
Clinical trialTNFRSF10A
Miscellaneous
canSAR (ICR)TNFRSF10A (select the gene name)
DataMed IndexTNFRSF10A
Probes
Litterature
PubMed239 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNFRSF10A
EVEXTNFRSF10A
GoPubMedTNFRSF10A
iHOPTNFRSF10A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Feb 3 15:29:25 CET 2020
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