Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TNFRSF10B (TNF receptor superfamily member 10b)

Identity

Alias (NCBI)CD262
DR5
KILLER
KILLER/DR5
TRAIL-R2
TRAILR2
TRICK2
TRICK2A
TRICK2B
TRICKB
ZTNFR9
HGNC (Hugo) TNFRSF10B
HGNC Alias symbDR5
KILLER
TRICK2A
TRAIL-R2
TRICKB
CD262
TRAILR2
HGNC Previous nametumor necrosis factor receptor superfamily, member 10b
LocusID (NCBI) 8795
Atlas_Id 42606
Location 8p21.3  [Link to chromosome band 8p21]
Location_base_pair Starts at 23020136 and ends at 23069031 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TNFRSF10B   11905
Cards
Entrez_Gene (NCBI)TNFRSF10B    TNF receptor superfamily member 10b
AliasesCD262; DR5; KILLER; KILLER/DR5; 
TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; ZTNFR9
GeneCards (Weizmann)TNFRSF10B
Ensembl hg19 (Hinxton)ENSG00000120889 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120889 [Gene_View]  ENSG00000120889 [Sequence]  chr8:23020136-23069031 [Contig_View]  TNFRSF10B [Vega]
ICGC DataPortalENSG00000120889
TCGA cBioPortalTNFRSF10B
AceView (NCBI)TNFRSF10B
Genatlas (Paris)TNFRSF10B
SOURCE (Princeton)TNFRSF10B
Genetics Home Reference (NIH)TNFRSF10B
Genomic and cartography
GoldenPath hg38 (UCSC)TNFRSF10B  -     chr8:23020136-23069031 -  8p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFRSF10B  -     8p21.3   [Description]    (hg19-Feb_2009)
GoldenPathTNFRSF10B - 8p21.3 [CytoView hg19]  TNFRSF10B - 8p21.3 [CytoView hg38]
ImmunoBaseENSG00000120889
genome Data Viewer NCBITNFRSF10B [Mapview hg19]  
OMIM275355   603612   
Gene and transcription
Genbank (Entrez)AB451272 AB451399 AF012535 AF012628 AF016266
RefSeq transcript (Entrez)NM_003842 NM_147187
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNFRSF10B
Alternative Splicing GalleryENSG00000120889
Gene ExpressionTNFRSF10B [ NCBI-GEO ]   TNFRSF10B [ EBI - ARRAY_EXPRESS ]   TNFRSF10B [ SEEK ]   TNFRSF10B [ MEM ]
Gene Expression Viewer (FireBrowse)TNFRSF10B [ Firebrowse - Broad ]
GenevisibleExpression of TNFRSF10B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8795
GTEX Portal (Tissue expression)TNFRSF10B
Human Protein AtlasENSG00000120889-TNFRSF10B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14763   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14763  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14763
Splice isoforms : SwissVarO14763
PhosPhoSitePlusO14763
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)DEATH-like_dom_sf    Death_domain    TNFR/NGFR_Cys_rich_reg    TNFR_10    TNFRSF10_N    TNFRSF10A/B_death   
Domain families : Pfam (Sanger)Death (PF00531)    TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00531    pfam00020   
Domain families : Smart (EMBL)DEATH (SM00005)  TNFR (SM00208)  
Conserved Domain (NCBI)TNFRSF10B
Blocks (Seattle)TNFRSF10B
PDB (RSDB)1D0G    1D4V    1DU3    1ZA3    2H9G    3X3F    4I9X    4N90    4OD2    6NHW    6NHY   
PDB Europe1D0G    1D4V    1DU3    1ZA3    2H9G    3X3F    4I9X    4N90    4OD2    6NHW    6NHY   
PDB (PDBSum)1D0G    1D4V    1DU3    1ZA3    2H9G    3X3F    4I9X    4N90    4OD2    6NHW    6NHY   
PDB (IMB)1D0G    1D4V    1DU3    1ZA3    2H9G    3X3F    4I9X    4N90    4OD2    6NHW    6NHY   
Structural Biology KnowledgeBase1D0G    1D4V    1DU3    1ZA3    2H9G    3X3F    4I9X    4N90    4OD2    6NHW    6NHY   
SCOP (Structural Classification of Proteins)1D0G    1D4V    1DU3    1ZA3    2H9G    3X3F    4I9X    4N90    4OD2    6NHW    6NHY   
CATH (Classification of proteins structures)1D0G    1D4V    1DU3    1ZA3    2H9G    3X3F    4I9X    4N90    4OD2    6NHW    6NHY   
SuperfamilyO14763
Human Protein Atlas [tissue]ENSG00000120889-TNFRSF10B [tissue]
Peptide AtlasO14763
HPRD04680
IPIIPI00296379   IPI00296380   IPI00965817   IPI01012165   IPI00796239   
Protein Interaction databases
DIP (DOE-UCLA)O14763
IntAct (EBI)O14763
BioGRIDTNFRSF10B
STRING (EMBL)TNFRSF10B
ZODIACTNFRSF10B
Ontologies - Pathways
QuickGOO14763
Ontology : AmiGOprotein binding  plasma membrane  plasma membrane  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  cell surface receptor signaling pathway  activation of NF-kappaB-inducing kinase activity  extrinsic apoptotic signaling pathway via death domain receptors  cell surface  cell surface  integral component of membrane  response to endoplasmic reticulum stress  TRAIL-activated apoptotic signaling pathway  signaling receptor activity  regulation of apoptotic process  regulation of apoptotic process  positive regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  TRAIL binding  leukocyte migration  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  cellular response to mechanical stimulus  regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
Ontology : EGO-EBIprotein binding  plasma membrane  plasma membrane  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  cell surface receptor signaling pathway  activation of NF-kappaB-inducing kinase activity  extrinsic apoptotic signaling pathway via death domain receptors  cell surface  cell surface  integral component of membrane  response to endoplasmic reticulum stress  TRAIL-activated apoptotic signaling pathway  signaling receptor activity  regulation of apoptotic process  regulation of apoptotic process  positive regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  TRAIL binding  leukocyte migration  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  cellular response to mechanical stimulus  regulation of extrinsic apoptotic signaling pathway via death domain receptors  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
Pathways : KEGGCytokine-cytokine receptor interaction    p53 signaling pathway    Apoptosis    Natural killer cell mediated cytotoxicity    Measles    Influenza A   
NDEx NetworkTNFRSF10B
Atlas of Cancer Signalling NetworkTNFRSF10B
Wikipedia pathwaysTNFRSF10B
Orthology - Evolution
OrthoDB8795
GeneTree (enSembl)ENSG00000120889
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF10B
HOGENOMO14763
Homologs : HomoloGeneTNFRSF10B
Homology/Alignments : Family Browser (UCSC)TNFRSF10B
Gene fusions - Rearrangements
Fusion : QuiverTNFRSF10B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFRSF10B [hg38]
dbVarTNFRSF10B
ClinVarTNFRSF10B
MonarchTNFRSF10B
1000_GenomesTNFRSF10B 
Exome Variant ServerTNFRSF10B
GNOMAD BrowserENSG00000120889
Varsome BrowserTNFRSF10B
Genomic Variants (DGV)TNFRSF10B [DGVbeta]
DECIPHERTNFRSF10B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFRSF10B 
Mutations
ICGC Data PortalTNFRSF10B 
TCGA Data PortalTNFRSF10B 
Broad Tumor PortalTNFRSF10B
OASIS PortalTNFRSF10B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFRSF10B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNFRSF10B
Mutations and Diseases : HGMDTNFRSF10B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Death Receptor Database (DRdb)
BioMutasearch TNFRSF10B
DgiDB (Drug Gene Interaction Database)TNFRSF10B
DoCM (Curated mutations)TNFRSF10B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF10B (select a term)
intoGenTNFRSF10B
Cancer3DTNFRSF10B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM275355    603612   
Orphanet
DisGeNETTNFRSF10B
MedgenTNFRSF10B
Genetic Testing Registry TNFRSF10B
NextProtO14763 [Medical]
GENETestsTNFRSF10B
Target ValidationTNFRSF10B
Huge Navigator TNFRSF10B [HugePedia]
ClinGenTNFRSF10B
Clinical trials, drugs, therapy
MyCancerGenomeTNFRSF10B
Protein Interactions : CTD
Pharm GKB GenePA36598
PharosO14763
Clinical trialTNFRSF10B
Miscellaneous
canSAR (ICR)TNFRSF10B (select the gene name)
HarmonizomeTNFRSF10B
DataMed IndexTNFRSF10B
Probes
Litterature
PubMed365 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNFRSF10B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:41:44 CET 2021
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