TNFRSF10B (TNF receptor superfamily member 10b)

2003-02-01  

Identity

HGNC
LOCATION
8p21.3
LOCUSID
ALIAS
CD262,DR5,KILLER,KILLER/DR5,TRAIL-R2,TRAILR2,TRICK2,TRICK2A,TRICK2B,TRICKB,ZTNFR9

Other Information

Locus ID:

NCBI: 8795
MIM: 603612
HGNC: 11905
Ensembl: ENSG00000120889

Variants:

dbSNP: 8795
ClinVar: 8795
TCGA: ENSG00000120889
COSMIC: TNFRSF10B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120889ENST00000276431O14763
ENSG00000120889ENST00000347739O14763
ENSG00000120889ENST00000523504E9PBT3

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
p53 signaling pathwayKEGGko04115
ApoptosisKEGGko04210
Natural killer cell mediated cytotoxicityKEGGko04650
Cytokine-cytokine receptor interactionKEGGhsa04060
p53 signaling pathwayKEGGhsa04115
ApoptosisKEGGhsa04210
Natural killer cell mediated cytotoxicityKEGGhsa04650
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
TRAIL signalingREACTOMER-HSA-75158
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-dependent caspase activationREACTOMER-HSA-140534
Dimerization of procaspase-8REACTOMER-HSA-69416
Regulation by c-FLIPREACTOMER-HSA-3371378
Regulated NecrosisREACTOMER-HSA-5218859
RIPK1-mediated regulated necrosisREACTOMER-HSA-5213460
Regulation of necroptotic cell deathREACTOMER-HSA-5675482
CASP8 activity is inhibitedREACTOMER-HSA-5218900
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Death Receptors and LigandsREACTOMER-HSA-6803211

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
249946552014Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis.181
166326042006Differential expression of IFN-alpha and TRAIL/DR5 in lymphoid tissue of progressor versus nonprogressor HIV-1-infected patients.101
232542872013Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion.95
190748312008TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5.89
169806092006Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2.86
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
155200162005Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signaling.72
105420981999Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.70
180799622008TRAIL-R deficiency in mice promotes susceptibility to chronic inflammation and tumorigenesis.66
182193212008Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5.61

Citation

Dessen P

TNFRSF10B (TNF receptor superfamily member 10b)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42606/tnfrsf10b