Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TNFRSF10B (tumor necrosis factor receptor superfamily member 10b)

Identity

Other namesCD262
DR5
KILLER
KILLER/DR5
TRAIL-R2
TRAILR2
TRICK2
TRICK2A
TRICK2B
TRICKB
ZTNFR9
HGNC (Hugo) TNFRSF10B
LocusID (NCBI) 8795
Atlas_Id 42606
Location 8p21.3
Location_base_pair Starts at 22877648 and ends at 22926700 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNFRSF10B   11905
Cards
Entrez_Gene (NCBI)TNFRSF10B  8795  tumor necrosis factor receptor superfamily member 10b
GeneCards (Weizmann)TNFRSF10B
Ensembl hg19 (Hinxton)ENSG00000120889 [Gene_View]  chr8:22877648-22926700 [Contig_View]  TNFRSF10B [Vega]
Ensembl hg38 (Hinxton)ENSG00000120889 [Gene_View]  chr8:22877648-22926700 [Contig_View]  TNFRSF10B [Vega]
ICGC DataPortalENSG00000120889
TCGA cBioPortalTNFRSF10B
AceView (NCBI)TNFRSF10B
Genatlas (Paris)TNFRSF10B
WikiGenes8795
SOURCE (Princeton)TNFRSF10B
Genomic and cartography
GoldenPath hg19 (UCSC)TNFRSF10B  -     chr8:22877648-22926700 -  8p21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TNFRSF10B  -     8p21.3   [Description]    (hg38-Dec_2013)
EnsemblTNFRSF10B - 8p21.3 [CytoView hg19]  TNFRSF10B - 8p21.3 [CytoView hg38]
Mapping of homologs : NCBITNFRSF10B [Mapview hg19]  TNFRSF10B [Mapview hg38]
OMIM275355   603612   
Gene and transcription
Genbank (Entrez)AB451272 AB451399 AF012535 AF012628 AF016266
RefSeq transcript (Entrez)NM_003842 NM_147187
RefSeq genomic (Entrez)NC_000008 NC_018919 NG_012145 NT_167187 NW_004929337
Consensus coding sequences : CCDS (NCBI)TNFRSF10B
Cluster EST : UnigeneHs.661668 [ NCBI ]
CGAP (NCI)Hs.661668
Alternative Splicing : Fast-db (Paris)GSHG0029464
Alternative Splicing GalleryENSG00000120889
Gene ExpressionTNFRSF10B [ NCBI-GEO ]     TNFRSF10B [ SEEK ]   TNFRSF10B [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)8795
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14763 (Uniprot)
NextProtO14763  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14763
Splice isoforms : SwissVarO14763 (Swissvar)
PhosPhoSitePlusO14763
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)DEATH-like_dom    Death_domain    TNFR/NGFR_Cys_rich_reg    TNFR_10   
Domain families : Pfam (Sanger)Death (PF00531)    TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00531    pfam00020   
Domain families : Smart (EMBL)DEATH (SM00005)  TNFR (SM00208)  
DMDM Disease mutations8795
Blocks (Seattle)TNFRSF10B
PDB (SRS)1D0G    1D4V    1DU3    1ZA3    2H9G    4I9X    4N90    4OD2   
PDB (PDBSum)1D0G    1D4V    1DU3    1ZA3    2H9G    4I9X    4N90    4OD2   
PDB (IMB)1D0G    1D4V    1DU3    1ZA3    2H9G    4I9X    4N90    4OD2   
PDB (RSDB)1D0G    1D4V    1DU3    1ZA3    2H9G    4I9X    4N90    4OD2   
Structural Biology KnowledgeBase1D0G    1D4V    1DU3    1ZA3    2H9G    4I9X    4N90    4OD2   
SCOP (Structural Classification of Proteins)1D0G    1D4V    1DU3    1ZA3    2H9G    4I9X    4N90    4OD2   
CATH (Classification of proteins structures)1D0G    1D4V    1DU3    1ZA3    2H9G    4I9X    4N90    4OD2   
Human Protein AtlasENSG00000120889
Peptide AtlasO14763
HPRD04680
IPIIPI00296379   IPI00296380   IPI00965817   IPI01012165   IPI00796239   
Protein Interaction databases
DIP (DOE-UCLA)O14763
IntAct (EBI)O14763
FunCoupENSG00000120889
BioGRIDTNFRSF10B
IntegromeDBTNFRSF10B
STRING (EMBL)TNFRSF10B
ZODIACTNFRSF10B
Ontologies - Pathways
QuickGOO14763
Ontology : AmiGOreceptor activity  tumor necrosis factor-activated receptor activity  protein binding  intracellular  intracellular  intracellular  plasma membrane  integral component of plasma membrane  apoptotic process  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  inflammatory response  immune response  cell surface receptor signaling pathway  activation of NF-kappaB-inducing kinase activity  multicellular organismal development  extrinsic apoptotic signaling pathway via death domain receptors  extrinsic apoptotic signaling pathway via death domain receptors  cell surface  regulation of necrotic cell death  programmed cell death  integral component of membrane  response to lipopolysaccharide  tumor necrosis factor-mediated signaling pathway  response to endoplasmic reticulum stress  regulation of cell proliferation  regulation of apoptotic process  regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  TRAIL binding  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  necroptotic process  cellular response to mechanical stimulus  extrinsic apoptotic signaling pathway  activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  programmed necrotic cell death  regulation of extrinsic apoptotic signaling pathway via death domain receptors  
Ontology : EGO-EBIreceptor activity  tumor necrosis factor-activated receptor activity  protein binding  intracellular  intracellular  intracellular  plasma membrane  integral component of plasma membrane  apoptotic process  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  inflammatory response  immune response  cell surface receptor signaling pathway  activation of NF-kappaB-inducing kinase activity  multicellular organismal development  extrinsic apoptotic signaling pathway via death domain receptors  extrinsic apoptotic signaling pathway via death domain receptors  cell surface  regulation of necrotic cell death  programmed cell death  integral component of membrane  response to lipopolysaccharide  tumor necrosis factor-mediated signaling pathway  response to endoplasmic reticulum stress  regulation of cell proliferation  regulation of apoptotic process  regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  TRAIL binding  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  necroptotic process  cellular response to mechanical stimulus  extrinsic apoptotic signaling pathway  activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  programmed necrotic cell death  regulation of extrinsic apoptotic signaling pathway via death domain receptors  
Pathways : KEGGCytokine-cytokine receptor interaction    p53 signaling pathway    Apoptosis    Natural killer cell mediated cytotoxicity    Measles    Influenza A   
Protein Interaction DatabaseTNFRSF10B
Atlas of Cancer Signalling NetworkTNFRSF10B
Wikipedia pathwaysTNFRSF10B
Orthology - Evolution
OrthoDB8795
GeneTree (enSembl)ENSG00000120889
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF10B
Homologs : HomoloGeneTNFRSF10B
Homology/Alignments : Family Browser (UCSC)TNFRSF10B
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTNFRSF10B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFRSF10B
dbVarTNFRSF10B
ClinVarTNFRSF10B
1000_GenomesTNFRSF10B 
Exome Variant ServerTNFRSF10B
Exome Aggregation Consortium (ExAC)ENSG00000120889
SNP (GeneSNP Utah)TNFRSF10B
SNP : HGBaseTNFRSF10B
Genetic variants : HAPMAPTNFRSF10B
Genomic Variants (DGV)TNFRSF10B [DGVbeta]
Mutations
ICGC Data PortalTNFRSF10B 
TCGA Data PortalTNFRSF10B 
Tumor PortalTNFRSF10B
TCGA Copy Number PortalTNFRSF10B
Somatic Mutations in Cancer : COSMICTNFRSF10B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Death Receptor Database (DRdb)
BioMutasearch TNFRSF10B
DgiDB (Drug Gene Interaction Database)TNFRSF10B
DoCM (Curated mutations)TNFRSF10B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF10B (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)8:22877648-22926700
CONAN: Copy Number AnalysisTNFRSF10B 
Mutations and Diseases : HGMDTNFRSF10B
OMIM275355    603612   
MedgenTNFRSF10B
NextProtO14763 [Medical]
TSGene8795
GENETestsTNFRSF10B
Huge Navigator TNFRSF10B [HugePedia]  TNFRSF10B [HugeCancerGEM]
snp3D : Map Gene to Disease8795
BioCentury BCIQTNFRSF10B
General knowledge
Chemical/Protein Interactions : CTD8795
Chemical/Pharm GKB GenePA36598
Clinical trialTNFRSF10B
Other databases
Probes
Litterature
PubMed283 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNFRSF10B
GoPubMedTNFRSF10B
iHOPTNFRSF10B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jan 16 19:39:04 CET 2016

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