TNFRSF10B (tumor necrosis factor receptor superfamily, member 10b)

Identity

Other names	CD262
	DR5
	KILLER
	KILLER/DR5
	TRAIL-R2
	TRAILR2
	TRICK2
	TRICK2A
	TRICK2B
	TRICKB
	ZTNFR9
HGNC	TNFRSF10B
Location	8p22-p21
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	TNFRSF10B   11905
Entrez_Gene	TNFRSF10B  8795  tumor necrosis factor receptor superfamily, member 10b
	Cards
GeneCards	TNFRSF10B
Ensembl	TNFRSF10B [Search_View]   ENSG00000120889 [Gene_View]
Genatlas	TNFRSF10B
GeneLynx	TNFRSF10B
eGenome	TNFRSF10B
euGene	8795
	Genomic and cartography
GoldenPath	TNFRSF10B  -     chr8:22933593-22982637 -  8p21.3   [Description]    (hg18-March_2006)
Ensembl	TNFRSF10B - 8p21.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TNFRSF10B
	Gene and transcription
Genbank	AF012535 [ ENTREZ ]
Genbank	AF012628 [ ENTREZ ]
Genbank	AF016266 [ ENTREZ ]
Genbank	AF016268 [ ENTREZ ]
Genbank	AF016849 [ ENTREZ ]
RefSeq	NM_003842 [ SRS ]    NM_003842 [ ENTREZ ]
RefSeq	NM_147187 [ SRS ]    NM_147187 [ ENTREZ ]
RefSeq	AC_000051 [ SRS ]    AC_000051 [ ENTREZ ]
RefSeq	AC_000140 [ SRS ]    AC_000140 [ ENTREZ ]
RefSeq	NC_000008 [ SRS ]    NC_000008 [ ENTREZ ]
RefSeq	NT_023666 [ SRS ]    NT_023666 [ ENTREZ ]
RefSeq	NW_001839127 [ SRS ]    NW_001839127 [ ENTREZ ]
RefSeq	NW_923907 [ SRS ]    NW_923907 [ ENTREZ ]
AceView	TNFRSF10B AceView - NCBI
Unigene	Hs.521456 [ SRS ]    Hs.521456 [ NCBI ]     HS521456 [ spliceNest ]
Fast-db	2588 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O14763 [ SRS]    O14763 [ EXPASY ]     O14763 [ INTERPRO ]     O14763 [ UNIPROT ]
Prosite	PS50017 DEATH_DOMAIN [ SRS ]    PS50017 DEATH_DOMAIN [ Expasy ]
Prosite	PS00652 TNFR_NGFR_1 [ SRS ]    PS00652 TNFR_NGFR_1 [ Expasy ]
Prosite	PS50050 TNFR_NGFR_2 [ SRS ]    PS50050 TNFR_NGFR_2 [ Expasy ]
Interpro	IPR000488 Death [ SRS ]    IPR000488 Death [ EBI ]
Interpro	IPR011029 DEATH_like [ SRS ]    IPR011029 DEATH_like [ EBI ]
Interpro	IPR017301 TNF-rel_apoptosis-ind_lig_rcpt [ SRS ]    IPR017301 TNF-rel_apoptosis-ind_lig_rcpt [ EBI ]
Interpro	IPR001368 TNFR_c6 [ SRS ]    IPR001368 TNFR_c6 [ EBI ]
CluSTr	O14763
Pfam	PF00531 Death [ SRS ]    PF00531 Death [ Sanger ]    pfam00531 [ NCBI-CDD ]
Pfam	PF00020 TNFR_c6 [ SRS ]    PF00020 TNFR_c6 [ Sanger ]    pfam00020 [ NCBI-CDD ]
Smart	SM00005 DEATH [EMBL]
Smart	SM00208 TNFR [EMBL]
Blocks	O14763
PDB	1D0G [ SRS ]    1D0G [ PdbSum ],   1D0G [ IMB ]   1D0G [ RSDB ]
PDB	1D4V [ SRS ]    1D4V [ PdbSum ],   1D4V [ IMB ]   1D4V [ RSDB ]
PDB	1DU3 [ SRS ]    1DU3 [ PdbSum ],   1DU3 [ IMB ]   1DU3 [ RSDB ]
PDB	1ZA3 [ SRS ]    1ZA3 [ PdbSum ],   1ZA3 [ IMB ]   1ZA3 [ RSDB ]
PDB	2H9G [ SRS ]    2H9G [ PdbSum ],   2H9G [ IMB ]   2H9G [ RSDB ]
HPRD	04680
	Protein Interaction databases
DIP	O14763
IntAct	O14763
	Polymorphism : SNP, mutations, diseases
OMIM	275355;603612    [ map ]
GENECLINICS	275355;603612
SNP	TNFRSF10B [dbSNP-NCBI]
SNP	NM_003842 [SNP-NCI]
SNP	NM_147187 [SNP-NCI]
SNP	TNFRSF10B [GeneSNPs - Utah]  TNFRSF10B] [HGBASE - SRS]
HAPMAP	TNFRSF10B [HAPMAP]
COSMIC	TNFRSF10B [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TNFRSF10B
	General knowledge
Family Browser	TNFRSF10B [UCSC Family Browser]
SOURCE	NM_003842
SOURCE	NM_147187
SMD	Hs.521456
SAGE	Hs.521456
GO	receptor activity [Amigo]  receptor activity
GO	receptor activity [Amigo]  receptor activity
GO	protein binding [Amigo]  protein binding
GO	plasma membrane [Amigo]  plasma membrane
GO	caspase activation [Amigo]  caspase activation
GO	signal transduction [Amigo]  signal transduction
GO	cell surface receptor linked signal transduction [Amigo]  cell surface receptor linked signal transduction
GO	activation of NF-kappaB-inducing kinase activity [Amigo]  activation of NF-kappaB-inducing kinase activity
GO	induction of apoptosis via death domain receptors [Amigo]  induction of apoptosis via death domain receptors
GO	activation of pro-apoptotic gene products [Amigo]  activation of pro-apoptotic gene products
GO	caspase activator activity [Amigo]  caspase activator activity
GO	integral to membrane [Amigo]  integral to membrane
GO	regulation of apoptosis [Amigo]  regulation of apoptosis
GO	positive regulation of I-kappaB kinase/NF-kappaB cascade [Amigo]  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO	TRAIL binding [Amigo]  TRAIL binding
KEGG	Cytokine-cytokine receptor interaction
KEGG	Apoptosis
KEGG	Natural killer cell mediated cytotoxicity
PubGene	TNFRSF10B
TreeFam	TNFRSF10B
CTD	8795 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TNFRSF10B Related clones (RZPD - Berlin)
	PubMed
PubMed	110 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:35:34 2008