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TNFRSF10B (tumor necrosis factor receptor superfamily, member 10b)

Identity

Other namesCD262
DR5
KILLER
KILLER/DR5
TRAIL-R2
TRAILR2
TRICK2
TRICK2A
TRICK2B
TRICKB
ZTNFR9
HGNC (Hugo) TNFRSF10B
LocusID (NCBI) 8795
Location 8p21.3
Location_base_pair Starts at 22877648 and ends at 22926700 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TNFRSF10B   11905
Cards
Entrez_Gene (NCBI)TNFRSF10B  8795  tumor necrosis factor receptor superfamily, member 10b
GeneCards (Weizmann)TNFRSF10B
Ensembl (Hinxton)ENSG00000120889 [Gene_View]  chr8:22877648-22926700 [Contig_View]  TNFRSF10B [Vega]
ICGC DataPortalENSG00000120889
AceView (NCBI)TNFRSF10B
Genatlas (Paris)TNFRSF10B
WikiGenes8795
SOURCE (Princeton)NM_003842 NM_147187
Genomic and cartography
GoldenPath (UCSC)TNFRSF10B  -  8p21.3   chr8:22877648-22926700 -  8p21.3   [Description]    (hg19-Feb_2009)
EnsemblTNFRSF10B - 8p21.3 [CytoView]
Mapping of homologs : NCBITNFRSF10B [Mapview]
OMIM275355   603612   
Gene and transcription
Genbank (Entrez)AB451272 AB451399 AF012535 AF012628 AF016266
RefSeq transcript (Entrez)NM_003842 NM_147187
RefSeq genomic (Entrez)AC_000140 NC_000008 NC_018919 NG_012145 NT_167187 NW_001839127 NW_004929337
Consensus coding sequences : CCDS (NCBI)TNFRSF10B
Cluster EST : UnigeneHs.521456 [ NCBI ]
CGAP (NCI)Hs.521456
Alternative Splicing : Fast-db (Paris)GSHG0029464
Alternative Splicing GalleryENSG00000120889
Gene ExpressionTNFRSF10B [ NCBI-GEO ]     TNFRSF10B [ SEEK ]   TNFRSF10B [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14763 (Uniprot)
NextProtO14763  [Medical]
With graphics : InterProO14763
Splice isoforms : SwissVarO14763 (Swissvar)
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)DEATH-like_dom    Death_domain    TNFR/NGFR_Cys_rich_reg    TNFR_10   
Related proteins : CluSTrO14763
Domain families : Pfam (Sanger)Death (PF00531)    TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00531    pfam00020   
Domain families : Smart (EMBL)DEATH (SM00005)  TNFR (SM00208)  
DMDM Disease mutations8795
Blocks (Seattle)O14763
PDB (SRS)1D0G    1D4V    1DU3    1ZA3    2H9G    4I9X   
PDB (PDBSum)1D0G    1D4V    1DU3    1ZA3    2H9G    4I9X   
PDB (IMB)1D0G    1D4V    1DU3    1ZA3    2H9G    4I9X   
PDB (RSDB)1D0G    1D4V    1DU3    1ZA3    2H9G    4I9X   
Human Protein AtlasENSG00000120889
Peptide AtlasO14763
HPRD04680
IPIIPI00296379   IPI00296380   IPI00965817   IPI01012165   IPI00796239   
Protein Interaction databases
DIP (DOE-UCLA)O14763
IntAct (EBI)O14763
FunCoupENSG00000120889
BioGRIDTNFRSF10B
IntegromeDBTNFRSF10B
STRING (EMBL)TNFRSF10B
Ontologies - Pathways
QuickGOO14763
Ontology : AmiGOreceptor activity  protein binding  plasma membrane  apoptotic process  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  cell surface receptor signaling pathway  activation of NF-kappaB-inducing kinase activity  extrinsic apoptotic signaling pathway via death domain receptors  integral component of membrane  response to endoplasmic reticulum stress  regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  TRAIL binding  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  cellular response to mechanical stimulus  apoptotic signaling pathway  regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBIreceptor activity  protein binding  plasma membrane  apoptotic process  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  cell surface receptor signaling pathway  activation of NF-kappaB-inducing kinase activity  extrinsic apoptotic signaling pathway via death domain receptors  integral component of membrane  response to endoplasmic reticulum stress  regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  TRAIL binding  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  cellular response to mechanical stimulus  apoptotic signaling pathway  regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : KEGGCytokine-cytokine receptor interaction    p53 signaling pathway    Apoptosis    Natural killer cell mediated cytotoxicity    Measles    Influenza A   
Protein Interaction DatabaseTNFRSF10B
Wikipedia pathwaysTNFRSF10B
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TNFRSF10B
SNP (GeneSNP Utah)TNFRSF10B
SNP : HGBaseTNFRSF10B
Genetic variants : HAPMAPTNFRSF10B
1000_GenomesTNFRSF10B 
ICGC programENSG00000120889 
CONAN: Copy Number AnalysisTNFRSF10B 
Somatic Mutations in Cancer : COSMICTNFRSF10B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Death Receptor Database (DRdb)
DECIPHER (Syndromes)8:22877648-22926700
Mutations and Diseases : HGMDTNFRSF10B
OMIM275355    603612   
MedgenTNFRSF10B
GENETestsTNFRSF10B
Disease Genetic AssociationTNFRSF10B
Huge Navigator TNFRSF10B [HugePedia]  TNFRSF10B [HugeCancerGEM]
Genomic VariantsTNFRSF10B  TNFRSF10B [DGVbeta]
Exome VariantTNFRSF10B
dbVarTNFRSF10B
ClinVarTNFRSF10B
snp3D : Map Gene to Disease8795
General knowledge
Homologs : HomoloGeneTNFRSF10B
Homology/Alignments : Family Browser (UCSC)TNFRSF10B
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF10B
Chemical/Protein Interactions : CTD8795
Chemical/Pharm GKB GenePA36598
Clinical trialTNFRSF10B
Cancer Resource (Charite)ENSG00000120889
Other databases
Probes
Litterature
PubMed258 Pubmed reference(s) in Entrez
CoreMineTNFRSF10B
GoPubMedTNFRSF10B
iHOPTNFRSF10B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 18:02:10 CET 2014

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