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TNFRSF10C (TNF receptor superfamily member 10c)

Identity

Alias (NCBI)CD263
DCR1
DCR1-TNFR
LIT
TRAIL-R3
TRAILR3
TRID
HGNC (Hugo) TNFRSF10C
HGNC Alias symbDcR1
TRAILR3
LIT
TRID
CD263
HGNC Previous nametumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
LocusID (NCBI) 8794
Atlas_Id 42607
Location 8p21.3  [Link to chromosome band 8p21]
Location_base_pair Starts at 23102921 and ends at 23117445 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AMMECR1L (2q14.3) / TNFRSF10C (8p21.3)NUCKS1 (1q32.1) / TNFRSF10C (8p21.3)AMMECR1L 2q14.3 / TNFRSF10C 8p21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;8)(q14;p21) AMMECR1L/TNFRSF10C

External links

Nomenclature
HGNC (Hugo)TNFRSF10C   11906
Cards
Entrez_Gene (NCBI)TNFRSF10C    TNF receptor superfamily member 10c
AliasesCD263; DCR1; DCR1-TNFR; LIT; 
TRAIL-R3; TRAILR3; TRID
GeneCards (Weizmann)TNFRSF10C
Ensembl hg19 (Hinxton)ENSG00000173535 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173535 [Gene_View]  ENSG00000173535 [Sequence]  chr8:23102921-23117445 [Contig_View]  TNFRSF10C [Vega]
ICGC DataPortalENSG00000173535
TCGA cBioPortalTNFRSF10C
AceView (NCBI)TNFRSF10C
Genatlas (Paris)TNFRSF10C
SOURCE (Princeton)TNFRSF10C
Genetics Home Reference (NIH)TNFRSF10C
Genomic and cartography
GoldenPath hg38 (UCSC)TNFRSF10C  -     chr8:23102921-23117445 +  8p21.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFRSF10C  -     8p21.3   [Description]    (hg19-Feb_2009)
GoldenPathTNFRSF10C - 8p21.3 [CytoView hg19]  TNFRSF10C - 8p21.3 [CytoView hg38]
ImmunoBaseENSG00000173535
genome Data Viewer NCBITNFRSF10C [Mapview hg19]  
OMIM603613   
Gene and transcription
Genbank (Entrez)AF012536 AF012629 AF014794 AF016267 AF020502
RefSeq transcript (Entrez)NM_003841
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNFRSF10C
Alternative Splicing GalleryENSG00000173535
Gene ExpressionTNFRSF10C [ NCBI-GEO ]   TNFRSF10C [ EBI - ARRAY_EXPRESS ]   TNFRSF10C [ SEEK ]   TNFRSF10C [ MEM ]
Gene Expression Viewer (FireBrowse)TNFRSF10C [ Firebrowse - Broad ]
GenevisibleExpression of TNFRSF10C in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8794
GTEX Portal (Tissue expression)TNFRSF10C
Human Protein AtlasENSG00000173535-TNFRSF10C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14798   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14798  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14798
Splice isoforms : SwissVarO14798
PhosPhoSitePlusO14798
Domaine pattern : Prosite (Expaxy)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)TNFR/NGFR_Cys_rich_reg    TNFR_10    TNFRSF10_N   
Domain families : Pfam (Sanger)TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00020   
Domain families : Smart (EMBL)TNFR (SM00208)  
Conserved Domain (NCBI)TNFRSF10C
Blocks (Seattle)TNFRSF10C
SuperfamilyO14798
Human Protein Atlas [tissue]ENSG00000173535-TNFRSF10C [tissue]
Peptide AtlasO14798
HPRD04681
Protein Interaction databases
DIP (DOE-UCLA)O14798
IntAct (EBI)O14798
BioGRIDTNFRSF10C
STRING (EMBL)TNFRSF10C
ZODIACTNFRSF10C
Ontologies - Pathways
QuickGOO14798
Ontology : AmiGOtransmembrane signaling receptor activity  plasma membrane  plasma membrane  cell surface  anchored component of membrane  TRAIL-activated apoptotic signaling pathway  regulation of apoptotic process  positive regulation of apoptotic process  TRAIL binding  
Ontology : EGO-EBItransmembrane signaling receptor activity  plasma membrane  plasma membrane  cell surface  anchored component of membrane  TRAIL-activated apoptotic signaling pathway  regulation of apoptotic process  positive regulation of apoptotic process  TRAIL binding  
Pathways : KEGGCytokine-cytokine receptor interaction    Apoptosis    Natural killer cell mediated cytotoxicity    Measles    Influenza A   
NDEx NetworkTNFRSF10C
Atlas of Cancer Signalling NetworkTNFRSF10C
Wikipedia pathwaysTNFRSF10C
Orthology - Evolution
OrthoDB8794
GeneTree (enSembl)ENSG00000173535
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF10C
HOGENOMO14798
Homologs : HomoloGeneTNFRSF10C
Homology/Alignments : Family Browser (UCSC)TNFRSF10C
Gene fusions - Rearrangements
Fusion : MitelmanAMMECR1L/TNFRSF10C [2q14.3/8p21.3]  
Fusion PortalAMMECR1L 2q14.3 TNFRSF10C 8p21.3 PRAD
Fusion : QuiverTNFRSF10C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFRSF10C [hg38]
dbVarTNFRSF10C
ClinVarTNFRSF10C
MonarchTNFRSF10C
1000_GenomesTNFRSF10C 
Exome Variant ServerTNFRSF10C
GNOMAD BrowserENSG00000173535
Varsome BrowserTNFRSF10C
Genomic Variants (DGV)TNFRSF10C [DGVbeta]
DECIPHERTNFRSF10C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFRSF10C 
Mutations
ICGC Data PortalTNFRSF10C 
TCGA Data PortalTNFRSF10C 
Broad Tumor PortalTNFRSF10C
OASIS PortalTNFRSF10C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFRSF10C  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNFRSF10C
Mutations and Diseases : HGMDTNFRSF10C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Death Receptor Database (DRdb)
BioMutasearch TNFRSF10C
DgiDB (Drug Gene Interaction Database)TNFRSF10C
DoCM (Curated mutations)TNFRSF10C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF10C (select a term)
intoGenTNFRSF10C
Cancer3DTNFRSF10C(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603613   
Orphanet
DisGeNETTNFRSF10C
MedgenTNFRSF10C
Genetic Testing Registry TNFRSF10C
NextProtO14798 [Medical]
GENETestsTNFRSF10C
Target ValidationTNFRSF10C
Huge Navigator TNFRSF10C [HugePedia]
ClinGenTNFRSF10C
Clinical trials, drugs, therapy
MyCancerGenomeTNFRSF10C
Protein Interactions : CTD
Pharm GKB GenePA36599
PharosO14798
Clinical trialTNFRSF10C
Miscellaneous
canSAR (ICR)TNFRSF10C (select the gene name)
HarmonizomeTNFRSF10C
DataMed IndexTNFRSF10C
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNFRSF10C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:41:44 CET 2021
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