TNFRSF11A (TNF receptor superfamily member 11a)

2013-05-01  

Identity

HGNC
TNFRSF11A
LOCATION
18q21.33
LOCUSID
8792
ALIAS
CD265,FEO,LOH18CR1,ODFR,OFE,OPTB7,OSTS,PDB2,RANK,TRANCE-R,TRANCER
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8792
MIM: 603499
HGNC: 11908
Ensembl: ENSG00000141655

Variants:

dbSNP: 8792
ClinVar: 8792
TCGA: ENSG00000141655
COSMIC: TNFRSF11A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141655ENST00000269485Q9Y6Q6
ENSG00000141655ENST00000586569Q9Y6Q6
ENSG00000141655ENST00000616710Q9Y6Q6
ENSG00000141655ENST00000617039Q9Y6Q6
ENSG00000141655ENST00000639222A0A1W2PR41

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
NF-kappa B signaling pathwayKEGGhsa04064
NF-kappa B signaling pathwayKEGGko04064
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathwayREACTOMER-HSA-5676594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713217PyrazolonesChemicalClinicalAnnotationassociatedPD26398624
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD
PA448015acetaminophenChemicalClinicalAnnotationassociatedPD26398624
PA448497aspirinChemicalClinicalAnnotationassociatedPD26398624
PA449293diclofenacChemicalClinicalAnnotationassociatedPD26398624
PA451140propionic acid derivativesChemicalClinicalAnnotationassociatedPD26398624
PA451257risperidoneChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
213262022011Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling.195
176341402007Biology of RANK, RANKL, and osteoprotegerin.172
190792622009New sequence variants associated with bone mineral density.123
155645642004Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin.99
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
227051162012New insights into osteoclastogenic signaling mechanisms.79
273227432016RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers.75
204364712010Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone.63
204364712010Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone.63
199409262009Central control of fever and female body temperature by RANKL/RANK.62

Citation

Dessen P

TNFRSF11A (TNF receptor superfamily member 11a)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53317/tnfrsf11a