Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TNFRSF11A (tumor necrosis factor receptor superfamily, member 11a, NFKB activator)

Identity

Other namesCD265
FEO
LOH18CR1
ODFR
OFE
OPTB7
OSTS
PDB2
RANK
TRANCER
HGNC (Hugo) TNFRSF11A
LocusID (NCBI) 8792
Location 18q21.33
Location_base_pair Starts at 59992520 and ends at 60054943 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TNFRSF11A   11908
Cards
Entrez_Gene (NCBI)TNFRSF11A  8792  tumor necrosis factor receptor superfamily, member 11a, NFKB activator
GeneCards (Weizmann)TNFRSF11A
Ensembl (Hinxton)ENSG00000141655 [Gene_View]  chr18:59992520-60054943 [Contig_View]  TNFRSF11A [Vega]
ICGC DataPortalENSG00000141655
cBioPortalTNFRSF11A
AceView (NCBI)TNFRSF11A
Genatlas (Paris)TNFRSF11A
WikiGenes8792
SOURCE (Princeton)NM_001270949 NM_001270950 NM_001270951 NM_001278268 NM_003839
Genomic and cartography
GoldenPath (UCSC)TNFRSF11A  -  18q21.33   chr18:59992520-60054943 +  18q21.33   [Description]    (hg19-Feb_2009)
EnsemblTNFRSF11A - 18q21.33 [CytoView]
Mapping of homologs : NCBITNFRSF11A [Mapview]
OMIM174810   602080   603499   612301   
Gene and transcription
Genbank (Entrez)AB209762 AF018253 AF086403 BC152906 DA403964
RefSeq transcript (Entrez)NM_001270949 NM_001270950 NM_001270951 NM_001278268 NM_003839
RefSeq genomic (Entrez)AC_000150 NC_000018 NC_018929 NG_008098 NT_010966 NW_001838469 NW_004929411
Consensus coding sequences : CCDS (NCBI)TNFRSF11A
Cluster EST : UnigeneHs.621477 [ NCBI ]
CGAP (NCI)Hs.621477
Alternative Splicing : Fast-db (Paris)GSHG0014090
Alternative Splicing GalleryENSG00000141655
Gene ExpressionTNFRSF11A [ NCBI-GEO ]     TNFRSF11A [ SEEK ]   TNFRSF11A [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6Q6 (Uniprot)
NextProtQ9Y6Q6  [Medical]
With graphics : InterProQ9Y6Q6
Splice isoforms : SwissVarQ9Y6Q6 (Swissvar)
Domaine pattern : Prosite (Expaxy)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)TNFR/NGFR_Cys_rich_reg [organisation]   TNFR_11 [organisation]   TNFR_11A [organisation]  
Related proteins : CluSTrQ9Y6Q6
Domain families : Pfam (Sanger)TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00020   
Domain families : Smart (EMBL)TNFR (SM00208)  
DMDM Disease mutations8792
Blocks (Seattle)Q9Y6Q6
PDB (SRS)1LB5   
PDB (PDBSum)1LB5   
PDB (IMB)1LB5   
PDB (RSDB)1LB5   
Human Protein AtlasENSG00000141655 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasQ9Y6Q6
HPRD04609
IPIIPI00021968   IPI00555635   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6Q6
IntAct (EBI)Q9Y6Q6
FunCoupENSG00000141655
BioGRIDTNFRSF11A
InParanoidQ9Y6Q6
Interologous Interaction database Q9Y6Q6
IntegromeDBTNFRSF11A
STRING (EMBL)TNFRSF11A
Ontologies - Pathways
Ontology : AmiGOossification  adaptive immune response  monocyte chemotaxis  receptor activity  transmembrane signaling receptor activity  tumor necrosis factor-activated receptor activity  protein binding  signal transduction  cell-cell signaling  positive regulation of cell proliferation  response to radiation  external side of plasma membrane  integral component of membrane  cytokine binding  osteoclast differentiation  response to lipopolysaccharide  tumor necrosis factor-mediated signaling pathway  response to cytokine  response to tumor necrosis factor  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of JUN kinase activity  metal ion binding  lymph node development  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  circadian temperature homeostasis  mammary gland alveolus development  response to interleukin-1  positive regulation of fever generation by positive regulation of prostaglandin secretion  TNFSF11-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling  
Ontology : EGO-EBIossification  adaptive immune response  monocyte chemotaxis  receptor activity  transmembrane signaling receptor activity  tumor necrosis factor-activated receptor activity  protein binding  signal transduction  cell-cell signaling  positive regulation of cell proliferation  response to radiation  external side of plasma membrane  integral component of membrane  cytokine binding  osteoclast differentiation  response to lipopolysaccharide  tumor necrosis factor-mediated signaling pathway  response to cytokine  response to tumor necrosis factor  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of JUN kinase activity  metal ion binding  lymph node development  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  circadian temperature homeostasis  mammary gland alveolus development  response to interleukin-1  positive regulation of fever generation by positive regulation of prostaglandin secretion  TNFSF11-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling  
Pathways : BIOCARTABone Remodelling [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    NF-kappa B signaling pathway    Osteoclast differentiation    Prolactin signaling pathway    Rheumatoid arthritis   
Protein Interaction DatabaseTNFRSF11A
Wikipedia pathwaysTNFRSF11A
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TNFRSF11A
snp3D : Map Gene to Disease8792
SNP (GeneSNP Utah)TNFRSF11A
SNP : HGBaseTNFRSF11A
Genetic variants : HAPMAPTNFRSF11A
Exome VariantTNFRSF11A
1000_GenomesTNFRSF11A 
ICGC programENSG00000141655 
Somatic Mutations in Cancer : COSMICTNFRSF11A 
CONAN: Copy Number AnalysisTNFRSF11A 
Mutations and Diseases : HGMDTNFRSF11A
Genomic VariantsTNFRSF11A  TNFRSF11A [DGVbeta]
dbVarTNFRSF11A
ClinVarTNFRSF11A
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM174810    602080    603499    612301   
MedgenTNFRSF11A
GENETestsTNFRSF11A
Disease Genetic AssociationTNFRSF11A
Huge Navigator TNFRSF11A [HugePedia]  TNFRSF11A [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneTNFRSF11A
Homology/Alignments : Family Browser (UCSC)TNFRSF11A
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF11A
Chemical/Protein Interactions : CTD8792
Chemical/Pharm GKB GenePA36601
Clinical trialTNFRSF11A
Cancer Resource (Charite)ENSG00000141655
Other databases
Probes
Litterature
PubMed158 Pubmed reference(s) in Entrez
CoreMineTNFRSF11A
iHOPTNFRSF11A
OncoSearchTNFRSF11A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:50:24 CEST 2014

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