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TNFRSF11A (TNF receptor superfamily member 11a)

Identity

Alias (NCBI)CD265
FEO
LOH18CR1
ODFR
OFE
OPTB7
OSTS
PDB2
RANK
TRANCE-R
TRANCER
HGNC (Hugo) TNFRSF11A
HGNC Alias symbRANK
CD265
FEO
ODFR
TRANCE-R
HGNC Alias nameosteoclast differentiation factor receptor
 receptor activator of nuclear factor kappa B
 familial expansile osteolysis
 TRANCE receptor
HGNC Previous namePDB2
 LOH18CR1
HGNC Previous nametumor necrosis factor receptor superfamily, member 11a, activator of NFKB
 Paget disease of bone 2
 loss of heterozygosity, 18, chromosomal region 1
 tumor necrosis factor receptor superfamily, member 11a, NFKB activator
LocusID (NCBI) 8792
Atlas_Id 53317
Location 18q21.33  [Link to chromosome band 18q21]
Location_base_pair Starts at 62325310 and ends at 62391285 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PAPPA (9q33.1) / TNFRSF11A (18q21.33)TNFRSF11A (18q21.33) / KIAA1468 (18q21.33)TNFRSF11A 18q21.33 / KIAA1468 18q21.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TNFRSF11A   11908
LRG (Locus Reference Genomic)LRG_194
Cards
Entrez_Gene (NCBI)TNFRSF11A    TNF receptor superfamily member 11a
AliasesCD265; FEO; LOH18CR1; ODFR; 
OFE; OPTB7; OSTS; PDB2; RANK; TRANCE-R; TRANCER
GeneCards (Weizmann)TNFRSF11A
Ensembl hg19 (Hinxton)ENSG00000141655 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141655 [Gene_View]  ENSG00000141655 [Sequence]  chr18:62325310-62391285 [Contig_View]  TNFRSF11A [Vega]
ICGC DataPortalENSG00000141655
TCGA cBioPortalTNFRSF11A
AceView (NCBI)TNFRSF11A
Genatlas (Paris)TNFRSF11A
SOURCE (Princeton)TNFRSF11A
Genetics Home Reference (NIH)TNFRSF11A
Genomic and cartography
GoldenPath hg38 (UCSC)TNFRSF11A  -     chr18:62325310-62391285 +  18q21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFRSF11A  -     18q21.33   [Description]    (hg19-Feb_2009)
GoldenPathTNFRSF11A - 18q21.33 [CytoView hg19]  TNFRSF11A - 18q21.33 [CytoView hg38]
ImmunoBaseENSG00000141655
Genome Data Viewer NCBITNFRSF11A [Mapview hg19]  
OMIM174810   602080   603499   612301   
Gene and transcription
Genbank (Entrez)AB209762 AF018253 AF086403 DA403964 HE647782
RefSeq transcript (Entrez)NM_001270949 NM_001270950 NM_001270951 NM_001278268 NM_003839
Consensus coding sequences : CCDS (NCBI)TNFRSF11A
Gene ExpressionTNFRSF11A [ NCBI-GEO ]   TNFRSF11A [ EBI - ARRAY_EXPRESS ]   TNFRSF11A [ SEEK ]   TNFRSF11A [ MEM ]
Gene Expression Viewer (FireBrowse)TNFRSF11A [ Firebrowse - Broad ]
GenevisibleExpression of TNFRSF11A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8792
GTEX Portal (Tissue expression)TNFRSF11A
Human Protein AtlasENSG00000141655-TNFRSF11A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6Q6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6Q6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6Q6
PhosPhoSitePlusQ9Y6Q6
Domaine pattern : Prosite (Expaxy)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)RANK_CRD_2    TNFR/NGFR_Cys_rich_reg    TNFR_11    TNFR_11A    TNFRSF11A_N   
Domain families : Pfam (Sanger)RANK_CRD_2 (PF18278)    TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam18278    pfam00020   
Domain families : Smart (EMBL)TNFR (SM00208)  
Conserved Domain (NCBI)TNFRSF11A
PDB (RSDB)1LB5   
PDB Europe1LB5   
PDB (PDBSum)1LB5   
PDB (IMB)1LB5   
Structural Biology KnowledgeBase1LB5   
SCOP (Structural Classification of Proteins)1LB5   
CATH (Classification of proteins structures)1LB5   
SuperfamilyQ9Y6Q6
AlphaFold pdb e-kbQ9Y6Q6   
Human Protein Atlas [tissue]ENSG00000141655-TNFRSF11A [tissue]
HPRD04609
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6Q6
IntAct (EBI)Q9Y6Q6
BioGRIDTNFRSF11A
STRING (EMBL)TNFRSF11A
ZODIACTNFRSF11A
Ontologies - Pathways
QuickGOQ9Y6Q6
Ontology : AmiGOossification  adaptive immune response  monocyte chemotaxis  transmembrane signaling receptor activity  tumor necrosis factor-activated receptor activity  tumor necrosis factor-activated receptor activity  protein binding  cytosol  plasma membrane  plasma membrane  signal transduction  cell-cell signaling  positive regulation of cell population proliferation  response to radiation  external side of plasma membrane  external side of plasma membrane  integral component of membrane  cytokine binding  cytokine binding  osteoclast differentiation  response to lipopolysaccharide  tumor necrosis factor-mediated signaling pathway  tumor necrosis factor-mediated signaling pathway  response to cytokine  response to tumor necrosis factor  signaling receptor activity  positive regulation of JUN kinase activity  positive regulation of bone resorption  metal ion binding  lymph node development  positive regulation of DNA-binding transcription factor activity  positive regulation of DNA-binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  circadian temperature homeostasis  mammary gland alveolus development  response to interleukin-1  response to interleukin-1  positive regulation of fever generation by positive regulation of prostaglandin secretion  TNFSF11-mediated signaling pathway  TNFSF11-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling  multinuclear osteoclast differentiation  
Ontology : EGO-EBIossification  adaptive immune response  monocyte chemotaxis  transmembrane signaling receptor activity  tumor necrosis factor-activated receptor activity  tumor necrosis factor-activated receptor activity  protein binding  cytosol  plasma membrane  plasma membrane  signal transduction  cell-cell signaling  positive regulation of cell population proliferation  response to radiation  external side of plasma membrane  external side of plasma membrane  integral component of membrane  cytokine binding  cytokine binding  osteoclast differentiation  response to lipopolysaccharide  tumor necrosis factor-mediated signaling pathway  tumor necrosis factor-mediated signaling pathway  response to cytokine  response to tumor necrosis factor  signaling receptor activity  positive regulation of JUN kinase activity  positive regulation of bone resorption  metal ion binding  lymph node development  positive regulation of DNA-binding transcription factor activity  positive regulation of DNA-binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  circadian temperature homeostasis  mammary gland alveolus development  response to interleukin-1  response to interleukin-1  positive regulation of fever generation by positive regulation of prostaglandin secretion  TNFSF11-mediated signaling pathway  TNFSF11-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling  multinuclear osteoclast differentiation  
Pathways : BIOCARTABone Remodelling [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    NF-kappa B signaling pathway    Osteoclast differentiation    Prolactin signaling pathway    Rheumatoid arthritis   
NDEx NetworkTNFRSF11A
Atlas of Cancer Signalling NetworkTNFRSF11A
Wikipedia pathwaysTNFRSF11A
Orthology - Evolution
OrthoDB8792
GeneTree (enSembl)ENSG00000141655
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF11A
Homologs : HomoloGeneTNFRSF11A
Homology/Alignments : Family Browser (UCSC)TNFRSF11A
Gene fusions - Rearrangements
Fusion : MitelmanTNFRSF11A/KIAA1468 [18q21.33/18q21.33]  
Fusion : QuiverTNFRSF11A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFRSF11A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFRSF11A
dbVarTNFRSF11A
ClinVarTNFRSF11A
MonarchTNFRSF11A
1000_GenomesTNFRSF11A 
Exome Variant ServerTNFRSF11A
GNOMAD BrowserENSG00000141655
Varsome BrowserTNFRSF11A
ACMGTNFRSF11A variants
VarityQ9Y6Q6
Genomic Variants (DGV)TNFRSF11A [DGVbeta]
DECIPHERTNFRSF11A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFRSF11A 
Mutations
ICGC Data PortalTNFRSF11A 
TCGA Data PortalTNFRSF11A 
Broad Tumor PortalTNFRSF11A
OASIS PortalTNFRSF11A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFRSF11A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNFRSF11A
Mutations and Diseases : HGMDTNFRSF11A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTNFRSF11A
DgiDB (Drug Gene Interaction Database)TNFRSF11A
DoCM (Curated mutations)TNFRSF11A
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF11A
Cancer3DTNFRSF11A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM174810    602080    603499    612301   
Orphanet18023    22629    11653   
DisGeNETTNFRSF11A
MedgenTNFRSF11A
Genetic Testing Registry TNFRSF11A
NextProtQ9Y6Q6 [Medical]
GENETestsTNFRSF11A
Target ValidationTNFRSF11A
Huge Navigator TNFRSF11A [HugePedia]
ClinGenTNFRSF11A
Clinical trials, drugs, therapy
MyCancerGenomeTNFRSF11A
Protein Interactions : CTDTNFRSF11A
Pharm GKB GenePA36601
PharosQ9Y6Q6
Clinical trialTNFRSF11A
Miscellaneous
canSAR (ICR)TNFRSF11A
HarmonizomeTNFRSF11A
DataMed IndexTNFRSF11A
Probes
Litterature
PubMed264 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNFRSF11A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:42 CEST 2021

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