Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TNFRSF11A (tumor necrosis factor receptor superfamily member 11a)

Identity

Alias_namesPDB2
LOH18CR1
tumor necrosis factor receptor superfamily, member 11a, activator of NFKB
Paget disease of bone 2
loss of heterozygosity, 18, chromosomal region 1
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Alias_symbol (synonym)RANK
CD265
FEO
HGNC (Hugo) TNFRSF11A
LocusID (NCBI) 8792
Atlas_Id 53317
Location 18q21.33  [Link to chromosome band 18q21]
Location_base_pair Starts at 59992520 and ends at 60054943 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PAPPA (9q33.1) / TNFRSF11A (18q21.33)TNFRSF11A (18q21.33) / KIAA1468 (18q21.33)TNFRSF11A 18q21.33 / KIAA1468 18q21.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNFRSF11A   11908
LRG (Locus Reference Genomic)LRG_194
Cards
Entrez_Gene (NCBI)TNFRSF11A  8792  tumor necrosis factor receptor superfamily member 11a
AliasesCD265; FEO; LOH18CR1; ODFR; 
OFE; OPTB7; OSTS; PDB2; RANK; TRANCER
GeneCards (Weizmann)TNFRSF11A
Ensembl hg19 (Hinxton)ENSG00000141655 [Gene_View]  chr18:59992520-60054943 [Contig_View]  TNFRSF11A [Vega]
Ensembl hg38 (Hinxton)ENSG00000141655 [Gene_View]  chr18:59992520-60054943 [Contig_View]  TNFRSF11A [Vega]
ICGC DataPortalENSG00000141655
TCGA cBioPortalTNFRSF11A
AceView (NCBI)TNFRSF11A
Genatlas (Paris)TNFRSF11A
WikiGenes8792
SOURCE (Princeton)TNFRSF11A
Genetics Home Reference (NIH)TNFRSF11A
Genomic and cartography
GoldenPath hg19 (UCSC)TNFRSF11A  -     chr18:59992520-60054943 +  18q21.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TNFRSF11A  -     18q21.33   [Description]    (hg38-Dec_2013)
EnsemblTNFRSF11A - 18q21.33 [CytoView hg19]  TNFRSF11A - 18q21.33 [CytoView hg38]
Mapping of homologs : NCBITNFRSF11A [Mapview hg19]  TNFRSF11A [Mapview hg38]
OMIM174810   602080   603499   612301   
Gene and transcription
Genbank (Entrez)AB209762 AF018253 AF086403 BC152906 DA403964
RefSeq transcript (Entrez)NM_001270949 NM_001270950 NM_001270951 NM_001278268 NM_003839
RefSeq genomic (Entrez)NC_000018 NC_018929 NG_008098 NT_010966 NW_004929411
Consensus coding sequences : CCDS (NCBI)TNFRSF11A
Cluster EST : UnigeneHs.621477 [ NCBI ]
CGAP (NCI)Hs.621477
Alternative Splicing GalleryENSG00000141655
Gene ExpressionTNFRSF11A [ NCBI-GEO ]   TNFRSF11A [ EBI - ARRAY_EXPRESS ]   TNFRSF11A [ SEEK ]   TNFRSF11A [ MEM ]
Gene Expression Viewer (FireBrowse)TNFRSF11A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8792
GTEX Portal (Tissue expression)TNFRSF11A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6Q6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6Q6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6Q6
Splice isoforms : SwissVarQ9Y6Q6
PhosPhoSitePlusQ9Y6Q6
Domaine pattern : Prosite (Expaxy)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)TNFR/NGFR_Cys_rich_reg    TNFR_11    TNFR_11A   
Domain families : Pfam (Sanger)TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00020   
Domain families : Smart (EMBL)TNFR (SM00208)  
Conserved Domain (NCBI)TNFRSF11A
DMDM Disease mutations8792
Blocks (Seattle)TNFRSF11A
PDB (SRS)1LB5   
PDB (PDBSum)1LB5   
PDB (IMB)1LB5   
PDB (RSDB)1LB5   
Structural Biology KnowledgeBase1LB5   
SCOP (Structural Classification of Proteins)1LB5   
CATH (Classification of proteins structures)1LB5   
SuperfamilyQ9Y6Q6
Human Protein AtlasENSG00000141655
Peptide AtlasQ9Y6Q6
HPRD04609
IPIIPI00021968   IPI00555635   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6Q6
IntAct (EBI)Q9Y6Q6
FunCoupENSG00000141655
BioGRIDTNFRSF11A
STRING (EMBL)TNFRSF11A
ZODIACTNFRSF11A
Ontologies - Pathways
QuickGOQ9Y6Q6
Ontology : AmiGOossification  adaptive immune response  monocyte chemotaxis  receptor activity  transmembrane signaling receptor activity  tumor necrosis factor-activated receptor activity  tumor necrosis factor-activated receptor activity  protein binding  plasma membrane  integral component of plasma membrane  inflammatory response  signal transduction  cell-cell signaling  positive regulation of cell proliferation  response to radiation  external side of plasma membrane  cytokine binding  osteoclast differentiation  response to lipopolysaccharide  response to lipopolysaccharide  tumor necrosis factor-mediated signaling pathway  tumor necrosis factor-mediated signaling pathway  response to cytokine  response to tumor necrosis factor  regulation of apoptotic process  positive regulation of JUN kinase activity  metal ion binding  lymph node development  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  circadian temperature homeostasis  mammary gland alveolus development  response to interleukin-1  positive regulation of fever generation by positive regulation of prostaglandin secretion  TNFSF11-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling  apoptotic signaling pathway  
Ontology : EGO-EBIossification  adaptive immune response  monocyte chemotaxis  receptor activity  transmembrane signaling receptor activity  tumor necrosis factor-activated receptor activity  tumor necrosis factor-activated receptor activity  protein binding  plasma membrane  integral component of plasma membrane  inflammatory response  signal transduction  cell-cell signaling  positive regulation of cell proliferation  response to radiation  external side of plasma membrane  cytokine binding  osteoclast differentiation  response to lipopolysaccharide  response to lipopolysaccharide  tumor necrosis factor-mediated signaling pathway  tumor necrosis factor-mediated signaling pathway  response to cytokine  response to tumor necrosis factor  regulation of apoptotic process  positive regulation of JUN kinase activity  metal ion binding  lymph node development  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of NF-kappaB transcription factor activity  positive regulation of NF-kappaB transcription factor activity  circadian temperature homeostasis  mammary gland alveolus development  response to interleukin-1  positive regulation of fever generation by positive regulation of prostaglandin secretion  TNFSF11-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling  apoptotic signaling pathway  
Pathways : BIOCARTABone Remodelling [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    NF-kappa B signaling pathway    Osteoclast differentiation    Prolactin signaling pathway    Rheumatoid arthritis   
NDEx NetworkTNFRSF11A
Atlas of Cancer Signalling NetworkTNFRSF11A
Wikipedia pathwaysTNFRSF11A
Orthology - Evolution
OrthoDB8792
GeneTree (enSembl)ENSG00000141655
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF11A
HOVERGENQ9Y6Q6
HOGENOMQ9Y6Q6
Homologs : HomoloGeneTNFRSF11A
Homology/Alignments : Family Browser (UCSC)TNFRSF11A
Gene fusions - Rearrangements
Fusion : MitelmanTNFRSF11A/KIAA1468 [18q21.33/18q21.33]  
Fusion: TCGATNFRSF11A 18q21.33 KIAA1468 18q21.33 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFRSF11A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFRSF11A
dbVarTNFRSF11A
ClinVarTNFRSF11A
1000_GenomesTNFRSF11A 
Exome Variant ServerTNFRSF11A
ExAC (Exome Aggregation Consortium)TNFRSF11A (select the gene name)
Genetic variants : HAPMAP8792
Genomic Variants (DGV)TNFRSF11A [DGVbeta]
DECIPHER (Syndromes)18:59992520-60054943  ENSG00000141655
CONAN: Copy Number AnalysisTNFRSF11A 
Mutations
ICGC Data PortalTNFRSF11A 
TCGA Data PortalTNFRSF11A 
Broad Tumor PortalTNFRSF11A
OASIS PortalTNFRSF11A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFRSF11A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNFRSF11A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFRSF11A
DgiDB (Drug Gene Interaction Database)TNFRSF11A
DoCM (Curated mutations)TNFRSF11A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF11A (select a term)
intoGenTNFRSF11A
Cancer3DTNFRSF11A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM174810    602080    603499    612301   
Orphanet18023    22629    11653   
MedgenTNFRSF11A
Genetic Testing Registry TNFRSF11A
NextProtQ9Y6Q6 [Medical]
TSGene8792
GENETestsTNFRSF11A
Huge Navigator TNFRSF11A [HugePedia]
snp3D : Map Gene to Disease8792
BioCentury BCIQTNFRSF11A
ClinGenTNFRSF11A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8792
Chemical/Pharm GKB GenePA36601
Clinical trialTNFRSF11A
Miscellaneous
canSAR (ICR)TNFRSF11A (select the gene name)
Probes
Litterature
PubMed190 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNFRSF11A
EVEXTNFRSF11A
GoPubMedTNFRSF11A
iHOPTNFRSF11A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:54:08 CET 2016

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