Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TNFRSF12A (TNF receptor superfamily member 12A)

Identity

Alias (NCBI)CD266
FN14
TWEAKR
HGNC (Hugo) TNFRSF12A
HGNC Alias symbFN14
TweakR
CD266
HGNC Previous nametumor necrosis factor receptor superfamily, member 12A
LocusID (NCBI) 51330
Atlas_Id 42611
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 3020368 and ends at 3022382 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TBCC (6p21.1) / TNFRSF12A (16p13.3)TNFRSF12A (16p13.3) / TMEM94 (17q25.1)TRMT2B (Xq22.1) / TNFRSF12A (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TNFRSF12A   18152
Cards
Entrez_Gene (NCBI)TNFRSF12A    TNF receptor superfamily member 12A
AliasesCD266; FN14; TWEAKR
GeneCards (Weizmann)TNFRSF12A
Ensembl hg19 (Hinxton)ENSG00000006327 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000006327 [Gene_View]  ENSG00000006327 [Sequence]  chr16:3020368-3022382 [Contig_View]  TNFRSF12A [Vega]
ICGC DataPortalENSG00000006327
TCGA cBioPortalTNFRSF12A
AceView (NCBI)TNFRSF12A
Genatlas (Paris)TNFRSF12A
SOURCE (Princeton)TNFRSF12A
Genetics Home Reference (NIH)TNFRSF12A
Genomic and cartography
GoldenPath hg38 (UCSC)TNFRSF12A  -     chr16:3020368-3022382 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFRSF12A  -     16p13.3   [Description]    (hg19-Feb_2009)
GoldenPathTNFRSF12A - 16p13.3 [CytoView hg19]  TNFRSF12A - 16p13.3 [CytoView hg38]
ImmunoBaseENSG00000006327
Genome Data Viewer NCBITNFRSF12A [Mapview hg19]  
OMIM605914   
Gene and transcription
Genbank (Entrez)AB035480 AB035481 AF191148 BC002718 BC020538
RefSeq transcript (Entrez)NM_016639
Consensus coding sequences : CCDS (NCBI)TNFRSF12A
Gene ExpressionTNFRSF12A [ NCBI-GEO ]   TNFRSF12A [ EBI - ARRAY_EXPRESS ]   TNFRSF12A [ SEEK ]   TNFRSF12A [ MEM ]
Gene Expression Viewer (FireBrowse)TNFRSF12A [ Firebrowse - Broad ]
GenevisibleExpression of TNFRSF12A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51330
GTEX Portal (Tissue expression)TNFRSF12A
Human Protein AtlasENSG00000006327-TNFRSF12A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NP84   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NP84  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NP84
PhosPhoSitePlusQ9NP84
Domains : Interpro (EBI)TNFR_12   
Domain families : Pfam (Sanger)stn_TNFRSF12A (PF12191)   
Domain families : Pfam (NCBI)pfam12191   
Conserved Domain (NCBI)TNFRSF12A
PDB (RSDB)2EQP    2KMZ    2RPJ   
PDB Europe2EQP    2KMZ    2RPJ   
PDB (PDBSum)2EQP    2KMZ    2RPJ   
PDB (IMB)2EQP    2KMZ    2RPJ   
Structural Biology KnowledgeBase2EQP    2KMZ    2RPJ   
SCOP (Structural Classification of Proteins)2EQP    2KMZ    2RPJ   
CATH (Classification of proteins structures)2EQP    2KMZ    2RPJ   
SuperfamilyQ9NP84
AlphaFold pdb e-kbQ9NP84   
Human Protein Atlas [tissue]ENSG00000006327-TNFRSF12A [tissue]
HPRD05801
Protein Interaction databases
DIP (DOE-UCLA)Q9NP84
IntAct (EBI)Q9NP84
BioGRIDTNFRSF12A
STRING (EMBL)TNFRSF12A
ZODIACTNFRSF12A
Ontologies - Pathways
QuickGOQ9NP84
Ontology : AmiGOangiogenesis  protein binding  plasma membrane  plasma membrane  apoptotic process  cell adhesion  integral component of membrane  cell differentiation  tumor necrosis factor-mediated signaling pathway  positive regulation of apoptotic process  regulation of wound healing  positive regulation of extrinsic apoptotic signaling pathway  positive regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIangiogenesis  protein binding  plasma membrane  plasma membrane  apoptotic process  cell adhesion  integral component of membrane  cell differentiation  tumor necrosis factor-mediated signaling pathway  positive regulation of apoptotic process  regulation of wound healing  positive regulation of extrinsic apoptotic signaling pathway  positive regulation of extrinsic apoptotic signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkTNFRSF12A
Atlas of Cancer Signalling NetworkTNFRSF12A
Wikipedia pathwaysTNFRSF12A
Orthology - Evolution
OrthoDB51330
GeneTree (enSembl)ENSG00000006327
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF12A
Homologs : HomoloGeneTNFRSF12A
Homology/Alignments : Family Browser (UCSC)TNFRSF12A
Gene fusions - Rearrangements
Fusion : QuiverTNFRSF12A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFRSF12A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFRSF12A
dbVarTNFRSF12A
ClinVarTNFRSF12A
MonarchTNFRSF12A
1000_GenomesTNFRSF12A 
Exome Variant ServerTNFRSF12A
GNOMAD BrowserENSG00000006327
Varsome BrowserTNFRSF12A
ACMGTNFRSF12A variants
VarityQ9NP84
Genomic Variants (DGV)TNFRSF12A [DGVbeta]
DECIPHERTNFRSF12A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFRSF12A 
Mutations
ICGC Data PortalTNFRSF12A 
TCGA Data PortalTNFRSF12A 
Broad Tumor PortalTNFRSF12A
OASIS PortalTNFRSF12A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFRSF12A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNFRSF12A
Mutations and Diseases : HGMDTNFRSF12A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTNFRSF12A
DgiDB (Drug Gene Interaction Database)TNFRSF12A
DoCM (Curated mutations)TNFRSF12A
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF12A
Cancer3DTNFRSF12A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605914   
Orphanet
DisGeNETTNFRSF12A
MedgenTNFRSF12A
Genetic Testing Registry TNFRSF12A
NextProtQ9NP84 [Medical]
GENETestsTNFRSF12A
Target ValidationTNFRSF12A
Huge Navigator TNFRSF12A [HugePedia]
ClinGenTNFRSF12A
Clinical trials, drugs, therapy
MyCancerGenomeTNFRSF12A
Protein Interactions : CTDTNFRSF12A
Pharm GKB GenePA134976874
PharosQ9NP84
Clinical trialTNFRSF12A
Miscellaneous
canSAR (ICR)TNFRSF12A
HarmonizomeTNFRSF12A
DataMed IndexTNFRSF12A
Probes
Litterature
PubMed124 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNFRSF12A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:42 CEST 2021

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