Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TNFRSF12A (TNF receptor superfamily member 12A)

Identity

Alias_namestumor necrosis factor receptor superfamily
Alias_symbol (synonym)FN14
TweakR
CD266
Other aliasTWEAKR
HGNC (Hugo) TNFRSF12A
LocusID (NCBI) 51330
Atlas_Id 42611
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 3020312 and ends at 3022382 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TBCC (6p21.1) / TNFRSF12A (16p13.3)TNFRSF12A (16p13.3) / TMEM94 (17q25.1)TRMT2B (Xq22.1) / TNFRSF12A (16p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNFRSF12A   18152
Cards
Entrez_Gene (NCBI)TNFRSF12A  51330  TNF receptor superfamily member 12A
AliasesCD266; FN14; TWEAKR
GeneCards (Weizmann)TNFRSF12A
Ensembl hg19 (Hinxton)ENSG00000006327 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000006327 [Gene_View]  chr16:3020312-3022382 [Contig_View]  TNFRSF12A [Vega]
ICGC DataPortalENSG00000006327
TCGA cBioPortalTNFRSF12A
AceView (NCBI)TNFRSF12A
Genatlas (Paris)TNFRSF12A
WikiGenes51330
SOURCE (Princeton)TNFRSF12A
Genetics Home Reference (NIH)TNFRSF12A
Genomic and cartography
GoldenPath hg38 (UCSC)TNFRSF12A  -     chr16:3020312-3022382 +  16p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFRSF12A  -     16p13.3   [Description]    (hg19-Feb_2009)
EnsemblTNFRSF12A - 16p13.3 [CytoView hg19]  TNFRSF12A - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBITNFRSF12A [Mapview hg19]  TNFRSF12A [Mapview hg38]
OMIM605914   
Gene and transcription
Genbank (Entrez)AB035480 AB035481 AF191148 BC002718 BC020538
RefSeq transcript (Entrez)NM_016639
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNFRSF12A
Cluster EST : UnigeneHs.355899 [ NCBI ]
CGAP (NCI)Hs.355899
Alternative Splicing GalleryENSG00000006327
Gene ExpressionTNFRSF12A [ NCBI-GEO ]   TNFRSF12A [ EBI - ARRAY_EXPRESS ]   TNFRSF12A [ SEEK ]   TNFRSF12A [ MEM ]
Gene Expression Viewer (FireBrowse)TNFRSF12A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51330
GTEX Portal (Tissue expression)TNFRSF12A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NP84   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NP84  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NP84
Splice isoforms : SwissVarQ9NP84
PhosPhoSitePlusQ9NP84
Domains : Interpro (EBI)TNFR_12   
Domain families : Pfam (Sanger)stn_TNFRSF12A (PF12191)   
Domain families : Pfam (NCBI)pfam12191   
Domain structure : Prodom (Prabi Lyon)TNFR_12 (PD336131)   
Conserved Domain (NCBI)TNFRSF12A
DMDM Disease mutations51330
Blocks (Seattle)TNFRSF12A
PDB (SRS)2EQP    2KMZ    2RPJ   
PDB (PDBSum)2EQP    2KMZ    2RPJ   
PDB (IMB)2EQP    2KMZ    2RPJ   
PDB (RSDB)2EQP    2KMZ    2RPJ   
Structural Biology KnowledgeBase2EQP    2KMZ    2RPJ   
SCOP (Structural Classification of Proteins)2EQP    2KMZ    2RPJ   
CATH (Classification of proteins structures)2EQP    2KMZ    2RPJ   
SuperfamilyQ9NP84
Human Protein AtlasENSG00000006327
Peptide AtlasQ9NP84
HPRD05801
IPIIPI00010277   IPI00219878   
Protein Interaction databases
DIP (DOE-UCLA)Q9NP84
IntAct (EBI)Q9NP84
FunCoupENSG00000006327
BioGRIDTNFRSF12A
STRING (EMBL)TNFRSF12A
ZODIACTNFRSF12A
Ontologies - Pathways
QuickGOQ9NP84
Ontology : AmiGOangiogenesis  ruffle  protein binding  plasma membrane  substrate-dependent cell migration, cell attachment to substrate  cell surface  integral component of membrane  tumor necrosis factor-mediated signaling pathway  positive regulation of apoptotic process  regulation of angiogenesis  positive regulation of axon extension  regulation of wound healing  extrinsic apoptotic signaling pathway  positive regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIangiogenesis  ruffle  protein binding  plasma membrane  substrate-dependent cell migration, cell attachment to substrate  cell surface  integral component of membrane  tumor necrosis factor-mediated signaling pathway  positive regulation of apoptotic process  regulation of angiogenesis  positive regulation of axon extension  regulation of wound healing  extrinsic apoptotic signaling pathway  positive regulation of extrinsic apoptotic signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkTNFRSF12A
Atlas of Cancer Signalling NetworkTNFRSF12A
Wikipedia pathwaysTNFRSF12A
Orthology - Evolution
OrthoDB51330
GeneTree (enSembl)ENSG00000006327
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF12A
HOVERGENQ9NP84
HOGENOMQ9NP84
Homologs : HomoloGeneTNFRSF12A
Homology/Alignments : Family Browser (UCSC)TNFRSF12A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFRSF12A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFRSF12A
dbVarTNFRSF12A
ClinVarTNFRSF12A
1000_GenomesTNFRSF12A 
Exome Variant ServerTNFRSF12A
ExAC (Exome Aggregation Consortium)TNFRSF12A (select the gene name)
Genetic variants : HAPMAP51330
Genomic Variants (DGV)TNFRSF12A [DGVbeta]
DECIPHERTNFRSF12A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFRSF12A 
Mutations
ICGC Data PortalTNFRSF12A 
TCGA Data PortalTNFRSF12A 
Broad Tumor PortalTNFRSF12A
OASIS PortalTNFRSF12A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFRSF12A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNFRSF12A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFRSF12A
DgiDB (Drug Gene Interaction Database)TNFRSF12A
DoCM (Curated mutations)TNFRSF12A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF12A (select a term)
intoGenTNFRSF12A
Cancer3DTNFRSF12A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605914   
Orphanet
MedgenTNFRSF12A
Genetic Testing Registry TNFRSF12A
NextProtQ9NP84 [Medical]
TSGene51330
GENETestsTNFRSF12A
Target ValidationTNFRSF12A
Huge Navigator TNFRSF12A [HugePedia]
snp3D : Map Gene to Disease51330
BioCentury BCIQTNFRSF12A
ClinGenTNFRSF12A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51330
Chemical/Pharm GKB GenePA134976874
Clinical trialTNFRSF12A
Miscellaneous
canSAR (ICR)TNFRSF12A (select the gene name)
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNFRSF12A
EVEXTNFRSF12A
GoPubMedTNFRSF12A
iHOPTNFRSF12A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:17:16 CEST 2017

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