TNFRSF13B (TNF receptor superfamily member 13B)

2003-06-01  

Identity

HGNC
LOCATION
17p11.2
LOCUSID
ALIAS
CD267,CVID,CVID2,IGAD2,RYZN,TACI,TNFRSF14B
FUSION GENES

Other Information

Locus ID:

NCBI: 23495
MIM: 604907
HGNC: 18153
Ensembl: ENSG00000240505

Variants:

dbSNP: 23495
ClinVar: 23495
TCGA: ENSG00000240505
COSMIC: TNFRSF13B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000240505ENST00000261652O14836
ENSG00000240505ENST00000261652Q4ACX1
ENSG00000240505ENST00000579315J3QR67
ENSG00000240505ENST00000583789O14836
ENSG00000240505ENST00000584950E7ER05

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Primary immunodeficiencyKEGGko05340
Cytokine-cytokine receptor interactionKEGGhsa04060
Primary immunodeficiencyKEGGhsa05340
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
160070862005TACI is mutant in common variable immunodeficiency and IgA deficiency.168
160070872005Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans.156
206760932010The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88.145
169143242006BAFF, APRIL and their receptors: structure, function and signaling.116
145122992004Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival.112
158271342005The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature.82
180251702007Regulated expression of BAFF-binding receptors during human B cell differentiation.71
189812942009Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes.70
189812942009Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes.70
173927972007Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency.67

Citation

Dessen P

TNFRSF13B (TNF receptor superfamily member 13B)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42613/tnfrsf13b