TNFRSF13C (TNF receptor superfamily member 13C)

2003-06-01 Affiliation

Identity

HGNC

TNFRSF13C

LOCATION

22q13.2

LOCUSID

115650

ALIAS

BAFF-R,BAFFR,BROMIX,CD268,CVID4,prolixin

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 115650
MIM: 606269
HGNC: 17755
Ensembl: ENSG00000159958

Variants:

dbSNP: 115650
ClinVar: 115650
TCGA: ENSG00000159958
COSMIC: TNFRSF13C

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000159958	ENST00000291232	Q96RJ3
ENSG00000159958	ENST00000291232	Q5H8V1

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Primary immunodeficiency	KEGG	ko05340
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Primary immunodeficiency	KEGG	hsa05340
Intestinal immune network for IgA production	KEGG	ko04672
Intestinal immune network for IgA production	KEGG	hsa04672
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
NF-kappa B signaling pathway	KEGG	hsa04064
NF-kappa B signaling pathway	KEGG	ko04064
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
TNFR2 non-canonical NF-kB pathway	REACTOME	R-HSA-5668541
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	REACTOME	R-HSA-5676594

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
16914324	2006	BAFF, APRIL and their receptors: structure, function and signaling.	116
14512299	2004	Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival.	112
19666484	2009	B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans.	99
18025170	2007	Regulated expression of BAFF-binding receptors during human B cell differentiation.	71
22124120	2012	Soluble BAFF levels inversely correlate with peripheral B cell numbers and the expression of BAFF receptors.	61
19726767	2009	B cell receptor and BAFF receptor signaling regulation of B cell homeostasis.	53
12471121	2002	TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production.	48
15644327	2005	An atypical tumor necrosis factor (TNF) receptor-associated factor-binding motif of B cell-activating factor belonging to the TNF family (BAFF) receptor mediates induction of the noncanonical NF-kappaB signaling pathway.	46
16931038	2006	Impact of the BAFF/BR3 axis on B cell survival, germinal center maintenance and antibody production.	42
16931039	2006	The role of the BAFF/APRIL system on T cell function.	41

Citation

Dessen P

TNFRSF13C (TNF receptor superfamily member 13C)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42614/tnfrsf13c