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TNFRSF14 (tumor necrosis factor receptor superfamily, member 14)

Identity

Other namesATAR
CD270
HVEA
HVEM
LIGHTR
TR2
HGNC (Hugo) TNFRSF14
LocusID (NCBI) 8764
Atlas_Id 42615
Location 1p36.32
Location_base_pair Starts at 2487804 and ends at 2497061 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TNFRSF14   11912
Cards
Entrez_Gene (NCBI)TNFRSF14  8764  tumor necrosis factor receptor superfamily, member 14
GeneCards (Weizmann)TNFRSF14
Ensembl hg19 (Hinxton)ENSG00000157873 [Gene_View]  chr1:2487804-2497061 [Contig_View]  TNFRSF14 [Vega]
Ensembl hg38 (Hinxton)ENSG00000157873 [Gene_View]  chr1:2487804-2497061 [Contig_View]  TNFRSF14 [Vega]
ICGC DataPortalENSG00000157873
TCGA cBioPortalTNFRSF14
AceView (NCBI)TNFRSF14
Genatlas (Paris)TNFRSF14
WikiGenes8764
SOURCE (Princeton)TNFRSF14
Genomic and cartography
GoldenPath hg19 (UCSC)TNFRSF14  -     chr1:2487804-2497061 +  1p36.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TNFRSF14  -     1p36.32   [Description]    (hg38-Dec_2013)
EnsemblTNFRSF14 - 1p36.32 [CytoView hg19]  TNFRSF14 - 1p36.32 [CytoView hg38]
Mapping of homologs : NCBITNFRSF14 [Mapview hg19]  TNFRSF14 [Mapview hg38]
OMIM602746   
Gene and transcription
Genbank (Entrez)AB208808 AF153978 AF373877 AF373878 AK124010
RefSeq transcript (Entrez)NM_001297605 NM_003820
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NT_187515 NW_004929288
Consensus coding sequences : CCDS (NCBI)TNFRSF14
Cluster EST : UnigeneHs.682060 [ NCBI ]
CGAP (NCI)Hs.682060
Alternative Splicing : Fast-db (Paris)GSHG0000055
Alternative Splicing GalleryENSG00000157873
Gene ExpressionTNFRSF14 [ NCBI-GEO ]     TNFRSF14 [ SEEK ]   TNFRSF14 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92956 (Uniprot)
NextProtQ92956  [Medical]  [Publications]
With graphics : InterProQ92956
Splice isoforms : SwissVarQ92956 (Swissvar)
Domaine pattern : Prosite (Expaxy)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)TNFR/NGFR_Cys_rich_reg    TNFR_14   
Related proteins : CluSTrQ92956
Domain families : Pfam (Sanger)TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00020   
Domain families : Smart (EMBL)TNFR (SM00208)  
DMDM Disease mutations8764
Blocks (Seattle)Q92956
PDB (SRS)1JMA    2AW2    4FHQ    4RSU   
PDB (PDBSum)1JMA    2AW2    4FHQ    4RSU   
PDB (IMB)1JMA    2AW2    4FHQ    4RSU   
PDB (RSDB)1JMA    2AW2    4FHQ    4RSU   
Human Protein AtlasENSG00000157873
Peptide AtlasQ92956
HPRD04122
IPIIPI00024331   IPI00384412   IPI00911011   IPI00556085   IPI00916996   IPI00916056   IPI00916172   
Protein Interaction databases
DIP (DOE-UCLA)Q92956
IntAct (EBI)Q92956
FunCoupENSG00000157873
BioGRIDTNFRSF14
IntegromeDBTNFRSF14
STRING (EMBL)TNFRSF14
ZODIACTNFRSF14
Ontologies - Pathways
QuickGOQ92956
Ontology : AmiGOvirus receptor activity  positive regulation of cytokine secretion involved in immune response  tumor necrosis factor-activated receptor activity  protein binding  plasma membrane  integral component of plasma membrane  immune response  cell surface receptor signaling pathway  external side of plasma membrane  T cell costimulation  ubiquitin protein ligase binding  tumor necrosis factor-mediated signaling pathway  negative regulation of alpha-beta T cell proliferation  viral entry into host cell  positive regulation of peptidyl-tyrosine phosphorylation  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  positive regulation of T cell migration  
Ontology : EGO-EBIvirus receptor activity  positive regulation of cytokine secretion involved in immune response  tumor necrosis factor-activated receptor activity  protein binding  plasma membrane  integral component of plasma membrane  immune response  cell surface receptor signaling pathway  external side of plasma membrane  T cell costimulation  ubiquitin protein ligase binding  tumor necrosis factor-mediated signaling pathway  negative regulation of alpha-beta T cell proliferation  viral entry into host cell  positive regulation of peptidyl-tyrosine phosphorylation  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  positive regulation of T cell migration  
Pathways : KEGGCytokine-cytokine receptor interaction    Herpes simplex infection   
Protein Interaction DatabaseTNFRSF14
Atlas of Cancer Signalling NetworkTNFRSF14
Wikipedia pathwaysTNFRSF14
Gene fusion - Rearrangements
Fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerTNFRSF14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFRSF14
dbVarTNFRSF14
ClinVarTNFRSF14
1000_GenomesTNFRSF14 
Exome Variant ServerTNFRSF14
SNP (GeneSNP Utah)TNFRSF14
SNP : HGBaseTNFRSF14
Genetic variants : HAPMAPTNFRSF14
Genomic Variants (DGV)TNFRSF14 [DGVbeta]
Mutations
ICGC Data PortalTNFRSF14 
TCGA Data PortalTNFRSF14 
Tumor PortalTNFRSF14
Cancer Gene: CensusTNFRSF14 
Somatic Mutations in Cancer : COSMICTNFRSF14 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
DoCM (Curated mutations) TNFRSF14
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:2487804-2497061
CONAN: Copy Number AnalysisTNFRSF14 
Mutations and Diseases : HGMDTNFRSF14
OMIM602746   
MedgenTNFRSF14
NextProtQ92956 [Medical]
GENETestsTNFRSF14
Disease Genetic AssociationTNFRSF14
Huge Navigator TNFRSF14 [HugePedia]  TNFRSF14 [HugeCancerGEM]
snp3D : Map Gene to Disease8764
DGIdb (Drug Gene Interaction db)TNFRSF14
BioCentury BCIQTNFRSF14
General knowledge
Homologs : HomoloGeneTNFRSF14
Homology/Alignments : Family Browser (UCSC)TNFRSF14
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF14
Chemical/Protein Interactions : CTD8764
Chemical/Pharm GKB GenePA36605
Clinical trialTNFRSF14
Cancer Resource (Charite)ENSG00000157873
Other databases
Probes
Litterature
PubMed100 Pubmed reference(s) in Entrez
CoreMineTNFRSF14
GoPubMedTNFRSF14
iHOPTNFRSF14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Sep 5 12:19:52 CEST 2015

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