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TNFRSF14 (TNF receptor superfamily member 14)

Identity

Alias (NCBI)ATAR
CD270
HVEA
HVEM
LIGHTR
TR2
HGNC (Hugo) TNFRSF14
HGNC Alias symbHVEM
ATAR
TR2
LIGHTR
HVEA
CD270
HGNC Alias nameherpesvirus entry mediator
HGNC Previous nametumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
 tumor necrosis factor receptor superfamily, member 14
LocusID (NCBI) 8764
Atlas_Id 42615
Location 1p36.32  [Link to chromosome band 1p36]
Location_base_pair Starts at 2556365 and ends at 2565622 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TNFRSF14 (1p36.32) / C1QA (1p36.12)TNFRSF14 (1p36.32) / MICAL1 (6q21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Pediatric-type Follicular Lymphoma


External links

 

Nomenclature
HGNC (Hugo)TNFRSF14   11912
Cards
Entrez_Gene (NCBI)TNFRSF14    TNF receptor superfamily member 14
AliasesATAR; CD270; HVEA; HVEM; 
LIGHTR; TR2
GeneCards (Weizmann)TNFRSF14
Ensembl hg19 (Hinxton)ENSG00000157873 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157873 [Gene_View]  ENSG00000157873 [Sequence]  chr1:2556365-2565622 [Contig_View]  TNFRSF14 [Vega]
ICGC DataPortalENSG00000157873
TCGA cBioPortalTNFRSF14
AceView (NCBI)TNFRSF14
Genatlas (Paris)TNFRSF14
SOURCE (Princeton)TNFRSF14
Genetics Home Reference (NIH)TNFRSF14
Genomic and cartography
GoldenPath hg38 (UCSC)TNFRSF14  -     chr1:2556365-2565622 +  1p36.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFRSF14  -     1p36.32   [Description]    (hg19-Feb_2009)
GoldenPathTNFRSF14 - 1p36.32 [CytoView hg19]  TNFRSF14 - 1p36.32 [CytoView hg38]
ImmunoBaseENSG00000157873
Genome Data Viewer NCBITNFRSF14 [Mapview hg19]  
OMIM602746   
Gene and transcription
Genbank (Entrez)AB208808 AF153978 AF373877 AF373878 AK124010
RefSeq transcript (Entrez)NM_001297605 NM_003820
Consensus coding sequences : CCDS (NCBI)TNFRSF14
Gene ExpressionTNFRSF14 [ NCBI-GEO ]   TNFRSF14 [ EBI - ARRAY_EXPRESS ]   TNFRSF14 [ SEEK ]   TNFRSF14 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFRSF14 [ Firebrowse - Broad ]
GenevisibleExpression of TNFRSF14 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8764
GTEX Portal (Tissue expression)TNFRSF14
Human Protein AtlasENSG00000157873-TNFRSF14 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92956   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92956  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92956
PhosPhoSitePlusQ92956
Domaine pattern : Prosite (Expaxy)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)TNFR/NGFR_Cys_rich_reg    TNFR_14    TNFRSF14/UL144_N   
Domain families : Pfam (Sanger)TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00020   
Domain families : Smart (EMBL)TNFR (SM00208)  
Conserved Domain (NCBI)TNFRSF14
PDB (RSDB)1JMA    2AW2    4FHQ    4RSU    5T2Q    5T2R    6NG3   
PDB Europe1JMA    2AW2    4FHQ    4RSU    5T2Q    5T2R    6NG3   
PDB (PDBSum)1JMA    2AW2    4FHQ    4RSU    5T2Q    5T2R    6NG3   
PDB (IMB)1JMA    2AW2    4FHQ    4RSU    5T2Q    5T2R    6NG3   
Structural Biology KnowledgeBase1JMA    2AW2    4FHQ    4RSU    5T2Q    5T2R    6NG3   
SCOP (Structural Classification of Proteins)1JMA    2AW2    4FHQ    4RSU    5T2Q    5T2R    6NG3   
CATH (Classification of proteins structures)1JMA    2AW2    4FHQ    4RSU    5T2Q    5T2R    6NG3   
SuperfamilyQ92956
AlphaFold pdb e-kbQ92956   
Human Protein Atlas [tissue]ENSG00000157873-TNFRSF14 [tissue]
HPRD04122
Protein Interaction databases
DIP (DOE-UCLA)Q92956
IntAct (EBI)Q92956
BioGRIDTNFRSF14
STRING (EMBL)TNFRSF14
ZODIACTNFRSF14
Ontologies - Pathways
QuickGOQ92956
Ontology : AmiGOvirus receptor activity  adaptive immune response  positive regulation of cytokine production involved in immune response  tumor necrosis factor-activated receptor activity  protein binding  plasma membrane  plasma membrane  immune response  cell surface receptor signaling pathway  external side of plasma membrane  integral component of membrane  cytokine binding  T cell costimulation  T cell costimulation  ubiquitin protein ligase binding  tumor necrosis factor-mediated signaling pathway  innate immune response  negative regulation of alpha-beta T cell proliferation  viral entry into host cell  positive regulation of peptidyl-tyrosine phosphorylation  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  negative regulation of adaptive immune memory response  positive regulation of T cell migration  
Ontology : EGO-EBIvirus receptor activity  adaptive immune response  positive regulation of cytokine production involved in immune response  tumor necrosis factor-activated receptor activity  protein binding  plasma membrane  plasma membrane  immune response  cell surface receptor signaling pathway  external side of plasma membrane  integral component of membrane  cytokine binding  T cell costimulation  T cell costimulation  ubiquitin protein ligase binding  tumor necrosis factor-mediated signaling pathway  innate immune response  negative regulation of alpha-beta T cell proliferation  viral entry into host cell  positive regulation of peptidyl-tyrosine phosphorylation  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  negative regulation of adaptive immune memory response  positive regulation of T cell migration  
Pathways : KEGGCytokine-cytokine receptor interaction    Herpes simplex infection   
NDEx NetworkTNFRSF14
Atlas of Cancer Signalling NetworkTNFRSF14
Wikipedia pathwaysTNFRSF14
Orthology - Evolution
OrthoDB8764
GeneTree (enSembl)ENSG00000157873
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF14
Homologs : HomoloGeneTNFRSF14
Homology/Alignments : Family Browser (UCSC)TNFRSF14
Gene fusions - Rearrangements
Fusion : QuiverTNFRSF14
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFRSF14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFRSF14
dbVarTNFRSF14
ClinVarTNFRSF14
MonarchTNFRSF14
1000_GenomesTNFRSF14 
Exome Variant ServerTNFRSF14
GNOMAD BrowserENSG00000157873
Varsome BrowserTNFRSF14
ACMGTNFRSF14 variants
VarityQ92956
Genomic Variants (DGV)TNFRSF14 [DGVbeta]
DECIPHERTNFRSF14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFRSF14 
Mutations
ICGC Data PortalTNFRSF14 
TCGA Data PortalTNFRSF14 
Broad Tumor PortalTNFRSF14
OASIS PortalTNFRSF14 [ Somatic mutations - Copy number]
Cancer Gene: CensusTNFRSF14 
Somatic Mutations in Cancer : COSMICTNFRSF14  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNFRSF14
Mutations and Diseases : HGMDTNFRSF14
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTNFRSF14
DgiDB (Drug Gene Interaction Database)TNFRSF14
DoCM (Curated mutations)TNFRSF14
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF14
Cancer3DTNFRSF14
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602746   
Orphanet
DisGeNETTNFRSF14
MedgenTNFRSF14
Genetic Testing Registry TNFRSF14
NextProtQ92956 [Medical]
GENETestsTNFRSF14
Target ValidationTNFRSF14
Huge Navigator TNFRSF14 [HugePedia]
ClinGenTNFRSF14
Clinical trials, drugs, therapy
MyCancerGenomeTNFRSF14
Protein Interactions : CTDTNFRSF14
Pharm GKB GenePA36605
PharosQ92956
Clinical trialTNFRSF14
Miscellaneous
canSAR (ICR)TNFRSF14
HarmonizomeTNFRSF14
DataMed IndexTNFRSF14
Probes
Litterature
PubMed137 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNFRSF14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:43 CEST 2021

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