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TNFRSF14 (tumor necrosis factor receptor superfamily member 14)

Identity

Other namesATAR
CD270
HVEA
HVEM
LIGHTR
TR2
HGNC (Hugo) TNFRSF14
LocusID (NCBI) 8764
Atlas_Id 42615
Location 1p36.32
Location_base_pair Starts at 2487804 and ends at 2497061 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TNFRSF14 (1p36.32) / C1QA (1p36.12)TNFRSF14 (1p36.32) / MICAL1 (6q21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNFRSF14   11912
Cards
Entrez_Gene (NCBI)TNFRSF14  8764  tumor necrosis factor receptor superfamily member 14
AliasesATAR; CD270; HVEA; HVEM; 
LIGHTR; TR2
GeneCards (Weizmann)TNFRSF14
Ensembl hg19 (Hinxton)ENSG00000157873 [Gene_View]  chr1:2487804-2497061 [Contig_View]  TNFRSF14 [Vega]
Ensembl hg38 (Hinxton)ENSG00000157873 [Gene_View]  chr1:2487804-2497061 [Contig_View]  TNFRSF14 [Vega]
ICGC DataPortalENSG00000157873
TCGA cBioPortalTNFRSF14
AceView (NCBI)TNFRSF14
Genatlas (Paris)TNFRSF14
WikiGenes8764
SOURCE (Princeton)TNFRSF14
Genomic and cartography
GoldenPath hg19 (UCSC)TNFRSF14  -     chr1:2487804-2497061 +  1p36.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TNFRSF14  -     1p36.32   [Description]    (hg38-Dec_2013)
EnsemblTNFRSF14 - 1p36.32 [CytoView hg19]  TNFRSF14 - 1p36.32 [CytoView hg38]
Mapping of homologs : NCBITNFRSF14 [Mapview hg19]  TNFRSF14 [Mapview hg38]
OMIM602746   
Gene and transcription
Genbank (Entrez)AB208808 AF153978 AF373877 AF373878 AK124010
RefSeq transcript (Entrez)NM_001297605 NM_003820
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NT_187515 NW_004929288
Consensus coding sequences : CCDS (NCBI)TNFRSF14
Cluster EST : UnigeneHs.682060 [ NCBI ]
CGAP (NCI)Hs.682060
Alternative Splicing GalleryENSG00000157873
Gene ExpressionTNFRSF14 [ NCBI-GEO ]   TNFRSF14 [ EBI - ARRAY_EXPRESS ]   TNFRSF14 [ SEEK ]   TNFRSF14 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFRSF14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8764
GTEX Portal (Tissue expression)TNFRSF14
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92956 (Uniprot)
NextProtQ92956  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92956
Splice isoforms : SwissVarQ92956 (Swissvar)
PhosPhoSitePlusQ92956
Domaine pattern : Prosite (Expaxy)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)TNFR/NGFR_Cys_rich_reg    TNFR_14   
Domain families : Pfam (Sanger)TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00020   
Domain families : Smart (EMBL)TNFR (SM00208)  
DMDM Disease mutations8764
Blocks (Seattle)TNFRSF14
PDB (SRS)1JMA    2AW2    4FHQ    4RSU   
PDB (PDBSum)1JMA    2AW2    4FHQ    4RSU   
PDB (IMB)1JMA    2AW2    4FHQ    4RSU   
PDB (RSDB)1JMA    2AW2    4FHQ    4RSU   
Structural Biology KnowledgeBase1JMA    2AW2    4FHQ    4RSU   
SCOP (Structural Classification of Proteins)1JMA    2AW2    4FHQ    4RSU   
CATH (Classification of proteins structures)1JMA    2AW2    4FHQ    4RSU   
SuperfamilyQ92956
Human Protein AtlasENSG00000157873
Peptide AtlasQ92956
HPRD04122
IPIIPI00024331   IPI00384412   IPI00911011   IPI00556085   IPI00916996   IPI00916056   IPI00916172   
Protein Interaction databases
DIP (DOE-UCLA)Q92956
IntAct (EBI)Q92956
FunCoupENSG00000157873
BioGRIDTNFRSF14
STRING (EMBL)TNFRSF14
ZODIACTNFRSF14
Ontologies - Pathways
QuickGOQ92956
Ontology : AmiGOvirus receptor activity  positive regulation of cytokine secretion involved in immune response  tumor necrosis factor-activated receptor activity  protein binding  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  cell surface receptor signaling pathway  multicellular organism development  external side of plasma membrane  T cell costimulation  ubiquitin protein ligase binding  response to lipopolysaccharide  tumor necrosis factor-mediated signaling pathway  regulation of cell proliferation  regulation of apoptotic process  positive regulation of MAPK cascade  negative regulation of alpha-beta T cell proliferation  viral entry into host cell  positive regulation of peptidyl-tyrosine phosphorylation  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  apoptotic signaling pathway  positive regulation of T cell migration  
Ontology : EGO-EBIvirus receptor activity  positive regulation of cytokine secretion involved in immune response  tumor necrosis factor-activated receptor activity  protein binding  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  cell surface receptor signaling pathway  multicellular organism development  external side of plasma membrane  T cell costimulation  ubiquitin protein ligase binding  response to lipopolysaccharide  tumor necrosis factor-mediated signaling pathway  regulation of cell proliferation  regulation of apoptotic process  positive regulation of MAPK cascade  negative regulation of alpha-beta T cell proliferation  viral entry into host cell  positive regulation of peptidyl-tyrosine phosphorylation  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  apoptotic signaling pathway  positive regulation of T cell migration  
Pathways : KEGGCytokine-cytokine receptor interaction    Herpes simplex infection   
NDEx Network
Atlas of Cancer Signalling NetworkTNFRSF14
Wikipedia pathwaysTNFRSF14
Orthology - Evolution
OrthoDB8764
GeneTree (enSembl)ENSG00000157873
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF14
Homologs : HomoloGeneTNFRSF14
Homology/Alignments : Family Browser (UCSC)TNFRSF14
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTNFRSF14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFRSF14
dbVarTNFRSF14
ClinVarTNFRSF14
1000_GenomesTNFRSF14 
Exome Variant ServerTNFRSF14
ExAC (Exome Aggregation Consortium)TNFRSF14 (select the gene name)
Genetic variants : HAPMAP8764
Genomic Variants (DGV)TNFRSF14 [DGVbeta]
Mutations
ICGC Data PortalTNFRSF14 
TCGA Data PortalTNFRSF14 
Broad Tumor PortalTNFRSF14
OASIS PortalTNFRSF14 [ Somatic mutations - Copy number]
Cancer Gene: CensusTNFRSF14 
Somatic Mutations in Cancer : COSMICTNFRSF14 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFRSF14
DgiDB (Drug Gene Interaction Database)TNFRSF14
DoCM (Curated mutations)TNFRSF14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF14 (select a term)
intoGenTNFRSF14
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:2487804-2497061  ENSG00000157873
CONAN: Copy Number AnalysisTNFRSF14 
Mutations and Diseases : HGMDTNFRSF14
OMIM602746   
MedgenTNFRSF14
Genetic Testing Registry TNFRSF14
NextProtQ92956 [Medical]
TSGene8764
GENETestsTNFRSF14
Huge Navigator TNFRSF14 [HugePedia]
snp3D : Map Gene to Disease8764
BioCentury BCIQTNFRSF14
ClinGenTNFRSF14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8764
Chemical/Pharm GKB GenePA36605
Clinical trialTNFRSF14
Miscellaneous
canSAR (ICR)TNFRSF14 (select the gene name)
Probes
Litterature
PubMed100 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNFRSF14
EVEXTNFRSF14
GoPubMedTNFRSF14
iHOPTNFRSF14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat May 28 11:24:57 CEST 2016

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