Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TNFRSF1A (tumor necrosis factor receptor superfamily, member 1A)

Identity

Other namesCD120a
FPF
MS5
TBP1
TNF-R
TNF-R-I
TNF-R55
TNFAR
TNFR1
TNFR1-d2
TNFR55
TNFR60
p55
p55-R
p60
HGNC (Hugo) TNFRSF1A
LocusID (NCBI) 7132
Location 12p13.31
Location_base_pair Starts at 6437923 and ends at 6451283 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TNFRSF1A   11916
Cards
Entrez_Gene (NCBI)TNFRSF1A  7132  tumor necrosis factor receptor superfamily, member 1A
GeneCards (Weizmann)TNFRSF1A
Ensembl (Hinxton)ENSG00000067182 [Gene_View]  chr12:6437923-6451283 [Contig_View]  TNFRSF1A [Vega]
ICGC DataPortalENSG00000067182
cBioPortalTNFRSF1A
AceView (NCBI)TNFRSF1A
Genatlas (Paris)TNFRSF1A
WikiGenes7132
SOURCE (Princeton)NM_001065
Genomic and cartography
GoldenPath (UCSC)TNFRSF1A  -  12p13.31   chr12:6437923-6451283 -  12p13.31   [Description]    (hg19-Feb_2009)
EnsemblTNFRSF1A - 12p13.31 [CytoView]
Mapping of homologs : NCBITNFRSF1A [Mapview]
OMIM142680   191190   614810   
Gene and transcription
Genbank (Entrez)A21522 AK056611 AK291088 AK298729 AK304517
RefSeq transcript (Entrez)NM_001065
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_007506 NT_009759 NW_001838050 NW_004929382
Consensus coding sequences : CCDS (NCBI)TNFRSF1A
Cluster EST : UnigeneHs.279594 [ NCBI ]
CGAP (NCI)Hs.279594
Alternative Splicing : Fast-db (Paris)GSHG0007197
Alternative Splicing GalleryENSG00000067182
Gene ExpressionTNFRSF1A [ NCBI-GEO ]     TNFRSF1A [ SEEK ]   TNFRSF1A [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19438 (Uniprot)
NextProtP19438  [Medical]
With graphics : InterProP19438
Splice isoforms : SwissVarP19438 (Swissvar)
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)DEATH-like_dom [organisation]   Death_domain [organisation]   TNFR/NGFR_Cys_rich_reg [organisation]   TNFR_1A [organisation]  
Related proteins : CluSTrP19438
Domain families : Pfam (Sanger)Death (PF00531)    TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00531    pfam00020   
Domain families : Smart (EMBL)DEATH (SM00005)  TNFR (SM00208)  
DMDM Disease mutations7132
Blocks (Seattle)P19438
PDB (SRS)1EXT    1FT4    1ICH    1NCF    1TNR   
PDB (PDBSum)1EXT    1FT4    1ICH    1NCF    1TNR   
PDB (IMB)1EXT    1FT4    1ICH    1NCF    1TNR   
PDB (RSDB)1EXT    1FT4    1ICH    1NCF    1TNR   
Human Protein AtlasENSG00000067182 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP19438
HPRD01861
IPIIPI00018880   IPI00795875   IPI01010586   IPI01009782   IPI00929211   IPI01013268   IPI00913887   IPI01014076   IPI01012807   IPI01011399   
Protein Interaction databases
DIP (DOE-UCLA)P19438
IntAct (EBI)P19438
FunCoupENSG00000067182
BioGRIDTNFRSF1A
InParanoidP19438
Interologous Interaction database P19438
IntegromeDBTNFRSF1A
STRING (EMBL)TNFRSF1A
Ontologies - Pathways
Ontology : AmiGOGolgi membrane  response to hypoxia  protease binding  tumor necrosis factor-activated receptor activity  protein binding  extracellular region  extracellular space  nucleus  plasma membrane  integral component of plasma membrane  prostaglandin metabolic process  apoptotic process  inflammatory response  extrinsic apoptotic signaling pathway via death domain receptors  intrinsic apoptotic signaling pathway in response to DNA damage  cell surface  negative regulation of gene expression  viral process  cytokine-mediated signaling pathway  axon  protein complex binding  response to lipopolysaccharide  negative regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  tetrapyrrole metabolic process  positive regulation of protein import into nucleus, translocation  tumor necrosis factor-mediated signaling pathway  positive regulation of tyrosine phosphorylation of Stat1 protein  defense response to bacterium  negative regulation of apoptotic process  tumor necrosis factor binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  response to amino acid  receptor complex  response to alkaloid  membrane raft  response to ethanol  positive regulation of angiogenesis  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  negative regulation of inflammatory response  positive regulation of inflammatory response  protein heterooligomerization  cellular response to mechanical stimulus  cellular response to estradiol stimulus  apoptotic signaling pathway  
Ontology : EGO-EBIGolgi membrane  response to hypoxia  protease binding  tumor necrosis factor-activated receptor activity  protein binding  extracellular region  extracellular space  nucleus  plasma membrane  integral component of plasma membrane  prostaglandin metabolic process  apoptotic process  inflammatory response  extrinsic apoptotic signaling pathway via death domain receptors  intrinsic apoptotic signaling pathway in response to DNA damage  cell surface  negative regulation of gene expression  viral process  cytokine-mediated signaling pathway  axon  protein complex binding  response to lipopolysaccharide  negative regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  tetrapyrrole metabolic process  positive regulation of protein import into nucleus, translocation  tumor necrosis factor-mediated signaling pathway  positive regulation of tyrosine phosphorylation of Stat1 protein  defense response to bacterium  negative regulation of apoptotic process  tumor necrosis factor binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  response to amino acid  receptor complex  response to alkaloid  membrane raft  response to ethanol  positive regulation of angiogenesis  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  negative regulation of inflammatory response  positive regulation of inflammatory response  protein heterooligomerization  cellular response to mechanical stimulus  cellular response to estradiol stimulus  apoptotic signaling pathway  
Pathways : BIOCARTAChaperones modulate interferon Signaling Pathway [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    Keratinocyte Differentiation [Genes]    SODD/TNFR1 Signaling Pathway [Genes]    NF-kB Signaling Pathway [Genes]    Acetylation and Deacetylation of RelA in The Nucleus [Genes]    Regulation of transcriptional activity by PML [Genes]    Ceramide Signaling Pathway [Genes]    TNF/Stress Related Signaling [Genes]    TNFR1 Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Cytokine-cytokine receptor interaction    NF-kappa B signaling pathway    Apoptosis    Osteoclast differentiation    TNF signaling pathway    Adipocytokine signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Amyotrophic lateral sclerosis (ALS)    Chagas disease (American trypanosomiasis)    Toxoplasmosis    Tuberculosis    Hepatitis C    Influenza A    HTLV-I infection    Herpes simplex infection   
Protein Interaction DatabaseTNFRSF1A
Wikipedia pathwaysTNFRSF1A
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TNFRSF1A
snp3D : Map Gene to Disease7132
SNP (GeneSNP Utah)TNFRSF1A
SNP : HGBaseTNFRSF1A
Genetic variants : HAPMAPTNFRSF1A
Exome VariantTNFRSF1A
1000_GenomesTNFRSF1A 
ICGC programENSG00000067182 
Somatic Mutations in Cancer : COSMICTNFRSF1A 
CONAN: Copy Number AnalysisTNFRSF1A 
Mutations and Diseases : HGMDTNFRSF1A
Genomic VariantsTNFRSF1A  TNFRSF1A [DGVbeta]
dbVarTNFRSF1A
ClinVarTNFRSF1A
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM142680    191190    614810   
MedgenTNFRSF1A
GENETestsTNFRSF1A
Disease Genetic AssociationTNFRSF1A
Huge Navigator TNFRSF1A [HugePedia]  TNFRSF1A [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneTNFRSF1A
Homology/Alignments : Family Browser (UCSC)TNFRSF1A
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF1A
Chemical/Protein Interactions : CTD7132
Chemical/Pharm GKB GenePA36609
Clinical trialTNFRSF1A
Cancer Resource (Charite)ENSG00000067182
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineTNFRSF1A
iHOPTNFRSF1A
OncoSearchTNFRSF1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:50:26 CEST 2014

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