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TNFRSF1B (tumor necrosis factor receptor superfamily member 1B)

Identity

Other namesCD120b
TBPII
TNF-R-II
TNF-R75
TNFBR
TNFR1B
TNFR2
TNFR80
p75
p75TNFR
HGNC (Hugo) TNFRSF1B
LocusID (NCBI) 7133
Atlas_Id 42621
Location 1p36.22  [Link to chromosome band 1p36]
Location_base_pair Starts at 12227060 and ends at 12269277 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NUP98 (11p15.4) / TNFRSF1B (1p36.22)SPEN (1p36.21) / TNFRSF1B (1p36.22)TNFRSF1B (1p36.22) / SLC30A7 (1p21.2)
SPEN 1p36.21 / TNFRSF1B 1p36.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNFRSF1B   11917
Cards
Entrez_Gene (NCBI)TNFRSF1B  7133  tumor necrosis factor receptor superfamily member 1B
AliasesCD120b; TBPII; TNF-R-II; TNF-R75; 
TNFBR; TNFR1B; TNFR2; TNFR80; p75; p75TNFR
GeneCards (Weizmann)TNFRSF1B
Ensembl hg19 (Hinxton)ENSG00000028137 [Gene_View]  chr1:12227060-12269277 [Contig_View]  TNFRSF1B [Vega]
Ensembl hg38 (Hinxton)ENSG00000028137 [Gene_View]  chr1:12227060-12269277 [Contig_View]  TNFRSF1B [Vega]
ICGC DataPortalENSG00000028137
TCGA cBioPortalTNFRSF1B
AceView (NCBI)TNFRSF1B
Genatlas (Paris)TNFRSF1B
WikiGenes7133
SOURCE (Princeton)TNFRSF1B
Genomic and cartography
GoldenPath hg19 (UCSC)TNFRSF1B  -     chr1:12227060-12269277 +  1p36.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TNFRSF1B  -     1p36.22   [Description]    (hg38-Dec_2013)
EnsemblTNFRSF1B - 1p36.22 [CytoView hg19]  TNFRSF1B - 1p36.22 [CytoView hg38]
Mapping of homologs : NCBITNFRSF1B [Mapview hg19]  TNFRSF1B [Mapview hg38]
OMIM191191   
Gene and transcription
Genbank (Entrez)AY148473 BC011844 BC042167 BC052977 BT019927
RefSeq transcript (Entrez)NM_001066
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_029791 NT_032977 NW_004929289
Consensus coding sequences : CCDS (NCBI)TNFRSF1B
Cluster EST : UnigeneHs.256278 [ NCBI ]
CGAP (NCI)Hs.256278
Alternative Splicing GalleryENSG00000028137
Gene ExpressionTNFRSF1B [ NCBI-GEO ]   TNFRSF1B [ EBI - ARRAY_EXPRESS ]   TNFRSF1B [ SEEK ]   TNFRSF1B [ MEM ]
Gene Expression Viewer (FireBrowse)TNFRSF1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7133
GTEX Portal (Tissue expression)TNFRSF1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20333 (Uniprot)
NextProtP20333  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20333
Splice isoforms : SwissVarP20333 (Swissvar)
PhosPhoSitePlusP20333
Domaine pattern : Prosite (Expaxy)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)TNFR/NGFR_Cys_rich_reg    TNFR_1B   
Domain families : Pfam (Sanger)TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00020   
Domain families : Smart (EMBL)TNFR (SM00208)  
DMDM Disease mutations7133
Blocks (Seattle)TNFRSF1B
PDB (SRS)1CA9    3ALQ   
PDB (PDBSum)1CA9    3ALQ   
PDB (IMB)1CA9    3ALQ   
PDB (RSDB)1CA9    3ALQ   
Structural Biology KnowledgeBase1CA9    3ALQ   
SCOP (Structural Classification of Proteins)1CA9    3ALQ   
CATH (Classification of proteins structures)1CA9    3ALQ   
SuperfamilyP20333
Human Protein AtlasENSG00000028137
Peptide AtlasP20333
HPRD01862
IPIIPI00023501   IPI00473089   IPI01009577   IPI00984120   IPI01011785   
Protein Interaction databases
DIP (DOE-UCLA)P20333
IntAct (EBI)P20333
FunCoupENSG00000028137
BioGRIDTNFRSF1B
STRING (EMBL)TNFRSF1B
ZODIACTNFRSF1B
Ontologies - Pathways
QuickGOP20333
Ontology : AmiGOtumor necrosis factor-activated receptor activity  protein binding  extracellular region  nucleus  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  multicellular organism development  aging  intrinsic apoptotic signaling pathway in response to DNA damage  ubiquitin protein ligase binding  tumor necrosis factor-mediated signaling pathway  regulation of cell proliferation  regulation of apoptotic process  neuronal cell body  varicosity  positive regulation of MAPK cascade  membrane raft  perinuclear region of cytoplasm  negative regulation of inflammatory response  RNA destabilization  positive regulation of membrane protein ectodomain proteolysis  cellular response to lipopolysaccharide  cellular response to growth factor stimulus  apoptotic signaling pathway  extrinsic apoptotic signaling pathway  
Ontology : EGO-EBItumor necrosis factor-activated receptor activity  protein binding  extracellular region  nucleus  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  multicellular organism development  aging  intrinsic apoptotic signaling pathway in response to DNA damage  ubiquitin protein ligase binding  tumor necrosis factor-mediated signaling pathway  regulation of cell proliferation  regulation of apoptotic process  neuronal cell body  varicosity  positive regulation of MAPK cascade  membrane raft  perinuclear region of cytoplasm  negative regulation of inflammatory response  RNA destabilization  positive regulation of membrane protein ectodomain proteolysis  cellular response to lipopolysaccharide  cellular response to growth factor stimulus  apoptotic signaling pathway  extrinsic apoptotic signaling pathway  
Pathways : BIOCARTARegulation of transcriptional activity by PML [Genes]    SODD/TNFR1 Signaling Pathway [Genes]    TNFR2 Signaling Pathway [Genes]    Keratinocyte Differentiation [Genes]    Acetylation and Deacetylation of RelA in The Nucleus [Genes]    NF-kB Signaling Pathway [Genes]    Chaperones modulate interferon Signaling Pathway [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    TNF signaling pathway    Adipocytokine signaling pathway    Amyotrophic lateral sclerosis (ALS)   
NDEx Network
Atlas of Cancer Signalling NetworkTNFRSF1B
Wikipedia pathwaysTNFRSF1B
Orthology - Evolution
OrthoDB7133
GeneTree (enSembl)ENSG00000028137
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF1B
Homologs : HomoloGeneTNFRSF1B
Homology/Alignments : Family Browser (UCSC)TNFRSF1B
Gene fusions - Rearrangements
Fusion: TCGASPEN 1p36.21 TNFRSF1B 1p36.22 PRAD
Polymorphisms : SNP, variants
NCBI Variation ViewerTNFRSF1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFRSF1B
dbVarTNFRSF1B
ClinVarTNFRSF1B
1000_GenomesTNFRSF1B 
Exome Variant ServerTNFRSF1B
ExAC (Exome Aggregation Consortium)TNFRSF1B (select the gene name)
Genetic variants : HAPMAP7133
Genomic Variants (DGV)TNFRSF1B [DGVbeta]
Mutations
ICGC Data PortalTNFRSF1B 
TCGA Data PortalTNFRSF1B 
Broad Tumor PortalTNFRSF1B
OASIS PortalTNFRSF1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFRSF1B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch TNFRSF1B
DgiDB (Drug Gene Interaction Database)TNFRSF1B
DoCM (Curated mutations)TNFRSF1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF1B (select a term)
intoGenTNFRSF1B
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:12227060-12269277  ENSG00000028137
CONAN: Copy Number AnalysisTNFRSF1B 
Mutations and Diseases : HGMDTNFRSF1B
OMIM191191   
MedgenTNFRSF1B
Genetic Testing Registry TNFRSF1B
NextProtP20333 [Medical]
TSGene7133
GENETestsTNFRSF1B
Huge Navigator TNFRSF1B [HugePedia]
snp3D : Map Gene to Disease7133
BioCentury BCIQTNFRSF1B
ClinGenTNFRSF1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7133
Chemical/Pharm GKB GenePA36610
Clinical trialTNFRSF1B
Miscellaneous
canSAR (ICR)TNFRSF1B (select the gene name)
Probes
Litterature
PubMed403 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNFRSF1B
EVEXTNFRSF1B
GoPubMedTNFRSF1B
iHOPTNFRSF1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:10:36 CEST 2016

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