Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TNFRSF21 (tumor necrosis factor receptor superfamily, member 21)

Identity

Other namesBM-018
CD358
DR6
HGNC (Hugo) TNFRSF21
LocusID (NCBI) 27242
Location 6p12.3
Location_base_pair Starts at 47199263 and ends at 47277683 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TNFRSF21   13469
Cards
Entrez_Gene (NCBI)TNFRSF21  27242  tumor necrosis factor receptor superfamily, member 21
GeneCards (Weizmann)TNFRSF21
Ensembl (Hinxton)ENSG00000146072 [Gene_View]  chr6:47199263-47277683 [Contig_View]  TNFRSF21 [Vega]
ICGC DataPortalENSG00000146072
cBioPortalTNFRSF21
AceView (NCBI)TNFRSF21
Genatlas (Paris)TNFRSF21
WikiGenes27242
SOURCE (Princeton)NM_014452
Genomic and cartography
GoldenPath (UCSC)TNFRSF21  -  6p12.3   chr6:47199263-47277683 -  6p12.3   [Description]    (hg19-Feb_2009)
EnsemblTNFRSF21 - 6p12.3 [CytoView]
Mapping of homologs : NCBITNFRSF21 [Mapview]
OMIM605732   
Gene and transcription
Genbank (Entrez)AB209394 AF068868 AF208860 AJ420531 AK001504
RefSeq transcript (Entrez)NM_014452
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NT_007592 NW_001838981 NW_004929326
Consensus coding sequences : CCDS (NCBI)TNFRSF21
Cluster EST : UnigeneHs.443577 [ NCBI ]
CGAP (NCI)Hs.443577
Alternative Splicing : Fast-db (Paris)GSHG0026659
Alternative Splicing GalleryENSG00000146072
Gene ExpressionTNFRSF21 [ NCBI-GEO ]     TNFRSF21 [ SEEK ]   TNFRSF21 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75509 (Uniprot)
NextProtO75509  [Medical]
With graphics : InterProO75509
Splice isoforms : SwissVarO75509 (Swissvar)
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)DEATH-like_dom [organisation]   Death_domain [organisation]   TNFR/NGFR_Cys_rich_reg [organisation]   TNFR_21 [organisation]  
Related proteins : CluSTrO75509
Domain families : Pfam (Sanger)Death (PF00531)   
Domain families : Pfam (NCBI)pfam00531   
Domain families : Smart (EMBL)DEATH (SM00005)  TNFR (SM00208)  
DMDM Disease mutations27242
Blocks (Seattle)O75509
PDB (SRS)2DBH    3QO4    3U3P    3U3Q    3U3S    3U3T    3U3V   
PDB (PDBSum)2DBH    3QO4    3U3P    3U3Q    3U3S    3U3T    3U3V   
PDB (IMB)2DBH    3QO4    3U3P    3U3Q    3U3S    3U3T    3U3V   
PDB (RSDB)2DBH    3QO4    3U3P    3U3Q    3U3S    3U3T    3U3V   
Human Protein AtlasENSG00000146072 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO75509
HPRD05759
IPIIPI00004413   IPI00940125   IPI00386244   
Protein Interaction databases
DIP (DOE-UCLA)O75509
IntAct (EBI)O75509
FunCoupENSG00000146072
BioGRIDTNFRSF21
InParanoidO75509
Interologous Interaction database O75509
IntegromeDBTNFRSF21
STRING (EMBL)TNFRSF21
Ontologies - Pathways
Ontology : AmiGOB cell apoptotic process  adaptive immune response  protein binding  plasma membrane  integral component of plasma membrane  apoptotic process  humoral immune response  axon  negative regulation of B cell proliferation  intrinsic component of plasma membrane  negative regulation of myelination  negative regulation of T cell proliferation  myelination  cellular lipid metabolic process  small molecule metabolic process  regulation of oligodendrocyte differentiation  T cell receptor signaling pathway  neuron apoptotic process  cellular response to tumor necrosis factor  oligodendrocyte apoptotic process  negative regulation of interleukin-5 secretion  negative regulation of interleukin-13 secretion  negative regulation of interleukin-10 secretion  
Ontology : EGO-EBIB cell apoptotic process  adaptive immune response  protein binding  plasma membrane  integral component of plasma membrane  apoptotic process  humoral immune response  axon  negative regulation of B cell proliferation  intrinsic component of plasma membrane  negative regulation of myelination  negative regulation of T cell proliferation  myelination  cellular lipid metabolic process  small molecule metabolic process  regulation of oligodendrocyte differentiation  T cell receptor signaling pathway  neuron apoptotic process  cellular response to tumor necrosis factor  oligodendrocyte apoptotic process  negative regulation of interleukin-5 secretion  negative regulation of interleukin-13 secretion  negative regulation of interleukin-10 secretion  
Pathways : KEGGCytokine-cytokine receptor interaction   
Protein Interaction DatabaseTNFRSF21
Wikipedia pathwaysTNFRSF21
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TNFRSF21
snp3D : Map Gene to Disease27242
SNP (GeneSNP Utah)TNFRSF21
SNP : HGBaseTNFRSF21
Genetic variants : HAPMAPTNFRSF21
Exome VariantTNFRSF21
1000_GenomesTNFRSF21 
ICGC programENSG00000146072 
Somatic Mutations in Cancer : COSMICTNFRSF21 
CONAN: Copy Number AnalysisTNFRSF21 
Mutations and Diseases : HGMDTNFRSF21
Genomic VariantsTNFRSF21  TNFRSF21 [DGVbeta]
dbVarTNFRSF21
ClinVarTNFRSF21
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM605732   
MedgenTNFRSF21
GENETestsTNFRSF21
Disease Genetic AssociationTNFRSF21
Huge Navigator TNFRSF21 [HugePedia]  TNFRSF21 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneTNFRSF21
Homology/Alignments : Family Browser (UCSC)TNFRSF21
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF21
Chemical/Protein Interactions : CTD27242
Chemical/Pharm GKB GenePA37775
Clinical trialTNFRSF21
Cancer Resource (Charite)ENSG00000146072
Other databases
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
CoreMineTNFRSF21
iHOPTNFRSF21
OncoSearchTNFRSF21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 14:19:12 CEST 2014
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