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TNFRSF21 (TNF receptor superfamily member 21)

Identity

Alias_namestumor necrosis factor receptor superfamily
Alias_symbol (synonym)DR6
CD358
Other aliasBM-018
HGNC (Hugo) TNFRSF21
LocusID (NCBI) 27242
Atlas_Id 42622
Location 6p12.3  [Link to chromosome band 6p12]
Location_base_pair Starts at 47231527 and ends at 47309947 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADGRF1 (6p12.3) / TNFRSF21 (6p12.3)RPL13 (16q24.3) / TNFRSF21 (6p12.3)SLC22A23 (6p25.2) / TNFRSF21 (6p12.3)
TNFRSF21 (6p12.3) / MAMLD1 (Xq28)SLC22A23 6p25.2 / TNFRSF21 6p12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p12;p25) SLC22A23/TNFRSF21

External links

Nomenclature
HGNC (Hugo)TNFRSF21   13469
Cards
Entrez_Gene (NCBI)TNFRSF21  27242  TNF receptor superfamily member 21
AliasesBM-018; CD358; DR6
GeneCards (Weizmann)TNFRSF21
Ensembl hg19 (Hinxton)ENSG00000146072 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000146072 [Gene_View]  ENSG00000146072 [Sequence]  chr6:47231527-47309947 [Contig_View]  TNFRSF21 [Vega]
ICGC DataPortalENSG00000146072
TCGA cBioPortalTNFRSF21
AceView (NCBI)TNFRSF21
Genatlas (Paris)TNFRSF21
WikiGenes27242
SOURCE (Princeton)TNFRSF21
Genetics Home Reference (NIH)TNFRSF21
Genomic and cartography
GoldenPath hg38 (UCSC)TNFRSF21  -     chr6:47231527-47309947 -  6p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFRSF21  -     6p12.3   [Description]    (hg19-Feb_2009)
TNFRSF21 - 6p12.3 [CytoView hg19]  TNFRSF21 - 6p12.3 [CytoView hg38]
Mapping of homologs : NCBITNFRSF21 [Mapview hg19]  TNFRSF21 [Mapview hg38]
OMIM605732   
Gene and transcription
Genbank (Entrez)AB209394 AF068868 AF208860 AJ420531 AK001504
RefSeq transcript (Entrez)NM_014452
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNFRSF21
Cluster EST : UnigeneHs.443577 [ NCBI ]
CGAP (NCI)Hs.443577
Alternative Splicing GalleryENSG00000146072
Gene ExpressionTNFRSF21 [ NCBI-GEO ]   TNFRSF21 [ EBI - ARRAY_EXPRESS ]   TNFRSF21 [ SEEK ]   TNFRSF21 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFRSF21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27242
GTEX Portal (Tissue expression)TNFRSF21
Human Protein AtlasENSG00000146072-TNFRSF21 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75509   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75509  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75509
Splice isoforms : SwissVarO75509
PhosPhoSitePlusO75509
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)DEATH-like_dom_sf    Death_domain    TNFR/NGFR_Cys_rich_reg    TNFR_21    TNFRSF21_death    TNFRSF21_N    Tyr-kin_ephrin_A/B_rcpt-like   
Domain families : Pfam (Sanger)Death (PF00531)    TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00531    pfam00020   
Domain families : Smart (EMBL)DEATH (SM00005)  Ephrin_rec_like (SM01411)  TNFR (SM00208)  
Conserved Domain (NCBI)TNFRSF21
DMDM Disease mutations27242
Blocks (Seattle)TNFRSF21
PDB (RSDB)2DBH    3QO4    3U3P    3U3Q    3U3S    3U3T    3U3V   
PDB Europe2DBH    3QO4    3U3P    3U3Q    3U3S    3U3T    3U3V   
PDB (PDBSum)2DBH    3QO4    3U3P    3U3Q    3U3S    3U3T    3U3V   
PDB (IMB)2DBH    3QO4    3U3P    3U3Q    3U3S    3U3T    3U3V   
Structural Biology KnowledgeBase2DBH    3QO4    3U3P    3U3Q    3U3S    3U3T    3U3V   
SCOP (Structural Classification of Proteins)2DBH    3QO4    3U3P    3U3Q    3U3S    3U3T    3U3V   
CATH (Classification of proteins structures)2DBH    3QO4    3U3P    3U3Q    3U3S    3U3T    3U3V   
SuperfamilyO75509
Human Protein Atlas [tissue]ENSG00000146072-TNFRSF21 [tissue]
Peptide AtlasO75509
HPRD05759
IPIIPI00004413   IPI00940125   IPI00386244   
Protein Interaction databases
DIP (DOE-UCLA)O75509
IntAct (EBI)O75509
FunCoupENSG00000146072
BioGRIDTNFRSF21
STRING (EMBL)TNFRSF21
ZODIACTNFRSF21
Ontologies - Pathways
QuickGOO75509
Ontology : AmiGOB cell apoptotic process  adaptive immune response  adaptive immune response  cytoplasm  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  apoptotic process  humoral immune response  humoral immune response  axonal fasciculation  regulation of lipid metabolic process  axon  negative regulation of B cell proliferation  negative regulation of B cell proliferation  intrinsic component of plasma membrane  negative regulation of myelination  negative regulation of myelination  negative regulation of T cell proliferation  negative regulation of T cell proliferation  myelination  regulation of oligodendrocyte differentiation  T cell receptor signaling pathway  neuron apoptotic process  neuron apoptotic process  cellular response to tumor necrosis factor  oligodendrocyte apoptotic process  oligodendrocyte apoptotic process  negative regulation of interleukin-5 secretion  negative regulation of interleukin-5 secretion  negative regulation of interleukin-13 secretion  negative regulation of interleukin-13 secretion  negative regulation of interleukin-10 secretion  negative regulation of interleukin-10 secretion  
Ontology : EGO-EBIB cell apoptotic process  adaptive immune response  adaptive immune response  cytoplasm  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  apoptotic process  humoral immune response  humoral immune response  axonal fasciculation  regulation of lipid metabolic process  axon  negative regulation of B cell proliferation  negative regulation of B cell proliferation  intrinsic component of plasma membrane  negative regulation of myelination  negative regulation of myelination  negative regulation of T cell proliferation  negative regulation of T cell proliferation  myelination  regulation of oligodendrocyte differentiation  T cell receptor signaling pathway  neuron apoptotic process  neuron apoptotic process  cellular response to tumor necrosis factor  oligodendrocyte apoptotic process  oligodendrocyte apoptotic process  negative regulation of interleukin-5 secretion  negative regulation of interleukin-5 secretion  negative regulation of interleukin-13 secretion  negative regulation of interleukin-13 secretion  negative regulation of interleukin-10 secretion  negative regulation of interleukin-10 secretion  
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkTNFRSF21
Atlas of Cancer Signalling NetworkTNFRSF21
Wikipedia pathwaysTNFRSF21
Orthology - Evolution
OrthoDB27242
GeneTree (enSembl)ENSG00000146072
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF21
HOGENOMO75509
Homologs : HomoloGeneTNFRSF21
Homology/Alignments : Family Browser (UCSC)TNFRSF21
Gene fusions - Rearrangements
Fusion : MitelmanSLC22A23/TNFRSF21 [6p25.2/6p12.3]  [t(6;6)(p12;p25)]  
Fusion PortalSLC22A23 6p25.2 TNFRSF21 6p12.3 GBM
Fusion : QuiverTNFRSF21
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFRSF21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFRSF21
dbVarTNFRSF21
ClinVarTNFRSF21
1000_GenomesTNFRSF21 
Exome Variant ServerTNFRSF21
ExAC (Exome Aggregation Consortium)ENSG00000146072
GNOMAD BrowserENSG00000146072
Varsome BrowserTNFRSF21
Genetic variants : HAPMAP27242
Genomic Variants (DGV)TNFRSF21 [DGVbeta]
DECIPHERTNFRSF21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFRSF21 
Mutations
ICGC Data PortalTNFRSF21 
TCGA Data PortalTNFRSF21 
Broad Tumor PortalTNFRSF21
OASIS PortalTNFRSF21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFRSF21  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNFRSF21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFRSF21
DgiDB (Drug Gene Interaction Database)TNFRSF21
DoCM (Curated mutations)TNFRSF21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF21 (select a term)
intoGenTNFRSF21
Cancer3DTNFRSF21(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605732   
Orphanet
DisGeNETTNFRSF21
MedgenTNFRSF21
Genetic Testing Registry TNFRSF21
NextProtO75509 [Medical]
TSGene27242
GENETestsTNFRSF21
Target ValidationTNFRSF21
Huge Navigator TNFRSF21 [HugePedia]
snp3D : Map Gene to Disease27242
BioCentury BCIQTNFRSF21
ClinGenTNFRSF21
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27242
Chemical/Pharm GKB GenePA37775
Clinical trialTNFRSF21
Miscellaneous
canSAR (ICR)TNFRSF21 (select the gene name)
DataMed IndexTNFRSF21
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNFRSF21
EVEXTNFRSF21
GoPubMedTNFRSF21
iHOPTNFRSF21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu May 2 13:14:43 CEST 2019
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