TNFRSF21 (tumor necrosis factor receptor superfamily, member 21)

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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

TNFRSF21 (tumor necrosis factor receptor superfamily, member 21)

Identity

Other names	BM-018
	CD358
	DR6
HGNC (Hugo)	TNFRSF21
LocusID (NCBI)	27242
Location	6p12.3
Location_base_pair	Starts at 47199263 and ends at 47277683 bp from pter ( according to hg19-Feb_2009)
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	TNFRSF21 13469
	Cards
Entrez_Gene (NCBI)	TNFRSF21 27242 tumor necrosis factor receptor superfamily, member 21
GeneCards (Weizmann)	TNFRSF21
Ensembl hg19 (Hinxton)	ENSG00000146072 [Gene_View] chr6:47199263-47277683 [Contig_View] TNFRSF21 [Vega]
Ensembl hg38 (Hinxton)	ENSG00000146072 [Gene_View] chr6:47199263-47277683 [Contig_View] TNFRSF21 [Vega]
ICGC DataPortal	ENSG00000146072
cBioPortal	TNFRSF21
AceView (NCBI)	TNFRSF21
Genatlas (Paris)	TNFRSF21
WikiGenes	27242
SOURCE (Princeton)	TNFRSF21
	Genomic and cartography
GoldenPath hg19 (UCSC)	TNFRSF21 - chr6:47199263-47277683 - 6p12.3 [Description] (hg19-Feb_2009)
GoldenPath hg38 (UCSC)	TNFRSF21 - 6p12.3 [Description] (hg38-Dec_2013)
Ensembl	TNFRSF21 - 6p12.3 [CytoView hg19] TNFRSF21 - 6p12.3 [CytoView hg38]
Mapping of homologs : NCBI	TNFRSF21 [Mapview hg19] TNFRSF21 [Mapview hg38]
OMIM	605732
	Gene and transcription
Genbank (Entrez)	AB209394 AF068868 AF208860 AJ420531 AK001504
RefSeq transcript (Entrez)	NM_014452
RefSeq genomic (Entrez)	AC_000138 NC_000006 NC_018917 NT_007592 NW_001838981 NW_004929326
Consensus coding sequences : CCDS (NCBI)	TNFRSF21
Cluster EST : Unigene	Hs.443577 [ NCBI ]
CGAP (NCI)	Hs.443577
Alternative Splicing : Fast-db (Paris)	GSHG0026659
Alternative Splicing Gallery	ENSG00000146072
Gene Expression	TNFRSF21 [ NCBI-GEO ] TNFRSF21 [ SEEK ] TNFRSF21 [ MEM ]
SOURCE (Princeton)	Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	O75509 (Uniprot)
NextProt	O75509 [Medical]
With graphics : InterPro	O75509
Splice isoforms : SwissVar	O75509 (Swissvar)
Domaine pattern : Prosite (Expaxy)	DEATH_DOMAIN (PS50017) TNFR_NGFR_1 (PS00652) TNFR_NGFR_2 (PS50050)
Domains : Interpro (EBI)	DEATH-like_dom Death_domain TNFR/NGFR_Cys_rich_reg TNFR_21
Related proteins : CluSTr	O75509
Domain families : Pfam (Sanger)	Death (PF00531)
Domain families : Pfam (NCBI)	pfam00531
Domain families : Smart (EMBL)	DEATH (SM00005) TNFR (SM00208)
DMDM Disease mutations	27242
Blocks (Seattle)	O75509
PDB (SRS)	2DBH 3QO4 3U3P 3U3Q 3U3S 3U3T 3U3V
PDB (PDBSum)	2DBH 3QO4 3U3P 3U3Q 3U3S 3U3T 3U3V
PDB (IMB)	2DBH 3QO4 3U3P 3U3Q 3U3S 3U3T 3U3V
PDB (RSDB)	2DBH 3QO4 3U3P 3U3Q 3U3S 3U3T 3U3V
Human Protein Atlas	ENSG00000146072
Peptide Atlas	O75509
HPRD	05759
IPI	IPI00004413 IPI00940125 IPI00386244
	Protein Interaction databases
DIP (DOE-UCLA)	O75509
IntAct (EBI)	O75509
FunCoup	ENSG00000146072
BioGRID	TNFRSF21
IntegromeDB	TNFRSF21
STRING (EMBL)	TNFRSF21
	Ontologies - Pathways
QuickGO	O75509
Ontology : AmiGO	B cell apoptotic process adaptive immune response protein binding plasma membrane integral component of plasma membrane apoptotic process humoral immune response axon negative regulation of B cell proliferation intrinsic component of plasma membrane negative regulation of myelination negative regulation of T cell proliferation myelination cellular lipid metabolic process small molecule metabolic process regulation of oligodendrocyte differentiation T cell receptor signaling pathway neuron apoptotic process cellular response to tumor necrosis factor oligodendrocyte apoptotic process negative regulation of interleukin-5 secretion negative regulation of interleukin-13 secretion negative regulation of interleukin-10 secretion
Ontology : EGO-EBI	B cell apoptotic process adaptive immune response protein binding plasma membrane integral component of plasma membrane apoptotic process humoral immune response axon negative regulation of B cell proliferation intrinsic component of plasma membrane negative regulation of myelination negative regulation of T cell proliferation myelination cellular lipid metabolic process small molecule metabolic process regulation of oligodendrocyte differentiation T cell receptor signaling pathway neuron apoptotic process cellular response to tumor necrosis factor oligodendrocyte apoptotic process negative regulation of interleukin-5 secretion negative regulation of interleukin-13 secretion negative regulation of interleukin-10 secretion
Pathways : KEGG	Cytokine-cytokine receptor interaction
Protein Interaction Database	TNFRSF21
DoCM (Curated mutations)	TNFRSF21
Wikipedia pathways	TNFRSF21
	Gene fusion - rearrangements
	Polymorphisms : SNP, variants
NCBI Variation Viewer	TNFRSF21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	TNFRSF21
dbVar	TNFRSF21
ClinVar	TNFRSF21
1000_Genomes	TNFRSF21
Exome Variant Server	TNFRSF21
SNP (GeneSNP Utah)	TNFRSF21
SNP : HGBase	TNFRSF21
Genetic variants : HAPMAP	TNFRSF21
Genomic Variants (DGV)	TNFRSF21 [DGVbeta]
	Mutations
ICGC Data Portal	ENSG00000146072
Somatic Mutations in Cancer : COSMIC	TNFRSF21
CONAN: Copy Number Analysis	TNFRSF21
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
Impact of mutations	[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor]
	Diseases
DECIPHER (Syndromes)	6:47199263-47277683
Mutations and Diseases : HGMD	TNFRSF21
OMIM	605732
Medgen	TNFRSF21
NextProt	O75509 [Medical]
GENETests	TNFRSF21
Disease Genetic Association	TNFRSF21
Huge Navigator	TNFRSF21 [HugePedia] TNFRSF21 [HugeCancerGEM]
snp3D : Map Gene to Disease	27242
DGIdb (Drug Gene Interaction db)	TNFRSF21
	General knowledge
Homologs : HomoloGene	TNFRSF21
Homology/Alignments : Family Browser (UCSC)	TNFRSF21
Phylogenetic Trees/Animal Genes : TreeFam	TNFRSF21
Chemical/Protein Interactions : CTD	27242
Chemical/Pharm GKB Gene	PA37775
Clinical trial	TNFRSF21
Cancer Resource (Charite)	ENSG00000146072
	Other databases
	Probes
	Litterature
PubMed	30 Pubmed reference(s) in Entrez
CoreMine	TNFRSF21
GoPubMed	TNFRSF21
iHOP	TNFRSF21

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S

Updated	12-2014	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Feb 14 19:07:02 CET 2015

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