Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TNFRSF25 (TNF receptor superfamily member 25)

Identity

Alias_namesTNFRSF12
tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein)
tumor necrosis factor receptor superfamily, member 25
Alias_symbol (synonym)DR3
TRAMP
WSL-1
LARD
WSL-LR
DDR3
TR3
APO-3
Other alias
HGNC (Hugo) TNFRSF25
LocusID (NCBI) 8718
Atlas_Id 42625
Location 1p36.31  [Link to chromosome band 1p36]
Location_base_pair Starts at 6461154 and ends at 6466195 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TNFRSF25   11910
Cards
Entrez_Gene (NCBI)TNFRSF25  8718  TNF receptor superfamily member 25
AliasesAPO-3; DDR3; DR3; LARD; 
TNFRSF12; TR3; TRAMP; WSL-1; WSL-LR
GeneCards (Weizmann)TNFRSF25
Ensembl hg19 (Hinxton)ENSG00000215788 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000215788 [Gene_View]  ENSG00000215788 [Sequence]  chr1:6461154-6466195 [Contig_View]  TNFRSF25 [Vega]
ICGC DataPortalENSG00000215788
TCGA cBioPortalTNFRSF25
AceView (NCBI)TNFRSF25
Genatlas (Paris)TNFRSF25
WikiGenes8718
SOURCE (Princeton)TNFRSF25
Genetics Home Reference (NIH)TNFRSF25
Genomic and cartography
GoldenPath hg38 (UCSC)TNFRSF25  -     chr1:6461154-6466195 -  1p36.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFRSF25  -     1p36.31   [Description]    (hg19-Feb_2009)
EnsemblTNFRSF25 - 1p36.31 [CytoView hg19]  TNFRSF25 - 1p36.31 [CytoView hg38]
Mapping of homologs : NCBITNFRSF25 [Mapview hg19]  TNFRSF25 [Mapview hg38]
OMIM603366   
Gene and transcription
Genbank (Entrez)AB308321 AF026070 AF026071 AK094463 AY358309
RefSeq transcript (Entrez)NM_001039664 NM_003790 NM_148965 NM_148966 NM_148967 NM_148968 NM_148969 NM_148970 NM_148974
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNFRSF25
Cluster EST : UnigeneHs.462529 [ NCBI ]
CGAP (NCI)Hs.462529
Alternative Splicing GalleryENSG00000215788
Gene ExpressionTNFRSF25 [ NCBI-GEO ]   TNFRSF25 [ EBI - ARRAY_EXPRESS ]   TNFRSF25 [ SEEK ]   TNFRSF25 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFRSF25 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8718
GTEX Portal (Tissue expression)TNFRSF25
Human Protein AtlasENSG00000215788-TNFRSF25 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ93038   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ93038  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ93038
Splice isoforms : SwissVarQ93038
PhosPhoSitePlusQ93038
Domaine pattern : Prosite (Expaxy)DEATH_DOMAIN (PS50017)    TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)DEATH-like_dom_sf    Death_domain    TNFR/NGFR_Cys_rich_reg    TNFR_25    TNFRSF25_N   
Domain families : Pfam (Sanger)Death (PF00531)    TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00531    pfam00020   
Domain families : Smart (EMBL)DEATH (SM00005)  TNFR (SM00208)  
Conserved Domain (NCBI)TNFRSF25
DMDM Disease mutations8718
Blocks (Seattle)TNFRSF25
SuperfamilyQ93038
Human Protein Atlas [tissue]ENSG00000215788-TNFRSF25 [tissue]
Peptide AtlasQ93038
HPRD04532
IPIIPI00003999   IPI00220675   IPI00220676   IPI00220677   IPI00219572   IPI00219573   IPI00299520   IPI00514425   IPI00219577   IPI00219578   IPI00219579   IPI00219580   IPI00513988   
Protein Interaction databases
DIP (DOE-UCLA)Q93038
IntAct (EBI)Q93038
FunCoupENSG00000215788
BioGRIDTNFRSF25
STRING (EMBL)TNFRSF25
ZODIACTNFRSF25
Ontologies - Pathways
QuickGOQ93038
Ontology : AmiGOtumor necrosis factor-activated receptor activity  extracellular region  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  apoptotic process  signal transduction  cell surface receptor signaling pathway  tumor necrosis factor-mediated signaling pathway  signaling receptor activity  regulation of apoptotic process  apoptotic signaling pathway  
Ontology : EGO-EBItumor necrosis factor-activated receptor activity  extracellular region  cytosol  plasma membrane  plasma membrane  integral component of plasma membrane  apoptotic process  signal transduction  cell surface receptor signaling pathway  tumor necrosis factor-mediated signaling pathway  signaling receptor activity  regulation of apoptotic process  apoptotic signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkTNFRSF25
Atlas of Cancer Signalling NetworkTNFRSF25
Wikipedia pathwaysTNFRSF25
Orthology - Evolution
OrthoDB8718
GeneTree (enSembl)ENSG00000215788
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF25
HOVERGENQ93038
HOGENOMQ93038
Homologs : HomoloGeneTNFRSF25
Homology/Alignments : Family Browser (UCSC)TNFRSF25
Gene fusions - Rearrangements
Fusion : QuiverTNFRSF25
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFRSF25 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFRSF25
dbVarTNFRSF25
ClinVarTNFRSF25
1000_GenomesTNFRSF25 
Exome Variant ServerTNFRSF25
ExAC (Exome Aggregation Consortium)ENSG00000215788
GNOMAD BrowserENSG00000215788
Varsome BrowserTNFRSF25
Genetic variants : HAPMAP8718
Genomic Variants (DGV)TNFRSF25 [DGVbeta]
DECIPHERTNFRSF25 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFRSF25 
Mutations
ICGC Data PortalTNFRSF25 
TCGA Data PortalTNFRSF25 
Broad Tumor PortalTNFRSF25
OASIS PortalTNFRSF25 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFRSF25  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNFRSF25
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFRSF25
DgiDB (Drug Gene Interaction Database)TNFRSF25
DoCM (Curated mutations)TNFRSF25 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF25 (select a term)
intoGenTNFRSF25
Cancer3DTNFRSF25(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603366   
Orphanet
DisGeNETTNFRSF25
MedgenTNFRSF25
Genetic Testing Registry TNFRSF25
NextProtQ93038 [Medical]
TSGene8718
GENETestsTNFRSF25
Target ValidationTNFRSF25
Huge Navigator TNFRSF25 [HugePedia]
snp3D : Map Gene to Disease8718
BioCentury BCIQTNFRSF25
ClinGenTNFRSF25
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8718
Chemical/Pharm GKB GenePA36603
Clinical trialTNFRSF25
Miscellaneous
canSAR (ICR)TNFRSF25 (select the gene name)
Probes
Litterature
PubMed64 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNFRSF25
EVEXTNFRSF25
GoPubMedTNFRSF25
iHOPTNFRSF25
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:58:17 CEST 2018
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