TNFRSF4 (TNF receptor superfamily member 4)

2003-05-01  

Identity

HGNC
LOCATION
1p36.33
LOCUSID
ALIAS
ACT35,CD134,IMD16,OX40,TXGP1L

Other Information

Locus ID:

NCBI: 7293
MIM: 600315
HGNC: 11918
Ensembl: ENSG00000186827

Variants:

dbSNP: 7293
ClinVar: 7293
TCGA: ENSG00000186827
COSMIC: TNFRSF4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186827ENST00000379236P43489

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
186450382008Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells.70
260704862015OX40 Ligand Contributes to Human Lupus Pathogenesis by Promoting T Follicular Helper Response.65
195381342009The role of OX40-mediated co-stimulation in T-cell activation and survival.61
157783432005Mice deficient in OX40 and CD30 signals lack memory antibody responses because of deficient CD4 T cell memory.50
236746712013CD134 is a cellular receptor specific for human herpesvirus-6B entry.38
218207132011Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways.37
190294462009Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells.36
212893042011OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling.34
189411882008OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells.33
258913572015PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity.33

Citation

Dessen P

TNFRSF4 (TNF receptor superfamily member 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/42626/tnfrsf4