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TNFRSF4 (TNF receptor superfamily member 4)

Identity

Alias (NCBI)ACT35
CD134
IMD16
OX40
TXGP1L
HGNC (Hugo) TNFRSF4
HGNC Alias symbACT35
OX40
CD134
HGNC Previous nameTXGP1L
HGNC Previous nametumor necrosis factor receptor superfamily, member 4
LocusID (NCBI) 7293
Atlas_Id 42626
Location 1p36.33  [Link to chromosome band 1p36]
Location_base_pair Starts at 1211340 and ends at 1214153 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)TNFRSF4   11918
Cards
Entrez_Gene (NCBI)TNFRSF4    TNF receptor superfamily member 4
AliasesACT35; CD134; IMD16; OX40; 
TXGP1L
GeneCards (Weizmann)TNFRSF4
Ensembl hg19 (Hinxton)ENSG00000186827 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186827 [Gene_View]  ENSG00000186827 [Sequence]  chr1:1211340-1214153 [Contig_View]  TNFRSF4 [Vega]
ICGC DataPortalENSG00000186827
TCGA cBioPortalTNFRSF4
AceView (NCBI)TNFRSF4
Genatlas (Paris)TNFRSF4
SOURCE (Princeton)TNFRSF4
Genetics Home Reference (NIH)TNFRSF4
Genomic and cartography
GoldenPath hg38 (UCSC)TNFRSF4  -     chr1:1211340-1214153 -  1p36.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFRSF4  -     1p36.33   [Description]    (hg19-Feb_2009)
GoldenPathTNFRSF4 - 1p36.33 [CytoView hg19]  TNFRSF4 - 1p36.33 [CytoView hg38]
ImmunoBaseENSG00000186827
genome Data Viewer NCBITNFRSF4 [Mapview hg19]  
OMIM600315   615593   
Gene and transcription
Genbank (Entrez)AW290885 AW293499 BC040257 BC105070 BC105072
RefSeq transcript (Entrez)NM_003327
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNFRSF4
Alternative Splicing GalleryENSG00000186827
Gene ExpressionTNFRSF4 [ NCBI-GEO ]   TNFRSF4 [ EBI - ARRAY_EXPRESS ]   TNFRSF4 [ SEEK ]   TNFRSF4 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFRSF4 [ Firebrowse - Broad ]
GenevisibleExpression of TNFRSF4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7293
GTEX Portal (Tissue expression)TNFRSF4
Human Protein AtlasENSG00000186827-TNFRSF4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43489   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP43489  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP43489
Splice isoforms : SwissVarP43489
PhosPhoSitePlusP43489
Domaine pattern : Prosite (Expaxy)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)TNFR/NGFR_Cys_rich_reg    TNFR_4    TNFRSF4_N    Tyr-kin_ephrin_A/B_rcpt-like   
Domain families : Pfam (Sanger)TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00020   
Domain families : Smart (EMBL)Ephrin_rec_like (SM01411)  TNFR (SM00208)  
Conserved Domain (NCBI)TNFRSF4
Blocks (Seattle)TNFRSF4
PDB (RSDB)1D0A    2HEV    2HEY    6OGX    6OKM    6OKN   
PDB Europe1D0A    2HEV    2HEY    6OGX    6OKM    6OKN   
PDB (PDBSum)1D0A    2HEV    2HEY    6OGX    6OKM    6OKN   
PDB (IMB)1D0A    2HEV    2HEY    6OGX    6OKM    6OKN   
Structural Biology KnowledgeBase1D0A    2HEV    2HEY    6OGX    6OKM    6OKN   
SCOP (Structural Classification of Proteins)1D0A    2HEV    2HEY    6OGX    6OKM    6OKN   
CATH (Classification of proteins structures)1D0A    2HEV    2HEY    6OGX    6OKM    6OKN   
SuperfamilyP43489
Human Protein Atlas [tissue]ENSG00000186827-TNFRSF4 [tissue]
Peptide AtlasP43489
HPRD02636
IPIIPI00018859   IPI00515079   
Protein Interaction databases
DIP (DOE-UCLA)P43489
IntAct (EBI)P43489
BioGRIDTNFRSF4
STRING (EMBL)TNFRSF4
ZODIACTNFRSF4
Ontologies - Pathways
QuickGOP43489
Ontology : AmiGOvirus receptor activity  positive regulation of immunoglobulin production  tumor necrosis factor-activated receptor activity  protein binding  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  external side of plasma membrane  cell surface  positive regulation of B cell proliferation  tumor necrosis factor-mediated signaling pathway  T cell proliferation  negative regulation of DNA-binding transcription factor activity  negative regulation of transcription, DNA-templated  viral entry into host cell  
Ontology : EGO-EBIvirus receptor activity  positive regulation of immunoglobulin production  tumor necrosis factor-activated receptor activity  protein binding  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  external side of plasma membrane  cell surface  positive regulation of B cell proliferation  tumor necrosis factor-mediated signaling pathway  T cell proliferation  negative regulation of DNA-binding transcription factor activity  negative regulation of transcription, DNA-templated  viral entry into host cell  
Pathways : BIOCARTAOX40 Signaling Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkTNFRSF4
Atlas of Cancer Signalling NetworkTNFRSF4
Wikipedia pathwaysTNFRSF4
Orthology - Evolution
OrthoDB7293
GeneTree (enSembl)ENSG00000186827
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF4
HOGENOMP43489
Homologs : HomoloGeneTNFRSF4
Homology/Alignments : Family Browser (UCSC)TNFRSF4
Gene fusions - Rearrangements
Fusion : QuiverTNFRSF4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFRSF4 [hg38]
dbVarTNFRSF4
ClinVarTNFRSF4
MonarchTNFRSF4
1000_GenomesTNFRSF4 
Exome Variant ServerTNFRSF4
GNOMAD BrowserENSG00000186827
Varsome BrowserTNFRSF4
Genomic Variants (DGV)TNFRSF4 [DGVbeta]
DECIPHERTNFRSF4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFRSF4 
Mutations
ICGC Data PortalTNFRSF4 
TCGA Data PortalTNFRSF4 
Broad Tumor PortalTNFRSF4
OASIS PortalTNFRSF4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFRSF4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNFRSF4
Mutations and Diseases : HGMDTNFRSF4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFRSF4
DgiDB (Drug Gene Interaction Database)TNFRSF4
DoCM (Curated mutations)TNFRSF4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF4 (select a term)
intoGenTNFRSF4
Cancer3DTNFRSF4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600315    615593   
Orphanet23233   
DisGeNETTNFRSF4
MedgenTNFRSF4
Genetic Testing Registry TNFRSF4
NextProtP43489 [Medical]
GENETestsTNFRSF4
Target ValidationTNFRSF4
Huge Navigator TNFRSF4 [HugePedia]
ClinGenTNFRSF4
Clinical trials, drugs, therapy
MyCancerGenomeTNFRSF4
Protein Interactions : CTD
Pharm GKB GenePA36611
PharosP43489
Clinical trialTNFRSF4
Miscellaneous
canSAR (ICR)TNFRSF4 (select the gene name)
HarmonizomeTNFRSF4
DataMed IndexTNFRSF4
Probes
Litterature
PubMed116 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNFRSF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 25 19:50:16 CET 2021

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