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TNFRSF8 (TNF receptor superfamily member 8)

Identity

Alias (NCBI)CD30
D1S166E
Ki-1
HGNC (Hugo) TNFRSF8
HGNC Alias symbKI-1
HGNC Previous nameCD30
 D1S166E
HGNC Previous nametumor necrosis factor receptor superfamily, member 8
LocusID (NCBI) 943
Atlas_Id 42630
Location 1p36.22  [Link to chromosome band 1p36]
Location_base_pair Starts at 12063377 and ends at 12144207 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PIK3CD (1p36.22) / TNFRSF8 (1p36.22)PLEKHG5 (1p36.31) / TNFRSF8 (1p36.22)STARD13 (13q13.1) / TNFRSF8 (1p36.22)
PLEKHG5 1p36.31 / TNFRSF8 1p36.22STARD13 13q13.1 / TNFRSF8 1p36.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;14)(p25.3;q11.2) TRA/IRF4

External links

 

Nomenclature
HGNC (Hugo)TNFRSF8   11923
Cards
Entrez_Gene (NCBI)TNFRSF8    TNF receptor superfamily member 8
AliasesCD30; D1S166E; Ki-1
GeneCards (Weizmann)TNFRSF8
Ensembl hg19 (Hinxton)ENSG00000120949 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120949 [Gene_View]  ENSG00000120949 [Sequence]  chr1:12063377-12144207 [Contig_View]  TNFRSF8 [Vega]
ICGC DataPortalENSG00000120949
TCGA cBioPortalTNFRSF8
AceView (NCBI)TNFRSF8
Genatlas (Paris)TNFRSF8
SOURCE (Princeton)TNFRSF8
Genetics Home Reference (NIH)TNFRSF8
Genomic and cartography
GoldenPath hg38 (UCSC)TNFRSF8  -     chr1:12063377-12144207 +  1p36.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFRSF8  -     1p36.22   [Description]    (hg19-Feb_2009)
GoldenPathTNFRSF8 - 1p36.22 [CytoView hg19]  TNFRSF8 - 1p36.22 [CytoView hg38]
ImmunoBaseENSG00000120949
Genome Data Viewer NCBITNFRSF8 [Mapview hg19]  
OMIM153243   
Gene and transcription
Genbank (Entrez)BC063482 BC073839 BC136400 BC141804 BC171762
RefSeq transcript (Entrez)NM_001243 NM_001281430 NM_152942
Consensus coding sequences : CCDS (NCBI)TNFRSF8
Gene ExpressionTNFRSF8 [ NCBI-GEO ]   TNFRSF8 [ EBI - ARRAY_EXPRESS ]   TNFRSF8 [ SEEK ]   TNFRSF8 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFRSF8 [ Firebrowse - Broad ]
GenevisibleExpression of TNFRSF8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)943
GTEX Portal (Tissue expression)TNFRSF8
Human Protein AtlasENSG00000120949-TNFRSF8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28908   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28908  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28908
PhosPhoSitePlusP28908
Domaine pattern : Prosite (Expaxy)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)TNFR/NGFR_Cys_rich_reg    TNFR_8    TNFRSF8_N   
Domain families : Pfam (Sanger)TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00020   
Domain families : Smart (EMBL)TNFR (SM00208)  
Conserved Domain (NCBI)TNFRSF8
PDB (RSDB)1D01   
PDB Europe1D01   
PDB (PDBSum)1D01   
PDB (IMB)1D01   
Structural Biology KnowledgeBase1D01   
SCOP (Structural Classification of Proteins)1D01   
CATH (Classification of proteins structures)1D01   
SuperfamilyP28908
AlphaFold pdb e-kbP28908   
Human Protein Atlas [tissue]ENSG00000120949-TNFRSF8 [tissue]
HPRD01074
Protein Interaction databases
DIP (DOE-UCLA)P28908
IntAct (EBI)P28908
BioGRIDTNFRSF8
STRING (EMBL)TNFRSF8
ZODIACTNFRSF8
Ontologies - Pathways
QuickGOP28908
Ontology : AmiGOtransmembrane signaling receptor activity  cytoplasm  plasma membrane  plasma membrane  signal transduction  negative regulation of cell population proliferation  integral component of membrane  positive regulation of TRAIL production  positive regulation of tumor necrosis factor production  tumor necrosis factor-mediated signaling pathway  positive regulation of apoptotic process  extracellular exosome  cellular response to mechanical stimulus  
Ontology : EGO-EBItransmembrane signaling receptor activity  cytoplasm  plasma membrane  plasma membrane  signal transduction  negative regulation of cell population proliferation  integral component of membrane  positive regulation of TRAIL production  positive regulation of tumor necrosis factor production  tumor necrosis factor-mediated signaling pathway  positive regulation of apoptotic process  extracellular exosome  cellular response to mechanical stimulus  
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkTNFRSF8
Atlas of Cancer Signalling NetworkTNFRSF8
Wikipedia pathwaysTNFRSF8
Orthology - Evolution
OrthoDB943
GeneTree (enSembl)ENSG00000120949
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF8
Homologs : HomoloGeneTNFRSF8
Homology/Alignments : Family Browser (UCSC)TNFRSF8
Gene fusions - Rearrangements
Fusion : MitelmanPLEKHG5/TNFRSF8 [1p36.31/1p36.22]  
Fusion : MitelmanSTARD13/TNFRSF8 [13q13.1/1p36.22]  
Fusion : QuiverTNFRSF8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFRSF8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFRSF8
dbVarTNFRSF8
ClinVarTNFRSF8
MonarchTNFRSF8
1000_GenomesTNFRSF8 
Exome Variant ServerTNFRSF8
GNOMAD BrowserENSG00000120949
Varsome BrowserTNFRSF8
ACMGTNFRSF8 variants
VarityP28908
Genomic Variants (DGV)TNFRSF8 [DGVbeta]
DECIPHERTNFRSF8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFRSF8 
Mutations
ICGC Data PortalTNFRSF8 
TCGA Data PortalTNFRSF8 
Broad Tumor PortalTNFRSF8
OASIS PortalTNFRSF8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFRSF8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNFRSF8
Mutations and Diseases : HGMDTNFRSF8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTNFRSF8
DgiDB (Drug Gene Interaction Database)TNFRSF8
DoCM (Curated mutations)TNFRSF8
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF8
Cancer3DTNFRSF8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM153243   
Orphanet
DisGeNETTNFRSF8
MedgenTNFRSF8
Genetic Testing Registry TNFRSF8
NextProtP28908 [Medical]
GENETestsTNFRSF8
Target ValidationTNFRSF8
Huge Navigator TNFRSF8 [HugePedia]
ClinGenTNFRSF8
Clinical trials, drugs, therapy
MyCancerGenomeTNFRSF8
Protein Interactions : CTDTNFRSF8
Pharm GKB GenePA36616
PharosP28908
Clinical trialTNFRSF8
Miscellaneous
canSAR (ICR)TNFRSF8
HarmonizomeTNFRSF8
DataMed IndexTNFRSF8
Probes
Litterature
PubMed215 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNFRSF8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:44 CEST 2021
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