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TNFRSF8 (tumor necrosis factor receptor superfamily, member 8)

Identity

Other namesCD30
D1S166E
Ki-1
HGNC (Hugo) TNFRSF8
LocusID (NCBI) 943
Location 1p36.22
Location_base_pair Starts at 12123434 and ends at 12204264 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615

External links

Nomenclature
HGNC (Hugo)TNFRSF8   11923
Cards
Entrez_Gene (NCBI)TNFRSF8  943  tumor necrosis factor receptor superfamily, member 8
GeneCards (Weizmann)TNFRSF8
Ensembl hg19 (Hinxton)ENSG00000120949 [Gene_View]  chr1:12123434-12204264 [Contig_View]  TNFRSF8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000120949 [Gene_View]  chr1:12123434-12204264 [Contig_View]  TNFRSF8 [Vega]
ICGC DataPortalENSG00000120949
cBioPortalTNFRSF8
AceView (NCBI)TNFRSF8
Genatlas (Paris)TNFRSF8
WikiGenes943
SOURCE (Princeton)TNFRSF8
Genomic and cartography
GoldenPath hg19 (UCSC)TNFRSF8  -     chr1:12123434-12204264 +  1p36.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TNFRSF8  -     1p36.22   [Description]    (hg38-Dec_2013)
EnsemblTNFRSF8 - 1p36.22 [CytoView hg19]  TNFRSF8 - 1p36.22 [CytoView hg38]
Mapping of homologs : NCBITNFRSF8 [Mapview hg19]  TNFRSF8 [Mapview hg38]
OMIM153243   
Gene and transcription
Genbank (Entrez)BC063482 BC073839 BC136400 BC141804 BC171762
RefSeq transcript (Entrez)NM_001243 NM_001281430 NM_152942
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_029573 NT_032977 NW_001838534 NW_004929289
Consensus coding sequences : CCDS (NCBI)TNFRSF8
Cluster EST : UnigeneHs.1314 [ NCBI ]
CGAP (NCI)Hs.1314
Alternative Splicing : Fast-db (Paris)GSHG0000132
Alternative Splicing GalleryENSG00000120949
Gene ExpressionTNFRSF8 [ NCBI-GEO ]     TNFRSF8 [ SEEK ]   TNFRSF8 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28908 (Uniprot)
NextProtP28908  [Medical]
With graphics : InterProP28908
Splice isoforms : SwissVarP28908 (Swissvar)
Domaine pattern : Prosite (Expaxy)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)TNFR/NGFR_Cys_rich_reg    TNFR_8   
Related proteins : CluSTrP28908
Domain families : Pfam (Sanger)TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00020   
Domain families : Smart (EMBL)TNFR (SM00208)  
DMDM Disease mutations943
Blocks (Seattle)P28908
PDB (SRS)1D01   
PDB (PDBSum)1D01   
PDB (IMB)1D01   
PDB (RSDB)1D01   
Human Protein AtlasENSG00000120949
Peptide AtlasP28908
HPRD01074
IPIIPI00006073   IPI00759738   IPI00873177   IPI00430795   IPI00966159   
Protein Interaction databases
DIP (DOE-UCLA)P28908
IntAct (EBI)P28908
FunCoupENSG00000120949
BioGRIDTNFRSF8
IntegromeDBTNFRSF8
STRING (EMBL)TNFRSF8
Ontologies - Pathways
QuickGOP28908
Ontology : AmiGOtransmembrane signaling receptor activity  tumor necrosis factor-activated receptor activity  cytoplasm  plasma membrane  signal transduction  negative regulation of cell proliferation  integral component of membrane  tumor necrosis factor-mediated signaling pathway  positive regulation of tumor necrosis factor biosynthetic process  positive regulation of apoptotic process  positive regulation of TRAIL biosynthetic process  extracellular vesicular exosome  cellular response to mechanical stimulus  
Ontology : EGO-EBItransmembrane signaling receptor activity  tumor necrosis factor-activated receptor activity  cytoplasm  plasma membrane  signal transduction  negative regulation of cell proliferation  integral component of membrane  tumor necrosis factor-mediated signaling pathway  positive regulation of tumor necrosis factor biosynthetic process  positive regulation of apoptotic process  positive regulation of TRAIL biosynthetic process  extracellular vesicular exosome  cellular response to mechanical stimulus  
Pathways : KEGGCytokine-cytokine receptor interaction   
Protein Interaction DatabaseTNFRSF8
DoCM (Curated mutations)TNFRSF8
Wikipedia pathwaysTNFRSF8
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTNFRSF8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFRSF8
dbVarTNFRSF8
ClinVarTNFRSF8
1000_GenomesTNFRSF8 
Exome Variant ServerTNFRSF8
SNP (GeneSNP Utah)TNFRSF8
SNP : HGBaseTNFRSF8
Genetic variants : HAPMAPTNFRSF8
Genomic VariantsTNFRSF8  TNFRSF8 [DGVbeta]
Mutations
ICGC Data PortalENSG00000120949 
Somatic Mutations in Cancer : COSMICTNFRSF8 
CONAN: Copy Number AnalysisTNFRSF8 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:12123434-12204264
Mutations and Diseases : HGMDTNFRSF8
OMIM153243   
MedgenTNFRSF8
NextProtP28908 [Medical]
GENETestsTNFRSF8
Disease Genetic AssociationTNFRSF8
Huge Navigator TNFRSF8 [HugePedia]  TNFRSF8 [HugeCancerGEM]
snp3D : Map Gene to Disease943
DGIdb (Drug Gene Interaction db)TNFRSF8
General knowledge
Homologs : HomoloGeneTNFRSF8
Homology/Alignments : Family Browser (UCSC)TNFRSF8
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF8
Chemical/Protein Interactions : CTD943
Chemical/Pharm GKB GenePA36616
Clinical trialTNFRSF8
Cancer Resource (Charite)ENSG00000120949
Other databases
Probes
Litterature
PubMed158 Pubmed reference(s) in Entrez
CoreMineTNFRSF8
GoPubMedTNFRSF8
iHOPTNFRSF8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 02:01:06 CET 2014
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