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TNFRSF9 (tumor necrosis factor receptor superfamily member 9)

Identity

Alias_namesILA
tumor necrosis factor receptor superfamily
Alias_symbol (synonym)CD137
4-1BB
HGNC (Hugo) TNFRSF9
LocusID (NCBI) 3604
Atlas_Id 42631
Location 1p36.23  [Link to chromosome band 1p36]
Location_base_pair Starts at 7975931 and ends at 8003225 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNFRSF9   11924
Cards
Entrez_Gene (NCBI)TNFRSF9  3604  tumor necrosis factor receptor superfamily member 9
Aliases4-1BB; CD137; CDw137; ILA
GeneCards (Weizmann)TNFRSF9
Ensembl hg19 (Hinxton)ENSG00000049249 [Gene_View]  chr1:7975931-8003225 [Contig_View]  TNFRSF9 [Vega]
Ensembl hg38 (Hinxton)ENSG00000049249 [Gene_View]  chr1:7975931-8003225 [Contig_View]  TNFRSF9 [Vega]
ICGC DataPortalENSG00000049249
TCGA cBioPortalTNFRSF9
AceView (NCBI)TNFRSF9
Genatlas (Paris)TNFRSF9
WikiGenes3604
SOURCE (Princeton)TNFRSF9
Genetics Home Reference (NIH)TNFRSF9
Genomic and cartography
GoldenPath hg19 (UCSC)TNFRSF9  -     chr1:7975931-8003225 -  1p36.23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TNFRSF9  -     1p36.23   [Description]    (hg38-Dec_2013)
EnsemblTNFRSF9 - 1p36.23 [CytoView hg19]  TNFRSF9 - 1p36.23 [CytoView hg38]
Mapping of homologs : NCBITNFRSF9 [Mapview hg19]  TNFRSF9 [Mapview hg38]
OMIM602250   
Gene and transcription
Genbank (Entrez)AK125490 AW449076 BC006196 BP381234 DQ892697
RefSeq transcript (Entrez)NM_001561
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929289
Consensus coding sequences : CCDS (NCBI)TNFRSF9
Cluster EST : UnigeneHs.738942 [ NCBI ]
CGAP (NCI)Hs.738942
Alternative Splicing GalleryENSG00000049249
Gene ExpressionTNFRSF9 [ NCBI-GEO ]   TNFRSF9 [ EBI - ARRAY_EXPRESS ]   TNFRSF9 [ SEEK ]   TNFRSF9 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFRSF9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3604
GTEX Portal (Tissue expression)TNFRSF9
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07011   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ07011  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07011
Splice isoforms : SwissVarQ07011
PhosPhoSitePlusQ07011
Domaine pattern : Prosite (Expaxy)TNFR_NGFR_1 (PS00652)    TNFR_NGFR_2 (PS50050)   
Domains : Interpro (EBI)Growth_fac_rcpt_    TNFR/NGFR_Cys_rich_reg    TNFR_9   
Domain families : Pfam (Sanger)TNFR_c6 (PF00020)   
Domain families : Pfam (NCBI)pfam00020   
Domain families : Smart (EMBL)TNFR (SM00208)  
Conserved Domain (NCBI)TNFRSF9
DMDM Disease mutations3604
Blocks (Seattle)TNFRSF9
SuperfamilyQ07011
Human Protein AtlasENSG00000049249
Peptide AtlasQ07011
HPRD03767
IPIIPI00549343   
Protein Interaction databases
DIP (DOE-UCLA)Q07011
IntAct (EBI)Q07011
FunCoupENSG00000049249
BioGRIDTNFRSF9
STRING (EMBL)TNFRSF9
ZODIACTNFRSF9
Ontologies - Pathways
QuickGOQ07011
Ontology : AmiGOreceptor activity  tumor necrosis factor-activated receptor activity  extracellular space  integral component of plasma membrane  apoptotic process  inflammatory response  immune response  multicellular organism development  negative regulation of cell proliferation  extrinsic apoptotic signaling pathway via death domain receptors  external side of plasma membrane  cytokine binding  response to lipopolysaccharide  tumor necrosis factor-mediated signaling pathway  regulation of apoptotic process  protein homotrimerization  negative regulation of interleukin-10 secretion  negative regulation of interleukin-12 secretion  
Ontology : EGO-EBIreceptor activity  tumor necrosis factor-activated receptor activity  extracellular space  integral component of plasma membrane  apoptotic process  inflammatory response  immune response  multicellular organism development  negative regulation of cell proliferation  extrinsic apoptotic signaling pathway via death domain receptors  external side of plasma membrane  cytokine binding  response to lipopolysaccharide  tumor necrosis factor-mediated signaling pathway  regulation of apoptotic process  protein homotrimerization  negative regulation of interleukin-10 secretion  negative regulation of interleukin-12 secretion  
Pathways : BIOCARTAThe 4-1BB-dependent immune response [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkTNFRSF9
Atlas of Cancer Signalling NetworkTNFRSF9
Wikipedia pathwaysTNFRSF9
Orthology - Evolution
OrthoDB3604
GeneTree (enSembl)ENSG00000049249
Phylogenetic Trees/Animal Genes : TreeFamTNFRSF9
HOVERGENQ07011
HOGENOMQ07011
Homologs : HomoloGeneTNFRSF9
Homology/Alignments : Family Browser (UCSC)TNFRSF9
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFRSF9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFRSF9
dbVarTNFRSF9
ClinVarTNFRSF9
1000_GenomesTNFRSF9 
Exome Variant ServerTNFRSF9
ExAC (Exome Aggregation Consortium)TNFRSF9 (select the gene name)
Genetic variants : HAPMAP3604
Genomic Variants (DGV)TNFRSF9 [DGVbeta]
DECIPHER (Syndromes)1:7975931-8003225  ENSG00000049249
CONAN: Copy Number AnalysisTNFRSF9 
Mutations
ICGC Data PortalTNFRSF9 
TCGA Data PortalTNFRSF9 
Broad Tumor PortalTNFRSF9
OASIS PortalTNFRSF9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFRSF9  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNFRSF9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFRSF9
DgiDB (Drug Gene Interaction Database)TNFRSF9
DoCM (Curated mutations)TNFRSF9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFRSF9 (select a term)
intoGenTNFRSF9
Cancer3DTNFRSF9(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602250   
Orphanet
MedgenTNFRSF9
Genetic Testing Registry TNFRSF9
NextProtQ07011 [Medical]
TSGene3604
GENETestsTNFRSF9
Huge Navigator TNFRSF9 [HugePedia]
snp3D : Map Gene to Disease3604
BioCentury BCIQTNFRSF9
ClinGenTNFRSF9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3604
Chemical/Pharm GKB GenePA36617
Clinical trialTNFRSF9
Miscellaneous
canSAR (ICR)TNFRSF9 (select the gene name)
Probes
Litterature
PubMed105 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNFRSF9
EVEXTNFRSF9
GoPubMedTNFRSF9
iHOPTNFRSF9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Nov 18 19:54:10 CET 2016

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