Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TNFSF12 (TNF superfamily member 12)

Identity

Alias_namestumor necrosis factor (ligand) superfamily
Alias_symbol (synonym)TWEAK
DR3LG
APO3L
Other aliasTNLG4A
HGNC (Hugo) TNFSF12
LocusID (NCBI) 8742
Atlas_Id 42634
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 7549058 and ends at 7557890 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TNFSF12 (17p13.1) / TNFSF13 (17p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNFSF12   11927
Cards
Entrez_Gene (NCBI)TNFSF12  8742  TNF superfamily member 12
AliasesAPO3L; DR3LG; TNLG4A; TWEAK
GeneCards (Weizmann)TNFSF12
Ensembl hg19 (Hinxton)ENSG00000239697 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000239697 [Gene_View]  chr17:7549058-7557890 [Contig_View]  TNFSF12 [Vega]
ICGC DataPortalENSG00000239697
TCGA cBioPortalTNFSF12
AceView (NCBI)TNFSF12
Genatlas (Paris)TNFSF12
WikiGenes8742
SOURCE (Princeton)TNFSF12
Genetics Home Reference (NIH)TNFSF12
Genomic and cartography
GoldenPath hg38 (UCSC)TNFSF12  -     chr17:7549058-7557890 +  17p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFSF12  -     17p13.1   [Description]    (hg19-Feb_2009)
EnsemblTNFSF12 - 17p13.1 [CytoView hg19]  TNFSF12 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBITNFSF12 [Mapview hg19]  TNFSF12 [Mapview hg38]
OMIM602695   
Gene and transcription
Genbank (Entrez)AF030099 AF055872 AI091441 AY358870 BC019047
RefSeq transcript (Entrez)NM_003809
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNFSF12
Cluster EST : UnigeneHs.54673 [ NCBI ]
CGAP (NCI)Hs.54673
Alternative Splicing GalleryENSG00000239697
Gene ExpressionTNFSF12 [ NCBI-GEO ]   TNFSF12 [ EBI - ARRAY_EXPRESS ]   TNFSF12 [ SEEK ]   TNFSF12 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFSF12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8742
GTEX Portal (Tissue expression)TNFSF12
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43508   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43508  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43508
Splice isoforms : SwissVarO43508
PhosPhoSitePlusO43508
Domaine pattern : Prosite (Expaxy)TNF_2 (PS50049)   
Domains : Interpro (EBI)TNF_dom    Tumour_necrosis_fac-like_dom   
Domain families : Pfam (Sanger)TNF (PF00229)   
Domain families : Pfam (NCBI)pfam00229   
Domain families : Smart (EMBL)TNF (SM00207)  
Conserved Domain (NCBI)TNFSF12
DMDM Disease mutations8742
Blocks (Seattle)TNFSF12
PDB (SRS)4HT1   
PDB (PDBSum)4HT1   
PDB (IMB)4HT1   
PDB (RSDB)4HT1   
Structural Biology KnowledgeBase4HT1   
SCOP (Structural Classification of Proteins)4HT1   
CATH (Classification of proteins structures)4HT1   
SuperfamilyO43508
Human Protein AtlasENSG00000239697
Peptide AtlasO43508
HPRD04074
IPIIPI00021900   IPI00027239   IPI00218935   IPI00218937   IPI00797285   IPI00979259   IPI00719357   IPI00789972   IPI00796683   IPI00171259   IPI00218017   
Protein Interaction databases
DIP (DOE-UCLA)O43508
IntAct (EBI)O43508
FunCoupENSG00000239697
BioGRIDTNFSF12
STRING (EMBL)TNFSF12
ZODIACTNFSF12
Ontologies - Pathways
QuickGOO43508
Ontology : AmiGOangiogenesis  positive regulation of endothelial cell proliferation  receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular region  extracellular space  plasma membrane  integral component of plasma membrane  apoptotic process  immune response  signal transduction  cell differentiation  tumor necrosis factor-mediated signaling pathway  endothelial cell migration  positive regulation of protein catabolic process  positive regulation of angiogenesis  perinuclear region of cytoplasm  extrinsic apoptotic signaling pathway  positive regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIangiogenesis  positive regulation of endothelial cell proliferation  receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular region  extracellular space  plasma membrane  integral component of plasma membrane  apoptotic process  immune response  signal transduction  cell differentiation  tumor necrosis factor-mediated signaling pathway  endothelial cell migration  positive regulation of protein catabolic process  positive regulation of angiogenesis  perinuclear region of cytoplasm  extrinsic apoptotic signaling pathway  positive regulation of extrinsic apoptotic signaling pathway  
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkTNFSF12
Atlas of Cancer Signalling NetworkTNFSF12
Wikipedia pathwaysTNFSF12
Orthology - Evolution
OrthoDB8742
GeneTree (enSembl)ENSG00000239697
Phylogenetic Trees/Animal Genes : TreeFamTNFSF12
HOVERGENO43508
HOGENOMO43508
Homologs : HomoloGeneTNFSF12
Homology/Alignments : Family Browser (UCSC)TNFSF12
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFSF12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFSF12
dbVarTNFSF12
ClinVarTNFSF12
1000_GenomesTNFSF12 
Exome Variant ServerTNFSF12
ExAC (Exome Aggregation Consortium)TNFSF12 (select the gene name)
Genetic variants : HAPMAP8742
Genomic Variants (DGV)TNFSF12 [DGVbeta]
DECIPHERTNFSF12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFSF12 
Mutations
ICGC Data PortalTNFSF12 
TCGA Data PortalTNFSF12 
Broad Tumor PortalTNFSF12
OASIS PortalTNFSF12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFSF12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNFSF12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFSF12
DgiDB (Drug Gene Interaction Database)TNFSF12
DoCM (Curated mutations)TNFSF12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFSF12 (select a term)
intoGenTNFSF12
Cancer3DTNFSF12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602695   
Orphanet3469    3469   
MedgenTNFSF12
Genetic Testing Registry TNFSF12
NextProtO43508 [Medical]
TSGene8742
GENETestsTNFSF12
Target ValidationTNFSF12
Huge Navigator TNFSF12 [HugePedia]
snp3D : Map Gene to Disease8742
BioCentury BCIQTNFSF12
ClinGenTNFSF12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8742
Chemical/Pharm GKB GenePA36620
Clinical trialTNFSF12
Miscellaneous
canSAR (ICR)TNFSF12 (select the gene name)
Probes
Litterature
PubMed162 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNFSF12
EVEXTNFSF12
GoPubMedTNFSF12
iHOPTNFSF12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 13:00:00 CEST 2017

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