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TNFSF14 (tumor necrosis factor superfamily member 14)

Identity

Other namesCD258
HVEML
LIGHT
LTg
HGNC (Hugo) TNFSF14
LocusID (NCBI) 8740
Atlas_Id 42637
Location 19p13.3
Location_base_pair Starts at 6663148 and ends at 6670599 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TNFSF14 (19p13.3) / GRAMD1A (19q13.11)TNFSF14 19p13.3 / GRAMD1A 19q13.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNFSF14   11930
Cards
Entrez_Gene (NCBI)TNFSF14  8740  tumor necrosis factor superfamily member 14
GeneCards (Weizmann)TNFSF14
Ensembl hg19 (Hinxton)ENSG00000125735 [Gene_View]  chr19:6663148-6670599 [Contig_View]  TNFSF14 [Vega]
Ensembl hg38 (Hinxton)ENSG00000125735 [Gene_View]  chr19:6663148-6670599 [Contig_View]  TNFSF14 [Vega]
ICGC DataPortalENSG00000125735
TCGA cBioPortalTNFSF14
AceView (NCBI)TNFSF14
Genatlas (Paris)TNFSF14
WikiGenes8740
SOURCE (Princeton)TNFSF14
Genomic and cartography
GoldenPath hg19 (UCSC)TNFSF14  -     chr19:6663148-6670599 -  19p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TNFSF14  -     19p13.3   [Description]    (hg38-Dec_2013)
EnsemblTNFSF14 - 19p13.3 [CytoView hg19]  TNFSF14 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBITNFSF14 [Mapview hg19]  TNFSF14 [Mapview hg38]
OMIM604520   
Gene and transcription
Genbank (Entrez)AF036581 AF064090 AK026704 AK292037 AY028261
RefSeq transcript (Entrez)NM_003807 NM_172014
RefSeq genomic (Entrez)NC_000019 NC_018930 NT_011295 NW_004929412
Consensus coding sequences : CCDS (NCBI)TNFSF14
Cluster EST : UnigeneHs.129708 [ NCBI ]
CGAP (NCI)Hs.129708
Alternative Splicing : Fast-db (Paris)GSHG0015424
Alternative Splicing GalleryENSG00000125735
Gene ExpressionTNFSF14 [ NCBI-GEO ]   TNFSF14 [ EBI - ARRAY_EXPRESS ]   TNFSF14 [ SEEK ]   TNFSF14 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFSF14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)8740
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43557 (Uniprot)
NextProtO43557  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43557
Splice isoforms : SwissVarO43557 (Swissvar)
PhosPhoSitePlusO43557
Domaine pattern : Prosite (Expaxy)TNF_2 (PS50049)   
Domains : Interpro (EBI)TNF    TNF_dom    Tumour_necrosis_fac-like_dom   
Domain families : Pfam (Sanger)TNF (PF00229)   
Domain families : Pfam (NCBI)pfam00229   
Domain families : Smart (EMBL)TNF (SM00207)  
DMDM Disease mutations8740
Blocks (Seattle)TNFSF14
PDB (SRS)4EN0    4J6G    4KG8    4KGG    4KGQ    4RSU   
PDB (PDBSum)4EN0    4J6G    4KG8    4KGG    4KGQ    4RSU   
PDB (IMB)4EN0    4J6G    4KG8    4KGG    4KGQ    4RSU   
PDB (RSDB)4EN0    4J6G    4KG8    4KGG    4KGQ    4RSU   
Structural Biology KnowledgeBase4EN0    4J6G    4KG8    4KGG    4KGQ    4RSU   
SCOP (Structural Classification of Proteins)4EN0    4J6G    4KG8    4KGG    4KGQ    4RSU   
CATH (Classification of proteins structures)4EN0    4J6G    4KG8    4KGG    4KGQ    4RSU   
SuperfamilyO43557
Human Protein AtlasENSG00000125735
Peptide AtlasO43557
HPRD05157
IPIIPI00307531   IPI00221341   
Protein Interaction databases
DIP (DOE-UCLA)O43557
IntAct (EBI)O43557
FunCoupENSG00000125735
BioGRIDTNFSF14
STRING (EMBL)TNFSF14
ZODIACTNFSF14
Ontologies - Pathways
QuickGOO43557
Ontology : AmiGOreceptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular space  cytoplasm  plasma membrane  apoptotic process  immune response  signal transduction  release of cytoplasmic sequestered NF-kappaB  positive regulation of T cell chemotaxis  integral component of membrane  T cell costimulation  tumor necrosis factor-mediated signaling pathway  T cell proliferation  T cell activation  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  T cell homeostasis  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of myoblast differentiation  cellular response to mechanical stimulus  positive regulation of myoblast fusion  
Ontology : EGO-EBIreceptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular space  cytoplasm  plasma membrane  apoptotic process  immune response  signal transduction  release of cytoplasmic sequestered NF-kappaB  positive regulation of T cell chemotaxis  integral component of membrane  T cell costimulation  tumor necrosis factor-mediated signaling pathway  T cell proliferation  T cell activation  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  T cell homeostasis  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of myoblast differentiation  cellular response to mechanical stimulus  positive regulation of myoblast fusion  
Pathways : KEGGCytokine-cytokine receptor interaction    NF-kappa B signaling pathway    Herpes simplex infection   
NDEx Network
Atlas of Cancer Signalling NetworkTNFSF14
Wikipedia pathwaysTNFSF14
Orthology - Evolution
OrthoDB8740
GeneTree (enSembl)ENSG00000125735
Phylogenetic Trees/Animal Genes : TreeFamTNFSF14
Homologs : HomoloGeneTNFSF14
Homology/Alignments : Family Browser (UCSC)TNFSF14
Gene fusions - Rearrangements
Fusion: TCGATNFSF14 19p13.3 GRAMD1A 19q13.11 HNSC
Polymorphisms : SNP, variants
NCBI Variation ViewerTNFSF14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFSF14
dbVarTNFSF14
ClinVarTNFSF14
1000_GenomesTNFSF14 
Exome Variant ServerTNFSF14
ExAC (Exome Aggregation Consortium)TNFSF14 (select the gene name)
SNP (GeneSNP Utah)TNFSF14
SNP : HGBaseTNFSF14
Genetic variants : HAPMAPTNFSF14
Genomic Variants (DGV)TNFSF14 [DGVbeta]
Mutations
ICGC Data PortalTNFSF14 
TCGA Data PortalTNFSF14 
Broad Tumor PortalTNFSF14
OASIS PortalTNFSF14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFSF14 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFSF14
DgiDB (Drug Gene Interaction Database)TNFSF14
DoCM (Curated mutations)TNFSF14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFSF14 (select a term)
intoGenTNFSF14
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:6663148-6670599
CONAN: Copy Number AnalysisTNFSF14 
Mutations and Diseases : HGMDTNFSF14
OMIM604520   
MedgenTNFSF14
Genetic Testing Registry TNFSF14
NextProtO43557 [Medical]
TSGene8740
GENETestsTNFSF14
Huge Navigator TNFSF14 [HugePedia]  TNFSF14 [HugeCancerGEM]
snp3D : Map Gene to Disease8740
BioCentury BCIQTNFSF14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8740
Chemical/Pharm GKB GenePA36622
Clinical trialTNFSF14
Miscellaneous
canSAR (ICR)TNFSF14 (select the gene name)
Probes
Litterature
PubMed88 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNFSF14
GoPubMedTNFSF14
iHOPTNFSF14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Apr 16 18:07:50 CEST 2016

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