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TNFSF14 (TNF superfamily member 14)

Identity

Alias (NCBI)CD258
HVEML
LIGHT
LTg
HGNC (Hugo) TNFSF14
HGNC Alias symbLIGHT
LTg
HVEM-L
CD258
HGNC Previous nametumor necrosis factor (ligand) superfamily, member 14
LocusID (NCBI) 8740
Atlas_Id 42637
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 6661253 and ends at 6670158 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TNFSF14 (19p13.3) / GRAMD1A (19q13.11)TNFSF14 19p13.3 / GRAMD1A 19q13.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TNFSF14   11930
Cards
Entrez_Gene (NCBI)TNFSF14    TNF superfamily member 14
AliasesCD258; HVEML; LIGHT; LTg
GeneCards (Weizmann)TNFSF14
Ensembl hg19 (Hinxton)ENSG00000125735 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125735 [Gene_View]  ENSG00000125735 [Sequence]  chr19:6661253-6670158 [Contig_View]  TNFSF14 [Vega]
ICGC DataPortalENSG00000125735
TCGA cBioPortalTNFSF14
AceView (NCBI)TNFSF14
Genatlas (Paris)TNFSF14
SOURCE (Princeton)TNFSF14
Genetics Home Reference (NIH)TNFSF14
Genomic and cartography
GoldenPath hg38 (UCSC)TNFSF14  -     chr19:6661253-6670158 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFSF14  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathTNFSF14 - 19p13.3 [CytoView hg19]  TNFSF14 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000125735
Genome Data Viewer NCBITNFSF14 [Mapview hg19]  
OMIM604520   
Gene and transcription
Genbank (Entrez)AF036581 AF064090 AK026704 AK292037 AY028261
RefSeq transcript (Entrez)NM_001376887 NM_003807 NM_172014
Consensus coding sequences : CCDS (NCBI)TNFSF14
Gene ExpressionTNFSF14 [ NCBI-GEO ]   TNFSF14 [ EBI - ARRAY_EXPRESS ]   TNFSF14 [ SEEK ]   TNFSF14 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFSF14 [ Firebrowse - Broad ]
GenevisibleExpression of TNFSF14 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8740
GTEX Portal (Tissue expression)TNFSF14
Human Protein AtlasENSG00000125735-TNFSF14 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43557   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43557  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43557
PhosPhoSitePlusO43557
Domaine pattern : Prosite (Expaxy)TNF_2 (PS50049)   
Domains : Interpro (EBI)TNF    TNF_dom    Tumour_necrosis_fac-like_dom   
Domain families : Pfam (Sanger)TNF (PF00229)   
Domain families : Pfam (NCBI)pfam00229   
Domain families : Smart (EMBL)TNF (SM00207)  
Conserved Domain (NCBI)TNFSF14
PDB (RSDB)4EN0    4J6G    4KG8    4KGG    4KGQ    4RSU   
PDB Europe4EN0    4J6G    4KG8    4KGG    4KGQ    4RSU   
PDB (PDBSum)4EN0    4J6G    4KG8    4KGG    4KGQ    4RSU   
PDB (IMB)4EN0    4J6G    4KG8    4KGG    4KGQ    4RSU   
Structural Biology KnowledgeBase4EN0    4J6G    4KG8    4KGG    4KGQ    4RSU   
SCOP (Structural Classification of Proteins)4EN0    4J6G    4KG8    4KGG    4KGQ    4RSU   
CATH (Classification of proteins structures)4EN0    4J6G    4KG8    4KGG    4KGQ    4RSU   
SuperfamilyO43557
AlphaFold pdb e-kbO43557   
Human Protein Atlas [tissue]ENSG00000125735-TNFSF14 [tissue]
HPRD05157
Protein Interaction databases
DIP (DOE-UCLA)O43557
IntAct (EBI)O43557
BioGRIDTNFSF14
STRING (EMBL)TNFSF14
ZODIACTNFSF14
Ontologies - Pathways
QuickGOO43557
Ontology : AmiGOsignaling receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular space  cytoplasm  plasma membrane  apoptotic process  immune response  signal transduction  integral component of membrane  T cell costimulation  tumor necrosis factor-mediated signaling pathway  T cell proliferation  T cell activation  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  T cell homeostasis  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  cellular response to mechanical stimulus  positive regulation of NIK/NF-kappaB signaling  
Ontology : EGO-EBIsignaling receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular space  cytoplasm  plasma membrane  apoptotic process  immune response  signal transduction  integral component of membrane  T cell costimulation  tumor necrosis factor-mediated signaling pathway  T cell proliferation  T cell activation  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  T cell homeostasis  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  cellular response to mechanical stimulus  positive regulation of NIK/NF-kappaB signaling  
Pathways : KEGGCytokine-cytokine receptor interaction    NF-kappa B signaling pathway    Herpes simplex infection   
NDEx NetworkTNFSF14
Atlas of Cancer Signalling NetworkTNFSF14
Wikipedia pathwaysTNFSF14
Orthology - Evolution
OrthoDB8740
GeneTree (enSembl)ENSG00000125735
Phylogenetic Trees/Animal Genes : TreeFamTNFSF14
Homologs : HomoloGeneTNFSF14
Homology/Alignments : Family Browser (UCSC)TNFSF14
Gene fusions - Rearrangements
Fusion : MitelmanTNFSF14/GRAMD1A [19p13.3/19q13.11]  
Fusion : QuiverTNFSF14
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFSF14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFSF14
dbVarTNFSF14
ClinVarTNFSF14
MonarchTNFSF14
1000_GenomesTNFSF14 
Exome Variant ServerTNFSF14
GNOMAD BrowserENSG00000125735
Varsome BrowserTNFSF14
ACMGTNFSF14 variants
VarityO43557
Genomic Variants (DGV)TNFSF14 [DGVbeta]
DECIPHERTNFSF14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFSF14 
Mutations
ICGC Data PortalTNFSF14 
TCGA Data PortalTNFSF14 
Broad Tumor PortalTNFSF14
OASIS PortalTNFSF14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFSF14  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNFSF14
Mutations and Diseases : HGMDTNFSF14
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTNFSF14
DgiDB (Drug Gene Interaction Database)TNFSF14
DoCM (Curated mutations)TNFSF14
CIViC (Clinical Interpretations of Variants in Cancer)TNFSF14
Cancer3DTNFSF14
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604520   
Orphanet
DisGeNETTNFSF14
MedgenTNFSF14
Genetic Testing Registry TNFSF14
NextProtO43557 [Medical]
GENETestsTNFSF14
Target ValidationTNFSF14
Huge Navigator TNFSF14 [HugePedia]
ClinGenTNFSF14
Clinical trials, drugs, therapy
MyCancerGenomeTNFSF14
Protein Interactions : CTDTNFSF14
Pharm GKB GenePA36622
PharosO43557
Clinical trialTNFSF14
Miscellaneous
canSAR (ICR)TNFSF14
HarmonizomeTNFSF14
DataMed IndexTNFSF14
Probes
Litterature
PubMed109 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNFSF14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:35:45 CEST 2021

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