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TNFSF4 (tumor necrosis factor superfamily member 4)

Identity

Other namesCD134L
CD252
GP34
OX-40L
OX4OL
TNLG2B
TXGP1
HGNC (Hugo) TNFSF4
LocusID (NCBI) 7292
Atlas_Id 42640
Location 1q25.1  [Link to chromosome band 1q25]
Location_base_pair Starts at 173152870 and ends at 173174697 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TNFSF4 (1q25.1) / BBX (3q13.12)TNFSF4 (1q25.1) / CIR1 (2q31.1)TNFSF4 (1q25.1) / FAM169A (5q13.3)
TNFSF4 (1q25.1) / LOC728190 ()

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNFSF4   11934
Cards
Entrez_Gene (NCBI)TNFSF4  7292  tumor necrosis factor superfamily member 4
AliasesCD134L; CD252; GP34; OX-40L; 
OX4OL; TNLG2B; TXGP1
GeneCards (Weizmann)TNFSF4
Ensembl hg19 (Hinxton)ENSG00000117586 [Gene_View]  chr1:173152870-173174697 [Contig_View]  TNFSF4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000117586 [Gene_View]  chr1:173152870-173174697 [Contig_View]  TNFSF4 [Vega]
ICGC DataPortalENSG00000117586
TCGA cBioPortalTNFSF4
AceView (NCBI)TNFSF4
Genatlas (Paris)TNFSF4
WikiGenes7292
SOURCE (Princeton)TNFSF4
Genomic and cartography
GoldenPath hg19 (UCSC)TNFSF4  -     chr1:173152870-173174697 -  1q25.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TNFSF4  -     1q25.1   [Description]    (hg38-Dec_2013)
EnsemblTNFSF4 - 1q25.1 [CytoView hg19]  TNFSF4 - 1q25.1 [CytoView hg38]
Mapping of homologs : NCBITNFSF4 [Mapview hg19]  TNFSF4 [Mapview hg38]
OMIM603594   608446   
Gene and transcription
Genbank (Entrez)AK297932 BC041663 BQ007105 CR542033 D90224
RefSeq transcript (Entrez)NM_001297562 NM_003326
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_011477 NT_004487 NW_004929293
Consensus coding sequences : CCDS (NCBI)TNFSF4
Cluster EST : UnigeneHs.181097 [ NCBI ]
CGAP (NCI)Hs.181097
Alternative Splicing GalleryENSG00000117586
Gene ExpressionTNFSF4 [ NCBI-GEO ]   TNFSF4 [ EBI - ARRAY_EXPRESS ]   TNFSF4 [ SEEK ]   TNFSF4 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFSF4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7292
GTEX Portal (Tissue expression)TNFSF4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23510 (Uniprot)
NextProtP23510  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23510
Splice isoforms : SwissVarP23510 (Swissvar)
PhosPhoSitePlusP23510
Domaine pattern : Prosite (Expaxy)TNF_1 (PS00251)   
Domains : Interpro (EBI)TNF_CS    TNF_dom    Tumour_necrosis_fac-like_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)TNF (SM00207)  
DMDM Disease mutations7292
Blocks (Seattle)TNFSF4
PDB (SRS)2HEV   
PDB (PDBSum)2HEV   
PDB (IMB)2HEV   
PDB (RSDB)2HEV   
Structural Biology KnowledgeBase2HEV   
SCOP (Structural Classification of Proteins)2HEV   
CATH (Classification of proteins structures)2HEV   
SuperfamilyP23510
Human Protein AtlasENSG00000117586
Peptide AtlasP23510
HPRD04668
IPIIPI00011974   IPI00647536   
Protein Interaction databases
DIP (DOE-UCLA)P23510
IntAct (EBI)P23510
FunCoupENSG00000117586
BioGRIDTNFSF4
STRING (EMBL)TNFSF4
ZODIACTNFSF4
Ontologies - Pathways
QuickGOP23510
Ontology : AmiGOdefense response to nematode  acute inflammatory response  positive regulation of T cell cytokine production  regulation of adaptive immune response  positive regulation of type 2 immune response  positive regulation of immunoglobulin mediated immune response  receptor binding  cytokine activity  tumor necrosis factor receptor binding  extracellular space  plasma membrane  integral component of plasma membrane  immune response  signal transduction  cholesterol metabolic process  positive regulation of cell proliferation  response to virus  cell surface  negative regulation of interferon-gamma production  negative regulation of interleukin-17 production  positive regulation of interferon-gamma production  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-13 production  positive regulation of interleukin-2 production  positive regulation of interleukin-4 production  positive regulation of interleukin-6 production  tumor necrosis factor receptor superfamily binding  tumor necrosis factor receptor superfamily binding  tumor necrosis factor-mediated signaling pathway  memory T cell activation  T-helper 2 cell activation  response to nitrogen dioxide  cellular response to nitrogen dioxide  CD4-positive, alpha-beta T cell costimulation  T cell proliferation  positive regulation of T cell proliferation  positive regulation of activated T cell proliferation  positive regulation of CD4-positive, alpha-beta T cell differentiation  positive regulation of memory T cell differentiation  negative regulation of sequence-specific DNA binding transcription factor activity  negative regulation of regulatory T cell differentiation  negative regulation of T-helper 1 cell differentiation  positive regulation of T-helper 2 cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of alpha-beta T cell proliferation  negative regulation of cytokine secretion  regulation of inflammatory response  positive regulation of inflammatory response  positive regulation of B cell activation  positive regulation of immunoglobulin secretion  cellular response to lipopolysaccharide  cellular response to prostaglandin E stimulus  chemokine (C-C motif) ligand 11 production  positive regulation of CD4-positive, alpha-beta T cell costimulation  positive regulation of memory T cell activation  positive regulation of T-helper 2 cell activation  positive regulation of interleukin-4-dependent isotype switching to IgE isotypes  
Ontology : EGO-EBIdefense response to nematode  acute inflammatory response  positive regulation of T cell cytokine production  regulation of adaptive immune response  positive regulation of type 2 immune response  positive regulation of immunoglobulin mediated immune response  receptor binding  cytokine activity  tumor necrosis factor receptor binding  extracellular space  plasma membrane  integral component of plasma membrane  immune response  signal transduction  cholesterol metabolic process  positive regulation of cell proliferation  response to virus  cell surface  negative regulation of interferon-gamma production  negative regulation of interleukin-17 production  positive regulation of interferon-gamma production  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-13 production  positive regulation of interleukin-2 production  positive regulation of interleukin-4 production  positive regulation of interleukin-6 production  tumor necrosis factor receptor superfamily binding  tumor necrosis factor receptor superfamily binding  tumor necrosis factor-mediated signaling pathway  memory T cell activation  T-helper 2 cell activation  response to nitrogen dioxide  cellular response to nitrogen dioxide  CD4-positive, alpha-beta T cell costimulation  T cell proliferation  positive regulation of T cell proliferation  positive regulation of activated T cell proliferation  positive regulation of CD4-positive, alpha-beta T cell differentiation  positive regulation of memory T cell differentiation  negative regulation of sequence-specific DNA binding transcription factor activity  negative regulation of regulatory T cell differentiation  negative regulation of T-helper 1 cell differentiation  positive regulation of T-helper 2 cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of alpha-beta T cell proliferation  negative regulation of cytokine secretion  regulation of inflammatory response  positive regulation of inflammatory response  positive regulation of B cell activation  positive regulation of immunoglobulin secretion  cellular response to lipopolysaccharide  cellular response to prostaglandin E stimulus  chemokine (C-C motif) ligand 11 production  positive regulation of CD4-positive, alpha-beta T cell costimulation  positive regulation of memory T cell activation  positive regulation of T-helper 2 cell activation  positive regulation of interleukin-4-dependent isotype switching to IgE isotypes  
Pathways : BIOCARTAOX40 Signaling Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx Network
Atlas of Cancer Signalling NetworkTNFSF4
Wikipedia pathwaysTNFSF4
Orthology - Evolution
OrthoDB7292
GeneTree (enSembl)ENSG00000117586
Phylogenetic Trees/Animal Genes : TreeFamTNFSF4
Homologs : HomoloGeneTNFSF4
Homology/Alignments : Family Browser (UCSC)TNFSF4
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTNFSF4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFSF4
dbVarTNFSF4
ClinVarTNFSF4
1000_GenomesTNFSF4 
Exome Variant ServerTNFSF4
ExAC (Exome Aggregation Consortium)TNFSF4 (select the gene name)
Genetic variants : HAPMAP7292
Genomic Variants (DGV)TNFSF4 [DGVbeta]
Mutations
ICGC Data PortalTNFSF4 
TCGA Data PortalTNFSF4 
Broad Tumor PortalTNFSF4
OASIS PortalTNFSF4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFSF4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFSF4
DgiDB (Drug Gene Interaction Database)TNFSF4
DoCM (Curated mutations)TNFSF4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFSF4 (select a term)
intoGenTNFSF4
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:173152870-173174697  ENSG00000117586
CONAN: Copy Number AnalysisTNFSF4 
Mutations and Diseases : HGMDTNFSF4
OMIM603594    608446   
MedgenTNFSF4
Genetic Testing Registry TNFSF4
NextProtP23510 [Medical]
TSGene7292
GENETestsTNFSF4
Huge Navigator TNFSF4 [HugePedia]
snp3D : Map Gene to Disease7292
BioCentury BCIQTNFSF4
ClinGenTNFSF4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7292
Chemical/Pharm GKB GenePA36625
Clinical trialTNFSF4
Miscellaneous
canSAR (ICR)TNFSF4 (select the gene name)
Probes
Litterature
PubMed114 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNFSF4
EVEXTNFSF4
GoPubMedTNFSF4
iHOPTNFSF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 19:10:54 CEST 2016

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