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TNFSF4 (TNF superfamily member 4)

Identity

Alias (NCBI)CD134L
CD252
GP34
OX-40L
OX4OL
TNLG2B
TXGP1
HGNC (Hugo) TNFSF4
HGNC Alias symbOX-40L
gp34
CD252
HGNC Previous nameTXGP1
HGNC Previous nametax-transcriptionally activated glycoprotein 1, 34kD
 tumor necrosis factor (ligand) superfamily, member 4
LocusID (NCBI) 7292
Atlas_Id 42640
Location 1q25.1  [Link to chromosome band 1q25]
Location_base_pair Starts at 173183731 and ends at 173207331 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TNFSF4 (1q25.1) / BBX (3q13.12)TNFSF4 (1q25.1) / CIR1 (2q31.1)TNFSF4 (1q25.1) / FAM169A (5q13.3)
TNFSF4 (1q25.1) / LOC728190 ()

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)TNFSF4   11934
Cards
Entrez_Gene (NCBI)TNFSF4    TNF superfamily member 4
AliasesCD134L; CD252; GP34; OX-40L; 
OX4OL; TNLG2B; TXGP1
GeneCards (Weizmann)TNFSF4
Ensembl hg19 (Hinxton)ENSG00000117586 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117586 [Gene_View]  ENSG00000117586 [Sequence]  chr1:173183731-173207331 [Contig_View]  TNFSF4 [Vega]
ICGC DataPortalENSG00000117586
TCGA cBioPortalTNFSF4
AceView (NCBI)TNFSF4
Genatlas (Paris)TNFSF4
SOURCE (Princeton)TNFSF4
Genetics Home Reference (NIH)TNFSF4
Genomic and cartography
GoldenPath hg38 (UCSC)TNFSF4  -     chr1:173183731-173207331 -  1q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFSF4  -     1q25.1   [Description]    (hg19-Feb_2009)
GoldenPathTNFSF4 - 1q25.1 [CytoView hg19]  TNFSF4 - 1q25.1 [CytoView hg38]
ImmunoBaseENSG00000117586
genome Data Viewer NCBITNFSF4 [Mapview hg19]  
OMIM603594   608446   
Gene and transcription
Genbank (Entrez)AK297932 BC041663 BQ007105 CR542033 D90224
RefSeq transcript (Entrez)NM_001297562 NM_003326
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNFSF4
Alternative Splicing GalleryENSG00000117586
Gene ExpressionTNFSF4 [ NCBI-GEO ]   TNFSF4 [ EBI - ARRAY_EXPRESS ]   TNFSF4 [ SEEK ]   TNFSF4 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFSF4 [ Firebrowse - Broad ]
GenevisibleExpression of TNFSF4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7292
GTEX Portal (Tissue expression)TNFSF4
Human Protein AtlasENSG00000117586-TNFSF4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23510   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23510  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23510
Splice isoforms : SwissVarP23510
PhosPhoSitePlusP23510
Domaine pattern : Prosite (Expaxy)TNF_1 (PS00251)   
Domains : Interpro (EBI)TNF_CS    TNF_dom    TNFSF4    Tumour_necrosis_fac-like_dom   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)TNF (SM00207)  
Conserved Domain (NCBI)TNFSF4
Blocks (Seattle)TNFSF4
PDB (RSDB)2HEV   
PDB Europe2HEV   
PDB (PDBSum)2HEV   
PDB (IMB)2HEV   
Structural Biology KnowledgeBase2HEV   
SCOP (Structural Classification of Proteins)2HEV   
CATH (Classification of proteins structures)2HEV   
SuperfamilyP23510
Human Protein Atlas [tissue]ENSG00000117586-TNFSF4 [tissue]
Peptide AtlasP23510
HPRD04668
IPIIPI00011974   IPI00647536   
Protein Interaction databases
DIP (DOE-UCLA)P23510
IntAct (EBI)P23510
BioGRIDTNFSF4
STRING (EMBL)TNFSF4
ZODIACTNFSF4
Ontologies - Pathways
QuickGOP23510
Ontology : AmiGOpositive regulation of cytokine production  defense response to nematode  acute inflammatory response  positive regulation of immunoglobulin production  positive regulation of T cell cytokine production  regulation of adaptive immune response  positive regulation of type 2 immune response  positive regulation of immunoglobulin mediated immune response  signaling receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular space  extracellular space  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  signal transduction  positive regulation of cell population proliferation  response to virus  cell surface  negative regulation of interferon-gamma production  negative regulation of interleukin-17 production  positive regulation of interferon-gamma production  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-13 production  positive regulation of interleukin-4 production  positive regulation of interleukin-6 production  tumor necrosis factor receptor superfamily binding  tumor necrosis factor receptor superfamily binding  tumor necrosis factor-mediated signaling pathway  memory T cell activation  T-helper 2 cell activation  response to nitrogen dioxide  positive regulation of T cell proliferation  positive regulation of CD4-positive, alpha-beta T cell differentiation  positive regulation of memory T cell differentiation  negative regulation of DNA-binding transcription factor activity  negative regulation of regulatory T cell differentiation  negative regulation of T-helper 1 cell differentiation  positive regulation of T-helper 2 cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of alpha-beta T cell proliferation  regulation of inflammatory response  positive regulation of inflammatory response  positive regulation of B cell activation  cellular response to lipopolysaccharide  cellular response to prostaglandin E stimulus  chemokine (C-C motif) ligand 11 production  positive regulation of CD4-positive, alpha-beta T cell costimulation  positive regulation of interleukin-4-dependent isotype switching to IgE isotypes  
Ontology : EGO-EBIpositive regulation of cytokine production  defense response to nematode  acute inflammatory response  positive regulation of immunoglobulin production  positive regulation of T cell cytokine production  regulation of adaptive immune response  positive regulation of type 2 immune response  positive regulation of immunoglobulin mediated immune response  signaling receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular space  extracellular space  plasma membrane  integral component of plasma membrane  inflammatory response  immune response  signal transduction  positive regulation of cell population proliferation  response to virus  cell surface  negative regulation of interferon-gamma production  negative regulation of interleukin-17 production  positive regulation of interferon-gamma production  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-13 production  positive regulation of interleukin-4 production  positive regulation of interleukin-6 production  tumor necrosis factor receptor superfamily binding  tumor necrosis factor receptor superfamily binding  tumor necrosis factor-mediated signaling pathway  memory T cell activation  T-helper 2 cell activation  response to nitrogen dioxide  positive regulation of T cell proliferation  positive regulation of CD4-positive, alpha-beta T cell differentiation  positive regulation of memory T cell differentiation  negative regulation of DNA-binding transcription factor activity  negative regulation of regulatory T cell differentiation  negative regulation of T-helper 1 cell differentiation  positive regulation of T-helper 2 cell differentiation  negative regulation of transcription, DNA-templated  positive regulation of alpha-beta T cell proliferation  regulation of inflammatory response  positive regulation of inflammatory response  positive regulation of B cell activation  cellular response to lipopolysaccharide  cellular response to prostaglandin E stimulus  chemokine (C-C motif) ligand 11 production  positive regulation of CD4-positive, alpha-beta T cell costimulation  positive regulation of interleukin-4-dependent isotype switching to IgE isotypes  
Pathways : BIOCARTAOX40 Signaling Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkTNFSF4
Atlas of Cancer Signalling NetworkTNFSF4
Wikipedia pathwaysTNFSF4
Orthology - Evolution
OrthoDB7292
GeneTree (enSembl)ENSG00000117586
Phylogenetic Trees/Animal Genes : TreeFamTNFSF4
HOGENOMP23510
Homologs : HomoloGeneTNFSF4
Homology/Alignments : Family Browser (UCSC)TNFSF4
Gene fusions - Rearrangements
Fusion : QuiverTNFSF4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFSF4 [hg38]
dbVarTNFSF4
ClinVarTNFSF4
MonarchTNFSF4
1000_GenomesTNFSF4 
Exome Variant ServerTNFSF4
GNOMAD BrowserENSG00000117586
Varsome BrowserTNFSF4
Genomic Variants (DGV)TNFSF4 [DGVbeta]
DECIPHERTNFSF4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFSF4 
Mutations
ICGC Data PortalTNFSF4 
TCGA Data PortalTNFSF4 
Broad Tumor PortalTNFSF4
OASIS PortalTNFSF4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFSF4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNFSF4
Mutations and Diseases : HGMDTNFSF4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFSF4
DgiDB (Drug Gene Interaction Database)TNFSF4
DoCM (Curated mutations)TNFSF4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFSF4 (select a term)
intoGenTNFSF4
Cancer3DTNFSF4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603594    608446   
Orphanet3637   
DisGeNETTNFSF4
MedgenTNFSF4
Genetic Testing Registry TNFSF4
NextProtP23510 [Medical]
GENETestsTNFSF4
Target ValidationTNFSF4
Huge Navigator TNFSF4 [HugePedia]
ClinGenTNFSF4
Clinical trials, drugs, therapy
MyCancerGenomeTNFSF4
Protein Interactions : CTD
Pharm GKB GenePA36625
PharosP23510
Clinical trialTNFSF4
Miscellaneous
canSAR (ICR)TNFSF4 (select the gene name)
HarmonizomeTNFSF4
DataMed IndexTNFSF4
Probes
Litterature
PubMed149 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNFSF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 25 19:50:17 CET 2021

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