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TNFSF4 (tumor necrosis factor (ligand) superfamily, member 4)

Identity

Other namesCD134L
CD252
GP34
OX-40L
OX4OL
TXGP1
HGNC (Hugo) TNFSF4
LocusID (NCBI) 7292
Location 1q25.1
Location_base_pair Starts at 173152870 and ends at 173176471 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TNFSF4   11934
Cards
Entrez_Gene (NCBI)TNFSF4  7292  tumor necrosis factor (ligand) superfamily, member 4
GeneCards (Weizmann)TNFSF4
Ensembl (Hinxton)ENSG00000117586 [Gene_View]  chr1:173152870-173176471 [Contig_View]  TNFSF4 [Vega]
AceView (NCBI)TNFSF4
Genatlas (Paris)TNFSF4
WikiGenes7292
SOURCE (Princeton)NM_003326
Genomic and cartography
GoldenPath (UCSC)TNFSF4  -  1q25.1   chr1:173152870-173176471 -  1q25.1   [Description]    (hg19-Feb_2009)
EnsemblTNFSF4 - 1q25.1 [CytoView]
Mapping of homologs : NCBITNFSF4 [Mapview]
OMIM603594   608446   
Gene and transcription
Genbank (Entrez)AK297932 BC041663 BQ007105 CR542033 D90224
RefSeq transcript (Entrez)NM_003326
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_011477 NT_004487 NW_001838533 NW_004929293
Consensus coding sequences : CCDS (NCBI)TNFSF4
Cluster EST : UnigeneHs.181097 [ NCBI ]
CGAP (NCI)Hs.181097
Alternative Splicing : Fast-db (Paris)GSHG0002742
Alternative Splicing GalleryENSG00000117586
Gene ExpressionTNFSF4 [ NCBI-GEO ]     TNFSF4 [ SEEK ]   TNFSF4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23510 (Uniprot)
NextProtP23510  [Medical]
With graphics : InterProP23510
Splice isoforms : SwissVarP23510 (Swissvar)
Domaine pattern : Prosite (Expaxy)TNF_1 (PS00251)    TNF_2 (PS50049)   
Domains : Interpro (EBI)TNF_CS    TNF_dom    Tumour_necrosis_fac-like_dom   
Related proteins : CluSTrP23510
Domain families : Pfam (Sanger)TNF (PF00229)   
Domain families : Pfam (NCBI)pfam00229   
Domain families : Smart (EMBL)TNF (SM00207)  
DMDM Disease mutations7292
Blocks (Seattle)P23510
PDB (SRS)2HEV   
PDB (PDBSum)2HEV   
PDB (IMB)2HEV   
PDB (RSDB)2HEV   
Human Protein AtlasENSG00000117586
Peptide AtlasP23510
HPRD04668
IPIIPI00011974   IPI00647536   
Protein Interaction databases
DIP (DOE-UCLA)P23510
IntAct (EBI)P23510
FunCoupENSG00000117586
BioGRIDTNFSF4
InParanoidP23510
Interologous Interaction database P23510
IntegromeDBTNFSF4
STRING (EMBL)TNFSF4
Ontologies - Pathways
Ontology : AmiGOdefense response to nematode  acute inflammatory response  positive regulation of T cell cytokine production  regulation of adaptive immune response  positive regulation of type 2 immune response  positive regulation of immunoglobulin mediated immune response  receptor binding  cytokine activity  tumor necrosis factor receptor binding  extracellular space  integral to plasma membrane  signal transduction  cholesterol metabolic process  positive regulation of cell proliferation  response to virus  cell surface  negative regulation of interferon-gamma production  negative regulation of interleukin-17 production  positive regulation of interferon-gamma production  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-13 production  positive regulation of interleukin-2 production  positive regulation of interleukin-4 production  positive regulation of interleukin-6 production  tumor necrosis factor receptor superfamily binding  interleukin-4-dependent isotype switching to IgE isotypes  memory T cell activation  T-helper 2 cell activation  response to nitrogen dioxide  T cell proliferation  positive regulation of activated T cell proliferation  positive regulation of CD4-positive, alpha-beta T cell differentiation  positive regulation of memory T cell differentiation  negative regulation of sequence-specific DNA binding transcription factor activity  negative regulation of regulatory T cell differentiation  negative regulation of T-helper 1 cell differentiation  positive regulation of T-helper 2 cell differentiation  negative regulation of transcription, DNA-dependent  positive regulation of alpha-beta T cell proliferation  negative regulation of cytokine secretion  regulation of inflammatory response  positive regulation of inflammatory response  positive regulation of B cell activation  positive regulation of immunoglobulin secretion  cellular response to lipopolysaccharide  cellular response to prostaglandin E stimulus  chemokine (C-C motif) ligand 11 production  positive regulation of CD4-positive, alpha-beta T cell costimulation  positive regulation of interleukin-4-dependent isotype switching to IgE isotypes  
Ontology : EGO-EBIdefense response to nematode  acute inflammatory response  positive regulation of T cell cytokine production  regulation of adaptive immune response  positive regulation of type 2 immune response  positive regulation of immunoglobulin mediated immune response  receptor binding  cytokine activity  tumor necrosis factor receptor binding  extracellular space  integral to plasma membrane  signal transduction  cholesterol metabolic process  positive regulation of cell proliferation  response to virus  cell surface  negative regulation of interferon-gamma production  negative regulation of interleukin-17 production  positive regulation of interferon-gamma production  positive regulation of interleukin-10 production  positive regulation of interleukin-12 production  positive regulation of interleukin-13 production  positive regulation of interleukin-2 production  positive regulation of interleukin-4 production  positive regulation of interleukin-6 production  tumor necrosis factor receptor superfamily binding  interleukin-4-dependent isotype switching to IgE isotypes  memory T cell activation  T-helper 2 cell activation  response to nitrogen dioxide  T cell proliferation  positive regulation of activated T cell proliferation  positive regulation of CD4-positive, alpha-beta T cell differentiation  positive regulation of memory T cell differentiation  negative regulation of sequence-specific DNA binding transcription factor activity  negative regulation of regulatory T cell differentiation  negative regulation of T-helper 1 cell differentiation  positive regulation of T-helper 2 cell differentiation  negative regulation of transcription, DNA-dependent  positive regulation of alpha-beta T cell proliferation  negative regulation of cytokine secretion  regulation of inflammatory response  positive regulation of inflammatory response  positive regulation of B cell activation  positive regulation of immunoglobulin secretion  cellular response to lipopolysaccharide  cellular response to prostaglandin E stimulus  chemokine (C-C motif) ligand 11 production  positive regulation of CD4-positive, alpha-beta T cell costimulation  positive regulation of interleukin-4-dependent isotype switching to IgE isotypes  
Pathways : BIOCARTAOX40 Signaling Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction   
REACTOMETNFSF4
Protein Interaction DatabaseTNFSF4
Wikipedia pathwaysTNFSF4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TNFSF4
SNP (GeneSNP Utah)TNFSF4
SNP : HGBaseTNFSF4
Genetic variants : HAPMAPTNFSF4
1000_GenomesTNFSF4 
ICGC programENSG00000117586 
Somatic Mutations in Cancer : COSMICTNFSF4 
CONAN: Copy Number AnalysisTNFSF4 
Mutations and Diseases : HGMDTNFSF4
OMIM603594    608446   
GENETestsTNFSF4
Disease Genetic AssociationTNFSF4
Huge Navigator TNFSF4 [HugePedia]  TNFSF4 [HugeCancerGEM]
Genomic VariantsTNFSF4  TNFSF4 [DGVbeta]
Exome VariantTNFSF4
dbVarTNFSF4
ClinVarTNFSF4
snp3D : Map Gene to Disease7292
General knowledge
Homologs : HomoloGeneTNFSF4
Homology/Alignments : Family Browser (UCSC)TNFSF4
Phylogenetic Trees/Animal Genes : TreeFamTNFSF4
Chemical/Protein Interactions : CTD7292
Chemical/Pharm GKB GenePA36625
Clinical trialTNFSF4
Cancer Resource (Charite)ENSG00000117586
Other databases
Probes
Litterature
PubMed97 Pubmed reference(s) in Entrez
CoreMineTNFSF4
iHOPTNFSF4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Mar 31 09:17:01 CEST 2014

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