TNFSF8 (TNF superfamily member 8)

2003-06-01 Affiliation

Identity

HGNC

TNFSF8

LOCATION

9q32

LOCUSID

944

ALIAS

CD153,CD30L,CD30LG,TNLG3A

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 944
MIM: 603875
HGNC: 11938
Ensembl: ENSG00000106952

Variants:

dbSNP: 944
ClinVar: 944
TCGA: ENSG00000106952
COSMIC: TNFSF8

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000106952	ENST00000223795	P32971
ENSG00000106952	ENST00000223795	Q52M88
ENSG00000106952	ENST00000618336	A0A087X228

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
TNFR2 non-canonical NF-kB pathway	REACTOME	R-HSA-5668541
TNFs bind their physiological receptors	REACTOME	R-HSA-5669034

References

Pubmed ID	Year	Title	Citations
18636124	2008	Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.	32
16964309	2006	Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion.	30
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
25320285	2015	Association of TNFSF8 regulatory variants with excessive inflammatory responses but not leprosy per se.	16
19573080	2009	Common genetic variants in candidate genes and risk of familial lymphoid malignancies.	12
27105521	2016	CD30 on extracellular vesicles from malignant Hodgkin cells supports damaging of CD30 ligand-expressing bystander cells with Brentuximab-Vedotin, in vitro.	9
12553555	2002	Co-expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) in thyroid nodules is associated with co-expression of CD30 ligand/CD30 receptor.	7
19657367	2009	Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma.	6
19773279	2009	Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.	6
21292647	2011	Association of a novel functional promoter variant (rs2075533 C>T) in the apoptosis gene TNFSF8 with risk of lung cancer--a finding from Texas lung cancer genome-wide association study.	6

Citation

Dessen P

TNFSF8 (TNF superfamily member 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42644/tnfsf8