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TNFSF8 (TNF superfamily member 8)

Identity

Alias (NCBI)CD153
CD30L
CD30LG
TNLG3A
HGNC (Hugo) TNFSF8
HGNC Alias symbCD153
HGNC Previous nameCD30LG
HGNC Previous nametumor necrosis factor (ligand) superfamily, member 8
LocusID (NCBI) 944
Atlas_Id 42644
Location 9q32  [Link to chromosome band 9q32]
Location_base_pair Starts at 114893343 and ends at 114930595 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TNFSF8   11938
Cards
Entrez_Gene (NCBI)TNFSF8    TNF superfamily member 8
AliasesCD153; CD30L; CD30LG; TNLG3A
GeneCards (Weizmann)TNFSF8
Ensembl hg19 (Hinxton)ENSG00000106952 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000106952 [Gene_View]  ENSG00000106952 [Sequence]  chr9:114893343-114930595 [Contig_View]  TNFSF8 [Vega]
ICGC DataPortalENSG00000106952
TCGA cBioPortalTNFSF8
AceView (NCBI)TNFSF8
Genatlas (Paris)TNFSF8
SOURCE (Princeton)TNFSF8
Genetics Home Reference (NIH)TNFSF8
Genomic and cartography
GoldenPath hg38 (UCSC)TNFSF8  -     chr9:114893343-114930595 -  9q32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFSF8  -     9q32   [Description]    (hg19-Feb_2009)
GoldenPathTNFSF8 - 9q32 [CytoView hg19]  TNFSF8 - 9q32 [CytoView hg38]
ImmunoBaseENSG00000106952
Genome Data Viewer NCBITNFSF8 [Mapview hg19]  
OMIM603875   
Gene and transcription
Genbank (Entrez)AA748015 AK313619 AL583443 AW118787 BC093630
RefSeq transcript (Entrez)NM_001244 NM_001252290
Consensus coding sequences : CCDS (NCBI)TNFSF8
Gene ExpressionTNFSF8 [ NCBI-GEO ]   TNFSF8 [ EBI - ARRAY_EXPRESS ]   TNFSF8 [ SEEK ]   TNFSF8 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFSF8 [ Firebrowse - Broad ]
GenevisibleExpression of TNFSF8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)944
GTEX Portal (Tissue expression)TNFSF8
Human Protein AtlasENSG00000106952-TNFSF8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32971   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP32971  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP32971
PhosPhoSitePlusP32971
Domaine pattern : Prosite (Expaxy)TNF_1 (PS00251)    TNF_2 (PS50049)   
Domains : Interpro (EBI)TNF_CD30_ligand_type    TNF_CS    TNF_dom    Tumour_necrosis_fac-like_dom   
Domain families : Pfam (Sanger)TNF (PF00229)   
Domain families : Pfam (NCBI)pfam00229   
Domain families : Smart (EMBL)TNF (SM00207)  
Conserved Domain (NCBI)TNFSF8
SuperfamilyP32971
AlphaFold pdb e-kbP32971   
Human Protein Atlas [tissue]ENSG00000106952-TNFSF8 [tissue]
HPRD04852
Protein Interaction databases
DIP (DOE-UCLA)P32971
IntAct (EBI)P32971
BioGRIDTNFSF8
STRING (EMBL)TNFSF8
ZODIACTNFSF8
Ontologies - Pathways
QuickGOP32971
Ontology : AmiGOsignaling receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular space  plasma membrane  integral component of plasma membrane  cell-cell signaling  tumor necrosis factor-mediated signaling pathway  regulation of T cell proliferation  CD8-positive, alpha-beta T cell differentiation  positive regulation of transcription by RNA polymerase II  defense response to Gram-positive bacterium  
Ontology : EGO-EBIsignaling receptor binding  cytokine activity  tumor necrosis factor receptor binding  protein binding  extracellular space  plasma membrane  integral component of plasma membrane  cell-cell signaling  tumor necrosis factor-mediated signaling pathway  regulation of T cell proliferation  CD8-positive, alpha-beta T cell differentiation  positive regulation of transcription by RNA polymerase II  defense response to Gram-positive bacterium  
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkTNFSF8
Atlas of Cancer Signalling NetworkTNFSF8
Wikipedia pathwaysTNFSF8
Orthology - Evolution
OrthoDB944
GeneTree (enSembl)ENSG00000106952
Phylogenetic Trees/Animal Genes : TreeFamTNFSF8
Homologs : HomoloGeneTNFSF8
Homology/Alignments : Family Browser (UCSC)TNFSF8
Gene fusions - Rearrangements
Fusion : QuiverTNFSF8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFSF8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFSF8
dbVarTNFSF8
ClinVarTNFSF8
MonarchTNFSF8
1000_GenomesTNFSF8 
Exome Variant ServerTNFSF8
GNOMAD BrowserENSG00000106952
Varsome BrowserTNFSF8
ACMGTNFSF8 variants
VarityP32971
Genomic Variants (DGV)TNFSF8 [DGVbeta]
DECIPHERTNFSF8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFSF8 
Mutations
ICGC Data PortalTNFSF8 
TCGA Data PortalTNFSF8 
Broad Tumor PortalTNFSF8
OASIS PortalTNFSF8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFSF8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNFSF8
Mutations and Diseases : HGMDTNFSF8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTNFSF8
DgiDB (Drug Gene Interaction Database)TNFSF8
DoCM (Curated mutations)TNFSF8
CIViC (Clinical Interpretations of Variants in Cancer)TNFSF8
Cancer3DTNFSF8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603875   
Orphanet
DisGeNETTNFSF8
MedgenTNFSF8
Genetic Testing Registry TNFSF8
NextProtP32971 [Medical]
GENETestsTNFSF8
Target ValidationTNFSF8
Huge Navigator TNFSF8 [HugePedia]
ClinGenTNFSF8
Clinical trials, drugs, therapy
MyCancerGenomeTNFSF8
Protein Interactions : CTDTNFSF8
Pharm GKB GenePA36628
PharosP32971
Clinical trialTNFSF8
Miscellaneous
canSAR (ICR)TNFSF8
HarmonizomeTNFSF8
DataMed IndexTNFSF8
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNFSF8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:46 CEST 2021

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