Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TNFSF9 (TNF superfamily member 9)

Identity

Alias (NCBI)4-1BB-L
CD137L
TNLG5A
HGNC (Hugo) TNFSF9
HGNC Alias symb4-1BB-L
4-1BBL
HGNC Alias namereceptor 4-1BB ligand
 homolog of mouse 4-1BB-L
HGNC Previous nametumor necrosis factor (ligand) superfamily, member 9
LocusID (NCBI) 8744
Atlas_Id 42645
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 6531026 and ends at 6535924 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TNFSF9 (19p13.3) / ST8SIA6 (10p12.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TNFSF9   11939
Cards
Entrez_Gene (NCBI)TNFSF9    TNF superfamily member 9
Aliases4-1BB-L; CD137L; TNLG5A
GeneCards (Weizmann)TNFSF9
Ensembl hg19 (Hinxton)ENSG00000125657 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125657 [Gene_View]  ENSG00000125657 [Sequence]  chr19:6531026-6535924 [Contig_View]  TNFSF9 [Vega]
ICGC DataPortalENSG00000125657
TCGA cBioPortalTNFSF9
AceView (NCBI)TNFSF9
Genatlas (Paris)TNFSF9
SOURCE (Princeton)TNFSF9
Genetics Home Reference (NIH)TNFSF9
Genomic and cartography
GoldenPath hg38 (UCSC)TNFSF9  -     chr19:6531026-6535924 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFSF9  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathTNFSF9 - 19p13.3 [CytoView hg19]  TNFSF9 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000125657
genome Data Viewer NCBITNFSF9 [Mapview hg19]  
OMIM606182   
Gene and transcription
Genbank (Entrez)AI357267 AK313999 BC104805 BC104807 BM790119
RefSeq transcript (Entrez)NM_003811
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNFSF9
Alternative Splicing GalleryENSG00000125657
Gene ExpressionTNFSF9 [ NCBI-GEO ]   TNFSF9 [ EBI - ARRAY_EXPRESS ]   TNFSF9 [ SEEK ]   TNFSF9 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFSF9 [ Firebrowse - Broad ]
GenevisibleExpression of TNFSF9 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8744
GTEX Portal (Tissue expression)TNFSF9
Human Protein AtlasENSG00000125657-TNFSF9 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41273   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41273  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41273
Splice isoforms : SwissVarP41273
PhosPhoSitePlusP41273
Domaine pattern : Prosite (Expaxy)TNF_1 (PS00251)    TNF_2 (PS50049)   
Domains : Interpro (EBI)TNF_CS    TNF_dom    TNFSF9    Tumour_necrosis_fac-like_dom   
Domain families : Pfam (Sanger)TNF (PF00229)   
Domain families : Pfam (NCBI)pfam00229   
Domain families : Smart (EMBL)TNF (SM00207)  
Conserved Domain (NCBI)TNFSF9
Blocks (Seattle)TNFSF9
PDB (RSDB)2X29    6A3V    6BWV    6CPR    6CU0    6D3N    6FIB    6MGE    6MGP   
PDB Europe2X29    6A3V    6BWV    6CPR    6CU0    6D3N    6FIB    6MGE    6MGP   
PDB (PDBSum)2X29    6A3V    6BWV    6CPR    6CU0    6D3N    6FIB    6MGE    6MGP   
PDB (IMB)2X29    6A3V    6BWV    6CPR    6CU0    6D3N    6FIB    6MGE    6MGP   
Structural Biology KnowledgeBase2X29    6A3V    6BWV    6CPR    6CU0    6D3N    6FIB    6MGE    6MGP   
SCOP (Structural Classification of Proteins)2X29    6A3V    6BWV    6CPR    6CU0    6D3N    6FIB    6MGE    6MGP   
CATH (Classification of proteins structures)2X29    6A3V    6BWV    6CPR    6CU0    6D3N    6FIB    6MGE    6MGP   
SuperfamilyP41273
Human Protein Atlas [tissue]ENSG00000125657-TNFSF9 [tissue]
Peptide AtlasP41273
HPRD05861
IPIIPI00013301   
Protein Interaction databases
DIP (DOE-UCLA)P41273
IntAct (EBI)P41273
BioGRIDTNFSF9
STRING (EMBL)TNFSF9
ZODIACTNFSF9
Ontologies - Pathways
QuickGOP41273
Ontology : AmiGOsignaling receptor binding  cytokine activity  tumor necrosis factor receptor binding  extracellular space  plasma membrane  plasma membrane  immune response  cell-cell signaling  integral component of membrane  tumor necrosis factor receptor superfamily binding  tumor necrosis factor-mediated signaling pathway  positive regulation of activated T cell proliferation  regulation of T cell proliferation  regulation of apoptotic process  positive regulation of cytotoxic T cell differentiation  
Ontology : EGO-EBIsignaling receptor binding  cytokine activity  tumor necrosis factor receptor binding  extracellular space  plasma membrane  plasma membrane  immune response  cell-cell signaling  integral component of membrane  tumor necrosis factor receptor superfamily binding  tumor necrosis factor-mediated signaling pathway  positive regulation of activated T cell proliferation  regulation of T cell proliferation  regulation of apoptotic process  positive regulation of cytotoxic T cell differentiation  
Pathways : BIOCARTAThe 4-1BB-dependent immune response [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkTNFSF9
Atlas of Cancer Signalling NetworkTNFSF9
Wikipedia pathwaysTNFSF9
Orthology - Evolution
OrthoDB8744
GeneTree (enSembl)ENSG00000125657
Phylogenetic Trees/Animal Genes : TreeFamTNFSF9
HOGENOMP41273
Homologs : HomoloGeneTNFSF9
Homology/Alignments : Family Browser (UCSC)TNFSF9
Gene fusions - Rearrangements
Fusion : QuiverTNFSF9
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFSF9 [hg38]
dbVarTNFSF9
ClinVarTNFSF9
MonarchTNFSF9
1000_GenomesTNFSF9 
Exome Variant ServerTNFSF9
GNOMAD BrowserENSG00000125657
Varsome BrowserTNFSF9
Genomic Variants (DGV)TNFSF9 [DGVbeta]
DECIPHERTNFSF9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFSF9 
Mutations
ICGC Data PortalTNFSF9 
TCGA Data PortalTNFSF9 
Broad Tumor PortalTNFSF9
OASIS PortalTNFSF9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFSF9  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNFSF9
Mutations and Diseases : HGMDTNFSF9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFSF9
DgiDB (Drug Gene Interaction Database)TNFSF9
DoCM (Curated mutations)TNFSF9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFSF9 (select a term)
intoGenTNFSF9
Cancer3DTNFSF9(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606182   
Orphanet
DisGeNETTNFSF9
MedgenTNFSF9
Genetic Testing Registry TNFSF9
NextProtP41273 [Medical]
GENETestsTNFSF9
Target ValidationTNFSF9
Huge Navigator TNFSF9 [HugePedia]
ClinGenTNFSF9
Clinical trials, drugs, therapy
MyCancerGenomeTNFSF9
Protein Interactions : CTD
Pharm GKB GenePA36629
PharosP41273
Clinical trialTNFSF9
Miscellaneous
canSAR (ICR)TNFSF9 (select the gene name)
HarmonizomeTNFSF9
DataMed IndexTNFSF9
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNFSF9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 25 19:50:18 CET 2021
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