Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TNFSF9 (TNF superfamily member 9)

Identity

Alias_namestumor necrosis factor (ligand) superfamily
Alias_symbol (synonym)4-1BB-L
Other aliasCD137L
TNLG5A
HGNC (Hugo) TNFSF9
LocusID (NCBI) 8744
Atlas_Id 42645
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 6530999 and ends at 6535928 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		TNFSF9 (19p13.3) / ST8SIA6 (10p12.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TNFSF9   11939
Cards
Entrez_Gene (NCBI)TNFSF9  8744  TNF superfamily member 9
Aliases4-1BB-L; CD137L; TNLG5A
GeneCards (Weizmann)TNFSF9
Ensembl hg19 (Hinxton)ENSG00000125657 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125657 [Gene_View]  chr19:6530999-6535928 [Contig_View]  TNFSF9 [Vega]
ICGC DataPortalENSG00000125657
TCGA cBioPortalTNFSF9
AceView (NCBI)TNFSF9
Genatlas (Paris)TNFSF9
WikiGenes8744
SOURCE (Princeton)TNFSF9
Genetics Home Reference (NIH)TNFSF9
Genomic and cartography
GoldenPath hg38 (UCSC)TNFSF9  -     chr19:6530999-6535928 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNFSF9  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblTNFSF9 - 19p13.3 [CytoView hg19]  TNFSF9 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBITNFSF9 [Mapview hg19]  TNFSF9 [Mapview hg38]
OMIM606182   
Gene and transcription
Genbank (Entrez)AI357267 AK313999 BC104805 BC104807 BM790119
RefSeq transcript (Entrez)NM_003811
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNFSF9
Cluster EST : UnigeneHs.1524 [ NCBI ]
CGAP (NCI)Hs.1524
Alternative Splicing GalleryENSG00000125657
Gene ExpressionTNFSF9 [ NCBI-GEO ]   TNFSF9 [ EBI - ARRAY_EXPRESS ]   TNFSF9 [ SEEK ]   TNFSF9 [ MEM ]
Gene Expression Viewer (FireBrowse)TNFSF9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8744
GTEX Portal (Tissue expression)TNFSF9
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41273   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41273  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41273
Splice isoforms : SwissVarP41273
PhosPhoSitePlusP41273
Domaine pattern : Prosite (Expaxy)TNF_1 (PS00251)    TNF_2 (PS50049)   
Domains : Interpro (EBI)TNF_CS    TNF_dom    Tumour_necrosis_fac-like_dom   
Domain families : Pfam (Sanger)TNF (PF00229)   
Domain families : Pfam (NCBI)pfam00229   
Domain families : Smart (EMBL)TNF (SM00207)  
Conserved Domain (NCBI)TNFSF9
DMDM Disease mutations8744
Blocks (Seattle)TNFSF9
PDB (SRS)2X29   
PDB (PDBSum)2X29   
PDB (IMB)2X29   
PDB (RSDB)2X29   
Structural Biology KnowledgeBase2X29   
SCOP (Structural Classification of Proteins)2X29   
CATH (Classification of proteins structures)2X29   
SuperfamilyP41273
Human Protein AtlasENSG00000125657
Peptide AtlasP41273
HPRD05861
IPIIPI00013301   
Protein Interaction databases
DIP (DOE-UCLA)P41273
IntAct (EBI)P41273
FunCoupENSG00000125657
BioGRIDTNFSF9
STRING (EMBL)TNFSF9
ZODIACTNFSF9
Ontologies - Pathways
QuickGOP41273
Ontology : AmiGOreceptor binding  cytokine activity  tumor necrosis factor receptor binding  extracellular space  plasma membrane  plasma membrane  apoptotic process  immune response  signal transduction  cell-cell signaling  cell proliferation  integral component of membrane  tumor necrosis factor receptor superfamily binding  tumor necrosis factor-mediated signaling pathway  positive regulation of activated T cell proliferation  positive regulation of cytotoxic T cell differentiation  
Ontology : EGO-EBIreceptor binding  cytokine activity  tumor necrosis factor receptor binding  extracellular space  plasma membrane  plasma membrane  apoptotic process  immune response  signal transduction  cell-cell signaling  cell proliferation  integral component of membrane  tumor necrosis factor receptor superfamily binding  tumor necrosis factor-mediated signaling pathway  positive regulation of activated T cell proliferation  positive regulation of cytotoxic T cell differentiation  
Pathways : BIOCARTAThe 4-1BB-dependent immune response [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction   
NDEx NetworkTNFSF9
Atlas of Cancer Signalling NetworkTNFSF9
Wikipedia pathwaysTNFSF9
Orthology - Evolution
OrthoDB8744
GeneTree (enSembl)ENSG00000125657
Phylogenetic Trees/Animal Genes : TreeFamTNFSF9
HOVERGENP41273
HOGENOMP41273
Homologs : HomoloGeneTNFSF9
Homology/Alignments : Family Browser (UCSC)TNFSF9
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNFSF9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNFSF9
dbVarTNFSF9
ClinVarTNFSF9
1000_GenomesTNFSF9 
Exome Variant ServerTNFSF9
ExAC (Exome Aggregation Consortium)TNFSF9 (select the gene name)
Genetic variants : HAPMAP8744
Genomic Variants (DGV)TNFSF9 [DGVbeta]
DECIPHERTNFSF9 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNFSF9 
Mutations
ICGC Data PortalTNFSF9 
TCGA Data PortalTNFSF9 
Broad Tumor PortalTNFSF9
OASIS PortalTNFSF9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNFSF9  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNFSF9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNFSF9
DgiDB (Drug Gene Interaction Database)TNFSF9
DoCM (Curated mutations)TNFSF9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNFSF9 (select a term)
intoGenTNFSF9
Cancer3DTNFSF9(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606182   
Orphanet
MedgenTNFSF9
Genetic Testing Registry TNFSF9
NextProtP41273 [Medical]
TSGene8744
GENETestsTNFSF9
Target ValidationTNFSF9
Huge Navigator TNFSF9 [HugePedia]
snp3D : Map Gene to Disease8744
BioCentury BCIQTNFSF9
ClinGenTNFSF9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8744
Chemical/Pharm GKB GenePA36629
Clinical trialTNFSF9
Miscellaneous
canSAR (ICR)TNFSF9 (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNFSF9
EVEXTNFSF9
GoPubMedTNFSF9
iHOPTNFSF9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:00:03 CEST 2017
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