Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TNIK (TRAF2 and NCK interacting kinase)

Identity

Alias_symbol (synonym)KIAA0551
Other aliasMRT54
HGNC (Hugo) TNIK
LocusID (NCBI) 23043
Atlas_Id 43532
Location 3q26.2  [Link to chromosome band 3q26]
Location_base_pair Starts at 171058414 and ends at 171460408 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADGRB3 (6q12) / TNIK (3q26.2)PRKCI (3q26.2) / TNIK (3q26.2)SMPDL3A (6q22.31) / TNIK (3q26.2)
TNIK (3q26.2) / MTHFD1L (6q25.1)TNIK (3q26.2) / RNF8 (6p21.2)PRKCI 3q26.2 / TNIK 3q26.2
TNIK 3q26.2 / MTHFD1L 6q25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNIK   30765
Cards
Entrez_Gene (NCBI)TNIK  23043  TRAF2 and NCK interacting kinase
AliasesMRT54
GeneCards (Weizmann)TNIK
Ensembl hg19 (Hinxton)ENSG00000154310 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154310 [Gene_View]  chr3:171058414-171460408 [Contig_View]  TNIK [Vega]
ICGC DataPortalENSG00000154310
TCGA cBioPortalTNIK
AceView (NCBI)TNIK
Genatlas (Paris)TNIK
WikiGenes23043
SOURCE (Princeton)TNIK
Genetics Home Reference (NIH)TNIK
Genomic and cartography
GoldenPath hg38 (UCSC)TNIK  -     chr3:171058414-171460408 -  3q26.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNIK  -     3q26.2   [Description]    (hg19-Feb_2009)
EnsemblTNIK - 3q26.2 [CytoView hg19]  TNIK - 3q26.2 [CytoView hg38]
Mapping of homologs : NCBITNIK [Mapview hg19]  TNIK [Mapview hg38]
OMIM610005   617028   
Gene and transcription
Genbank (Entrez)AB011123 AB017115 AF172264 AF172265 AF172266
RefSeq transcript (Entrez)NM_001161560 NM_001161561 NM_001161562 NM_001161563 NM_001161564 NM_001161565 NM_001161566 NM_015028
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNIK
Cluster EST : UnigeneHs.723245 [ NCBI ]
CGAP (NCI)Hs.723245
Alternative Splicing GalleryENSG00000154310
Gene ExpressionTNIK [ NCBI-GEO ]   TNIK [ EBI - ARRAY_EXPRESS ]   TNIK [ SEEK ]   TNIK [ MEM ]
Gene Expression Viewer (FireBrowse)TNIK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23043
GTEX Portal (Tissue expression)TNIK
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKE5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKE5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKE5
Splice isoforms : SwissVarQ9UKE5
PhosPhoSitePlusQ9UKE5
Domaine pattern : Prosite (Expaxy)CNH (PS50219)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)CNH_dom    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)CNH (PF00780)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00780    pfam00069   
Domain families : Smart (EMBL)CNH (SM00036)  S_TKc (SM00220)  
Conserved Domain (NCBI)TNIK
DMDM Disease mutations23043
Blocks (Seattle)TNIK
PDB (SRS)2X7F    5AX9    5CWZ    5D7A   
PDB (PDBSum)2X7F    5AX9    5CWZ    5D7A   
PDB (IMB)2X7F    5AX9    5CWZ    5D7A   
PDB (RSDB)2X7F    5AX9    5CWZ    5D7A   
Structural Biology KnowledgeBase2X7F    5AX9    5CWZ    5D7A   
SCOP (Structural Classification of Proteins)2X7F    5AX9    5CWZ    5D7A   
CATH (Classification of proteins structures)2X7F    5AX9    5CWZ    5D7A   
SuperfamilyQ9UKE5
Human Protein AtlasENSG00000154310
Peptide AtlasQ9UKE5
HPRD18206
IPIIPI00145805   IPI00218901   IPI00218902   IPI00514275   IPI00218904   IPI00218906   IPI00218907   IPI00943704   IPI00789304   IPI00946842   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKE5
IntAct (EBI)Q9UKE5
FunCoupENSG00000154310
BioGRIDTNIK
STRING (EMBL)TNIK
ZODIACTNIK
Ontologies - Pathways
QuickGOQ9UKE5
Ontology : AmiGOpositive regulation of protein phosphorylation  protein kinase activity  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytoskeleton  protein phosphorylation  cytoskeleton organization  activation of JNKK activity  activation of JNKK activity  Wnt signaling pathway  apical plasma membrane  microvillus assembly  actin cytoskeleton reorganization  intracellular signal transduction  protein autophosphorylation  regulation of dendrite morphogenesis  recycling endosome  extracellular exosome  protein localization to plasma membrane  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  protein kinase activity  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytoskeleton  protein phosphorylation  cytoskeleton organization  activation of JNKK activity  activation of JNKK activity  Wnt signaling pathway  apical plasma membrane  microvillus assembly  actin cytoskeleton reorganization  intracellular signal transduction  protein autophosphorylation  regulation of dendrite morphogenesis  recycling endosome  extracellular exosome  protein localization to plasma membrane  
NDEx NetworkTNIK
Atlas of Cancer Signalling NetworkTNIK
Wikipedia pathwaysTNIK
Orthology - Evolution
OrthoDB23043
GeneTree (enSembl)ENSG00000154310
Phylogenetic Trees/Animal Genes : TreeFamTNIK
HOVERGENQ9UKE5
HOGENOMQ9UKE5
Homologs : HomoloGeneTNIK
Homology/Alignments : Family Browser (UCSC)TNIK
Gene fusions - Rearrangements
Fusion : MitelmanPRKCI/TNIK [3q26.2/3q26.2]  [t(3;3)(q26;q26)]  
Fusion : MitelmanTNIK/MTHFD1L [3q26.2/6q25.1]  [t(3;6)(q26;q25)]  
Fusion: TCGAPRKCI 3q26.2 TNIK 3q26.2 BRCA
Fusion: TCGATNIK 3q26.2 MTHFD1L 6q25.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNIK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNIK
dbVarTNIK
ClinVarTNIK
1000_GenomesTNIK 
Exome Variant ServerTNIK
ExAC (Exome Aggregation Consortium)TNIK (select the gene name)
Genetic variants : HAPMAP23043
Genomic Variants (DGV)TNIK [DGVbeta]
DECIPHERTNIK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNIK 
Mutations
ICGC Data PortalTNIK 
TCGA Data PortalTNIK 
Broad Tumor PortalTNIK
OASIS PortalTNIK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNIK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNIK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNIK
DgiDB (Drug Gene Interaction Database)TNIK
DoCM (Curated mutations)TNIK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNIK (select a term)
intoGenTNIK
Cancer3DTNIK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610005    617028   
Orphanet11804   
MedgenTNIK
Genetic Testing Registry TNIK
NextProtQ9UKE5 [Medical]
TSGene23043
GENETestsTNIK
Target ValidationTNIK
Huge Navigator TNIK [HugePedia]
snp3D : Map Gene to Disease23043
BioCentury BCIQTNIK
ClinGenTNIK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23043
Chemical/Pharm GKB GenePA134893180
Clinical trialTNIK
Miscellaneous
canSAR (ICR)TNIK (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNIK
EVEXTNIK
GoPubMedTNIK
iHOPTNIK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:35:43 CEST 2017

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