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TNIP2 (TNFAIP3 interacting protein 2)

Identity

Alias_symbol (synonym)ABIN-2
MGC4289
KLIP
FLIP1
Other aliasABIN2
HGNC (Hugo) TNIP2
LocusID (NCBI) 79155
Atlas_Id 46223
Location 4p16.3  [Link to chromosome band 4p16]
Location_base_pair Starts at 2741660 and ends at 2756025 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FAM193A (4p16.3) / TNIP2 (4p16.3)FAM193A 4p16.3 / TNIP2 4p16.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNIP2   19118
Cards
Entrez_Gene (NCBI)TNIP2  79155  TNFAIP3 interacting protein 2
AliasesABIN2; FLIP1; KLIP
GeneCards (Weizmann)TNIP2
Ensembl hg19 (Hinxton)ENSG00000168884 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168884 [Gene_View]  chr4:2741660-2756025 [Contig_View]  TNIP2 [Vega]
ICGC DataPortalENSG00000168884
TCGA cBioPortalTNIP2
AceView (NCBI)TNIP2
Genatlas (Paris)TNIP2
WikiGenes79155
SOURCE (Princeton)TNIP2
Genetics Home Reference (NIH)TNIP2
Genomic and cartography
GoldenPath hg38 (UCSC)TNIP2  -     chr4:2741660-2756025 -  4p16.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNIP2  -     4p16.3   [Description]    (hg19-Feb_2009)
EnsemblTNIP2 - 4p16.3 [CytoView hg19]  TNIP2 - 4p16.3 [CytoView hg38]
Mapping of homologs : NCBITNIP2 [Mapview hg19]  TNIP2 [Mapview hg38]
OMIM610669   
Gene and transcription
Genbank (Entrez)AF372839 AJ304866 AK026176 AK096296 AL137262
RefSeq transcript (Entrez)NM_001161527 NM_001292016 NM_024309
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNIP2
Cluster EST : UnigeneHs.368551 [ NCBI ]
CGAP (NCI)Hs.368551
Alternative Splicing GalleryENSG00000168884
Gene ExpressionTNIP2 [ NCBI-GEO ]   TNIP2 [ EBI - ARRAY_EXPRESS ]   TNIP2 [ SEEK ]   TNIP2 [ MEM ]
Gene Expression Viewer (FireBrowse)TNIP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79155
GTEX Portal (Tissue expression)TNIP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NFZ5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NFZ5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NFZ5
Splice isoforms : SwissVarQ8NFZ5
PhosPhoSitePlusQ8NFZ5
Domaine pattern : Prosite (Expaxy)ZF_CCHC_NOA (PS51801)   
Domains : Interpro (EBI)CC2-LZ_dom    EABR   
Domain families : Pfam (Sanger)EABR (PF12180)   
Domain families : Pfam (NCBI)pfam12180   
Conserved Domain (NCBI)TNIP2
DMDM Disease mutations79155
Blocks (Seattle)TNIP2
SuperfamilyQ8NFZ5
Human Protein AtlasENSG00000168884
Peptide AtlasQ8NFZ5
HPRD18207
IPIIPI00168953   IPI00884948   IPI00967179   
Protein Interaction databases
DIP (DOE-UCLA)Q8NFZ5
IntAct (EBI)Q8NFZ5
FunCoupENSG00000168884
BioGRIDTNIP2
STRING (EMBL)TNIP2
ZODIACTNIP2
Ontologies - Pathways
QuickGOQ8NFZ5
Ontology : AmiGOprotein binding  nucleus  cytosol  cytosol  transcription, DNA-templated  apoptotic process  inflammatory response  I-kappaB kinase/NF-kappaB signaling  protein deubiquitination  protein kinase binding  CD40 signaling pathway  polyubiquitin binding  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 9 signaling pathway  positive regulation of macrophage activation  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  protein stabilization  positive regulation of B cell activation  stress-activated MAPK cascade  interleukin-1-mediated signaling pathway  cellular response to lipopolysaccharide  negative regulation of endothelial cell apoptotic process  
Ontology : EGO-EBIprotein binding  nucleus  cytosol  cytosol  transcription, DNA-templated  apoptotic process  inflammatory response  I-kappaB kinase/NF-kappaB signaling  protein deubiquitination  protein kinase binding  CD40 signaling pathway  polyubiquitin binding  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 9 signaling pathway  positive regulation of macrophage activation  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  protein stabilization  positive regulation of B cell activation  stress-activated MAPK cascade  interleukin-1-mediated signaling pathway  cellular response to lipopolysaccharide  negative regulation of endothelial cell apoptotic process  
NDEx NetworkTNIP2
Atlas of Cancer Signalling NetworkTNIP2
Wikipedia pathwaysTNIP2
Orthology - Evolution
OrthoDB79155
GeneTree (enSembl)ENSG00000168884
Phylogenetic Trees/Animal Genes : TreeFamTNIP2
HOVERGENQ8NFZ5
HOGENOMQ8NFZ5
Homologs : HomoloGeneTNIP2
Homology/Alignments : Family Browser (UCSC)TNIP2
Gene fusions - Rearrangements
Fusion : MitelmanFAM193A/TNIP2 [4p16.3/4p16.3]  [t(4;4)(p16;p16)]  
Fusion: TCGAFAM193A 4p16.3 TNIP2 4p16.3 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNIP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNIP2
dbVarTNIP2
ClinVarTNIP2
1000_GenomesTNIP2 
Exome Variant ServerTNIP2
ExAC (Exome Aggregation Consortium)TNIP2 (select the gene name)
Genetic variants : HAPMAP79155
Genomic Variants (DGV)TNIP2 [DGVbeta]
DECIPHERTNIP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNIP2 
Mutations
ICGC Data PortalTNIP2 
TCGA Data PortalTNIP2 
Broad Tumor PortalTNIP2
OASIS PortalTNIP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNIP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNIP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNIP2
DgiDB (Drug Gene Interaction Database)TNIP2
DoCM (Curated mutations)TNIP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNIP2 (select a term)
intoGenTNIP2
Cancer3DTNIP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610669   
Orphanet
MedgenTNIP2
Genetic Testing Registry TNIP2
NextProtQ8NFZ5 [Medical]
TSGene79155
GENETestsTNIP2
Huge Navigator TNIP2 [HugePedia]
snp3D : Map Gene to Disease79155
BioCentury BCIQTNIP2
ClinGenTNIP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79155
Chemical/Pharm GKB GenePA134957006
Clinical trialTNIP2
Miscellaneous
canSAR (ICR)TNIP2 (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNIP2
EVEXTNIP2
GoPubMedTNIP2
iHOPTNIP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:41:40 CEST 2017

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