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TNIP2 (TNFAIP3 interacting protein 2)

Identity

Alias (NCBI)ABIN2
FLIP1
KLIP
HGNC (Hugo) TNIP2
HGNC Alias symbABIN-2
MGC4289
KLIP
FLIP1
LocusID (NCBI) 79155
Atlas_Id 46223
Location 4p16.3  [Link to chromosome band 4p16]
Location_base_pair Starts at 2741648 and ends at 2756336 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM193A (4p16.3) / TNIP2 (4p16.3)FAM193A 4p16.3 / TNIP2 4p16.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TNIP2   19118
Cards
Entrez_Gene (NCBI)TNIP2    TNFAIP3 interacting protein 2
AliasesABIN2; FLIP1; KLIP
GeneCards (Weizmann)TNIP2
Ensembl hg19 (Hinxton)ENSG00000168884 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168884 [Gene_View]  ENSG00000168884 [Sequence]  chr4:2741648-2756336 [Contig_View]  TNIP2 [Vega]
ICGC DataPortalENSG00000168884
TCGA cBioPortalTNIP2
AceView (NCBI)TNIP2
Genatlas (Paris)TNIP2
SOURCE (Princeton)TNIP2
Genetics Home Reference (NIH)TNIP2
Genomic and cartography
GoldenPath hg38 (UCSC)TNIP2  -     chr4:2741648-2756336 -  4p16.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNIP2  -     4p16.3   [Description]    (hg19-Feb_2009)
GoldenPathTNIP2 - 4p16.3 [CytoView hg19]  TNIP2 - 4p16.3 [CytoView hg38]
ImmunoBaseENSG00000168884
Genome Data Viewer NCBITNIP2 [Mapview hg19]  
OMIM610669   
Gene and transcription
Genbank (Entrez)AF372839 AJ304866 AK026176 AK096296 AL137262
RefSeq transcript (Entrez)NM_001161527 NM_001292016 NM_024309
Consensus coding sequences : CCDS (NCBI)TNIP2
Gene ExpressionTNIP2 [ NCBI-GEO ]   TNIP2 [ EBI - ARRAY_EXPRESS ]   TNIP2 [ SEEK ]   TNIP2 [ MEM ]
Gene Expression Viewer (FireBrowse)TNIP2 [ Firebrowse - Broad ]
GenevisibleExpression of TNIP2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79155
GTEX Portal (Tissue expression)TNIP2
Human Protein AtlasENSG00000168884-TNIP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NFZ5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NFZ5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NFZ5
PhosPhoSitePlusQ8NFZ5
Domaine pattern : Prosite (Expaxy)ZF_CCHC_NOA (PS51801)   
Domains : Interpro (EBI)EABR    NEMO_ZF   
Domain families : Pfam (Sanger)EABR (PF12180)   
Domain families : Pfam (NCBI)pfam12180   
Conserved Domain (NCBI)TNIP2
PDB (RSDB)5H07   
PDB Europe5H07   
PDB (PDBSum)5H07   
PDB (IMB)5H07   
Structural Biology KnowledgeBase5H07   
SCOP (Structural Classification of Proteins)5H07   
CATH (Classification of proteins structures)5H07   
SuperfamilyQ8NFZ5
AlphaFold pdb e-kbQ8NFZ5   
Human Protein Atlas [tissue]ENSG00000168884-TNIP2 [tissue]
HPRD18207
Protein Interaction databases
DIP (DOE-UCLA)Q8NFZ5
IntAct (EBI)Q8NFZ5
BioGRIDTNIP2
STRING (EMBL)TNIP2
ZODIACTNIP2
Ontologies - Pathways
QuickGOQ8NFZ5
Ontology : AmiGOprotein binding  nucleoplasm  cytosol  cytosol  apoptotic process  inflammatory response  protein deubiquitination  protein kinase binding  CD40 signaling pathway  polyubiquitin modification-dependent protein binding  polyubiquitin modification-dependent protein binding  toll-like receptor 2 signaling pathway  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 9 signaling pathway  positive regulation of macrophage activation  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  metal ion binding  protein stabilization  positive regulation of B cell activation  stress-activated MAPK cascade  interleukin-1-mediated signaling pathway  interleukin-1-mediated signaling pathway  K63-linked polyubiquitin modification-dependent protein binding  cellular response to lipopolysaccharide  negative regulation of endothelial cell apoptotic process  
Ontology : EGO-EBIprotein binding  nucleoplasm  cytosol  cytosol  apoptotic process  inflammatory response  protein deubiquitination  protein kinase binding  CD40 signaling pathway  polyubiquitin modification-dependent protein binding  polyubiquitin modification-dependent protein binding  toll-like receptor 2 signaling pathway  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 9 signaling pathway  positive regulation of macrophage activation  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of transcription by RNA polymerase II  positive regulation of transcription by RNA polymerase II  metal ion binding  protein stabilization  positive regulation of B cell activation  stress-activated MAPK cascade  interleukin-1-mediated signaling pathway  interleukin-1-mediated signaling pathway  K63-linked polyubiquitin modification-dependent protein binding  cellular response to lipopolysaccharide  negative regulation of endothelial cell apoptotic process  
NDEx NetworkTNIP2
Atlas of Cancer Signalling NetworkTNIP2
Wikipedia pathwaysTNIP2
Orthology - Evolution
OrthoDB79155
GeneTree (enSembl)ENSG00000168884
Phylogenetic Trees/Animal Genes : TreeFamTNIP2
Homologs : HomoloGeneTNIP2
Homology/Alignments : Family Browser (UCSC)TNIP2
Gene fusions - Rearrangements
Fusion : MitelmanFAM193A/TNIP2 [4p16.3/4p16.3]  
Fusion : QuiverTNIP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNIP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNIP2
dbVarTNIP2
ClinVarTNIP2
MonarchTNIP2
1000_GenomesTNIP2 
Exome Variant ServerTNIP2
GNOMAD BrowserENSG00000168884
Varsome BrowserTNIP2
ACMGTNIP2 variants
VarityQ8NFZ5
Genomic Variants (DGV)TNIP2 [DGVbeta]
DECIPHERTNIP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNIP2 
Mutations
ICGC Data PortalTNIP2 
TCGA Data PortalTNIP2 
Broad Tumor PortalTNIP2
OASIS PortalTNIP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNIP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNIP2
Mutations and Diseases : HGMDTNIP2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTNIP2
DgiDB (Drug Gene Interaction Database)TNIP2
DoCM (Curated mutations)TNIP2
CIViC (Clinical Interpretations of Variants in Cancer)TNIP2
Cancer3DTNIP2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610669   
Orphanet
DisGeNETTNIP2
MedgenTNIP2
Genetic Testing Registry TNIP2
NextProtQ8NFZ5 [Medical]
GENETestsTNIP2
Target ValidationTNIP2
Huge Navigator TNIP2 [HugePedia]
ClinGenTNIP2
Clinical trials, drugs, therapy
MyCancerGenomeTNIP2
Protein Interactions : CTDTNIP2
Pharm GKB GenePA134957006
PharosQ8NFZ5
Clinical trialTNIP2
Miscellaneous
canSAR (ICR)TNIP2
HarmonizomeTNIP2
DataMed IndexTNIP2
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNIP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:35:46 CEST 2021

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