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TNK1 (tyrosine kinase, non-receptor 1)

Identity

Alias_namestyrosine kinase
Other alias-
HGNC (Hugo) TNK1
LocusID (NCBI) 8711
Atlas_Id 43533
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 7284293 and ends at 7293092 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TNK1 (17p13.1) / TMEM256 (17p13.1)ZBTB7A (19p13.3) / TNK1 (17p13.1)ZBTB7A 19p13.3 / TNK1 17p13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNK1   11940
Cards
Entrez_Gene (NCBI)TNK1  8711  tyrosine kinase, non-receptor 1
Aliases
GeneCards (Weizmann)TNK1
Ensembl hg19 (Hinxton)ENSG00000174292 [Gene_View]  chr17:7284293-7293092 [Contig_View]  TNK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000174292 [Gene_View]  chr17:7284293-7293092 [Contig_View]  TNK1 [Vega]
ICGC DataPortalENSG00000174292
TCGA cBioPortalTNK1
AceView (NCBI)TNK1
Genatlas (Paris)TNK1
WikiGenes8711
SOURCE (Princeton)TNK1
Genetics Home Reference (NIH)TNK1
Genomic and cartography
GoldenPath hg19 (UCSC)TNK1  -     chr17:7284293-7293092 +  17p13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TNK1  -     17p13.1   [Description]    (hg38-Dec_2013)
EnsemblTNK1 - 17p13.1 [CytoView hg19]  TNK1 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBITNK1 [Mapview hg19]  TNK1 [Mapview hg38]
OMIM608076   
Gene and transcription
Genbank (Entrez)AI810287 AK225403 AK310684 AK311063 BC035782
RefSeq transcript (Entrez)NM_001251902 NM_003985
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)TNK1
Cluster EST : UnigeneHs.739114 [ NCBI ]
CGAP (NCI)Hs.739114
Alternative Splicing GalleryENSG00000174292
Gene ExpressionTNK1 [ NCBI-GEO ]   TNK1 [ EBI - ARRAY_EXPRESS ]   TNK1 [ SEEK ]   TNK1 [ MEM ]
Gene Expression Viewer (FireBrowse)TNK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8711
GTEX Portal (Tissue expression)TNK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13470   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13470  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13470
Splice isoforms : SwissVarQ13470
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
PhosPhoSitePlusQ13470
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH3_domain    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
Domain families : Smart (EMBL)SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)TNK1
DMDM Disease mutations8711
Blocks (Seattle)TNK1
SuperfamilyQ13470
Human Protein AtlasENSG00000174292
Peptide AtlasQ13470
HPRD09730
IPIIPI00022633   IPI00552691   
Protein Interaction databases
DIP (DOE-UCLA)Q13470
IntAct (EBI)Q13470
FunCoupENSG00000174292
BioGRIDTNK1
STRING (EMBL)TNK1
ZODIACTNK1
Ontologies - Pathways
QuickGOQ13470
Ontology : AmiGOprotein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signal transducer activity  receptor binding  protein binding  ATP binding  cytoplasm  cytosol  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  membrane  cell differentiation  negative regulation of cell growth  extrinsic component of cytoplasmic side of plasma membrane  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  innate immune response  negative regulation of Ras protein signal transduction  protein autophosphorylation  
Ontology : EGO-EBIprotein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signal transducer activity  receptor binding  protein binding  ATP binding  cytoplasm  cytosol  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  membrane  cell differentiation  negative regulation of cell growth  extrinsic component of cytoplasmic side of plasma membrane  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  innate immune response  negative regulation of Ras protein signal transduction  protein autophosphorylation  
NDEx NetworkTNK1
Atlas of Cancer Signalling NetworkTNK1
Wikipedia pathwaysTNK1
Orthology - Evolution
OrthoDB8711
GeneTree (enSembl)ENSG00000174292
Phylogenetic Trees/Animal Genes : TreeFamTNK1
HOVERGENQ13470
HOGENOMQ13470
Homologs : HomoloGeneTNK1
Homology/Alignments : Family Browser (UCSC)TNK1
Gene fusions - Rearrangements
Fusion : MitelmanZBTB7A/TNK1 [19p13.3/17p13.1]  [t(17;19)(p13;p13)]  
Fusion: TCGAZBTB7A 19p13.3 TNK1 17p13.1 LAML
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNK1
dbVarTNK1
ClinVarTNK1
1000_GenomesTNK1 
Exome Variant ServerTNK1
ExAC (Exome Aggregation Consortium)TNK1 (select the gene name)
Genetic variants : HAPMAP8711
Genomic Variants (DGV)TNK1 [DGVbeta]
DECIPHER (Syndromes)17:7284293-7293092  ENSG00000174292
CONAN: Copy Number AnalysisTNK1 
Mutations
ICGC Data PortalTNK1 
TCGA Data PortalTNK1 
Broad Tumor PortalTNK1
OASIS PortalTNK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNK1
DgiDB (Drug Gene Interaction Database)TNK1
DoCM (Curated mutations)TNK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNK1 (select a term)
intoGenTNK1
Cancer3DTNK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608076   
Orphanet
MedgenTNK1
Genetic Testing Registry TNK1
NextProtQ13470 [Medical]
TSGene8711
GENETestsTNK1
Huge Navigator TNK1 [HugePedia]
snp3D : Map Gene to Disease8711
BioCentury BCIQTNK1
ClinGenTNK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8711
Chemical/Pharm GKB GenePA36630
Clinical trialTNK1
Miscellaneous
canSAR (ICR)TNK1 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNK1
EVEXTNK1
GoPubMedTNK1
iHOPTNK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:31:45 CET 2017

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