TNK1 (tyrosine kinase non receptor 1)

2006-10-01  

Identity

HGNC
TNK1
LOCATION
17p13.1
LOCUSID
8711
ALIAS
KOS1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8711
MIM: 608076
HGNC: 11940
Ensembl: ENSG00000174292

Variants:

dbSNP: 8711
ClinVar: 8711
TCGA: ENSG00000174292
COSMIC: TNK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174292ENST00000570896Q13470
ENSG00000174292ENST00000576207U3KPR9
ENSG00000174292ENST00000576716I3L334
ENSG00000174292ENST00000576812Q13470

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
205347412010Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.108
204138502010Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.29
205745322010Intermediate phenotypes identify divergent pathways to Alzheimer's disease.24
188307242009Assessment of Alzheimer's disease case-control associations using family-based methods.21
244498622014Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.13
174712392007Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation.12
215366872011High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells.11
200907802010Identification of activated Tnk1 kinase in Hodgkin's lymphoma.10
286311882018Role of CLU, PICALM, and TNK1 Genotypes in Aging With and Without Alzheimer's Disease.4
303206002018Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.4

Citation

Dessen P

TNK1 (tyrosine kinase non receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43533/tnk1