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TNK2 (tyrosine kinase non receptor 2)

Identity

Alias (NCBI)ACK
ACK-1
ACK1
p21cdc42Hs
HGNC (Hugo) TNK2
HGNC Alias symbp21cdc42Hs
ACK
ACK1
HGNC Alias nameactivated Cdc42-associated kinase 1
HGNC Previous nametyrosine kinase, non-receptor, 2
LocusID (NCBI) 10188
Atlas_Id 44030
Location 3q29  [Link to chromosome band 3q29]
Location_base_pair Starts at 195863365 and ends at 195909009 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
IFNAR2 (21q22.11)::TNK2 (3q29)TNK2 (3q29)::CELF1 (11p11.2)TNK2 (3q29)::RNF187 (1q42.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TNK2   19297
Cards
Entrez_Gene (NCBI)TNK2    tyrosine kinase non receptor 2
AliasesACK; ACK-1; ACK1; p21cdc42Hs
GeneCards (Weizmann)TNK2
Ensembl hg19 (Hinxton)ENSG00000061938 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000061938 [Gene_View]  ENSG00000061938 [Sequence]  chr3:195863365-195909009 [Contig_View]  TNK2 [Vega]
ICGC DataPortalENSG00000061938
TCGA cBioPortalTNK2
AceView (NCBI)TNK2
Genatlas (Paris)TNK2
SOURCE (Princeton)TNK2
Genetics Home Reference (NIH)TNK2
Genomic and cartography
GoldenPath hg38 (UCSC)TNK2  -     chr3:195863365-195909009 -  3q29   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNK2  -     3q29   [Description]    (hg19-Feb_2009)
GoldenPathTNK2 - 3q29 [CytoView hg19]  TNK2 - 3q29 [CytoView hg38]
ImmunoBaseENSG00000061938
Genome Data Viewer NCBITNK2 [Mapview hg19]  
OMIM606994   
Gene and transcription
Genbank (Entrez)AB209338 AK024904 AK126712 AK127455 AK131539
RefSeq transcript (Entrez)NM_001010938 NM_001308046 NM_001382271 NM_001382272 NM_001382273 NM_001382274 NM_001382275 NM_001386164 NM_001387707 NM_001387708 NM_001387709 NM_001387710 NM_001387711 NM_001387712 NM_001387713 NM_001387714 NM_001387715 NM_001387716 NM_001387717 NM_001387718 NM_001387719 NM_001387720 NM_001387721 NM_005781
Consensus coding sequences : CCDS (NCBI)TNK2
Gene ExpressionTNK2 [ NCBI-GEO ]   TNK2 [ EBI - ARRAY_EXPRESS ]   TNK2 [ SEEK ]   TNK2 [ MEM ]
Gene Expression Viewer (FireBrowse)TNK2 [ Firebrowse - Broad ]
GenevisibleExpression of TNK2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10188
GTEX Portal (Tissue expression)TNK2
Human Protein AtlasENSG00000061938-TNK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07912   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ07912  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07912
PhosPhoSitePlusQ07912
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH3 (PS50002)   
Domains : Interpro (EBI)Ack1    Cdc42-bd-like    Cdc42-bd-like_dom_sf    Kinase-like_dom_sf    Mig-6    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH3-like_dom_sf    SH3_domain    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)GTPase_binding (PF09027)    Inhibitor_Mig-6 (PF11555)    PK_Tyr_Ser-Thr (PF07714)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam09027    pfam11555    pfam07714    pfam14604   
Domain families : Smart (EMBL)SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)TNK2
PDB (RSDB)1CF4    1U46    1U4D    1U54    3EQP    3EQR    4EWH    4HZR    4HZS    4ID7    5ZXB   
PDB Europe1CF4    1U46    1U4D    1U54    3EQP    3EQR    4EWH    4HZR    4HZS    4ID7    5ZXB   
PDB (PDBSum)1CF4    1U46    1U4D    1U54    3EQP    3EQR    4EWH    4HZR    4HZS    4ID7    5ZXB   
PDB (IMB)1CF4    1U46    1U4D    1U54    3EQP    3EQR    4EWH    4HZR    4HZS    4ID7    5ZXB   
Structural Biology KnowledgeBase1CF4    1U46    1U4D    1U54    3EQP    3EQR    4EWH    4HZR    4HZS    4ID7    5ZXB   
SCOP (Structural Classification of Proteins)1CF4    1U46    1U4D    1U54    3EQP    3EQR    4EWH    4HZR    4HZS    4ID7    5ZXB   
CATH (Classification of proteins structures)1CF4    1U46    1U4D    1U54    3EQP    3EQR    4EWH    4HZR    4HZS    4ID7    5ZXB   
SuperfamilyQ07912
AlphaFold pdb e-kbQ07912   
Human Protein Atlas [tissue]ENSG00000061938-TNK2 [tissue]
HPRD06104
Protein Interaction databases
DIP (DOE-UCLA)Q07912
IntAct (EBI)Q07912
BioGRIDTNK2
STRING (EMBL)TNK2
ZODIACTNK2
Ontologies - Pathways
QuickGOQ07912
Ontology : AmiGOprotein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  GTPase inhibitor activity  signaling receptor binding  epidermal growth factor receptor binding  protein binding  ATP binding  nucleus  cytoplasm  endosome  cytosol  plasma membrane  clathrin-coated pit  adherens junction  endocytosis  cell surface receptor signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  small GTPase mediated signal transduction  membrane  phosphorylation  peptidyl-tyrosine phosphorylation  clathrin-coated vesicle  cell differentiation  cytoplasmic vesicle membrane  extrinsic component of cytoplasmic side of plasma membrane  ubiquitin protein ligase binding  identical protein binding  innate immune response  metal ion binding  perinuclear region of cytoplasm  WW domain binding  positive regulation of peptidyl-tyrosine phosphorylation  regulation of catalytic activity  Grb2-EGFR complex  cytoophidium  protein serine kinase activity  protein threonine kinase activity  regulation of clathrin-dependent endocytosis  
Ontology : EGO-EBIprotein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  GTPase inhibitor activity  signaling receptor binding  epidermal growth factor receptor binding  protein binding  ATP binding  nucleus  cytoplasm  endosome  cytosol  plasma membrane  clathrin-coated pit  adherens junction  endocytosis  cell surface receptor signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  small GTPase mediated signal transduction  membrane  phosphorylation  peptidyl-tyrosine phosphorylation  clathrin-coated vesicle  cell differentiation  cytoplasmic vesicle membrane  extrinsic component of cytoplasmic side of plasma membrane  ubiquitin protein ligase binding  identical protein binding  innate immune response  metal ion binding  perinuclear region of cytoplasm  WW domain binding  positive regulation of peptidyl-tyrosine phosphorylation  regulation of catalytic activity  Grb2-EGFR complex  cytoophidium  protein serine kinase activity  protein threonine kinase activity  regulation of clathrin-dependent endocytosis  
NDEx NetworkTNK2
Atlas of Cancer Signalling NetworkTNK2
Wikipedia pathwaysTNK2
Orthology - Evolution
OrthoDB10188
GeneTree (enSembl)ENSG00000061938
Phylogenetic Trees/Animal Genes : TreeFamTNK2
Homologs : HomoloGeneTNK2
Homology/Alignments : Family Browser (UCSC)TNK2
Gene fusions - Rearrangements
Fusion : QuiverTNK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNK2
dbVarTNK2
ClinVarTNK2
MonarchTNK2
1000_GenomesTNK2 
Exome Variant ServerTNK2
GNOMAD BrowserENSG00000061938
Varsome BrowserTNK2
ACMGTNK2 variants
VarityQ07912
Genomic Variants (DGV)TNK2 [DGVbeta]
DECIPHERTNK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNK2 
Mutations
ICGC Data PortalTNK2 
TCGA Data PortalTNK2 
Broad Tumor PortalTNK2
OASIS PortalTNK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNK2
Mutations and Diseases : HGMDTNK2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTNK2
DgiDB (Drug Gene Interaction Database)TNK2
DoCM (Curated mutations)TNK2
CIViC (Clinical Interpretations of Variants in Cancer)TNK2
Cancer3DTNK2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606994   
Orphanet22603   
DisGeNETTNK2
MedgenTNK2
Genetic Testing Registry TNK2
NextProtQ07912 [Medical]
GENETestsTNK2
Target ValidationTNK2
Huge Navigator TNK2 [HugePedia]
ClinGenTNK2
Clinical trials, drugs, therapy
MyCancerGenomeTNK2
Protein Interactions : CTDTNK2
Pharm GKB GenePA134909759
PharosQ07912
Clinical trialTNK2
Miscellaneous
canSAR (ICR)TNK2
HarmonizomeTNK2
ARCHS4TNK2
DataMed IndexTNK2
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sun Jan 16 18:38:10 CET 2022

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