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TNK2 (tyrosine kinase non receptor 2)

Identity

Alias_namestyrosine kinase
Alias_symbol (synonym)p21cdc42Hs
ACK
ACK1
Other aliasACK-1
HGNC (Hugo) TNK2
LocusID (NCBI) 10188
Atlas_Id 44030
Location 3q29  [Link to chromosome band 3q29]
Location_base_pair Starts at 195863365 and ends at 195895561 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
IFNAR2 (21q22.11) / TNK2 (3q29)TNK2 (3q29) / CELF1 (11p11.2)TNK2 (3q29) / RNF187 (1q42.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNK2   19297
Cards
Entrez_Gene (NCBI)TNK2  10188  tyrosine kinase non receptor 2
AliasesACK; ACK-1; ACK1; p21cdc42Hs
GeneCards (Weizmann)TNK2
Ensembl hg19 (Hinxton)ENSG00000061938 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000061938 [Gene_View]  chr3:195863365-195895561 [Contig_View]  TNK2 [Vega]
ICGC DataPortalENSG00000061938
TCGA cBioPortalTNK2
AceView (NCBI)TNK2
Genatlas (Paris)TNK2
WikiGenes10188
SOURCE (Princeton)TNK2
Genetics Home Reference (NIH)TNK2
Genomic and cartography
GoldenPath hg38 (UCSC)TNK2  -     chr3:195863365-195895561 -  3q29   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNK2  -     3q29   [Description]    (hg19-Feb_2009)
EnsemblTNK2 - 3q29 [CytoView hg19]  TNK2 - 3q29 [CytoView hg38]
Mapping of homologs : NCBITNK2 [Mapview hg19]  TNK2 [Mapview hg38]
OMIM606994   
Gene and transcription
Genbank (Entrez)AB209338 AK024904 AK126712 AK127455 AK131539
RefSeq transcript (Entrez)NM_001010938 NM_001308046 NM_005781
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNK2
Cluster EST : UnigeneHs.518513 [ NCBI ]
CGAP (NCI)Hs.518513
Alternative Splicing GalleryENSG00000061938
Gene ExpressionTNK2 [ NCBI-GEO ]   TNK2 [ EBI - ARRAY_EXPRESS ]   TNK2 [ SEEK ]   TNK2 [ MEM ]
Gene Expression Viewer (FireBrowse)TNK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10188
GTEX Portal (Tissue expression)TNK2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07912   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ07912  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07912
Splice isoforms : SwissVarQ07912
PhosPhoSitePlusQ07912
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH3 (PS50002)   
Domains : Interpro (EBI)Cdc42_binding_dom-like    Kinase-like_dom    Mig-6    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH3_domain    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)GTPase_binding (PF09027)    Inhibitor_Mig-6 (PF11555)    Pkinase_Tyr (PF07714)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam09027    pfam11555    pfam07714    pfam14604   
Domain families : Smart (EMBL)SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)TNK2
DMDM Disease mutations10188
Blocks (Seattle)TNK2
PDB (SRS)1CF4    1U46    1U4D    1U54    3EQP    3EQR    4EWH    4HZR    4HZS    4ID7   
PDB (PDBSum)1CF4    1U46    1U4D    1U54    3EQP    3EQR    4EWH    4HZR    4HZS    4ID7   
PDB (IMB)1CF4    1U46    1U4D    1U54    3EQP    3EQR    4EWH    4HZR    4HZS    4ID7   
PDB (RSDB)1CF4    1U46    1U4D    1U54    3EQP    3EQR    4EWH    4HZR    4HZS    4ID7   
Structural Biology KnowledgeBase1CF4    1U46    1U4D    1U54    3EQP    3EQR    4EWH    4HZR    4HZS    4ID7   
SCOP (Structural Classification of Proteins)1CF4    1U46    1U4D    1U54    3EQP    3EQR    4EWH    4HZR    4HZS    4ID7   
CATH (Classification of proteins structures)1CF4    1U46    1U4D    1U54    3EQP    3EQR    4EWH    4HZR    4HZS    4ID7   
SuperfamilyQ07912
Human Protein AtlasENSG00000061938
Peptide AtlasQ07912
HPRD06104
IPIIPI00167089   IPI00442025   IPI00926536   IPI00556375   IPI00552750   IPI00926216   IPI00926782   IPI00927021   IPI00927251   IPI00927946   IPI00924620   IPI00924840   IPI00925038   
Protein Interaction databases
DIP (DOE-UCLA)Q07912
IntAct (EBI)Q07912
FunCoupENSG00000061938
BioGRIDTNK2
STRING (EMBL)TNK2
ZODIACTNK2
Ontologies - Pathways
QuickGOQ07912
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  GTPase inhibitor activity  epidermal growth factor receptor binding  protein binding  ATP binding  nucleus  cytoplasm  endosome  plasma membrane  clathrin-coated pit  adherens junction  endocytosis  cell surface receptor signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  small GTPase mediated signal transduction  membrane  phosphorylation  cell migration  clathrin-coated vesicle  cell differentiation  cytoplasmic vesicle membrane  extrinsic component of cytoplasmic side of plasma membrane  ubiquitin protein ligase binding  negative regulation of GTPase activity  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  identical protein binding  innate immune response  metal ion binding  WW domain binding  positive regulation of peptidyl-tyrosine phosphorylation  Grb2-EGFR complex  regulation of clathrin-dependent endocytosis  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  GTPase inhibitor activity  epidermal growth factor receptor binding  protein binding  ATP binding  nucleus  cytoplasm  endosome  plasma membrane  clathrin-coated pit  adherens junction  endocytosis  cell surface receptor signaling pathway  transmembrane receptor protein tyrosine kinase signaling pathway  small GTPase mediated signal transduction  membrane  phosphorylation  cell migration  clathrin-coated vesicle  cell differentiation  cytoplasmic vesicle membrane  extrinsic component of cytoplasmic side of plasma membrane  ubiquitin protein ligase binding  negative regulation of GTPase activity  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  identical protein binding  innate immune response  metal ion binding  WW domain binding  positive regulation of peptidyl-tyrosine phosphorylation  Grb2-EGFR complex  regulation of clathrin-dependent endocytosis  
NDEx NetworkTNK2
Atlas of Cancer Signalling NetworkTNK2
Wikipedia pathwaysTNK2
Orthology - Evolution
OrthoDB10188
GeneTree (enSembl)ENSG00000061938
Phylogenetic Trees/Animal Genes : TreeFamTNK2
HOVERGENQ07912
HOGENOMQ07912
Homologs : HomoloGeneTNK2
Homology/Alignments : Family Browser (UCSC)TNK2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNK2
dbVarTNK2
ClinVarTNK2
1000_GenomesTNK2 
Exome Variant ServerTNK2
ExAC (Exome Aggregation Consortium)TNK2 (select the gene name)
Genetic variants : HAPMAP10188
Genomic Variants (DGV)TNK2 [DGVbeta]
DECIPHERTNK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNK2 
Mutations
ICGC Data PortalTNK2 
TCGA Data PortalTNK2 
Broad Tumor PortalTNK2
OASIS PortalTNK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNK2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNK2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNK2
DgiDB (Drug Gene Interaction Database)TNK2
DoCM (Curated mutations)TNK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNK2 (select a term)
intoGenTNK2
Cancer3DTNK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606994   
Orphanet22603   
MedgenTNK2
Genetic Testing Registry TNK2
NextProtQ07912 [Medical]
TSGene10188
GENETestsTNK2
Target ValidationTNK2
Huge Navigator TNK2 [HugePedia]
snp3D : Map Gene to Disease10188
BioCentury BCIQTNK2
ClinGenTNK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10188
Chemical/Pharm GKB GenePA134909759
Clinical trialTNK2
Miscellaneous
canSAR (ICR)TNK2 (select the gene name)
Probes
Litterature
PubMed99 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNK2
EVEXTNK2
GoPubMedTNK2
iHOPTNK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:17:20 CEST 2017

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