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TNKS2 (tankyrase 2)

Identity

Alias_namestankyrase
Alias_symbol (synonym)TNKL
TANK2
PARP-5b
PARP-5c
PARP5B
PARP5C
pART6
Other aliasARTD6
HGNC (Hugo) TNKS2
LocusID (NCBI) 80351
Atlas_Id 43535
Location 10q23.32  [Link to chromosome band 10q23]
Location_base_pair Starts at 93558151 and ends at 93625232 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ADCY2 (5p15.31) / TNKS2 (10q23.32)HBG2 (11p15.4) / TNKS2 (10q23.32)RPL31 (2q11.2) / TNKS2 (10q23.32)
TNKS2 (10q23.32) / BTBD2 (19p13.3)TNKS2 (10q23.32) / C3orf70 (3q27.2)TNKS2 (10q23.32) / CLCNKB (1p36.13)
TNKS2 (10q23.32) / HECTD2 (10q23.32)TNKS2 (10q23.32) / RP11-451M19.3 ()TNKS2 10q23.32 RP11-451M19.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(4;10)(q12;q23) PDGFRA/TNKS2


External links

Nomenclature
HGNC (Hugo)TNKS2   15677
Cards
Entrez_Gene (NCBI)TNKS2  80351  tankyrase 2
AliasesARTD6; PARP-5b; PARP-5c; PARP5B; 
PARP5C; TANK2; TNKL; pART6
GeneCards (Weizmann)TNKS2
Ensembl hg19 (Hinxton)ENSG00000107854 [Gene_View]  chr10:93558151-93625232 [Contig_View]  TNKS2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000107854 [Gene_View]  chr10:93558151-93625232 [Contig_View]  TNKS2 [Vega]
ICGC DataPortalENSG00000107854
TCGA cBioPortalTNKS2
AceView (NCBI)TNKS2
Genatlas (Paris)TNKS2
WikiGenes80351
SOURCE (Princeton)TNKS2
Genetics Home Reference (NIH)TNKS2
Genomic and cartography
GoldenPath hg19 (UCSC)TNKS2  -     chr10:93558151-93625232 +  10q23.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TNKS2  -     10q23.32   [Description]    (hg38-Dec_2013)
EnsemblTNKS2 - 10q23.32 [CytoView hg19]  TNKS2 - 10q23.32 [CytoView hg38]
Mapping of homologs : NCBITNKS2 [Mapview hg19]  TNKS2 [Mapview hg38]
OMIM607128   
Gene and transcription
Genbank (Entrez)AF264912 AF305081 AF309033 AF329696 AF342982
RefSeq transcript (Entrez)NM_025235
RefSeq genomic (Entrez)NC_000010 NC_018921 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)TNKS2
Cluster EST : UnigeneHs.329327 [ NCBI ]
CGAP (NCI)Hs.329327
Alternative Splicing GalleryENSG00000107854
Gene ExpressionTNKS2 [ NCBI-GEO ]   TNKS2 [ EBI - ARRAY_EXPRESS ]   TNKS2 [ SEEK ]   TNKS2 [ MEM ]
Gene Expression Viewer (FireBrowse)TNKS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80351
GTEX Portal (Tissue expression)TNKS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H2K2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H2K2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H2K2
Splice isoforms : SwissVarQ9H2K2
Catalytic activity : Enzyme2.4.2.30 [ Enzyme-Expasy ]   2.4.2.302.4.2.30 [ IntEnz-EBI ]   2.4.2.30 [ BRENDA ]   2.4.2.30 [ KEGG ]   
PhosPhoSitePlusQ9H2K2
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    PARP_CATALYTIC (PS51059)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Poly(ADP-ribose)pol_cat_dom    SAM    SAM/pointed   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    PARP (PF00644)    SAM_2 (PF07647)   
Domain families : Pfam (NCBI)pfam12796    pfam00644    pfam07647   
Domain families : Smart (EMBL)ANK (SM00248)  SAM (SM00454)  
Conserved Domain (NCBI)TNKS2
DMDM Disease mutations80351
Blocks (Seattle)TNKS2
PDB (SRS)2Y0I    3KR7    3KR8    3MHJ    3MHK    3P0N    3P0P    3P0Q    3TWQ    3TWR    3TWS    3TWT    3TWU    3TWV    3TWW    3TWX    3U9H    3U9Y    3UA9    3W51    4AVU    4AVW    4BFP    4BJ9    4BJB    4BJC    4BS4    4BU3    4BU5    4BU6    4BU7    4BU8    4BU9    4BUA    4BUD    4BUE    4BUF    4BUI    4BUS    4BUT    4BUU    4BUV    4BUW    4BUX    4BUY    4HKI    4HKK    4HKN    4HL5    4HLF    4HLG    4HLH    4HLK    4HLM    4HMH    4HYF    4IUE    4J1Z    4J21    4J22    4J3L    4J3M    4KZL    4KZQ    4KZU    4L09    4L0B    4L0I    4L0S    4L0T    4L0V    4L10    4L2F    4L2G    4L2K    4L31    4L32    4L33    4L34    4M7B    4PML    4PNL    4PNM    4PNN    4PNQ    4PNR    4PNS    4PNT    4TJU    4TJW    4TJY    4TK0    4TK5    4TKF    4TKG    4TKI    4UVL    4UVN    4UVO    4UVP    4UVS    4UVT    4UVU    4UVV    4UVW    4UVX    4UVY    4UVZ    4UX4    4W5I    4Z68    5ADQ    5ADR    5ADS    5ADT    5AEH    5AKU    5AKW    5AL1    5AL2    5AL3    5AL4    5AL5    5C5P    5C5Q    5C5R   
PDB (PDBSum)2Y0I    3KR7    3KR8    3MHJ    3MHK    3P0N    3P0P    3P0Q    3TWQ    3TWR    3TWS    3TWT    3TWU    3TWV    3TWW    3TWX    3U9H    3U9Y    3UA9    3W51    4AVU    4AVW    4BFP    4BJ9    4BJB    4BJC    4BS4    4BU3    4BU5    4BU6    4BU7    4BU8    4BU9    4BUA    4BUD    4BUE    4BUF    4BUI    4BUS    4BUT    4BUU    4BUV    4BUW    4BUX    4BUY    4HKI    4HKK    4HKN    4HL5    4HLF    4HLG    4HLH    4HLK    4HLM    4HMH    4HYF    4IUE    4J1Z    4J21    4J22    4J3L    4J3M    4KZL    4KZQ    4KZU    4L09    4L0B    4L0I    4L0S    4L0T    4L0V    4L10    4L2F    4L2G    4L2K    4L31    4L32    4L33    4L34    4M7B    4PML    4PNL    4PNM    4PNN    4PNQ    4PNR    4PNS    4PNT    4TJU    4TJW    4TJY    4TK0    4TK5    4TKF    4TKG    4TKI    4UVL    4UVN    4UVO    4UVP    4UVS    4UVT    4UVU    4UVV    4UVW    4UVX    4UVY    4UVZ    4UX4    4W5I    4Z68    5ADQ    5ADR    5ADS    5ADT    5AEH    5AKU    5AKW    5AL1    5AL2    5AL3    5AL4    5AL5    5C5P    5C5Q    5C5R   
PDB (IMB)2Y0I    3KR7    3KR8    3MHJ    3MHK    3P0N    3P0P    3P0Q    3TWQ    3TWR    3TWS    3TWT    3TWU    3TWV    3TWW    3TWX    3U9H    3U9Y    3UA9    3W51    4AVU    4AVW    4BFP    4BJ9    4BJB    4BJC    4BS4    4BU3    4BU5    4BU6    4BU7    4BU8    4BU9    4BUA    4BUD    4BUE    4BUF    4BUI    4BUS    4BUT    4BUU    4BUV    4BUW    4BUX    4BUY    4HKI    4HKK    4HKN    4HL5    4HLF    4HLG    4HLH    4HLK    4HLM    4HMH    4HYF    4IUE    4J1Z    4J21    4J22    4J3L    4J3M    4KZL    4KZQ    4KZU    4L09    4L0B    4L0I    4L0S    4L0T    4L0V    4L10    4L2F    4L2G    4L2K    4L31    4L32    4L33    4L34    4M7B    4PML    4PNL    4PNM    4PNN    4PNQ    4PNR    4PNS    4PNT    4TJU    4TJW    4TJY    4TK0    4TK5    4TKF    4TKG    4TKI    4UVL    4UVN    4UVO    4UVP    4UVS    4UVT    4UVU    4UVV    4UVW    4UVX    4UVY    4UVZ    4UX4    4W5I    4Z68    5ADQ    5ADR    5ADS    5ADT    5AEH    5AKU    5AKW    5AL1    5AL2    5AL3    5AL4    5AL5    5C5P    5C5Q    5C5R   
PDB (RSDB)2Y0I    3KR7    3KR8    3MHJ    3MHK    3P0N    3P0P    3P0Q    3TWQ    3TWR    3TWS    3TWT    3TWU    3TWV    3TWW    3TWX    3U9H    3U9Y    3UA9    3W51    4AVU    4AVW    4BFP    4BJ9    4BJB    4BJC    4BS4    4BU3    4BU5    4BU6    4BU7    4BU8    4BU9    4BUA    4BUD    4BUE    4BUF    4BUI    4BUS    4BUT    4BUU    4BUV    4BUW    4BUX    4BUY    4HKI    4HKK    4HKN    4HL5    4HLF    4HLG    4HLH    4HLK    4HLM    4HMH    4HYF    4IUE    4J1Z    4J21    4J22    4J3L    4J3M    4KZL    4KZQ    4KZU    4L09    4L0B    4L0I    4L0S    4L0T    4L0V    4L10    4L2F    4L2G    4L2K    4L31    4L32    4L33    4L34    4M7B    4PML    4PNL    4PNM    4PNN    4PNQ    4PNR    4PNS    4PNT    4TJU    4TJW    4TJY    4TK0    4TK5    4TKF    4TKG    4TKI    4UVL    4UVN    4UVO    4UVP    4UVS    4UVT    4UVU    4UVV    4UVW    4UVX    4UVY    4UVZ    4UX4    4W5I    4Z68    5ADQ    5ADR    5ADS    5ADT    5AEH    5AKU    5AKW    5AL1    5AL2    5AL3    5AL4    5AL5    5C5P    5C5Q    5C5R   
Structural Biology KnowledgeBase2Y0I    3KR7    3KR8    3MHJ    3MHK    3P0N    3P0P    3P0Q    3TWQ    3TWR    3TWS    3TWT    3TWU    3TWV    3TWW    3TWX    3U9H    3U9Y    3UA9    3W51    4AVU    4AVW    4BFP    4BJ9    4BJB    4BJC    4BS4    4BU3    4BU5    4BU6    4BU7    4BU8    4BU9    4BUA    4BUD    4BUE    4BUF    4BUI    4BUS    4BUT    4BUU    4BUV    4BUW    4BUX    4BUY    4HKI    4HKK    4HKN    4HL5    4HLF    4HLG    4HLH    4HLK    4HLM    4HMH    4HYF    4IUE    4J1Z    4J21    4J22    4J3L    4J3M    4KZL    4KZQ    4KZU    4L09    4L0B    4L0I    4L0S    4L0T    4L0V    4L10    4L2F    4L2G    4L2K    4L31    4L32    4L33    4L34    4M7B    4PML    4PNL    4PNM    4PNN    4PNQ    4PNR    4PNS    4PNT    4TJU    4TJW    4TJY    4TK0    4TK5    4TKF    4TKG    4TKI    4UVL    4UVN    4UVO    4UVP    4UVS    4UVT    4UVU    4UVV    4UVW    4UVX    4UVY    4UVZ    4UX4    4W5I    4Z68    5ADQ    5ADR    5ADS    5ADT    5AEH    5AKU    5AKW    5AL1    5AL2    5AL3    5AL4    5AL5    5C5P    5C5Q    5C5R   
SCOP (Structural Classification of Proteins)2Y0I    3KR7    3KR8    3MHJ    3MHK    3P0N    3P0P    3P0Q    3TWQ    3TWR    3TWS    3TWT    3TWU    3TWV    3TWW    3TWX    3U9H    3U9Y    3UA9    3W51    4AVU    4AVW    4BFP    4BJ9    4BJB    4BJC    4BS4    4BU3    4BU5    4BU6    4BU7    4BU8    4BU9    4BUA    4BUD    4BUE    4BUF    4BUI    4BUS    4BUT    4BUU    4BUV    4BUW    4BUX    4BUY    4HKI    4HKK    4HKN    4HL5    4HLF    4HLG    4HLH    4HLK    4HLM    4HMH    4HYF    4IUE    4J1Z    4J21    4J22    4J3L    4J3M    4KZL    4KZQ    4KZU    4L09    4L0B    4L0I    4L0S    4L0T    4L0V    4L10    4L2F    4L2G    4L2K    4L31    4L32    4L33    4L34    4M7B    4PML    4PNL    4PNM    4PNN    4PNQ    4PNR    4PNS    4PNT    4TJU    4TJW    4TJY    4TK0    4TK5    4TKF    4TKG    4TKI    4UVL    4UVN    4UVO    4UVP    4UVS    4UVT    4UVU    4UVV    4UVW    4UVX    4UVY    4UVZ    4UX4    4W5I    4Z68    5ADQ    5ADR    5ADS    5ADT    5AEH    5AKU    5AKW    5AL1    5AL2    5AL3    5AL4    5AL5    5C5P    5C5Q    5C5R   
CATH (Classification of proteins structures)2Y0I    3KR7    3KR8    3MHJ    3MHK    3P0N    3P0P    3P0Q    3TWQ    3TWR    3TWS    3TWT    3TWU    3TWV    3TWW    3TWX    3U9H    3U9Y    3UA9    3W51    4AVU    4AVW    4BFP    4BJ9    4BJB    4BJC    4BS4    4BU3    4BU5    4BU6    4BU7    4BU8    4BU9    4BUA    4BUD    4BUE    4BUF    4BUI    4BUS    4BUT    4BUU    4BUV    4BUW    4BUX    4BUY    4HKI    4HKK    4HKN    4HL5    4HLF    4HLG    4HLH    4HLK    4HLM    4HMH    4HYF    4IUE    4J1Z    4J21    4J22    4J3L    4J3M    4KZL    4KZQ    4KZU    4L09    4L0B    4L0I    4L0S    4L0T    4L0V    4L10    4L2F    4L2G    4L2K    4L31    4L32    4L33    4L34    4M7B    4PML    4PNL    4PNM    4PNN    4PNQ    4PNR    4PNS    4PNT    4TJU    4TJW    4TJY    4TK0    4TK5    4TKF    4TKG    4TKI    4UVL    4UVN    4UVO    4UVP    4UVS    4UVT    4UVU    4UVV    4UVW    4UVX    4UVY    4UVZ    4UX4    4W5I    4Z68    5ADQ    5ADR    5ADS    5ADT    5AEH    5AKU    5AKW    5AL1    5AL2    5AL3    5AL4    5AL5    5C5P    5C5Q    5C5R   
SuperfamilyQ9H2K2
Human Protein AtlasENSG00000107854
Peptide AtlasQ9H2K2
HPRD06182
IPIIPI00019270   
Protein Interaction databases
DIP (DOE-UCLA)Q9H2K2
IntAct (EBI)Q9H2K2
FunCoupENSG00000107854
BioGRIDTNKS2
STRING (EMBL)TNKS2
ZODIACTNKS2
Ontologies - Pathways
QuickGOQ9H2K2
Ontology : AmiGOGolgi membrane  protein polyubiquitination  pericentriolar material  nuclear chromosome, telomeric region  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  nuclear envelope  cytoplasm  cytosol  protein ADP-ribosylation  Wnt signaling pathway  enzyme binding  positive regulation of telomere maintenance via telomerase  multicellular organism growth  regulation of multicellular organism growth  metal ion binding  perinuclear region of cytoplasm  protein localization to chromosome, telomeric region  protein auto-ADP-ribosylation  positive regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of telomere capping  positive regulation of telomere capping  negative regulation of telomere maintenance via telomere lengthening  
Ontology : EGO-EBIGolgi membrane  protein polyubiquitination  pericentriolar material  nuclear chromosome, telomeric region  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  nuclear envelope  cytoplasm  cytosol  protein ADP-ribosylation  Wnt signaling pathway  enzyme binding  positive regulation of telomere maintenance via telomerase  multicellular organism growth  regulation of multicellular organism growth  metal ion binding  perinuclear region of cytoplasm  protein localization to chromosome, telomeric region  protein auto-ADP-ribosylation  positive regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of telomere capping  positive regulation of telomere capping  negative regulation of telomere maintenance via telomere lengthening  
NDEx NetworkTNKS2
Atlas of Cancer Signalling NetworkTNKS2
Wikipedia pathwaysTNKS2
Orthology - Evolution
OrthoDB80351
GeneTree (enSembl)ENSG00000107854
Phylogenetic Trees/Animal Genes : TreeFamTNKS2
HOVERGENQ9H2K2
HOGENOMQ9H2K2
Homologs : HomoloGeneTNKS2
Homology/Alignments : Family Browser (UCSC)TNKS2
Gene fusions - Rearrangements
Fusion: TCGATNKS2 10q23.32 RP11-451M19.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNKS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNKS2
dbVarTNKS2
ClinVarTNKS2
1000_GenomesTNKS2 
Exome Variant ServerTNKS2
ExAC (Exome Aggregation Consortium)TNKS2 (select the gene name)
Genetic variants : HAPMAP80351
Genomic Variants (DGV)TNKS2 [DGVbeta]
DECIPHER (Syndromes)10:93558151-93625232  ENSG00000107854
CONAN: Copy Number AnalysisTNKS2 
Mutations
ICGC Data PortalTNKS2 
TCGA Data PortalTNKS2 
Broad Tumor PortalTNKS2
OASIS PortalTNKS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNKS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNKS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNKS2
DgiDB (Drug Gene Interaction Database)TNKS2
DoCM (Curated mutations)TNKS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNKS2 (select a term)
intoGenTNKS2
Cancer3DTNKS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607128   
Orphanet
MedgenTNKS2
Genetic Testing Registry TNKS2
NextProtQ9H2K2 [Medical]
TSGene80351
GENETestsTNKS2
Huge Navigator TNKS2 [HugePedia]
snp3D : Map Gene to Disease80351
BioCentury BCIQTNKS2
ClinGenTNKS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80351
Chemical/Pharm GKB GenePA38019
Clinical trialTNKS2
Miscellaneous
canSAR (ICR)TNKS2 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNKS2
EVEXTNKS2
GoPubMedTNKS2
iHOPTNKS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:31:46 CET 2017

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