TNKS2 (tankyrase 2)

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TNKS2 (tankyrase 2)

Identity

Alias_names	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Alias_symbol (synonym)	TNKL
	TANK2
	PARP-5b
	PARP-5c
	PARP5B
	PARP5C
	pART6
Other alias	ARTD6
HGNC (Hugo)	TNKS2
LocusID (NCBI)	80351
Atlas_Id	43535
Location	10q23.32 [Link to chromosome band 10q23]
Location_base_pair	Starts at 91798394 and ends at 91865475 bp from pter ( according to hg38-Dec_2013)

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

ADCY2 (5p15.31) / TNKS2 (10q23.32)	HBG2 (11p15.4) / TNKS2 (10q23.32)	RPL31 (2q11.2) / TNKS2 (10q23.32)
TNKS2 (10q23.32) / BTBD2 (19p13.3)	TNKS2 (10q23.32) / C3orf70 (3q27.2)	TNKS2 (10q23.32) / CLCNKB (1p36.13)
TNKS2 (10q23.32) / HECTD2 (10q23.32)	TNKS2 (10q23.32) / RP11-451M19.3 ()	TNKS2 10q23.32 RP11-451M19.3

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias

t0410qq12q23ID1468

External links

	Nomenclature
HGNC (Hugo)	TNKS2 15677
	Cards
Entrez_Gene (NCBI)	TNKS2 80351 tankyrase 2
Aliases	ARTD6; PARP-5b; PARP-5c; PARP5B;
	PARP5C; TANK2; TNKL; pART6
GeneCards (Weizmann)	TNKS2
Ensembl hg19 (Hinxton)	ENSG00000107854 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000107854 [Gene_View] ENSG00000107854 [Sequence] chr10:91798394-91865475 [Contig_View] TNKS2 [Vega]
ICGC DataPortal	ENSG00000107854
TCGA cBioPortal	TNKS2
AceView (NCBI)	TNKS2
Genatlas (Paris)	TNKS2
WikiGenes	80351
SOURCE (Princeton)	TNKS2
Genetics Home Reference (NIH)	TNKS2
	Genomic and cartography
GoldenPath hg38 (UCSC)	TNKS2 - chr10:91798394-91865475 + 10q23.32 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	TNKS2 - 10q23.32 [Description] (hg19-Feb_2009)
GoldenPath	TNKS2 - 10q23.32 [CytoView hg19] TNKS2 - 10q23.32 [CytoView hg38]
ImmunoBase	ENSG00000107854
Mapping of homologs : NCBI	TNKS2 [Mapview hg19] TNKS2 [Mapview hg38]
OMIM	607128
	Gene and transcription
Genbank (Entrez)	AF264912 AF305081 AF309033 AF329696 AF342982
RefSeq transcript (Entrez)	NM_025235
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	TNKS2
Cluster EST : Unigene	Hs.329327 [ NCBI ]
CGAP (NCI)	Hs.329327
Alternative Splicing Gallery	ENSG00000107854
Gene Expression	TNKS2 [ NCBI-GEO ] TNKS2 [ EBI - ARRAY_EXPRESS ] TNKS2 [ SEEK ] TNKS2 [ MEM ]
Gene Expression Viewer (FireBrowse)	TNKS2 [ Firebrowse - Broad ]
SOURCE (Princeton)	Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
Genevestigator	Expression in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	80351
GTEX Portal (Tissue expression)	TNKS2
Human Protein Atlas	ENSG00000107854-TNKS2 [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	Q9H2K2 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	Q9H2K2 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	Q9H2K2
Splice isoforms : SwissVar	Q9H2K2
PhosPhoSitePlus	Q9H2K2
Domaine pattern : Prosite (Expaxy)	ANK_REP_REGION (PS50297) ANK_REPEAT (PS50088) PARP_CATALYTIC (PS51059) SAM_DOMAIN (PS50105)
Domains : Interpro (EBI)	Ankyrin_rpt Ankyrin_rpt-contain_dom Ankyrin_rpt-contain_sf Poly(ADP-ribose)pol_cat_dom SAM SAM/pointed_sf
Domain families : Pfam (Sanger)	Ank (PF00023) Ank_2 (PF12796) PARP (PF00644) SAM_2 (PF07647)
Domain families : Pfam (NCBI)	pfam00023 pfam12796 pfam00644 pfam07647
Domain families : Smart (EMBL)	ANK (SM00248) SAM (SM00454)
Conserved Domain (NCBI)	TNKS2
DMDM Disease mutations	80351
Blocks (Seattle)	TNKS2
PDB (RSDB)	2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT
PDB Europe	2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT
PDB (PDBSum)	2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT
PDB (IMB)	2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT
Structural Biology KnowledgeBase	2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT
SCOP (Structural Classification of Proteins)	2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT
CATH (Classification of proteins structures)	2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT
Superfamily	Q9H2K2
Human Protein Atlas [tissue]	ENSG00000107854-TNKS2 [tissue]
Peptide Atlas	Q9H2K2
HPRD	06182
IPI	IPI00019270
	Protein Interaction databases
DIP (DOE-UCLA)	Q9H2K2
IntAct (EBI)	Q9H2K2
FunCoup	ENSG00000107854
BioGRID	TNKS2
STRING (EMBL)	TNKS2
ZODIAC	TNKS2
	Ontologies - Pathways
QuickGO	Q9H2K2
Ontology : AmiGO	Golgi membrane protein polyubiquitination pericentriolar material nuclear chromosome, telomeric region NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity protein binding nucleus nucleus nuclear envelope cytoplasm cytoplasm cytosol protein ADP-ribosylation protein ADP-ribosylation Wnt signaling pathway enzyme binding positive regulation of telomere maintenance via telomerase multicellular organism growth regulation of multicellular organism growth metal ion binding perinuclear region of cytoplasm protein localization to chromosome, telomeric region protein localization to chromosome, telomeric region protein poly-ADP-ribosylation protein auto-ADP-ribosylation positive regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of telomere capping positive regulation of telomere capping positive regulation of telomere capping negative regulation of telomere maintenance via telomere lengthening protein ADP-ribosylase activity
Ontology : EGO-EBI	Golgi membrane protein polyubiquitination pericentriolar material nuclear chromosome, telomeric region NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity protein binding nucleus nucleus nuclear envelope cytoplasm cytoplasm cytosol protein ADP-ribosylation protein ADP-ribosylation Wnt signaling pathway enzyme binding positive regulation of telomere maintenance via telomerase multicellular organism growth regulation of multicellular organism growth metal ion binding perinuclear region of cytoplasm protein localization to chromosome, telomeric region protein localization to chromosome, telomeric region protein poly-ADP-ribosylation protein auto-ADP-ribosylation positive regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of telomere capping positive regulation of telomere capping positive regulation of telomere capping negative regulation of telomere maintenance via telomere lengthening protein ADP-ribosylase activity
NDEx Network	TNKS2
Atlas of Cancer Signalling Network	TNKS2
Wikipedia pathways	TNKS2
	Orthology - Evolution
OrthoDB	80351
GeneTree (enSembl)	ENSG00000107854
Phylogenetic Trees/Animal Genes : TreeFam	TNKS2
HOGENOM	Q9H2K2
Homologs : HomoloGene	TNKS2
Homology/Alignments : Family Browser (UCSC)	TNKS2
	Gene fusions - Rearrangements
Fusion Portal	TNKS2 10q23.32 RP11-451M19.3 BRCA
Fusion : Quiver	TNKS2
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	TNKS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	TNKS2
dbVar	TNKS2
ClinVar	TNKS2
1000_Genomes	TNKS2
Exome Variant Server	TNKS2
ExAC (Exome Aggregation Consortium)	ENSG00000107854
GNOMAD Browser	ENSG00000107854
Varsome Browser	TNKS2
Genetic variants : HAPMAP	80351
Genomic Variants (DGV)	TNKS2 [DGVbeta]
DECIPHER	TNKS2 [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	TNKS2
	Mutations
ICGC Data Portal	TNKS2
TCGA Data Portal	TNKS2
Broad Tumor Portal	TNKS2
OASIS Portal	TNKS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	TNKS2 [overview] [genome browser] [tissue] [distribution]
Somatic Mutations in Cancer : COSMIC3D	TNKS2
Mutations and Diseases : HGMD	TNKS2
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
BioMuta	search TNKS2
DgiDB (Drug Gene Interaction Database)	TNKS2
DoCM (Curated mutations)	TNKS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	TNKS2 (select a term)
intoGen	TNKS2
Cancer3D	TNKS2(select the gene name)
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	607128
Orphanet
DisGeNET	TNKS2
Medgen	TNKS2
Genetic Testing Registry	TNKS2
NextProt	Q9H2K2 [Medical]
TSGene	80351
GENETests	TNKS2
Target Validation	TNKS2
Huge Navigator	TNKS2 [HugePedia]
snp3D : Map Gene to Disease	80351
BioCentury BCIQ	TNKS2
ClinGen	TNKS2
	Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD	80351
Chemical/Pharm GKB Gene	PA38019
Clinical trial	TNKS2
	Miscellaneous
canSAR (ICR)	TNKS2 (select the gene name)
DataMed Index	TNKS2
	Probes
	Litterature
PubMed	60 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	TNKS2
EVEX	TNKS2
GoPubMed	TNKS2
iHOP	TNKS2

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Mon Aug 26 18:32:56 CEST 2019

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Atlas of Genetics and Cytogenetics in Oncology and Haematology

TNKS2 (tankyrase 2)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute