| ADCY2 (5p15.31) / TNKS2 (10q23.32) | HBG2 (11p15.4) / TNKS2 (10q23.32) | RPL31 (2q11.2) / TNKS2 (10q23.32) |
|
TNKS2 (10q23.32) / BTBD2 (19p13.3) | TNKS2 (10q23.32) / C3orf70 (3q27.2) | TNKS2 (10q23.32) / CLCNKB (1p36.13) |
|
TNKS2 (10q23.32) / HECTD2 (10q23.32) | TNKS2 (10q23.32) / RP11-451M19.3 () | TNKS2 10q23.32 RP11-451M19.3 |
|
| Nomenclature |
HGNC (Hugo) | TNKS2 15677 |
| Cards |
Entrez_Gene (NCBI) | TNKS2 80351 tankyrase 2 |
Aliases | ARTD6; PARP-5b; PARP-5c; PARP5B; |
| PARP5C; TANK2; TNKL; pART6 |
GeneCards (Weizmann) | TNKS2 |
Ensembl hg19 (Hinxton) | ENSG00000107854 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000107854 [Gene_View]  ENSG00000107854 [Sequence] chr10:91798394-91865475 [Contig_View] TNKS2 [Vega] |
ICGC DataPortal | ENSG00000107854 |
TCGA cBioPortal | TNKS2 |
AceView (NCBI) | TNKS2 |
Genatlas (Paris) | TNKS2 |
WikiGenes | 80351 |
SOURCE (Princeton) | TNKS2 |
Genetics Home Reference (NIH) | TNKS2 |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | TNKS2 - chr10:91798394-91865475 + 10q23.32 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | TNKS2 - 10q23.32 [Description] (hg19-Feb_2009) |
GoldenPath | TNKS2 - 10q23.32 [CytoView hg19] TNKS2 - 10q23.32 [CytoView hg38] |
ImmunoBase | ENSG00000107854 |
Mapping of homologs : NCBI | TNKS2 [Mapview hg19] TNKS2 [Mapview hg38] |
OMIM | 607128 |
| Gene and transcription |
Genbank (Entrez) | AF264912 AF305081 AF309033 AF329696 AF342982 |
RefSeq transcript (Entrez) | NM_025235 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | TNKS2 |
Cluster EST : Unigene | Hs.329327 [ NCBI ] |
CGAP (NCI) | Hs.329327 |
Alternative Splicing Gallery | ENSG00000107854 |
Gene Expression | TNKS2 [ NCBI-GEO ] TNKS2 [ EBI - ARRAY_EXPRESS ]
TNKS2 [ SEEK ] TNKS2 [ MEM ] |
Gene Expression Viewer (FireBrowse) | TNKS2 [ Firebrowse - Broad ] |
SOURCE (Princeton) | Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60] |
Genevestigator | Expression in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 80351 |
GTEX Portal (Tissue expression) | TNKS2 |
Human Protein Atlas | ENSG00000107854-TNKS2 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | Q9H2K2 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | Q9H2K2 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | Q9H2K2 |
Splice isoforms : SwissVar | Q9H2K2 |
PhosPhoSitePlus | Q9H2K2 |
Domaine pattern : Prosite (Expaxy) | ANK_REP_REGION (PS50297) ANK_REPEAT (PS50088) PARP_CATALYTIC (PS51059) SAM_DOMAIN (PS50105) |
Domains : Interpro (EBI) | Ankyrin_rpt Ankyrin_rpt-contain_dom Ankyrin_rpt-contain_sf Poly(ADP-ribose)pol_cat_dom SAM SAM/pointed_sf |
Domain families : Pfam (Sanger) | Ank (PF00023) Ank_2 (PF12796) PARP (PF00644) SAM_2 (PF07647) |
Domain families : Pfam (NCBI) | pfam00023 pfam12796 pfam00644 pfam07647 |
Domain families : Smart (EMBL) | ANK (SM00248) SAM (SM00454) |
Conserved Domain (NCBI) | TNKS2 |
DMDM Disease mutations | 80351 |
Blocks (Seattle) | TNKS2 |
PDB (RSDB) | 2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT |
PDB Europe | 2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT |
PDB (PDBSum) | 2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT |
PDB (IMB) | 2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT |
Structural Biology KnowledgeBase | 2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT |
SCOP (Structural Classification of Proteins) | 2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT |
CATH (Classification of proteins structures) | 2Y0I 3KR7 3KR8 3MHJ 3MHK 3P0N 3P0P 3P0Q 3TWQ 3TWR 3TWS 3TWT 3TWU 3TWV 3TWW 3TWX 3U9H 3U9Y 3UA9 3W51 4AVU 4AVW 4BFP 4BJ9 4BJB 4BJC 4BS4 4BU3 4BU5 4BU6 4BU7 4BU8 4BU9 4BUA 4BUD 4BUE 4BUF 4BUI 4BUS 4BUT 4BUU 4BUV 4BUW 4BUX 4BUY 4HKI 4HKK 4HKN 4HL5 4HLF 4HLG 4HLH 4HLK 4HLM 4HMH 4HYF 4IUE 4J1Z 4J21 4J22 4J3L 4J3M 4KZL 4KZQ 4KZU 4L09 4L0B 4L0I 4L0S 4L0T 4L0V 4L10 4L2F 4L2G 4L2K 4L31 4L32 4L33 4L34 4M7B 4PML 4PNL 4PNM 4PNN 4PNQ 4PNR 4PNS 4PNT 4TJU 4TJW 4TJY 4TK0 4TK5 4TKF 4TKG 4TKI 4UFU 4UFY 4UHG 4UI3 4UI4 4UI5 4UI6 4UI7 4UI8 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ 4UX4 4W5I 4Z68 5ADQ 5ADR 5ADS 5ADT 5AEH 5AKU 5AKW 5AL1 5AL2 5AL3 5AL4 5AL5 5BXO 5BXU 5C5P 5C5Q 5C5R 5DCZ 5FPF 5FPG 5JRT 5NOB 5NSP 5NUT |
Superfamily | Q9H2K2 |
Human Protein Atlas [tissue] | ENSG00000107854-TNKS2 [tissue] |
Peptide Atlas | Q9H2K2 |
HPRD | 06182 |
IPI | IPI00019270 |
| Protein Interaction databases |
DIP (DOE-UCLA) | Q9H2K2 |
IntAct (EBI) | Q9H2K2 |
FunCoup | ENSG00000107854 |
BioGRID | TNKS2 |
STRING (EMBL) | TNKS2 |
ZODIAC | TNKS2 |
| Ontologies - Pathways |
QuickGO | Q9H2K2 |
Ontology : AmiGO | Golgi membrane protein polyubiquitination pericentriolar material nuclear chromosome, telomeric region NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity protein binding nucleus nucleus nuclear envelope cytoplasm cytoplasm cytosol protein ADP-ribosylation protein ADP-ribosylation Wnt signaling pathway enzyme binding positive regulation of telomere maintenance via telomerase multicellular organism growth regulation of multicellular organism growth metal ion binding perinuclear region of cytoplasm protein localization to chromosome, telomeric region protein localization to chromosome, telomeric region protein poly-ADP-ribosylation protein auto-ADP-ribosylation positive regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of telomere capping positive regulation of telomere capping positive regulation of telomere capping negative regulation of telomere maintenance via telomere lengthening protein ADP-ribosylase activity |
Ontology : EGO-EBI | Golgi membrane protein polyubiquitination pericentriolar material nuclear chromosome, telomeric region NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity protein binding nucleus nucleus nuclear envelope cytoplasm cytoplasm cytosol protein ADP-ribosylation protein ADP-ribosylation Wnt signaling pathway enzyme binding positive regulation of telomere maintenance via telomerase multicellular organism growth regulation of multicellular organism growth metal ion binding perinuclear region of cytoplasm protein localization to chromosome, telomeric region protein localization to chromosome, telomeric region protein poly-ADP-ribosylation protein auto-ADP-ribosylation positive regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of canonical Wnt signaling pathway positive regulation of telomere capping positive regulation of telomere capping positive regulation of telomere capping negative regulation of telomere maintenance via telomere lengthening protein ADP-ribosylase activity |
NDEx Network | TNKS2 |
Atlas of Cancer Signalling Network | TNKS2 |
Wikipedia pathways | TNKS2 |
| Orthology - Evolution |
OrthoDB | 80351 |
GeneTree (enSembl) | ENSG00000107854 |
Phylogenetic Trees/Animal Genes : TreeFam | TNKS2 |
HOGENOM | Q9H2K2 |
Homologs : HomoloGene | TNKS2 |
Homology/Alignments : Family Browser (UCSC) | TNKS2 |
| Gene fusions - Rearrangements |
Fusion Portal | TNKS2 10q23.32 RP11-451M19.3 BRCA |
Fusion : Quiver | TNKS2 |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | TNKS2 [hg38] |
dbSNP Single Nucleotide Polymorphism (NCBI) | TNKS2 |
dbVar | TNKS2 |
ClinVar | TNKS2 |
1000_Genomes | TNKS2 |
Exome Variant Server | TNKS2 |
ExAC (Exome Aggregation Consortium) | ENSG00000107854 |
GNOMAD Browser | ENSG00000107854 |
Varsome Browser | TNKS2 |
Genetic variants : HAPMAP | 80351 |
Genomic Variants (DGV) | TNKS2 [DGVbeta] |
DECIPHER | TNKS2 [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | TNKS2 |
| Mutations |
ICGC Data Portal | TNKS2 |
TCGA Data Portal | TNKS2 |
Broad Tumor Portal | TNKS2 |
OASIS Portal | TNKS2 [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | TNKS2 [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | TNKS2 |
Mutations and Diseases : HGMD | TNKS2 |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search TNKS2 |
DgiDB (Drug Gene Interaction Database) | TNKS2 |
DoCM (Curated mutations) | TNKS2 (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | TNKS2 (select a term) |
intoGen | TNKS2 |
Cancer3D | TNKS2(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
---|
OMIM | 607128 |
Orphanet | |
DisGeNET | TNKS2 |
Medgen | TNKS2 |
Genetic Testing Registry | TNKS2
|
NextProt | Q9H2K2 [Medical] |
TSGene | 80351 |
GENETests | TNKS2 |
Target Validation | TNKS2 |
Huge Navigator |
TNKS2 [HugePedia] |
snp3D : Map Gene to Disease | 80351 |
BioCentury BCIQ | TNKS2 |
ClinGen | TNKS2 |
| Clinical trials, drugs, therapy |
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Chemical/Protein Interactions : CTD | 80351 |
Chemical/Pharm GKB Gene | PA38019 |
Clinical trial | TNKS2 |
| Miscellaneous |
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canSAR (ICR) | TNKS2 (select the gene name) |
DataMed Index | TNKS2 |
| Probes |
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| Litterature |
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PubMed | 60 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
CoreMine | TNKS2 |
EVEX | TNKS2 |
GoPubMed | TNKS2 |
iHOP | TNKS2 |