Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TNKS2 (tankyrase 2)

Identity

Alias_namestankyrase
Alias_symbol (synonym)TNKL
TANK2
PARP-5b
PARP-5c
PARP5B
PARP5C
pART6
Other aliasARTD6
HGNC (Hugo) TNKS2
LocusID (NCBI) 80351
Atlas_Id 43535
Location 10q23.32  [Link to chromosome band 10q23]
Location_base_pair Starts at 91798394 and ends at 91865475 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		ADCY2 (5p15.31) / TNKS2 (10q23.32)HBG2 (11p15.4) / TNKS2 (10q23.32)RPL31 (2q11.2) / TNKS2 (10q23.32)
TNKS2 (10q23.32) / BTBD2 (19p13.3)TNKS2 (10q23.32) / C3orf70 (3q27.2)TNKS2 (10q23.32) / CLCNKB (1p36.13)
TNKS2 (10q23.32) / HECTD2 (10q23.32)TNKS2 (10q23.32) / RP11-451M19.3 ()TNKS2 10q23.32 RP11-451M19.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(4;10)(q12;q23) PDGFRA/TNKS2

External links

Nomenclature
HGNC (Hugo)TNKS2   15677
Cards
Entrez_Gene (NCBI)TNKS2  80351  tankyrase 2
AliasesARTD6; PARP-5b; PARP-5c; PARP5B; 
PARP5C; TANK2; TNKL; pART6
GeneCards (Weizmann)TNKS2
Ensembl hg19 (Hinxton)ENSG00000107854 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107854 [Gene_View]  chr10:91798394-91865475 [Contig_View]  TNKS2 [Vega]
ICGC DataPortalENSG00000107854
TCGA cBioPortalTNKS2
AceView (NCBI)TNKS2
Genatlas (Paris)TNKS2
WikiGenes80351
SOURCE (Princeton)TNKS2
Genetics Home Reference (NIH)TNKS2
Genomic and cartography
GoldenPath hg38 (UCSC)TNKS2  -     chr10:91798394-91865475 +  10q23.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNKS2  -     10q23.32   [Description]    (hg19-Feb_2009)
EnsemblTNKS2 - 10q23.32 [CytoView hg19]  TNKS2 - 10q23.32 [CytoView hg38]
Mapping of homologs : NCBITNKS2 [Mapview hg19]  TNKS2 [Mapview hg38]
OMIM607128   
Gene and transcription
Genbank (Entrez)AF264912 AF305081 AF309033 AF329696 AF342982
RefSeq transcript (Entrez)NM_025235
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNKS2
Cluster EST : UnigeneHs.329327 [ NCBI ]
CGAP (NCI)Hs.329327
Alternative Splicing GalleryENSG00000107854
Gene ExpressionTNKS2 [ NCBI-GEO ]   TNKS2 [ EBI - ARRAY_EXPRESS ]   TNKS2 [ SEEK ]   TNKS2 [ MEM ]
Gene Expression Viewer (FireBrowse)TNKS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80351
GTEX Portal (Tissue expression)TNKS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H2K2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H2K2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H2K2
Splice isoforms : SwissVarQ9H2K2
Catalytic activity : Enzyme2.4.2.30 [ Enzyme-Expasy ]   2.4.2.302.4.2.30 [ IntEnz-EBI ]   2.4.2.30 [ BRENDA ]   2.4.2.30 [ KEGG ]   
PhosPhoSitePlusQ9H2K2
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    PARP_CATALYTIC (PS51059)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Poly(ADP-ribose)pol_cat_dom    SAM    SAM/pointed   
Domain families : Pfam (Sanger)Ank (PF00023)    Ank_2 (PF12796)    PARP (PF00644)    SAM_2 (PF07647)   
Domain families : Pfam (NCBI)pfam00023    pfam12796    pfam00644    pfam07647   
Domain families : Smart (EMBL)ANK (SM00248)  SAM (SM00454)  
Conserved Domain (NCBI)TNKS2
DMDM Disease mutations80351
Blocks (Seattle)TNKS2
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyQ9H2K2
Human Protein AtlasENSG00000107854
Peptide AtlasQ9H2K2
HPRD06182
IPIIPI00019270   
Protein Interaction databases
DIP (DOE-UCLA)Q9H2K2
IntAct (EBI)Q9H2K2
FunCoupENSG00000107854
BioGRIDTNKS2
STRING (EMBL)TNKS2
ZODIACTNKS2
Ontologies - Pathways
QuickGOQ9H2K2
Ontology : AmiGOGolgi membrane  protein polyubiquitination  pericentriolar material  nuclear chromosome, telomeric region  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  nuclear envelope  cytoplasm  cytosol  protein ADP-ribosylation  Wnt signaling pathway  protein deubiquitination  enzyme binding  positive regulation of telomere maintenance via telomerase  multicellular organism growth  regulation of multicellular organism growth  metal ion binding  perinuclear region of cytoplasm  protein localization to chromosome, telomeric region  protein auto-ADP-ribosylation  positive regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of telomere capping  positive regulation of telomere capping  negative regulation of telomere maintenance via telomere lengthening  
Ontology : EGO-EBIGolgi membrane  protein polyubiquitination  pericentriolar material  nuclear chromosome, telomeric region  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  nuclear envelope  cytoplasm  cytosol  protein ADP-ribosylation  Wnt signaling pathway  protein deubiquitination  enzyme binding  positive regulation of telomere maintenance via telomerase  multicellular organism growth  regulation of multicellular organism growth  metal ion binding  perinuclear region of cytoplasm  protein localization to chromosome, telomeric region  protein auto-ADP-ribosylation  positive regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  positive regulation of telomere capping  positive regulation of telomere capping  negative regulation of telomere maintenance via telomere lengthening  
NDEx NetworkTNKS2
Atlas of Cancer Signalling NetworkTNKS2
Wikipedia pathwaysTNKS2
Orthology - Evolution
OrthoDB80351
GeneTree (enSembl)ENSG00000107854
Phylogenetic Trees/Animal Genes : TreeFamTNKS2
HOVERGENQ9H2K2
HOGENOMQ9H2K2
Homologs : HomoloGeneTNKS2
Homology/Alignments : Family Browser (UCSC)TNKS2
Gene fusions - Rearrangements
Fusion: TCGATNKS2 10q23.32 RP11-451M19.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNKS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNKS2
dbVarTNKS2
ClinVarTNKS2
1000_GenomesTNKS2 
Exome Variant ServerTNKS2
ExAC (Exome Aggregation Consortium)TNKS2 (select the gene name)
Genetic variants : HAPMAP80351
Genomic Variants (DGV)TNKS2 [DGVbeta]
DECIPHERTNKS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNKS2 
Mutations
ICGC Data PortalTNKS2 
TCGA Data PortalTNKS2 
Broad Tumor PortalTNKS2
OASIS PortalTNKS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNKS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNKS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNKS2
DgiDB (Drug Gene Interaction Database)TNKS2
DoCM (Curated mutations)TNKS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNKS2 (select a term)
intoGenTNKS2
Cancer3DTNKS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607128   
Orphanet
MedgenTNKS2
Genetic Testing Registry TNKS2
NextProtQ9H2K2 [Medical]
TSGene80351
GENETestsTNKS2
Target ValidationTNKS2
Huge Navigator TNKS2 [HugePedia]
snp3D : Map Gene to Disease80351
BioCentury BCIQTNKS2
ClinGenTNKS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80351
Chemical/Pharm GKB GenePA38019
Clinical trialTNKS2
Miscellaneous
canSAR (ICR)TNKS2 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNKS2
EVEXTNKS2
GoPubMedTNKS2
iHOPTNKS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 13:00:06 CEST 2017
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