Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TNNC1 (troponin C1, slow skeletal and cardiac type)

Identity

Alias (NCBI)CMD1Z
CMH13
TN-C
TNC
TNNC
HGNC (Hugo) TNNC1
HGNC Previous nameTNNC
HGNC Previous nametroponin C type 1 (slow)
LocusID (NCBI) 7134
Atlas_Id 55584
Location 3p21.1  [Link to chromosome band 3p21]
Location_base_pair Starts at 52451100 and ends at 52454041 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EIF4B (12q13.13) / TNNC1 (3p21.1)KITLG (12q21.32) / TNNC1 (3p21.1)SOX4 (6p22.3) / TNNC1 (3p21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TNNC1   11943
LRG (Locus Reference Genomic)LRG_378
Cards
Entrez_Gene (NCBI)TNNC1    troponin C1, slow skeletal and cardiac type
AliasesCMD1Z; CMH13; TN-C; TNC; 
TNNC
GeneCards (Weizmann)TNNC1
Ensembl hg19 (Hinxton)ENSG00000114854 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114854 [Gene_View]  ENSG00000114854 [Sequence]  chr3:52451100-52454041 [Contig_View]  TNNC1 [Vega]
ICGC DataPortalENSG00000114854
TCGA cBioPortalTNNC1
AceView (NCBI)TNNC1
Genatlas (Paris)TNNC1
SOURCE (Princeton)TNNC1
Genetics Home Reference (NIH)TNNC1
Genomic and cartography
GoldenPath hg38 (UCSC)TNNC1  -     chr3:52451100-52454041 -  3p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNNC1  -     3p21.1   [Description]    (hg19-Feb_2009)
GoldenPathTNNC1 - 3p21.1 [CytoView hg19]  TNNC1 - 3p21.1 [CytoView hg38]
ImmunoBaseENSG00000114854
Genome Data Viewer NCBITNNC1 [Mapview hg19]  
OMIM191040   611879   613243   
Gene and transcription
Genbank (Entrez)AF020769 AJ574625 AK313743 BC030244 CR541865
RefSeq transcript (Entrez)NM_003280
Consensus coding sequences : CCDS (NCBI)TNNC1
Gene ExpressionTNNC1 [ NCBI-GEO ]   TNNC1 [ EBI - ARRAY_EXPRESS ]   TNNC1 [ SEEK ]   TNNC1 [ MEM ]
Gene Expression Viewer (FireBrowse)TNNC1 [ Firebrowse - Broad ]
GenevisibleExpression of TNNC1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7134
GTEX Portal (Tissue expression)TNNC1
Human Protein AtlasENSG00000114854-TNNC1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63316   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63316  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63316
PhosPhoSitePlusP63316
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom   
Domain families : Pfam (Sanger)EF-hand_7 (PF13499)    EF-hand_8 (PF13833)   
Domain families : Pfam (NCBI)pfam13499    pfam13833   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)TNNC1
PDB (RSDB)1AP4    1IH0    1J1D    1J1E    1LXF    1MXL    1OZS    1SPY    1WRK    1WRL    2JT0    2JT3    2JT8    2JTZ    2JXL    2KDH    2KFX    2KGB    2KRD    2L1R    2L98    2MKP    2MLE    2MLF    2MZP    2N79    2N7L    3RV5    3SD6    3SWB    4GJE    4GJF    4GJG    4Y99    5VLN    5W88    5WCL    6KN7    6KN8    6MV3    7JGI   
PDB Europe1AP4    1IH0    1J1D    1J1E    1LXF    1MXL    1OZS    1SPY    1WRK    1WRL    2JT0    2JT3    2JT8    2JTZ    2JXL    2KDH    2KFX    2KGB    2KRD    2L1R    2L98    2MKP    2MLE    2MLF    2MZP    2N79    2N7L    3RV5    3SD6    3SWB    4GJE    4GJF    4GJG    4Y99    5VLN    5W88    5WCL    6KN7    6KN8    6MV3    7JGI   
PDB (PDBSum)1AP4    1IH0    1J1D    1J1E    1LXF    1MXL    1OZS    1SPY    1WRK    1WRL    2JT0    2JT3    2JT8    2JTZ    2JXL    2KDH    2KFX    2KGB    2KRD    2L1R    2L98    2MKP    2MLE    2MLF    2MZP    2N79    2N7L    3RV5    3SD6    3SWB    4GJE    4GJF    4GJG    4Y99    5VLN    5W88    5WCL    6KN7    6KN8    6MV3    7JGI   
PDB (IMB)1AP4    1IH0    1J1D    1J1E    1LXF    1MXL    1OZS    1SPY    1WRK    1WRL    2JT0    2JT3    2JT8    2JTZ    2JXL    2KDH    2KFX    2KGB    2KRD    2L1R    2L98    2MKP    2MLE    2MLF    2MZP    2N79    2N7L    3RV5    3SD6    3SWB    4GJE    4GJF    4GJG    4Y99    5VLN    5W88    5WCL    6KN7    6KN8    6MV3    7JGI   
Structural Biology KnowledgeBase1AP4    1IH0    1J1D    1J1E    1LXF    1MXL    1OZS    1SPY    1WRK    1WRL    2JT0    2JT3    2JT8    2JTZ    2JXL    2KDH    2KFX    2KGB    2KRD    2L1R    2L98    2MKP    2MLE    2MLF    2MZP    2N79    2N7L    3RV5    3SD6    3SWB    4GJE    4GJF    4GJG    4Y99    5VLN    5W88    5WCL    6KN7    6KN8    6MV3    7JGI   
SCOP (Structural Classification of Proteins)1AP4    1IH0    1J1D    1J1E    1LXF    1MXL    1OZS    1SPY    1WRK    1WRL    2JT0    2JT3    2JT8    2JTZ    2JXL    2KDH    2KFX    2KGB    2KRD    2L1R    2L98    2MKP    2MLE    2MLF    2MZP    2N79    2N7L    3RV5    3SD6    3SWB    4GJE    4GJF    4GJG    4Y99    5VLN    5W88    5WCL    6KN7    6KN8    6MV3    7JGI   
CATH (Classification of proteins structures)1AP4    1IH0    1J1D    1J1E    1LXF    1MXL    1OZS    1SPY    1WRK    1WRL    2JT0    2JT3    2JT8    2JTZ    2JXL    2KDH    2KFX    2KGB    2KRD    2L1R    2L98    2MKP    2MLE    2MLF    2MZP    2N79    2N7L    3RV5    3SD6    3SWB    4GJE    4GJF    4GJG    4Y99    5VLN    5W88    5WCL    6KN7    6KN8    6MV3    7JGI   
SuperfamilyP63316
AlphaFold pdb e-kbP63316   
Human Protein Atlas [tissue]ENSG00000114854-TNNC1 [tissue]
HPRD08930
Protein Interaction databases
DIP (DOE-UCLA)P63316
IntAct (EBI)P63316
BioGRIDTNNC1
STRING (EMBL)TNNC1
ZODIACTNNC1
Ontologies - Pathways
QuickGOP63316
Ontology : AmiGOdiaphragm contraction  skeletal muscle contraction  calcium ion binding  calcium ion binding  protein binding  cytosol  troponin complex  troponin complex  regulation of muscle contraction  regulation of muscle contraction  regulation of muscle contraction  response to metal ion  transition between fast and slow fiber  muscle filament sliding  troponin I binding  troponin I binding  troponin T binding  regulation of muscle filament sliding speed  protein homodimerization activity  regulation of ATPase activity  calcium-dependent protein binding  calcium-dependent protein binding  actin filament binding  actin filament binding  ventricular cardiac muscle tissue morphogenesis  cardiac muscle contraction  cardiac muscle contraction  cardiac Troponin complex  
Ontology : EGO-EBIdiaphragm contraction  skeletal muscle contraction  calcium ion binding  calcium ion binding  protein binding  cytosol  troponin complex  troponin complex  regulation of muscle contraction  regulation of muscle contraction  regulation of muscle contraction  response to metal ion  transition between fast and slow fiber  muscle filament sliding  troponin I binding  troponin I binding  troponin T binding  regulation of muscle filament sliding speed  protein homodimerization activity  regulation of ATPase activity  calcium-dependent protein binding  calcium-dependent protein binding  actin filament binding  actin filament binding  ventricular cardiac muscle tissue morphogenesis  cardiac muscle contraction  cardiac muscle contraction  cardiac Troponin complex  
Pathways : KEGGCalcium signaling pathway    Cardiac muscle contraction    Adrenergic signaling in cardiomyocytes    Hypertrophic cardiomyopathy (HCM)    Dilated cardiomyopathy   
NDEx NetworkTNNC1
Atlas of Cancer Signalling NetworkTNNC1
Wikipedia pathwaysTNNC1
Orthology - Evolution
OrthoDB7134
GeneTree (enSembl)ENSG00000114854
Phylogenetic Trees/Animal Genes : TreeFamTNNC1
Homologs : HomoloGeneTNNC1
Homology/Alignments : Family Browser (UCSC)TNNC1
Gene fusions - Rearrangements
Fusion : QuiverTNNC1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNNC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNNC1
dbVarTNNC1
ClinVarTNNC1
MonarchTNNC1
1000_GenomesTNNC1 
Exome Variant ServerTNNC1
GNOMAD BrowserENSG00000114854
Varsome BrowserTNNC1
ACMGTNNC1 variants
VarityP63316
Genomic Variants (DGV)TNNC1 [DGVbeta]
DECIPHERTNNC1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNNC1 
Mutations
ICGC Data PortalTNNC1 
TCGA Data PortalTNNC1 
Broad Tumor PortalTNNC1
OASIS PortalTNNC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNNC1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNNC1
Mutations and Diseases : HGMDTNNC1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTNNC1
DgiDB (Drug Gene Interaction Database)TNNC1
DoCM (Curated mutations)TNNC1
CIViC (Clinical Interpretations of Variants in Cancer)TNNC1
Cancer3DTNNC1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191040    611879    613243   
Orphanet635   
DisGeNETTNNC1
MedgenTNNC1
Genetic Testing Registry TNNC1
NextProtP63316 [Medical]
GENETestsTNNC1
Target ValidationTNNC1
Huge Navigator TNNC1 [HugePedia]
ClinGenTNNC1
Clinical trials, drugs, therapy
MyCancerGenomeTNNC1
Protein Interactions : CTDTNNC1
Pharm GKB GenePA36632
PharosP63316
Clinical trialTNNC1
Miscellaneous
canSAR (ICR)TNNC1
HarmonizomeTNNC1
DataMed IndexTNNC1
Probes
Litterature
PubMed108 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNNC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:35:48 CEST 2021

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