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TNNI1 (troponin I1, slow skeletal type)

Identity

Alias_namestroponin I type 1 (skeletal, slow)
Other aliasSSTNI
TNN1
HGNC (Hugo) TNNI1
LocusID (NCBI) 7135
Atlas_Id 75038
Location 1q32.1  [Link to chromosome band 1q32]
Location_base_pair Starts at 201403767 and ends at 201421746 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LEFTY1 (1q42.12) / TNNI1 (1q32.1)TNNI1 (1q32.1) / TNNI1 (1q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNNI1   11945
Cards
Entrez_Gene (NCBI)TNNI1  7135  troponin I1, slow skeletal type
AliasesSSTNI; TNN1
GeneCards (Weizmann)TNNI1
Ensembl hg19 (Hinxton)ENSG00000159173 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159173 [Gene_View]  chr1:201403767-201421746 [Contig_View]  TNNI1 [Vega]
ICGC DataPortalENSG00000159173
TCGA cBioPortalTNNI1
AceView (NCBI)TNNI1
Genatlas (Paris)TNNI1
WikiGenes7135
SOURCE (Princeton)TNNI1
Genetics Home Reference (NIH)TNNI1
Genomic and cartography
GoldenPath hg38 (UCSC)TNNI1  -     chr1:201403767-201421746 -  1q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNNI1  -     1q32.1   [Description]    (hg19-Feb_2009)
EnsemblTNNI1 - 1q32.1 [CytoView hg19]  TNNI1 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBITNNI1 [Mapview hg19]  TNNI1 [Mapview hg38]
OMIM191042   
Gene and transcription
Genbank (Entrez)AJ315823 AK123965 AK223588 AK311896 AL831820
RefSeq transcript (Entrez)NM_003281
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNNI1
Cluster EST : UnigeneHs.320890 [ NCBI ]
CGAP (NCI)Hs.320890
Alternative Splicing GalleryENSG00000159173
Gene ExpressionTNNI1 [ NCBI-GEO ]   TNNI1 [ EBI - ARRAY_EXPRESS ]   TNNI1 [ SEEK ]   TNNI1 [ MEM ]
Gene Expression Viewer (FireBrowse)TNNI1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7135
GTEX Portal (Tissue expression)TNNI1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19237   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP19237  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19237
Splice isoforms : SwissVarP19237
PhosPhoSitePlusP19237
Domains : Interpro (EBI)Troponin   
Domain families : Pfam (Sanger)Troponin (PF00992)   
Domain families : Pfam (NCBI)pfam00992   
Conserved Domain (NCBI)TNNI1
DMDM Disease mutations7135
Blocks (Seattle)TNNI1
SuperfamilyP19237
Human Protein AtlasENSG00000159173
Peptide AtlasP19237
HPRD01842
IPIIPI00453474   IPI00473081   IPI01026357   IPI01025106   IPI01024772   
Protein Interaction databases
DIP (DOE-UCLA)P19237
IntAct (EBI)P19237
FunCoupENSG00000159173
BioGRIDTNNI1
STRING (EMBL)TNNI1
ZODIACTNNI1
Ontologies - Pathways
QuickGOP19237
Ontology : AmiGOskeletal muscle contraction  actin binding  protein binding  cytosol  troponin complex  regulation of striated muscle contraction  transition between fast and slow fiber  muscle filament sliding  metal ion binding  ventricular cardiac muscle tissue morphogenesis  cardiac muscle contraction  
Ontology : EGO-EBIskeletal muscle contraction  actin binding  protein binding  cytosol  troponin complex  regulation of striated muscle contraction  transition between fast and slow fiber  muscle filament sliding  metal ion binding  ventricular cardiac muscle tissue morphogenesis  cardiac muscle contraction  
Pathways : BIOCARTAActions of Nitric Oxide in the Heart [Genes]   
NDEx NetworkTNNI1
Atlas of Cancer Signalling NetworkTNNI1
Wikipedia pathwaysTNNI1
Orthology - Evolution
OrthoDB7135
GeneTree (enSembl)ENSG00000159173
Phylogenetic Trees/Animal Genes : TreeFamTNNI1
HOVERGENP19237
HOGENOMP19237
Homologs : HomoloGeneTNNI1
Homology/Alignments : Family Browser (UCSC)TNNI1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNNI1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNNI1
dbVarTNNI1
ClinVarTNNI1
1000_GenomesTNNI1 
Exome Variant ServerTNNI1
ExAC (Exome Aggregation Consortium)TNNI1 (select the gene name)
Genetic variants : HAPMAP7135
Genomic Variants (DGV)TNNI1 [DGVbeta]
DECIPHERTNNI1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNNI1 
Mutations
ICGC Data PortalTNNI1 
TCGA Data PortalTNNI1 
Broad Tumor PortalTNNI1
OASIS PortalTNNI1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNNI1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNNI1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNNI1
DgiDB (Drug Gene Interaction Database)TNNI1
DoCM (Curated mutations)TNNI1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNNI1 (select a term)
intoGenTNNI1
Cancer3DTNNI1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191042   
Orphanet
MedgenTNNI1
Genetic Testing Registry TNNI1
NextProtP19237 [Medical]
TSGene7135
GENETestsTNNI1
Target ValidationTNNI1
Huge Navigator TNNI1 [HugePedia]
snp3D : Map Gene to Disease7135
BioCentury BCIQTNNI1
ClinGenTNNI1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7135
Chemical/Pharm GKB GenePA36634
Clinical trialTNNI1
Miscellaneous
canSAR (ICR)TNNI1 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNNI1
EVEXTNNI1
GoPubMedTNNI1
iHOPTNNI1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:42:13 CEST 2017

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