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TNNI2 (troponin I2, fast skeletal type)

Identity

Other namesAMCD2B
DA2B
FSSV
fsTnI
HGNC (Hugo) TNNI2
LocusID (NCBI) 7136
Atlas_Id 47647
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 1860719 and ends at 1862910 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)		SYT8 (11p15.5) / TNNI2 (11p15.5)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TNNI2   11946
Cards
Entrez_Gene (NCBI)TNNI2  7136  troponin I2, fast skeletal type
AliasesAMCD2B; DA2B; FSSV; fsTnI
GeneCards (Weizmann)TNNI2
Ensembl hg19 (Hinxton)ENSG00000130598 [Gene_View]  chr11:1860719-1862910 [Contig_View]  TNNI2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000130598 [Gene_View]  chr11:1860719-1862910 [Contig_View]  TNNI2 [Vega]
ICGC DataPortalENSG00000130598
TCGA cBioPortalTNNI2
AceView (NCBI)TNNI2
Genatlas (Paris)TNNI2
WikiGenes7136
SOURCE (Princeton)TNNI2
Genomic and cartography
GoldenPath hg19 (UCSC)TNNI2  -     chr11:1860719-1862910 +  11p15.5   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TNNI2  -     11p15.5   [Description]    (hg38-Dec_2013)
EnsemblTNNI2 - 11p15.5 [CytoView hg19]  TNNI2 - 11p15.5 [CytoView hg38]
Mapping of homologs : NCBITNNI2 [Mapview hg19]  TNNI2 [Mapview hg38]
OMIM191043   601680   
Gene and transcription
Genbank (Entrez)AW984315 BC032148 BI833431 BP233165 BQ926240
RefSeq transcript (Entrez)NM_001145829 NM_001145841 NM_003282
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_011621 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)TNNI2
Cluster EST : UnigeneHs.523403 [ NCBI ]
CGAP (NCI)Hs.523403
Alternative Splicing GalleryENSG00000130598
Gene ExpressionTNNI2 [ NCBI-GEO ]   TNNI2 [ EBI - ARRAY_EXPRESS ]   TNNI2 [ SEEK ]   TNNI2 [ MEM ]
Gene Expression Viewer (FireBrowse)TNNI2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7136
GTEX Portal (Tissue expression)TNNI2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48788 (Uniprot)
NextProtP48788  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48788
Splice isoforms : SwissVarP48788 (Swissvar)
PhosPhoSitePlusP48788
Domains : Interpro (EBI)Troponin   
Domain families : Pfam (Sanger)Troponin (PF00992)   
Domain families : Pfam (NCBI)pfam00992   
DMDM Disease mutations7136
Blocks (Seattle)TNNI2
PDB (SRS)2MKP   
PDB (PDBSum)2MKP   
PDB (IMB)2MKP   
PDB (RSDB)2MKP   
Structural Biology KnowledgeBase2MKP   
SCOP (Structural Classification of Proteins)2MKP   
CATH (Classification of proteins structures)2MKP   
SuperfamilyP48788
Human Protein AtlasENSG00000130598
Peptide AtlasP48788
HPRD01843
IPIIPI00216236   IPI00657955   
Protein Interaction databases
DIP (DOE-UCLA)P48788
IntAct (EBI)P48788
FunCoupENSG00000130598
BioGRIDTNNI2
STRING (EMBL)TNNI2
ZODIACTNNI2
Ontologies - Pathways
QuickGOP48788
Ontology : AmiGOskeletal muscle contraction  actin binding  protein binding  nucleus  cytosol  troponin complex  regulation of muscle contraction  muscle filament sliding  troponin T binding  positive regulation of transcription, DNA-templated  cardiac muscle contraction  
Ontology : EGO-EBIskeletal muscle contraction  actin binding  protein binding  nucleus  cytosol  troponin complex  regulation of muscle contraction  muscle filament sliding  troponin T binding  positive regulation of transcription, DNA-templated  cardiac muscle contraction  
NDEx NetworkTNNI2
Atlas of Cancer Signalling NetworkTNNI2
Wikipedia pathwaysTNNI2
Orthology - Evolution
OrthoDB7136
GeneTree (enSembl)ENSG00000130598
Phylogenetic Trees/Animal Genes : TreeFamTNNI2
Homologs : HomoloGeneTNNI2
Homology/Alignments : Family Browser (UCSC)TNNI2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTNNI2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNNI2
dbVarTNNI2
ClinVarTNNI2
1000_GenomesTNNI2 
Exome Variant ServerTNNI2
ExAC (Exome Aggregation Consortium)TNNI2 (select the gene name)
Genetic variants : HAPMAP7136
Genomic Variants (DGV)TNNI2 [DGVbeta]
Mutations
ICGC Data PortalTNNI2 
TCGA Data PortalTNNI2 
Broad Tumor PortalTNNI2
OASIS PortalTNNI2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNNI2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNNI2
DgiDB (Drug Gene Interaction Database)TNNI2
DoCM (Curated mutations)TNNI2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNNI2 (select a term)
intoGenTNNI2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:1860719-1862910  ENSG00000130598
CONAN: Copy Number AnalysisTNNI2 
Mutations and Diseases : HGMDTNNI2
OMIM191043    601680   
MedgenTNNI2
Genetic Testing Registry TNNI2
NextProtP48788 [Medical]
TSGene7136
GENETestsTNNI2
Huge Navigator TNNI2 [HugePedia]
snp3D : Map Gene to Disease7136
BioCentury BCIQTNNI2
ClinGenTNNI2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7136
Chemical/Pharm GKB GenePA36635
Clinical trialTNNI2
Miscellaneous
canSAR (ICR)TNNI2 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNNI2
EVEXTNNI2
GoPubMedTNNI2
iHOPTNNI2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 19:17:20 CEST 2016
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