Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TNNI3K (TNNI3 interacting kinase)

Identity

Alias_symbol (synonym)CARK
Other aliasCCDD
HGNC (Hugo) TNNI3K
LocusID (NCBI) 51086
Atlas_Id 52080
Location 1p31.1  [Link to chromosome band 1p31]
Location_base_pair Starts at 74701071 and ends at 75010116 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FPGT (1p31.1) / TNNI3K (1p31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNNI3K   19661
LRG (Locus Reference Genomic)LRG_678
Cards
Entrez_Gene (NCBI)TNNI3K  51086  TNNI3 interacting kinase
AliasesCARK; CCDD
GeneCards (Weizmann)TNNI3K
Ensembl hg19 (Hinxton)ENSG00000116783 [Gene_View]  chr1:74701071-75010116 [Contig_View]  TNNI3K [Vega]
Ensembl hg38 (Hinxton)ENSG00000116783 [Gene_View]  chr1:74701071-75010116 [Contig_View]  TNNI3K [Vega]
ICGC DataPortalENSG00000116783
TCGA cBioPortalTNNI3K
AceView (NCBI)TNNI3K
Genatlas (Paris)TNNI3K
WikiGenes51086
SOURCE (Princeton)TNNI3K
Genetics Home Reference (NIH)TNNI3K
Genomic and cartography
GoldenPath hg19 (UCSC)TNNI3K  -     chr1:74701071-75010116 +  1p31.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TNNI3K  -     1p31.1   [Description]    (hg38-Dec_2013)
EnsemblTNNI3K - 1p31.1 [CytoView hg19]  TNNI3K - 1p31.1 [CytoView hg38]
Mapping of homologs : NCBITNNI3K [Mapview hg19]  TNNI3K [Mapview hg38]
OMIM613932   616117   
Gene and transcription
Genbank (Entrez)AA758546 AF116826 AK307984 AY303691 BC113539
RefSeq transcript (Entrez)NM_015978
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_032939 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)TNNI3K
Cluster EST : UnigeneHs.480085 [ NCBI ]
CGAP (NCI)Hs.480085
Alternative Splicing GalleryENSG00000116783
Gene ExpressionTNNI3K [ NCBI-GEO ]   TNNI3K [ EBI - ARRAY_EXPRESS ]   TNNI3K [ SEEK ]   TNNI3K [ MEM ]
Gene Expression Viewer (FireBrowse)TNNI3K [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51086
GTEX Portal (Tissue expression)TNNI3K
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ59H18   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ59H18  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ59H18
Splice isoforms : SwissVarQ59H18
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ59H18
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    Ank_3 (PF13606)    Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam12796    pfam13606    pfam07714   
Domain families : Smart (EMBL)ANK (SM00248)  
Conserved Domain (NCBI)TNNI3K
DMDM Disease mutations51086
Blocks (Seattle)TNNI3K
PDB (SRS)4YFF    4YFI   
PDB (PDBSum)4YFF    4YFI   
PDB (IMB)4YFF    4YFI   
PDB (RSDB)4YFF    4YFI   
Structural Biology KnowledgeBase4YFF    4YFI   
SCOP (Structural Classification of Proteins)4YFF    4YFI   
CATH (Classification of proteins structures)4YFF    4YFI   
SuperfamilyQ59H18
Human Protein AtlasENSG00000116783
Peptide AtlasQ59H18
HPRD18208
IPIIPI00646389   IPI00984924   IPI00984408   IPI00983087   IPI00910762   
Protein Interaction databases
DIP (DOE-UCLA)Q59H18
IntAct (EBI)Q59H18
FunCoupENSG00000116783
BioGRIDTNNI3K
STRING (EMBL)TNNI3K
ZODIACTNNI3K
Ontologies - Pathways
QuickGOQ59H18
Ontology : AmiGOregulation of heart rate  regulation of heart rate  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  protein phosphorylation  protein C-terminus binding  troponin I binding  metal ion binding  regulation of cardiac muscle contraction  bundle of His cell to Purkinje myocyte communication  regulation of cardiac conduction  
Ontology : EGO-EBIregulation of heart rate  regulation of heart rate  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  protein phosphorylation  protein C-terminus binding  troponin I binding  metal ion binding  regulation of cardiac muscle contraction  bundle of His cell to Purkinje myocyte communication  regulation of cardiac conduction  
NDEx NetworkTNNI3K
Atlas of Cancer Signalling NetworkTNNI3K
Wikipedia pathwaysTNNI3K
Orthology - Evolution
OrthoDB51086
GeneTree (enSembl)ENSG00000116783
Phylogenetic Trees/Animal Genes : TreeFamTNNI3K
HOVERGENQ59H18
HOGENOMQ59H18
Homologs : HomoloGeneTNNI3K
Homology/Alignments : Family Browser (UCSC)TNNI3K
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNNI3K [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNNI3K
dbVarTNNI3K
ClinVarTNNI3K
1000_GenomesTNNI3K 
Exome Variant ServerTNNI3K
ExAC (Exome Aggregation Consortium)TNNI3K (select the gene name)
Genetic variants : HAPMAP51086
Genomic Variants (DGV)TNNI3K [DGVbeta]
DECIPHER (Syndromes)1:74701071-75010116  ENSG00000116783
CONAN: Copy Number AnalysisTNNI3K 
Mutations
ICGC Data PortalTNNI3K 
TCGA Data PortalTNNI3K 
Broad Tumor PortalTNNI3K
OASIS PortalTNNI3K [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNNI3K  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNNI3K
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNNI3K
DgiDB (Drug Gene Interaction Database)TNNI3K
DoCM (Curated mutations)TNNI3K (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNNI3K (select a term)
intoGenTNNI3K
Cancer3DTNNI3K(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613932    616117   
Orphanet23334   
MedgenTNNI3K
Genetic Testing Registry TNNI3K
NextProtQ59H18 [Medical]
TSGene51086
GENETestsTNNI3K
Huge Navigator TNNI3K [HugePedia]
snp3D : Map Gene to Disease51086
BioCentury BCIQTNNI3K
ClinGenTNNI3K
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51086
Chemical/Pharm GKB GenePA134976654
Clinical trialTNNI3K
Miscellaneous
canSAR (ICR)TNNI3K (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNNI3K
EVEXTNNI3K
GoPubMedTNNI3K
iHOPTNNI3K
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:31:47 CET 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.