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TNNT1 (troponin T1, slow skeletal type)

Identity

Alias (NCBI)ANM
NEM5
STNT
TNT
TNTS
HGNC (Hugo) TNNT1
HGNC Alias symbANM
STNT
TNT
TNTS
FLJ98147
MGC104241
NEM5
HGNC Alias nameslow skeletal muscle troponin T
 troponin T1, skeletal, slow
 nemaline myopathy type 5
HGNC Previous nametroponin T type 1 (skeletal, slow)
LocusID (NCBI) 7138
Atlas_Id 57640
Location 19q13.42  [Link to chromosome band 19q13]
Location_base_pair Starts at 55132698 and ends at 55149206 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TNNT1 (19q13.42) / TNNT1 (19q13.42)TNNT1 (19q13.42) / TSPAN9 (12p13.33)TSPAN9 (12p13.33) / TNNT1 (19q13.42)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TNNT1   11948
Cards
Entrez_Gene (NCBI)TNNT1    troponin T1, slow skeletal type
AliasesANM; NEM5; STNT; TNT; 
TNTS
GeneCards (Weizmann)TNNT1
Ensembl hg19 (Hinxton)ENSG00000105048 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105048 [Gene_View]  ENSG00000105048 [Sequence]  chr19:55132698-55149206 [Contig_View]  TNNT1 [Vega]
ICGC DataPortalENSG00000105048
TCGA cBioPortalTNNT1
AceView (NCBI)TNNT1
Genatlas (Paris)TNNT1
SOURCE (Princeton)TNNT1
Genetics Home Reference (NIH)TNNT1
Genomic and cartography
GoldenPath hg38 (UCSC)TNNT1  -     chr19:55132698-55149206 -  19q13.42   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNNT1  -     19q13.42   [Description]    (hg19-Feb_2009)
GoldenPathTNNT1 - 19q13.42 [CytoView hg19]  TNNT1 - 19q13.42 [CytoView hg38]
ImmunoBaseENSG00000105048
Genome Data Viewer NCBITNNT1 [Mapview hg19]  
OMIM191041   605355   
Gene and transcription
Genbank (Entrez)AK291352 AK308199 AY762903 AY762904 BC007074
RefSeq transcript (Entrez)NM_001126132 NM_001126133 NM_001291774 NM_003283
Consensus coding sequences : CCDS (NCBI)TNNT1
Gene ExpressionTNNT1 [ NCBI-GEO ]   TNNT1 [ EBI - ARRAY_EXPRESS ]   TNNT1 [ SEEK ]   TNNT1 [ MEM ]
Gene Expression Viewer (FireBrowse)TNNT1 [ Firebrowse - Broad ]
GenevisibleExpression of TNNT1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7138
GTEX Portal (Tissue expression)TNNT1
Human Protein AtlasENSG00000105048-TNNT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13805   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13805  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13805
PhosPhoSitePlusP13805
Domains : Interpro (EBI)TNNT    Troponin    Troponin_sf   
Domain families : Pfam (Sanger)Troponin (PF00992)   
Domain families : Pfam (NCBI)pfam00992   
Conserved Domain (NCBI)TNNT1
SuperfamilyP13805
AlphaFold pdb e-kbP13805   
Human Protein Atlas [tissue]ENSG00000105048-TNNT1 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)P13805
IntAct (EBI)P13805
BioGRIDTNNT1
STRING (EMBL)TNNT1
ZODIACTNNT1
Ontologies - Pathways
QuickGOP13805
Ontology : AmiGOskeletal muscle contraction  protein binding  tropomyosin binding  tropomyosin binding  cytosol  troponin complex  troponin complex  troponin complex  muscle contraction  transition between fast and slow fiber  muscle filament sliding  troponin T binding  slow-twitch skeletal muscle fiber contraction  sarcomere organization  negative regulation of muscle contraction  
Ontology : EGO-EBIskeletal muscle contraction  protein binding  tropomyosin binding  tropomyosin binding  cytosol  troponin complex  troponin complex  troponin complex  muscle contraction  transition between fast and slow fiber  muscle filament sliding  troponin T binding  slow-twitch skeletal muscle fiber contraction  sarcomere organization  negative regulation of muscle contraction  
NDEx NetworkTNNT1
Atlas of Cancer Signalling NetworkTNNT1
Wikipedia pathwaysTNNT1
Orthology - Evolution
OrthoDB7138
GeneTree (enSembl)ENSG00000105048
Phylogenetic Trees/Animal Genes : TreeFamTNNT1
Homologs : HomoloGeneTNNT1
Homology/Alignments : Family Browser (UCSC)TNNT1
Gene fusions - Rearrangements
Fusion : QuiverTNNT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNNT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNNT1
dbVarTNNT1
ClinVarTNNT1
MonarchTNNT1
1000_GenomesTNNT1 
Exome Variant ServerTNNT1
GNOMAD BrowserENSG00000105048
Varsome BrowserTNNT1
ACMGTNNT1 variants
VarityP13805
Genomic Variants (DGV)TNNT1 [DGVbeta]
DECIPHERTNNT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNNT1 
Mutations
ICGC Data PortalTNNT1 
TCGA Data PortalTNNT1 
Broad Tumor PortalTNNT1
OASIS PortalTNNT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNNT1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNNT1
Mutations and Diseases : HGMDTNNT1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTNNT1
DgiDB (Drug Gene Interaction Database)TNNT1
DoCM (Curated mutations)TNNT1
CIViC (Clinical Interpretations of Variants in Cancer)TNNT1
Cancer3DTNNT1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191041    605355   
Orphanet
DisGeNETTNNT1
MedgenTNNT1
Genetic Testing Registry TNNT1
NextProtP13805 [Medical]
GENETestsTNNT1
Target ValidationTNNT1
Huge Navigator TNNT1 [HugePedia]
ClinGenTNNT1
Clinical trials, drugs, therapy
MyCancerGenomeTNNT1
Protein Interactions : CTDTNNT1
Pharm GKB GenePA36637
PharosP13805
Clinical trialTNNT1
Miscellaneous
canSAR (ICR)TNNT1
HarmonizomeTNNT1
DataMed IndexTNNT1
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNNT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:35:49 CEST 2021

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