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TNNT1 (troponin T1, slow skeletal type)

Identity

Alias_namestroponin T type 1 (skeletal, slow)
Alias_symbol (synonym)ANM
STNT
TNT
TNTS
FLJ98147
MGC104241
NEM5
Other alias
HGNC (Hugo) TNNT1
LocusID (NCBI) 7138
Atlas_Id 75039
Location 19q13.42  [Link to chromosome band 19q13]
Location_base_pair Starts at 55132698 and ends at 55149354 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TNNT1 (19q13.42) / TNNT1 (19q13.42)TNNT1 (19q13.42) / TSPAN9 (12p13.33)TSPAN9 (12p13.33) / TNNT1 (19q13.42)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNNT1   11948
LRG (Locus Reference Genomic)LRG_679
Cards
Entrez_Gene (NCBI)TNNT1  7138  troponin T1, slow skeletal type
AliasesANM; NEM5; STNT; TNT; 
TNTS
GeneCards (Weizmann)TNNT1
Ensembl hg19 (Hinxton)ENSG00000105048 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105048 [Gene_View]  chr19:55132698-55149354 [Contig_View]  TNNT1 [Vega]
ICGC DataPortalENSG00000105048
TCGA cBioPortalTNNT1
AceView (NCBI)TNNT1
Genatlas (Paris)TNNT1
WikiGenes7138
SOURCE (Princeton)TNNT1
Genetics Home Reference (NIH)TNNT1
Genomic and cartography
GoldenPath hg38 (UCSC)TNNT1  -     chr19:55132698-55149354 -  19q13.42   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNNT1  -     19q13.42   [Description]    (hg19-Feb_2009)
EnsemblTNNT1 - 19q13.42 [CytoView hg19]  TNNT1 - 19q13.42 [CytoView hg38]
Mapping of homologs : NCBITNNT1 [Mapview hg19]  TNNT1 [Mapview hg38]
OMIM191041   605355   
Gene and transcription
Genbank (Entrez)AK291352 AK308199 AY762903 AY762904 BC007074
RefSeq transcript (Entrez)NM_001126132 NM_001126133 NM_001291774 NM_003283
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNNT1
Cluster EST : UnigeneHs.631558 [ NCBI ]
CGAP (NCI)Hs.631558
Alternative Splicing GalleryENSG00000105048
Gene ExpressionTNNT1 [ NCBI-GEO ]   TNNT1 [ EBI - ARRAY_EXPRESS ]   TNNT1 [ SEEK ]   TNNT1 [ MEM ]
Gene Expression Viewer (FireBrowse)TNNT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7138
GTEX Portal (Tissue expression)TNNT1
Human Protein AtlasENSG00000105048-TNNT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13805   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13805  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13805
Splice isoforms : SwissVarP13805
PhosPhoSitePlusP13805
Domains : Interpro (EBI)TNNT    Troponin   
Domain families : Pfam (Sanger)Troponin (PF00992)   
Domain families : Pfam (NCBI)pfam00992   
Conserved Domain (NCBI)TNNT1
DMDM Disease mutations7138
Blocks (Seattle)TNNT1
SuperfamilyP13805
Human Protein Atlas [tissue]ENSG00000105048-TNNT1 [tissue]
Peptide AtlasP13805
HPRD01841
IPIIPI00395442   IPI00220467   IPI00643758   IPI00807661   IPI01013399   
Protein Interaction databases
DIP (DOE-UCLA)P13805
IntAct (EBI)P13805
FunCoupENSG00000105048
BioGRIDTNNT1
STRING (EMBL)TNNT1
ZODIACTNNT1
Ontologies - Pathways
QuickGOP13805
Ontology : AmiGOskeletal muscle contraction  protein binding  tropomyosin binding  cytosol  troponin complex  troponin complex  transition between fast and slow fiber  muscle filament sliding  troponin T binding  slow-twitch skeletal muscle fiber contraction  negative regulation of muscle contraction  
Ontology : EGO-EBIskeletal muscle contraction  protein binding  tropomyosin binding  cytosol  troponin complex  troponin complex  transition between fast and slow fiber  muscle filament sliding  troponin T binding  slow-twitch skeletal muscle fiber contraction  negative regulation of muscle contraction  
NDEx NetworkTNNT1
Atlas of Cancer Signalling NetworkTNNT1
Wikipedia pathwaysTNNT1
Orthology - Evolution
OrthoDB7138
GeneTree (enSembl)ENSG00000105048
Phylogenetic Trees/Animal Genes : TreeFamTNNT1
HOVERGENP13805
HOGENOMP13805
Homologs : HomoloGeneTNNT1
Homology/Alignments : Family Browser (UCSC)TNNT1
Gene fusions - Rearrangements
Tumor Fusion PortalTNNT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNNT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNNT1
dbVarTNNT1
ClinVarTNNT1
1000_GenomesTNNT1 
Exome Variant ServerTNNT1
ExAC (Exome Aggregation Consortium)ENSG00000105048
GNOMAD BrowserENSG00000105048
Genetic variants : HAPMAP7138
Genomic Variants (DGV)TNNT1 [DGVbeta]
DECIPHERTNNT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNNT1 
Mutations
ICGC Data PortalTNNT1 
TCGA Data PortalTNNT1 
Broad Tumor PortalTNNT1
OASIS PortalTNNT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNNT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNNT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNNT1
DgiDB (Drug Gene Interaction Database)TNNT1
DoCM (Curated mutations)TNNT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNNT1 (select a term)
intoGenTNNT1
Cancer3DTNNT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191041    605355   
Orphanet13919   
DisGeNETTNNT1
MedgenTNNT1
Genetic Testing Registry TNNT1
NextProtP13805 [Medical]
TSGene7138
GENETestsTNNT1
Target ValidationTNNT1
Huge Navigator TNNT1 [HugePedia]
snp3D : Map Gene to Disease7138
BioCentury BCIQTNNT1
ClinGenTNNT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7138
Chemical/Pharm GKB GenePA36637
Clinical trialTNNT1
Miscellaneous
canSAR (ICR)TNNT1 (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNNT1
EVEXTNNT1
GoPubMedTNNT1
iHOPTNNT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:40:13 CET 2017

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