Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TNNT2 (troponin T type 2 (cardiac))

Identity

Other namesCMD1D
CMH2
CMPD2
LVNC6
RCM3
TnTC
cTnT
HGNC (Hugo) TNNT2
LocusID (NCBI) 7139
Location 1q32.1
Location_base_pair Starts at 201328136 and ends at 201346828 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TNNT2   11949
Cards
Entrez_Gene (NCBI)TNNT2  7139  troponin T type 2 (cardiac)
GeneCards (Weizmann)TNNT2
Ensembl (Hinxton)ENSG00000118194 [Gene_View]  chr1:201328136-201346828 [Contig_View]  TNNT2 [Vega]
ICGC DataPortalENSG00000118194
cBioPortalTNNT2
AceView (NCBI)TNNT2
Genatlas (Paris)TNNT2
WikiGenes7139
SOURCE (Princeton)NM_000364 NM_001001430 NM_001001431 NM_001001432 NM_001276345 NM_001276346 NM_001276347
Genomic and cartography
GoldenPath (UCSC)TNNT2  -  1q32.1   chr1:201328136-201346828 -  1q32.1   [Description]    (hg19-Feb_2009)
EnsemblTNNT2 - 1q32.1 [CytoView]
Mapping of homologs : NCBITNNT2 [Mapview]
OMIM115195   191045   601494   612422   
Gene and transcription
Genbank (Entrez)AA865519 AJ709280 AK055533 AK125236 AK290621
RefSeq transcript (Entrez)NM_000364 NM_001001430 NM_001001431 NM_001001432 NM_001276345 NM_001276346 NM_001276347
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_007556 NT_004487 NW_001838533 NW_004929293
Consensus coding sequences : CCDS (NCBI)TNNT2
Cluster EST : UnigeneHs.533613 [ NCBI ]
CGAP (NCI)Hs.533613
Alternative Splicing : Fast-db (Paris)GSHG0002839
Alternative Splicing GalleryENSG00000118194
Gene ExpressionTNNT2 [ NCBI-GEO ]     TNNT2 [ SEEK ]   TNNT2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP45379 (Uniprot)
NextProtP45379  [Medical]
With graphics : InterProP45379
Splice isoforms : SwissVarP45379 (Swissvar)
Domains : Interpro (EBI)TNNT [organisation]   Troponin [organisation]  
Related proteins : CluSTrP45379
Domain families : Pfam (Sanger)Troponin (PF00992)   
Domain families : Pfam (NCBI)pfam00992   
DMDM Disease mutations7139
Blocks (Seattle)P45379
PDB (SRS)1J1D    1J1E   
PDB (PDBSum)1J1D    1J1E   
PDB (IMB)1J1D    1J1E   
PDB (RSDB)1J1D    1J1E   
Human Protein AtlasENSG00000118194 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP45379
HPRD01844
IPIIPI00021292   IPI00478301   IPI00218306   IPI00218307   IPI00218308   IPI00218309   IPI00471956   IPI00654551   IPI00747844   IPI00218313   IPI01025127   IPI01011661   IPI01011154   IPI01015597   IPI00145107   IPI00641922   IPI01011621   
Protein Interaction databases
DIP (DOE-UCLA)P45379
IntAct (EBI)P45379
FunCoupENSG00000118194
BioGRIDTNNT2
InParanoidP45379
Interologous Interaction database P45379
IntegromeDBTNNT2
STRING (EMBL)TNNT2
Ontologies - Pathways
Ontology : AmiGOactin binding  structural constituent of cytoskeleton  tropomyosin binding  cytosol  troponin complex  striated muscle thin filament  ATP catabolic process  regulation of muscle contraction  regulation of heart contraction  ATPase activity  sarcomere  muscle filament sliding  muscle filament sliding  troponin C binding  troponin I binding  negative regulation of ATPase activity  positive regulation of ATPase activity  sarcomere organization  response to calcium ion  response to calcium ion  atrial cardiac muscle tissue morphogenesis  ventricular cardiac muscle tissue morphogenesis  
Ontology : EGO-EBIactin binding  structural constituent of cytoskeleton  tropomyosin binding  cytosol  troponin complex  striated muscle thin filament  ATP catabolic process  regulation of muscle contraction  regulation of heart contraction  ATPase activity  sarcomere  muscle filament sliding  muscle filament sliding  troponin C binding  troponin I binding  negative regulation of ATPase activity  positive regulation of ATPase activity  sarcomere organization  response to calcium ion  response to calcium ion  atrial cardiac muscle tissue morphogenesis  ventricular cardiac muscle tissue morphogenesis  
Pathways : KEGGCardiac muscle contraction    Adrenergic signaling in cardiomyocytes    Hypertrophic cardiomyopathy (HCM)    Dilated cardiomyopathy   
Protein Interaction DatabaseTNNT2
Wikipedia pathwaysTNNT2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TNNT2
snp3D : Map Gene to Disease7139
SNP (GeneSNP Utah)TNNT2
SNP : HGBaseTNNT2
Genetic variants : HAPMAPTNNT2
Exome VariantTNNT2
1000_GenomesTNNT2 
ICGC programENSG00000118194 
Somatic Mutations in Cancer : COSMICTNNT2 
CONAN: Copy Number AnalysisTNNT2 
Mutations and Diseases : HGMDTNNT2
Genomic VariantsTNNT2  TNNT2 [DGVbeta]
dbVarTNNT2
ClinVarTNNT2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM115195    191045    601494    612422   
MedgenTNNT2
GENETestsTNNT2
Disease Genetic AssociationTNNT2
Huge Navigator TNNT2 [HugePedia]  TNNT2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneTNNT2
Homology/Alignments : Family Browser (UCSC)TNNT2
Phylogenetic Trees/Animal Genes : TreeFamTNNT2
Chemical/Protein Interactions : CTD7139
Chemical/Pharm GKB GenePA36638
Clinical trialTNNT2
Cancer Resource (Charite)ENSG00000118194
Other databases
Probes
Litterature
PubMed238 Pubmed reference(s) in Entrez
CoreMineTNNT2
iHOPTNNT2
OncoSearchTNNT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 14:19:18 CEST 2014
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