TNNT2 (troponin T type 2 (cardiac))

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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

TNNT2 (troponin T type 2 (cardiac))

Identity

Other names	CMD1D
	CMH2
	CMPD2
	LVNC6
	RCM3
	TnTC
	cTnT
HGNC (Hugo)	TNNT2
LocusID (NCBI)	7139
Location	1q32.1
Location_base_pair	Starts at 201328136 and ends at 201346828 bp from pter ( according to hg19-Feb_2009)
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	TNNT2 11949
	Cards
Entrez_Gene (NCBI)	TNNT2 7139 troponin T type 2 (cardiac)
GeneCards (Weizmann)	TNNT2
Ensembl hg19 (Hinxton)	ENSG00000118194 [Gene_View] chr1:201328136-201346828 [Contig_View] TNNT2 [Vega]
Ensembl hg38 (Hinxton)	ENSG00000118194 [Gene_View] chr1:201328136-201346828 [Contig_View] TNNT2 [Vega]
ICGC DataPortal	ENSG00000118194
cBioPortal	TNNT2
AceView (NCBI)	TNNT2
Genatlas (Paris)	TNNT2
WikiGenes	7139
SOURCE (Princeton)	TNNT2
	Genomic and cartography
GoldenPath hg19 (UCSC)	TNNT2 - chr1:201328136-201346828 - 1q32.1 [Description] (hg19-Feb_2009)
GoldenPath hg38 (UCSC)	TNNT2 - 1q32.1 [Description] (hg38-Dec_2013)
Ensembl	TNNT2 - 1q32.1 [CytoView hg19] TNNT2 - 1q32.1 [CytoView hg38]
Mapping of homologs : NCBI	TNNT2 [Mapview hg19] TNNT2 [Mapview hg38]
OMIM	115195 191045 601494 612422
	Gene and transcription
Genbank (Entrez)	AA865519 AJ709280 AK055533 AK125236 AK290621
RefSeq transcript (Entrez)	NM_000364 NM_001001430 NM_001001431 NM_001001432 NM_001276345 NM_001276346 NM_001276347
RefSeq genomic (Entrez)	AC_000133 NC_000001 NC_018912 NG_007556 NT_004487 NW_001838533 NW_004929293
Consensus coding sequences : CCDS (NCBI)	TNNT2
Cluster EST : Unigene	Hs.533613 [ NCBI ]
CGAP (NCI)	Hs.533613
Alternative Splicing : Fast-db (Paris)	GSHG0002839
Alternative Splicing Gallery	ENSG00000118194
Gene Expression	TNNT2 [ NCBI-GEO ] TNNT2 [ SEEK ] TNNT2 [ MEM ]
SOURCE (Princeton)	Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P45379 (Uniprot)
NextProt	P45379 [Medical]
With graphics : InterPro	P45379
Splice isoforms : SwissVar	P45379 (Swissvar)
Domains : Interpro (EBI)	TNNT Troponin
Related proteins : CluSTr	P45379
Domain families : Pfam (Sanger)	Troponin (PF00992)
Domain families : Pfam (NCBI)	pfam00992
DMDM Disease mutations	7139
Blocks (Seattle)	P45379
PDB (SRS)	1J1D 1J1E
PDB (PDBSum)	1J1D 1J1E
PDB (IMB)	1J1D 1J1E
PDB (RSDB)	1J1D 1J1E
Human Protein Atlas	ENSG00000118194
Peptide Atlas	P45379
HPRD	01844
IPI	IPI00021292 IPI00478301 IPI00218306 IPI00218307 IPI00218308 IPI00218309 IPI00471956 IPI00654551 IPI00747844 IPI00218313 IPI01025127 IPI01011661 IPI01011154 IPI01015597 IPI00145107 IPI00641922 IPI01011621
	Protein Interaction databases
DIP (DOE-UCLA)	P45379
IntAct (EBI)	P45379
FunCoup	ENSG00000118194
BioGRID	TNNT2
IntegromeDB	TNNT2
STRING (EMBL)	TNNT2
	Ontologies - Pathways
QuickGO	P45379
Ontology : AmiGO	actin binding structural constituent of cytoskeleton tropomyosin binding cytosol troponin complex striated muscle thin filament ATP catabolic process regulation of muscle contraction regulation of heart contraction ATPase activity sarcomere muscle filament sliding muscle filament sliding troponin C binding troponin I binding negative regulation of ATPase activity positive regulation of ATPase activity sarcomere organization response to calcium ion response to calcium ion atrial cardiac muscle tissue morphogenesis ventricular cardiac muscle tissue morphogenesis
Ontology : EGO-EBI	actin binding structural constituent of cytoskeleton tropomyosin binding cytosol troponin complex striated muscle thin filament ATP catabolic process regulation of muscle contraction regulation of heart contraction ATPase activity sarcomere muscle filament sliding muscle filament sliding troponin C binding troponin I binding negative regulation of ATPase activity positive regulation of ATPase activity sarcomere organization response to calcium ion response to calcium ion atrial cardiac muscle tissue morphogenesis ventricular cardiac muscle tissue morphogenesis
Pathways : KEGG	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy
Protein Interaction Database	TNNT2
DoCM (Curated mutations)	TNNT2
Wikipedia pathways	TNNT2
	Gene fusion - rearrangements
	Polymorphisms : SNP, variants
NCBI Variation Viewer	TNNT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	TNNT2
dbVar	TNNT2
ClinVar	TNNT2
1000_Genomes	TNNT2
Exome Variant Server	TNNT2
SNP (GeneSNP Utah)	TNNT2
SNP : HGBase	TNNT2
Genetic variants : HAPMAP	TNNT2
Genomic Variants (DGV)	TNNT2 [DGVbeta]
	Mutations
ICGC Data Portal	ENSG00000118194
Somatic Mutations in Cancer : COSMIC	TNNT2
CONAN: Copy Number Analysis	TNNT2
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)	Zhejiang University Center for Genetic and Genomic Medicine (ZJU-CGGM)
LOVD (Leiden Open Variation Database)	MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
Impact of mutations	[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor]
	Diseases
DECIPHER (Syndromes)	1:201328136-201346828
Mutations and Diseases : HGMD	TNNT2
OMIM	115195 191045 601494 612422
Medgen	TNNT2
NextProt	P45379 [Medical]
GENETests	TNNT2
Disease Genetic Association	TNNT2
Huge Navigator	TNNT2 [HugePedia] TNNT2 [HugeCancerGEM]
snp3D : Map Gene to Disease	7139
DGIdb (Drug Gene Interaction db)	TNNT2
	General knowledge
Homologs : HomoloGene	TNNT2
Homology/Alignments : Family Browser (UCSC)	TNNT2
Phylogenetic Trees/Animal Genes : TreeFam	TNNT2
Chemical/Protein Interactions : CTD	7139
Chemical/Pharm GKB Gene	PA36638
Clinical trial	TNNT2
Cancer Resource (Charite)	ENSG00000118194
	Other databases
	Probes
	Litterature
PubMed	238 Pubmed reference(s) in Entrez
CoreMine	TNNT2
GoPubMed	TNNT2
iHOP	TNNT2

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

Updated	12-2014	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Feb 14 19:07:25 CET 2015

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jlhuret@AtlasGeneticsOncology.org.