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TNNT3 (troponin T3, fast skeletal type)

Identity

Alias_namesskeletal
fast
Alias_symbol (synonym)AMCD2B
DA2B
FSSV
DKFZp779M2348
Other aliasTNTF
HGNC (Hugo) TNNT3
LocusID (NCBI) 7140
Atlas_Id 42646
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 1919569 and ends at 1938706 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
LSP1 (11p15.5) / TNNT3 (11p15.5)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;3)(q25;q27) MBNL1/BCL6


External links

Nomenclature
HGNC (Hugo)TNNT3   11950
LRG (Locus Reference Genomic)LRG_850
Cards
Entrez_Gene (NCBI)TNNT3  7140  troponin T3, fast skeletal type
AliasesTNTF
GeneCards (Weizmann)TNNT3
Ensembl hg19 (Hinxton)ENSG00000130595 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130595 [Gene_View]  chr11:1919569-1938706 [Contig_View]  TNNT3 [Vega]
ICGC DataPortalENSG00000130595
TCGA cBioPortalTNNT3
AceView (NCBI)TNNT3
Genatlas (Paris)TNNT3
WikiGenes7140
SOURCE (Princeton)TNNT3
Genetics Home Reference (NIH)TNNT3
Genomic and cartography
GoldenPath hg38 (UCSC)TNNT3  -     chr11:1919569-1938706 +  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNNT3  -     11p15.5   [Description]    (hg19-Feb_2009)
EnsemblTNNT3 - 11p15.5 [CytoView hg19]  TNNT3 - 11p15.5 [CytoView hg38]
Mapping of homologs : NCBITNNT3 [Mapview hg19]  TNNT3 [Mapview hg38]
OMIM600692   601680   
Gene and transcription
Genbank (Entrez)AI161366 AJ571879 AK056968 BC022275 BC050446
RefSeq transcript (Entrez)NM_001042780 NM_001042781 NM_001042782 NM_001297646 NM_006757
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNNT3
Cluster EST : UnigeneHs.73454 [ NCBI ]
CGAP (NCI)Hs.73454
Alternative Splicing GalleryENSG00000130595
Gene ExpressionTNNT3 [ NCBI-GEO ]   TNNT3 [ EBI - ARRAY_EXPRESS ]   TNNT3 [ SEEK ]   TNNT3 [ MEM ]
Gene Expression Viewer (FireBrowse)TNNT3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7140
GTEX Portal (Tissue expression)TNNT3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP45378   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP45378  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP45378
Splice isoforms : SwissVarP45378
PhosPhoSitePlusP45378
Domains : Interpro (EBI)TNNT    Tnnt3    Troponin   
Domain families : Pfam (Sanger)Troponin (PF00992)   
Domain families : Pfam (NCBI)pfam00992   
Conserved Domain (NCBI)TNNT3
DMDM Disease mutations7140
Blocks (Seattle)TNNT3
SuperfamilyP45378
Human Protein AtlasENSG00000130595
Peptide AtlasP45378
HPRD02822
IPIIPI00477427   IPI00641544   IPI00936731   IPI00337455   IPI00937352   IPI00852975   IPI00394740   IPI00872734   IPI00441080   IPI00943329   IPI00658138   IPI00657711   IPI00853392   IPI00853443   
Protein Interaction databases
DIP (DOE-UCLA)P45378
IntAct (EBI)P45378
FunCoupENSG00000130595
BioGRIDTNNT3
STRING (EMBL)TNNT3
ZODIACTNNT3
Ontologies - Pathways
QuickGOP45378
Ontology : AmiGOskeletal muscle contraction  actin binding  tropomyosin binding  tropomyosin binding  cytosol  troponin complex  regulation of striated muscle contraction  muscle filament sliding  troponin C binding  calcium-dependent ATPase activity  troponin I binding  regulation of ATPase activity  calcium-dependent protein binding  
Ontology : EGO-EBIskeletal muscle contraction  actin binding  tropomyosin binding  tropomyosin binding  cytosol  troponin complex  regulation of striated muscle contraction  muscle filament sliding  troponin C binding  calcium-dependent ATPase activity  troponin I binding  regulation of ATPase activity  calcium-dependent protein binding  
NDEx NetworkTNNT3
Atlas of Cancer Signalling NetworkTNNT3
Wikipedia pathwaysTNNT3
Orthology - Evolution
OrthoDB7140
GeneTree (enSembl)ENSG00000130595
Phylogenetic Trees/Animal Genes : TreeFamTNNT3
HOVERGENP45378
HOGENOMP45378
Homologs : HomoloGeneTNNT3
Homology/Alignments : Family Browser (UCSC)TNNT3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNNT3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNNT3
dbVarTNNT3
ClinVarTNNT3
1000_GenomesTNNT3 
Exome Variant ServerTNNT3
ExAC (Exome Aggregation Consortium)TNNT3 (select the gene name)
Genetic variants : HAPMAP7140
Genomic Variants (DGV)TNNT3 [DGVbeta]
DECIPHERTNNT3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNNT3 
Mutations
ICGC Data PortalTNNT3 
TCGA Data PortalTNNT3 
Broad Tumor PortalTNNT3
OASIS PortalTNNT3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNNT3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNNT3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNNT3
DgiDB (Drug Gene Interaction Database)TNNT3
DoCM (Curated mutations)TNNT3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNNT3 (select a term)
intoGenTNNT3
Cancer3DTNNT3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600692    601680   
Orphanet421    422   
MedgenTNNT3
Genetic Testing Registry TNNT3
NextProtP45378 [Medical]
TSGene7140
GENETestsTNNT3
Huge Navigator TNNT3 [HugePedia]
snp3D : Map Gene to Disease7140
BioCentury BCIQTNNT3
ClinGenTNNT3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7140
Chemical/Pharm GKB GenePA36639
Clinical trialTNNT3
Miscellaneous
canSAR (ICR)TNNT3 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNNT3
EVEXTNNT3
GoPubMedTNNT3
iHOPTNNT3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:41:42 CEST 2017

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