Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TNPO1 (transportin 1)

Identity

Alias (NCBI)IPO2
KPNB2
MIP
MIP1
TRN
HGNC (Hugo) TNPO1
HGNC Alias symbMIP
TRN
IPO2
MIP1
HGNC Alias nameimportin 2
HGNC Previous nameKPNB2
HGNC Previous namekaryopherin (importin) beta 2
LocusID (NCBI) 3842
Atlas_Id 42648
Location 5q13.2  [Link to chromosome band 5q13]
Location_base_pair Starts at 72848139 and ends at 72916740 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TNPO1 (5q13.2) / GTF2H1 (11p15.1)TNPO1 (5q13.2) / IKBKB (8p11.21)TNPO1 (5q13.2) / MCCC2 (5q13.2)
TNPO1 (5q13.2) / ZNF106 (15q15.1)ZNF106 (15q15.1) / TNPO1 (5q13.2)TNPO1 5q13.2 / GTF2H1 11p15.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(5;5)(q13;q14) TNPO1/MEF2C
t(5;8)(q13;p11) TNPO1/IKBKB
t(5;11)(q13;p15) TNPO1/GTF2H1

External links

Nomenclature
HGNC (Hugo)TNPO1   6401
Cards
Entrez_Gene (NCBI)TNPO1    transportin 1
AliasesIPO2; KPNB2; MIP; MIP1; 
TRN
GeneCards (Weizmann)TNPO1
Ensembl hg19 (Hinxton)ENSG00000083312 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000083312 [Gene_View]  ENSG00000083312 [Sequence]  chr5:72848139-72916740 [Contig_View]  TNPO1 [Vega]
ICGC DataPortalENSG00000083312
TCGA cBioPortalTNPO1
AceView (NCBI)TNPO1
Genatlas (Paris)TNPO1
SOURCE (Princeton)TNPO1
Genetics Home Reference (NIH)TNPO1
Genomic and cartography
GoldenPath hg38 (UCSC)TNPO1  -     chr5:72848139-72916740 +  5q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNPO1  -     5q13.2   [Description]    (hg19-Feb_2009)
GoldenPathTNPO1 - 5q13.2 [CytoView hg19]  TNPO1 - 5q13.2 [CytoView hg38]
ImmunoBaseENSG00000083312
genome Data Viewer NCBITNPO1 [Mapview hg19]  
OMIM602901   
Gene and transcription
Genbank (Entrez)AK055669 AK124768 AK299671 AK301021 AK308177
RefSeq transcript (Entrez)NM_001364292 NM_001364293 NM_001364294 NM_001364295 NM_001364296 NM_002270 NM_153188
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNPO1
Alternative Splicing GalleryENSG00000083312
Gene ExpressionTNPO1 [ NCBI-GEO ]   TNPO1 [ EBI - ARRAY_EXPRESS ]   TNPO1 [ SEEK ]   TNPO1 [ MEM ]
Gene Expression Viewer (FireBrowse)TNPO1 [ Firebrowse - Broad ]
GenevisibleExpression of TNPO1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3842
GTEX Portal (Tissue expression)TNPO1
Human Protein AtlasENSG00000083312-TNPO1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92973   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92973  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92973
Splice isoforms : SwissVarQ92973
PhosPhoSitePlusQ92973
Domaine pattern : Prosite (Expaxy)IMPORTIN_B_NT (PS50166)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Importin-beta_N    Importin_beta   
Domain families : Pfam (Sanger)IBN_N (PF03810)   
Domain families : Pfam (NCBI)pfam03810   
Domain families : Smart (EMBL)IBN_N (SM00913)  
Conserved Domain (NCBI)TNPO1
Blocks (Seattle)TNPO1
PDB (RSDB)1QBK    2H4M    2OT8    2QMR    2Z5J    2Z5K    2Z5M    2Z5N    2Z5O    4FDD    4FQ3    4JLQ    4OO6    5J3V    5TQC    5YVG    5YVH    5YVI   
PDB Europe1QBK    2H4M    2OT8    2QMR    2Z5J    2Z5K    2Z5M    2Z5N    2Z5O    4FDD    4FQ3    4JLQ    4OO6    5J3V    5TQC    5YVG    5YVH    5YVI   
PDB (PDBSum)1QBK    2H4M    2OT8    2QMR    2Z5J    2Z5K    2Z5M    2Z5N    2Z5O    4FDD    4FQ3    4JLQ    4OO6    5J3V    5TQC    5YVG    5YVH    5YVI   
PDB (IMB)1QBK    2H4M    2OT8    2QMR    2Z5J    2Z5K    2Z5M    2Z5N    2Z5O    4FDD    4FQ3    4JLQ    4OO6    5J3V    5TQC    5YVG    5YVH    5YVI   
Structural Biology KnowledgeBase1QBK    2H4M    2OT8    2QMR    2Z5J    2Z5K    2Z5M    2Z5N    2Z5O    4FDD    4FQ3    4JLQ    4OO6    5J3V    5TQC    5YVG    5YVH    5YVI   
SCOP (Structural Classification of Proteins)1QBK    2H4M    2OT8    2QMR    2Z5J    2Z5K    2Z5M    2Z5N    2Z5O    4FDD    4FQ3    4JLQ    4OO6    5J3V    5TQC    5YVG    5YVH    5YVI   
CATH (Classification of proteins structures)1QBK    2H4M    2OT8    2QMR    2Z5J    2Z5K    2Z5M    2Z5N    2Z5O    4FDD    4FQ3    4JLQ    4OO6    5J3V    5TQC    5YVG    5YVH    5YVI   
SuperfamilyQ92973
Human Protein Atlas [tissue]ENSG00000083312-TNPO1 [tissue]
Peptide AtlasQ92973
HPRD04210
IPIIPI00024364   IPI00843876   IPI00908817   IPI00975654   IPI00973310   IPI00974509   
Protein Interaction databases
DIP (DOE-UCLA)Q92973
IntAct (EBI)Q92973
BioGRIDTNPO1
STRING (EMBL)TNPO1
ZODIACTNPO1
Ontologies - Pathways
QuickGOQ92973
Ontology : AmiGORNA binding  protein binding  nucleus  cytoplasm  cytosol  cilium  protein import into nucleus  protein import into nucleus  nuclear localization sequence binding  Ran GTPase binding  viral process  intraciliary transport involved in cilium assembly  regulation of mRNA stability  nuclear import signal receptor activity  extracellular exosome  
Ontology : EGO-EBIRNA binding  protein binding  nucleus  cytoplasm  cytosol  cilium  protein import into nucleus  protein import into nucleus  nuclear localization sequence binding  Ran GTPase binding  viral process  intraciliary transport involved in cilium assembly  regulation of mRNA stability  nuclear import signal receptor activity  extracellular exosome  
NDEx NetworkTNPO1
Atlas of Cancer Signalling NetworkTNPO1
Wikipedia pathwaysTNPO1
Orthology - Evolution
OrthoDB3842
GeneTree (enSembl)ENSG00000083312
Phylogenetic Trees/Animal Genes : TreeFamTNPO1
HOGENOMQ92973
Homologs : HomoloGeneTNPO1
Homology/Alignments : Family Browser (UCSC)TNPO1
Gene fusions - Rearrangements
Fusion : MitelmanTNPO1/GTF2H1 [5q13.2/11p15.1]  
Fusion : MitelmanTNPO1/IKBKB [5q13.2/8p11.21]  
Fusion PortalTNPO1 5q13.2 GTF2H1 11p15.1 BRCA
Fusion : QuiverTNPO1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNPO1 [hg38]
dbVarTNPO1
ClinVarTNPO1
MonarchTNPO1
1000_GenomesTNPO1 
Exome Variant ServerTNPO1
GNOMAD BrowserENSG00000083312
Varsome BrowserTNPO1
Genomic Variants (DGV)TNPO1 [DGVbeta]
DECIPHERTNPO1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNPO1 
Mutations
ICGC Data PortalTNPO1 
TCGA Data PortalTNPO1 
Broad Tumor PortalTNPO1
OASIS PortalTNPO1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNPO1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNPO1
Mutations and Diseases : HGMDTNPO1
intOGen PortalTNPO1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNPO1
DgiDB (Drug Gene Interaction Database)TNPO1
DoCM (Curated mutations)TNPO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNPO1 (select a term)
intoGenTNPO1
Cancer3DTNPO1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602901   
Orphanet
DisGeNETTNPO1
MedgenTNPO1
Genetic Testing Registry TNPO1
NextProtQ92973 [Medical]
GENETestsTNPO1
Target ValidationTNPO1
Huge Navigator TNPO1 [HugePedia]
ClinGenTNPO1
Clinical trials, drugs, therapy
MyCancerGenomeTNPO1
Protein Interactions : CTD
Pharm GKB GenePA30192
PharosQ92973
Clinical trialTNPO1
Miscellaneous
canSAR (ICR)TNPO1 (select the gene name)
HarmonizomeTNPO1
DataMed IndexTNPO1
Probes
Litterature
PubMed156 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNPO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:41:53 CET 2021
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