Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TNPO1 (transportin 1)

Identity

Alias_namesKPNB2
karyopherin (importin) beta 2
Alias_symbol (synonym)MIP
TRN
IPO2
MIP1
Other alias
HGNC (Hugo) TNPO1
LocusID (NCBI) 3842
Atlas_Id 42648
Location 5q13.2  [Link to chromosome band 5q13]
Location_base_pair Starts at 72848103 and ends at 72914388 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TNPO1 (5q13.2) / GTF2H1 (11p15.1)TNPO1 (5q13.2) / IKBKB (8p11.21)TNPO1 (5q13.2) / MCCC2 (5q13.2)
TNPO1 (5q13.2) / ZNF106 (15q15.1)ZNF106 (15q15.1) / TNPO1 (5q13.2)TNPO1 5q13.2 / GTF2H1 11p15.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(5;5)(q13;q14) TNPO1/MEF2C
t(5;8)(q13;p11) TNPO1/IKBKB
t(5;11)(q13;p15) TNPO1/GTF2H1

External links

Nomenclature
HGNC (Hugo)TNPO1   6401
Cards
Entrez_Gene (NCBI)TNPO1  3842  transportin 1
AliasesIPO2; KPNB2; MIP; MIP1; 
TRN
GeneCards (Weizmann)TNPO1
Ensembl hg19 (Hinxton)ENSG00000083312 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000083312 [Gene_View]  ENSG00000083312 [Sequence]  chr5:72848103-72914388 [Contig_View]  TNPO1 [Vega]
ICGC DataPortalENSG00000083312
TCGA cBioPortalTNPO1
AceView (NCBI)TNPO1
Genatlas (Paris)TNPO1
WikiGenes3842
SOURCE (Princeton)TNPO1
Genetics Home Reference (NIH)TNPO1
Genomic and cartography
GoldenPath hg38 (UCSC)TNPO1  -     chr5:72848103-72914388 +  5q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNPO1  -     5q13.2   [Description]    (hg19-Feb_2009)
EnsemblTNPO1 - 5q13.2 [CytoView hg19]  TNPO1 - 5q13.2 [CytoView hg38]
Mapping of homologs : NCBITNPO1 [Mapview hg19]  TNPO1 [Mapview hg38]
OMIM602901   
Gene and transcription
Genbank (Entrez)AK055669 AK124768 AK299671 AK301021 AK308177
RefSeq transcript (Entrez)NM_001364292 NM_001364293 NM_001364294 NM_001364295 NM_001364296 NM_002270 NM_153188
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNPO1
Cluster EST : UnigeneHs.482497 [ NCBI ]
CGAP (NCI)Hs.482497
Alternative Splicing GalleryENSG00000083312
Gene ExpressionTNPO1 [ NCBI-GEO ]   TNPO1 [ EBI - ARRAY_EXPRESS ]   TNPO1 [ SEEK ]   TNPO1 [ MEM ]
Gene Expression Viewer (FireBrowse)TNPO1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3842
GTEX Portal (Tissue expression)TNPO1
Human Protein AtlasENSG00000083312-TNPO1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92973   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92973  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92973
Splice isoforms : SwissVarQ92973
PhosPhoSitePlusQ92973
Domaine pattern : Prosite (Expaxy)IMPORTIN_B_NT (PS50166)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Importin-beta_N   
Domain families : Pfam (Sanger)IBN_N (PF03810)   
Domain families : Pfam (NCBI)pfam03810   
Domain families : Smart (EMBL)IBN_N (SM00913)  
Conserved Domain (NCBI)TNPO1
DMDM Disease mutations3842
Blocks (Seattle)TNPO1
PDB (RSDB)1QBK    2H4M    2OT8    2QMR    2Z5J    2Z5K    2Z5M    2Z5N    2Z5O    4FDD    4FQ3    4JLQ    4OO6    5J3V    5TQC   
PDB Europe1QBK    2H4M    2OT8    2QMR    2Z5J    2Z5K    2Z5M    2Z5N    2Z5O    4FDD    4FQ3    4JLQ    4OO6    5J3V    5TQC   
PDB (PDBSum)1QBK    2H4M    2OT8    2QMR    2Z5J    2Z5K    2Z5M    2Z5N    2Z5O    4FDD    4FQ3    4JLQ    4OO6    5J3V    5TQC   
PDB (IMB)1QBK    2H4M    2OT8    2QMR    2Z5J    2Z5K    2Z5M    2Z5N    2Z5O    4FDD    4FQ3    4JLQ    4OO6    5J3V    5TQC   
Structural Biology KnowledgeBase1QBK    2H4M    2OT8    2QMR    2Z5J    2Z5K    2Z5M    2Z5N    2Z5O    4FDD    4FQ3    4JLQ    4OO6    5J3V    5TQC   
SCOP (Structural Classification of Proteins)1QBK    2H4M    2OT8    2QMR    2Z5J    2Z5K    2Z5M    2Z5N    2Z5O    4FDD    4FQ3    4JLQ    4OO6    5J3V    5TQC   
CATH (Classification of proteins structures)1QBK    2H4M    2OT8    2QMR    2Z5J    2Z5K    2Z5M    2Z5N    2Z5O    4FDD    4FQ3    4JLQ    4OO6    5J3V    5TQC   
SuperfamilyQ92973
Human Protein Atlas [tissue]ENSG00000083312-TNPO1 [tissue]
Peptide AtlasQ92973
HPRD04210
IPIIPI00024364   IPI00843876   IPI00908817   IPI00975654   IPI00973310   IPI00974509   
Protein Interaction databases
DIP (DOE-UCLA)Q92973
IntAct (EBI)Q92973
FunCoupENSG00000083312
BioGRIDTNPO1
STRING (EMBL)TNPO1
ZODIACTNPO1
Ontologies - Pathways
QuickGOQ92973
Ontology : AmiGOprotein import into nucleus, translocation  RNA binding  protein binding  nucleus  cytoplasm  cytoplasm  cytosol  cilium  NLS-bearing protein import into nucleus  ribosomal protein import into nucleus  nuclear localization sequence binding  Ran GTPase binding  protein transporter activity  viral process  nuclear membrane  nuclear periphery  intraciliary transport involved in cilium assembly  regulation of mRNA stability  extracellular exosome  
Ontology : EGO-EBIprotein import into nucleus, translocation  RNA binding  protein binding  nucleus  cytoplasm  cytoplasm  cytosol  cilium  NLS-bearing protein import into nucleus  ribosomal protein import into nucleus  nuclear localization sequence binding  Ran GTPase binding  protein transporter activity  viral process  nuclear membrane  nuclear periphery  intraciliary transport involved in cilium assembly  regulation of mRNA stability  extracellular exosome  
NDEx NetworkTNPO1
Atlas of Cancer Signalling NetworkTNPO1
Wikipedia pathwaysTNPO1
Orthology - Evolution
OrthoDB3842
GeneTree (enSembl)ENSG00000083312
Phylogenetic Trees/Animal Genes : TreeFamTNPO1
HOGENOMQ92973
Homologs : HomoloGeneTNPO1
Homology/Alignments : Family Browser (UCSC)TNPO1
Gene fusions - Rearrangements
Fusion : MitelmanTNPO1/GTF2H1 [5q13.2/11p15.1]  
Fusion : MitelmanTNPO1/IKBKB [5q13.2/8p11.21]  [t(5;8)(q13;p11)]  
Fusion PortalTNPO1 5q13.2 GTF2H1 11p15.1 BRCA
Fusion : QuiverTNPO1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNPO1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNPO1
dbVarTNPO1
ClinVarTNPO1
1000_GenomesTNPO1 
Exome Variant ServerTNPO1
ExAC (Exome Aggregation Consortium)ENSG00000083312
GNOMAD BrowserENSG00000083312
Varsome BrowserTNPO1
Genetic variants : HAPMAP3842
Genomic Variants (DGV)TNPO1 [DGVbeta]
DECIPHERTNPO1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNPO1 
Mutations
ICGC Data PortalTNPO1 
TCGA Data PortalTNPO1 
Broad Tumor PortalTNPO1
OASIS PortalTNPO1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNPO1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNPO1
intOGen PortalTNPO1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNPO1
DgiDB (Drug Gene Interaction Database)TNPO1
DoCM (Curated mutations)TNPO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNPO1 (select a term)
intoGenTNPO1
Cancer3DTNPO1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602901   
Orphanet
DisGeNETTNPO1
MedgenTNPO1
Genetic Testing Registry TNPO1
NextProtQ92973 [Medical]
TSGene3842
GENETestsTNPO1
Target ValidationTNPO1
Huge Navigator TNPO1 [HugePedia]
snp3D : Map Gene to Disease3842
BioCentury BCIQTNPO1
ClinGenTNPO1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3842
Chemical/Pharm GKB GenePA30192
Clinical trialTNPO1
Miscellaneous
canSAR (ICR)TNPO1 (select the gene name)
DataMed IndexTNPO1
Probes
Litterature
PubMed137 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNPO1
EVEXTNPO1
GoPubMedTNPO1
iHOPTNPO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 17 18:43:12 CET 2019
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