TNPO3 (transportin 3)

2007-04-01  

Identity

HGNC
TNPO3
LOCATION
7q32.1
LOCUSID
23534
ALIAS
IPO12,LGMD1F,LGMDD2,MTR10A,TRN-SR,TRN-SR2,TRNSR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23534
MIM: 610032
HGNC: 17103
Ensembl: ENSG00000064419

Variants:

dbSNP: 23534
ClinVar: 23534
TCGA: ENSG00000064419
COSMIC: TNPO3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000064419ENST00000265388Q9Y5L0
ENSG00000064419ENST00000265388A0A024R794
ENSG00000064419ENST00000471166C9J7E5
ENSG00000064419ENST00000471234Q9Y5L0
ENSG00000064419ENST00000482320E9PFH4
ENSG00000064419ENST00000627585C9J7E5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206398802010Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis.124
198465192010The requirement for cellular transportin 3 (TNPO3 or TRN-SR2) during infection maps to human immunodeficiency virus type 1 capsid and not integrase.110
206398792010Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.76
234145602013TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm.70
219010952011Transportin 3 promotes a nuclear maturation step required for efficient HIV-1 integration.69
230974352013The host proteins transportin SR2/TNPO3 and cyclophilin A exert opposing effects on HIV-1 uncoating.68
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
221458132011Inhibition of HIV-1 infection by TNPO3 depletion is determined by capsid and detectable after viral cDNA enters the nucleus.57
236221452013The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6.45
223982802012TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core.42

Citation

Dessen P

TNPO3 (transportin 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46863/tnpo3