TNRC6B (trinucleotide repeat containing adaptor 6B)

2019-05-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
GDSBA
FUSION GENES

Other Information

Locus ID:

NCBI: 23112
MIM: 610740
HGNC: 29190
Ensembl: ENSG00000100354

Variants:

dbSNP: 23112
ClinVar: 23112
TCGA: ENSG00000100354
COSMIC: TNRC6B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100354ENST00000301923Q9UPQ9
ENSG00000100354ENST00000301923A0A024R1N5
ENSG00000100354ENST00000335727Q9UPQ9
ENSG00000100354ENST00000402203Q9UPQ9
ENSG00000100354ENST00000402203A0A024R1N5
ENSG00000100354ENST00000441751B0QYM5
ENSG00000100354ENST00000446273H0Y720
ENSG00000100354ENST00000454349Q9UPQ9

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
PIP3 activates AKT signalingREACTOMER-HSA-1257604
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilizationREACTOMER-HSA-2730905
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GAB1 signalosomeREACTOMER-HSA-180292
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PI3K/AKT activationREACTOMER-HSA-198203
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by SCF-KITREACTOMER-HSA-1433557
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Transcription and TranslationREACTOMER-HSA-1912408
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Gene Silencing by RNAREACTOMER-HSA-211000
Post-transcriptional silencing by small RNAsREACTOMER-HSA-426496
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oncogene Induced SenescenceREACTOMER-HSA-2559585
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193837682009The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.73
191179812009Sequence variants at 22q13 are associated with prostate cancer risk.65
195498072009Prostate cancer risk associated loci in African Americans.37
206901392011Meta-analysis of genome-wide and replication association studies on prostate cancer.24
236046782013BET1L and TNRC6B associate with uterine fibroid risk among European Americans.17
238925402013Variants in BET1L and TNRC6B associate with increasing fibroid volume and fibroid type among European Americans.15
279873372017Replication of GWAS loci revealed the moderate effect of TNRC6B locus on susceptibility of Saudi women to develop uterine leiomyomas.6
294759682018miRNA-Processing Gene Methylation and Cancer Risk.3
309975012019TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.3
297435412018Association of BET1L and TNRC6B with uterine leiomyoma risk and its relevant clinical features in Han Chinese population.1

Citation

Dessen P

TNRC6B (trinucleotide repeat containing adaptor 6B)

Atlas Genet Cytogenet Oncol Haematol. 2019-05-01

Online version: http://atlasgeneticsoncology.org/gene/57998/tnrc6b