Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TNS1 (tensin 1)

Identity

Alias_namesregulatory subunit 155
TNS
MXRA6
Alias_symbol (synonym)DKFZp586K0617
PPP1R155
Other aliasMST091
MST122
MST127
MSTP091
MSTP122
MSTP127
HGNC (Hugo) TNS1
LocusID (NCBI) 7145
Atlas_Id 42650
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 217799789 and ends at 217920236 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		MIR548G (3q12.1) / TNS1 (2q35)PLD6 (17p11.2) / TNS1 (2q35)STON2 (14q31.1) / TNS1 (2q35)
TNS1 (2q35) / KIRREL (1q23.1)TNS1 (2q35) / PRR29 (17q23.3)TNS1 (2q35) / RPL41 (12q13.2)
TNS1 (2q35) / RPRM (2q23.3)TNS1 (2q35) / TNS1 (2q35)ZNF248 (10p11.1) / TNS1 (2q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma

External links

Nomenclature
HGNC (Hugo)TNS1   11973
Cards
Entrez_Gene (NCBI)TNS1  7145  tensin 1
AliasesMST091; MST122; MST127; MSTP091; 
MSTP122; MSTP127; MXRA6; PPP1R155; TNS
GeneCards (Weizmann)TNS1
Ensembl hg19 (Hinxton)ENSG00000079308 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000079308 [Gene_View]  chr2:217799789-217920236 [Contig_View]  TNS1 [Vega]
ICGC DataPortalENSG00000079308
TCGA cBioPortalTNS1
AceView (NCBI)TNS1
Genatlas (Paris)TNS1
WikiGenes7145
SOURCE (Princeton)TNS1
Genetics Home Reference (NIH)TNS1
Genomic and cartography
GoldenPath hg38 (UCSC)TNS1  -     chr2:217799789-217920236 -  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNS1  -     2q35   [Description]    (hg19-Feb_2009)
EnsemblTNS1 - 2q35 [CytoView hg19]  TNS1 - 2q35 [CytoView hg38]
Mapping of homologs : NCBITNS1 [Mapview hg19]  TNS1 [Mapview hg38]
OMIM600076   
Gene and transcription
Genbank (Entrez)AB209238 AF116610 AF172820 AF173897 AF176917
RefSeq transcript (Entrez)NM_001308022 NM_001308023 NM_022648
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNS1
Cluster EST : UnigeneHs.471381 [ NCBI ]
CGAP (NCI)Hs.471381
Alternative Splicing GalleryENSG00000079308
Gene ExpressionTNS1 [ NCBI-GEO ]   TNS1 [ EBI - ARRAY_EXPRESS ]   TNS1 [ SEEK ]   TNS1 [ MEM ]
Gene Expression Viewer (FireBrowse)TNS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7145
GTEX Portal (Tissue expression)TNS1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HBL0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HBL0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HBL0
Splice isoforms : SwissVarQ9HBL0
PhosPhoSitePlusQ9HBL0
Domaine pattern : Prosite (Expaxy)C2_TENSIN (PS51182)    PPASE_TENSIN (PS51181)    SH2 (PS50001)   
Domains : Interpro (EBI)C2_dom    PH_dom-like    Prot-tyrosine_phosphatase-like    PTB    PTB/PI_dom    SH2    Tensin_C2-dom    Tensin_lipid_phosphatase_dom    Tensin_PTB    Tyr_Pase_cat   
Domain families : Pfam (Sanger)PTB (PF08416)    PTEN_C2 (PF10409)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam08416    pfam10409    pfam00017   
Domain families : Smart (EMBL)PTB (SM00462)  PTEN_C2 (SM01326)  PTPc_motif (SM00404)  SH2 (SM00252)  
Conserved Domain (NCBI)TNS1
DMDM Disease mutations7145
Blocks (Seattle)TNS1
SuperfamilyQ9HBL0
Human Protein AtlasENSG00000079308
Peptide AtlasQ9HBL0
HPRD02512
IPIIPI00307545   IPI00973019   IPI00300936   IPI00927045   IPI00383375   IPI00925901   IPI00926129   IPI00925950   IPI00927516   IPI00384302   IPI00927341   IPI00927764   IPI00927104   IPI00924783   
Protein Interaction databases
DIP (DOE-UCLA)Q9HBL0
IntAct (EBI)Q9HBL0
FunCoupENSG00000079308
BioGRIDTNS1
STRING (EMBL)TNS1
ZODIACTNS1
Ontologies - Pathways
QuickGOQ9HBL0
Ontology : AmiGORNA binding  actin binding  protein binding  cytoplasm  cytoskeleton  focal adhesion  cell-substrate junction assembly  cell surface  fibroblast migration  
Ontology : EGO-EBIRNA binding  actin binding  protein binding  cytoplasm  cytoskeleton  focal adhesion  cell-substrate junction assembly  cell surface  fibroblast migration  
Pathways : BIOCARTAIntegrin Signaling Pathway [Genes]   
NDEx NetworkTNS1
Atlas of Cancer Signalling NetworkTNS1
Wikipedia pathwaysTNS1
Orthology - Evolution
OrthoDB7145
GeneTree (enSembl)ENSG00000079308
Phylogenetic Trees/Animal Genes : TreeFamTNS1
HOVERGENQ9HBL0
HOGENOMQ9HBL0
Homologs : HomoloGeneTNS1
Homology/Alignments : Family Browser (UCSC)TNS1
Gene fusions - Rearrangements
Fusion : MitelmanTNS1/RPRM [2q35/2q23.3]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNS1
dbVarTNS1
ClinVarTNS1
1000_GenomesTNS1 
Exome Variant ServerTNS1
ExAC (Exome Aggregation Consortium)TNS1 (select the gene name)
Genetic variants : HAPMAP7145
Genomic Variants (DGV)TNS1 [DGVbeta]
DECIPHERTNS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNS1 
Mutations
ICGC Data PortalTNS1 
TCGA Data PortalTNS1 
Broad Tumor PortalTNS1
OASIS PortalTNS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNS1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNS1
DgiDB (Drug Gene Interaction Database)TNS1
DoCM (Curated mutations)TNS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNS1 (select a term)
intoGenTNS1
Cancer3DTNS1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600076   
Orphanet
MedgenTNS1
Genetic Testing Registry TNS1
NextProtQ9HBL0 [Medical]
TSGene7145
GENETestsTNS1
Target ValidationTNS1
Huge Navigator TNS1 [HugePedia]
snp3D : Map Gene to Disease7145
BioCentury BCIQTNS1
ClinGenTNS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7145
Chemical/Pharm GKB GenePA36660
Clinical trialTNS1
Miscellaneous
canSAR (ICR)TNS1 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNS1
EVEXTNS1
GoPubMedTNS1
iHOPTNS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:00:12 CEST 2017
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