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TNS1 (tensin 1)

Identity

Alias (NCBI)MST091
MST122
MST127
MSTP091
MSTP122
MSTP127
MXRA6
PPP1R155
TNS
HGNC (Hugo) TNS1
HGNC Alias symbDKFZp586K0617
PPP1R155
HGNC Alias nameprotein phosphatase 1, regulatory subunit 155
HGNC Previous nameTNS
 MXRA6
HGNC Previous nametensin
 matrix-remodelling associated 6
LocusID (NCBI) 7145
Atlas_Id 42650
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 217799589 and ends at 217944070 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MIR548G (3q12.1) / TNS1 (2q35)PLD6 (17p11.2) / TNS1 (2q35)STON2 (14q31.1) / TNS1 (2q35)
TNS1 (2q35) / KIRREL (1q23.1)TNS1 (2q35) / PRR29 (17q23.3)TNS1 (2q35) / RPL41 (12q13.2)
TNS1 (2q35) / RPRM (2q23.3)TNS1 (2q35) / TNS1 (2q35)ZNF248 (10p11.1) / TNS1 (2q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)TNS1   11973
Cards
Entrez_Gene (NCBI)TNS1    tensin 1
AliasesMST091; MST122; MST127; MSTP091; 
MSTP122; MSTP127; MXRA6; PPP1R155; TNS
GeneCards (Weizmann)TNS1
Ensembl hg19 (Hinxton)ENSG00000079308 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000079308 [Gene_View]  ENSG00000079308 [Sequence]  chr2:217799589-217944070 [Contig_View]  TNS1 [Vega]
ICGC DataPortalENSG00000079308
TCGA cBioPortalTNS1
AceView (NCBI)TNS1
Genatlas (Paris)TNS1
SOURCE (Princeton)TNS1
Genetics Home Reference (NIH)TNS1
Genomic and cartography
GoldenPath hg38 (UCSC)TNS1  -     chr2:217799589-217944070 -  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNS1  -     2q35   [Description]    (hg19-Feb_2009)
GoldenPathTNS1 - 2q35 [CytoView hg19]  TNS1 - 2q35 [CytoView hg38]
ImmunoBaseENSG00000079308
Genome Data Viewer NCBITNS1 [Mapview hg19]  
OMIM600076   
Gene and transcription
Genbank (Entrez)AB209238 AF116610 AF172820 AF173897 AF176917
RefSeq transcript (Entrez)NM_001308022 NM_001308023 NM_001387777 NM_022648
Consensus coding sequences : CCDS (NCBI)TNS1
Gene ExpressionTNS1 [ NCBI-GEO ]   TNS1 [ EBI - ARRAY_EXPRESS ]   TNS1 [ SEEK ]   TNS1 [ MEM ]
Gene Expression Viewer (FireBrowse)TNS1 [ Firebrowse - Broad ]
GenevisibleExpression of TNS1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7145
GTEX Portal (Tissue expression)TNS1
Human Protein AtlasENSG00000079308-TNS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9HBL0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9HBL0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9HBL0
PhosPhoSitePlusQ9HBL0
Domaine pattern : Prosite (Expaxy)C2_TENSIN (PS51182)    PPASE_TENSIN (PS51181)    SH2 (PS50001)   
Domains : Interpro (EBI)PH-like_dom_sf    Prot-tyrosine_phosphatase-like    PTB    PTB/PI_dom    SH2    SH2_dom_sf    Tensin-like_SH2    Tensin_C2-dom    Tensin_phosphatase    Tensin_PTB    Tyr_Pase_cat   
Domain families : Pfam (Sanger)PTB (PF08416)    PTEN_C2 (PF10409)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam08416    pfam10409    pfam00017   
Domain families : Smart (EMBL)PTB (SM00462)  PTEN_C2 (SM01326)  PTPc_motif (SM00404)  SH2 (SM00252)  
Conserved Domain (NCBI)TNS1
SuperfamilyQ9HBL0
AlphaFold pdb e-kbQ9HBL0   
Human Protein Atlas [tissue]ENSG00000079308-TNS1 [tissue]
HPRD02512
Protein Interaction databases
DIP (DOE-UCLA)Q9HBL0
IntAct (EBI)Q9HBL0
BioGRIDTNS1
STRING (EMBL)TNS1
ZODIACTNS1
Ontologies - Pathways
QuickGOQ9HBL0
Ontology : AmiGORNA binding  actin binding  protein binding  cytoplasm  cytoskeleton  focal adhesion  focal adhesion  cell surface  
Ontology : EGO-EBIRNA binding  actin binding  protein binding  cytoplasm  cytoskeleton  focal adhesion  focal adhesion  cell surface  
Pathways : BIOCARTAIntegrin Signaling Pathway [Genes]   
NDEx NetworkTNS1
Atlas of Cancer Signalling NetworkTNS1
Wikipedia pathwaysTNS1
Orthology - Evolution
OrthoDB7145
GeneTree (enSembl)ENSG00000079308
Phylogenetic Trees/Animal Genes : TreeFamTNS1
Homologs : HomoloGeneTNS1
Homology/Alignments : Family Browser (UCSC)TNS1
Gene fusions - Rearrangements
Fusion : MitelmanTNS1/RPRM [2q35/2q23.3]  
Fusion : QuiverTNS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNS1
dbVarTNS1
ClinVarTNS1
MonarchTNS1
1000_GenomesTNS1 
Exome Variant ServerTNS1
GNOMAD BrowserENSG00000079308
Varsome BrowserTNS1
ACMGTNS1 variants
VarityQ9HBL0
Genomic Variants (DGV)TNS1 [DGVbeta]
DECIPHERTNS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNS1 
Mutations
ICGC Data PortalTNS1 
TCGA Data PortalTNS1 
Broad Tumor PortalTNS1
OASIS PortalTNS1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNS1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNS1
Mutations and Diseases : HGMDTNS1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTNS1
DgiDB (Drug Gene Interaction Database)TNS1
DoCM (Curated mutations)TNS1
CIViC (Clinical Interpretations of Variants in Cancer)TNS1
Cancer3DTNS1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600076   
Orphanet
DisGeNETTNS1
MedgenTNS1
Genetic Testing Registry TNS1
NextProtQ9HBL0 [Medical]
GENETestsTNS1
Target ValidationTNS1
Huge Navigator TNS1 [HugePedia]
ClinGenTNS1
Clinical trials, drugs, therapy
MyCancerGenomeTNS1
Protein Interactions : CTDTNS1
Pharm GKB GenePA36660
PharosQ9HBL0
Clinical trialTNS1
Miscellaneous
canSAR (ICR)TNS1
HarmonizomeTNS1
DataMed IndexTNS1
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:51 CEST 2021
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