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TNS2 (tensin 2)

Identity

Alias_namesTENC1
tensin like C1 domain-containing phosphatase
tensin like C1 domain containing phosphatase (tensin 2)
Alias_symbol (synonym)KIAA1075
C1-TEN
Other aliasC1TEN
HGNC (Hugo) TNS2
LocusID (NCBI) 23371
Atlas_Id 50833
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 53048949 and ends at 53064378 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTSZ (20q13.32) / TNS2 (12q13.13)TNS2 (12q13.13) / ACVR1B (12q13.13)TNS2 (12q13.13) / MMP12 (11q22.2)
TNS2 (12q13.13) / TPT1 (13q14.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNS2   19737
Cards
Entrez_Gene (NCBI)TNS2  23371  tensin 2
AliasesC1-TEN; C1TEN; TENC1
GeneCards (Weizmann)TNS2
Ensembl hg19 (Hinxton)ENSG00000111077 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000111077 [Gene_View]  chr12:53048949-53064378 [Contig_View]  TNS2 [Vega]
ICGC DataPortalENSG00000111077
TCGA cBioPortalTNS2
AceView (NCBI)TNS2
Genatlas (Paris)TNS2
WikiGenes23371
SOURCE (Princeton)TNS2
Genetics Home Reference (NIH)TNS2
Genomic and cartography
GoldenPath hg38 (UCSC)TNS2  -     chr12:53048949-53064378 +  12q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNS2  -     12q13.13   [Description]    (hg19-Feb_2009)
EnsemblTNS2 - 12q13.13 [CytoView hg19]  TNS2 - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBITNS2 [Mapview hg19]  TNS2 [Mapview hg38]
OMIM607717   
Gene and transcription
Genbank (Entrez)AB028998 AF417490 AF518728 AF518729 AK131320
RefSeq transcript (Entrez)NM_015319 NM_170754 NM_198316
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNS2
Cluster EST : UnigeneHs.343334 [ NCBI ]
CGAP (NCI)Hs.343334
Alternative Splicing GalleryENSG00000111077
Gene ExpressionTNS2 [ NCBI-GEO ]   TNS2 [ EBI - ARRAY_EXPRESS ]   TNS2 [ SEEK ]   TNS2 [ MEM ]
Gene Expression Viewer (FireBrowse)TNS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23371
GTEX Portal (Tissue expression)TNS2
Human Protein AtlasENSG00000111077-TNS2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ63HR2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ63HR2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ63HR2
Splice isoforms : SwissVarQ63HR2
Catalytic activity : Enzyme3.1.3.- [ Enzyme-Expasy ]   3.1.3.-3.1.3.- [ IntEnz-EBI ]   3.1.3.- [ BRENDA ]   3.1.3.- [ KEGG ]   
PhosPhoSitePlusQ63HR2
Domaine pattern : Prosite (Expaxy)C2_TENSIN (PS51182)    PPASE_TENSIN (PS51181)    SH2 (PS50001)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)C2_dom    PE/DAG-bd    PH_dom-like    Prot-tyrosine_phosphatase-like    PTB    PTB/PI_dom    SH2    Tensin_C2-dom    Tensin_lipid_phosphatase_dom    Tensin_PTB   
Domain families : Pfam (Sanger)PTB (PF08416)    PTEN_C2 (PF10409)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam08416    pfam10409    pfam00017   
Domain families : Smart (EMBL)C1 (SM00109)  PTB (SM00462)  PTEN_C2 (SM01326)  SH2 (SM00252)  
Conserved Domain (NCBI)TNS2
DMDM Disease mutations23371
Blocks (Seattle)TNS2
PDB (SRS)2DKQ    2KNO    2L6K    2LOZ    3HQC   
PDB (PDBSum)2DKQ    2KNO    2L6K    2LOZ    3HQC   
PDB (IMB)2DKQ    2KNO    2L6K    2LOZ    3HQC   
PDB (RSDB)2DKQ    2KNO    2L6K    2LOZ    3HQC   
Structural Biology KnowledgeBase2DKQ    2KNO    2L6K    2LOZ    3HQC   
SCOP (Structural Classification of Proteins)2DKQ    2KNO    2L6K    2LOZ    3HQC   
CATH (Classification of proteins structures)2DKQ    2KNO    2L6K    2LOZ    3HQC   
SuperfamilyQ63HR2
Human Protein Atlas [tissue]ENSG00000111077-TNS2 [tissue]
Peptide AtlasQ63HR2
HPRD16256
IPIIPI00465295   IPI00385317   IPI00550368   IPI00396051   IPI00848267   IPI00792617   IPI00848134   IPI00441958   IPI01021661   IPI01022985   IPI01022832   
Protein Interaction databases
DIP (DOE-UCLA)Q63HR2
IntAct (EBI)Q63HR2
FunCoupENSG00000111077
BioGRIDTNS2
STRING (EMBL)TNS2
ZODIACTNS2
Ontologies - Pathways
QuickGOQ63HR2
Ontology : AmiGOkidney development  phosphoprotein phosphatase activity  protein binding  intracellular  plasma membrane  focal adhesion  protein dephosphorylation  negative regulation of cell proliferation  response to muscle activity  cellular homeostasis  kinase binding  collagen metabolic process  multicellular organism growth  intracellular signal transduction  metal ion binding  multicellular organismal homeostasis  
Ontology : EGO-EBIkidney development  phosphoprotein phosphatase activity  protein binding  intracellular  plasma membrane  focal adhesion  protein dephosphorylation  negative regulation of cell proliferation  response to muscle activity  cellular homeostasis  kinase binding  collagen metabolic process  multicellular organism growth  intracellular signal transduction  metal ion binding  multicellular organismal homeostasis  
NDEx NetworkTNS2
Atlas of Cancer Signalling NetworkTNS2
Wikipedia pathwaysTNS2
Orthology - Evolution
OrthoDB23371
GeneTree (enSembl)ENSG00000111077
Phylogenetic Trees/Animal Genes : TreeFamTNS2
HOVERGENQ63HR2
HOGENOMQ63HR2
Homologs : HomoloGeneTNS2
Homology/Alignments : Family Browser (UCSC)TNS2
Gene fusions - Rearrangements
Fusion : MitelmanTNS2/ACVR1B [12q13.13/12q13.13]  
Tumor Fusion PortalTNS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNS2
dbVarTNS2
ClinVarTNS2
1000_GenomesTNS2 
Exome Variant ServerTNS2
ExAC (Exome Aggregation Consortium)ENSG00000111077
GNOMAD BrowserENSG00000111077
Genetic variants : HAPMAP23371
Genomic Variants (DGV)TNS2 [DGVbeta]
DECIPHERTNS2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNS2 
Mutations
ICGC Data PortalTNS2 
TCGA Data PortalTNS2 
Broad Tumor PortalTNS2
OASIS PortalTNS2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDTNS2
BioMutasearch TNS2
DgiDB (Drug Gene Interaction Database)TNS2
DoCM (Curated mutations)TNS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNS2 (select a term)
intoGenTNS2
Cancer3DTNS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607717   
Orphanet
DisGeNETTNS2
MedgenTNS2
Genetic Testing Registry TNS2
NextProtQ63HR2 [Medical]
TSGene23371
GENETestsTNS2
Target ValidationTNS2
Huge Navigator TNS2 [HugePedia]
snp3D : Map Gene to Disease23371
BioCentury BCIQTNS2
ClinGenTNS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23371
Chemical/Pharm GKB GenePA134976096
Clinical trialTNS2
Miscellaneous
canSAR (ICR)TNS2 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNS2
EVEXTNS2
GoPubMedTNS2
iHOPTNS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:39:13 CET 2017

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