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TNS3 (tensin 3)

Identity

Alias (NCBI)TEM6
TENS1
HGNC (Hugo) TNS3
HGNC Alias symbTEM6
H_NH0549I23.2
FLJ13732
HGNC Alias nametumor endothelial marker 6
HGNC Previous nameTENS1
HGNC Previous nametensin-like SH2 domain-containing 1
LocusID (NCBI) 64759
Atlas_Id 42518
Location 7p12.3  [Link to chromosome band 7p12]
Location_base_pair Starts at 47275154 and ends at 47582111 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP5S (14q21.3) / TNS3 (7p12.3)CSTL1 (20p11.21) / TNS3 (7p12.3)EXOC6B (2p13.2) / TNS3 (7p12.3)
HARBI1 (11p11.2) / TNS3 (7p12.3)MAP3K3 (17q23.3) / TNS3 (7p12.3)TNS3 (7p12.3) / APOOL (Xq21.1)
TNS3 (7p12.3) / EBF1 (5q33.3)TNS3 (7p12.3) / ELMO1 (7p14.2)TNS3 (7p12.3) / FOXI2 (10q26.2)
TNS3 (7p12.3) / HSPA1L (6p21.33)TNS3 (7p12.3) / MAP3K3 (17q23.3)TNS3 (7p12.3) / PAPPA2 (1q25.2)
TNS3 (7p12.3) / PKD1L1 (7p12.3)TNS3 (7p12.3) / VPS16 (20p13)TNS3 (7p12.3) / ZNRF2 (7p14.3)
HARBI1 11p11.2 / TNS3 7p12.3TNS3 7p12.3 / ELMO1 7p14.2TNS3 7p12.3 / FOXI2 10q26.2
TNS3 7p12.3 / HSPA1L 6p21.33TNS3 7p12.3 / ZNRF2 7p14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TNS3   21616
Cards
Entrez_Gene (NCBI)TNS3    tensin 3
AliasesTEM6; TENS1
GeneCards (Weizmann)TNS3
Ensembl hg19 (Hinxton)ENSG00000136205 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136205 [Gene_View]  ENSG00000136205 [Sequence]  chr7:47275154-47582111 [Contig_View]  TNS3 [Vega]
ICGC DataPortalENSG00000136205
TCGA cBioPortalTNS3
AceView (NCBI)TNS3
Genatlas (Paris)TNS3
SOURCE (Princeton)TNS3
Genetics Home Reference (NIH)TNS3
Genomic and cartography
GoldenPath hg38 (UCSC)TNS3  -     chr7:47275154-47582111 -  7p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNS3  -     7p12.3   [Description]    (hg19-Feb_2009)
GoldenPathTNS3 - 7p12.3 [CytoView hg19]  TNS3 - 7p12.3 [CytoView hg38]
ImmunoBaseENSG00000136205
Genome Data Viewer NCBITNS3 [Mapview hg19]  
OMIM606825   
Gene and transcription
Genbank (Entrez)AB062750 AB208995 AF378756 AF417489 AK001539
RefSeq transcript (Entrez)NM_022748
Consensus coding sequences : CCDS (NCBI)TNS3
Gene ExpressionTNS3 [ NCBI-GEO ]   TNS3 [ EBI - ARRAY_EXPRESS ]   TNS3 [ SEEK ]   TNS3 [ MEM ]
Gene Expression Viewer (FireBrowse)TNS3 [ Firebrowse - Broad ]
GenevisibleExpression of TNS3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64759
GTEX Portal (Tissue expression)TNS3
Human Protein AtlasENSG00000136205-TNS3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ68CZ2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ68CZ2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ68CZ2
PhosPhoSitePlusQ68CZ2
Domaine pattern : Prosite (Expaxy)C2_TENSIN (PS51182)    PPASE_TENSIN (PS51181)    SH2 (PS50001)   
Domains : Interpro (EBI)PH-like_dom_sf    Prot-tyrosine_phosphatase-like    PTB    PTB/PI_dom    SH2    SH2_dom_sf    Tensin-like_SH2    Tensin_C2-dom    Tensin_phosphatase    Tensin_PTB    Tyr_Pase_cat   
Domain families : Pfam (Sanger)PTB (PF08416)    PTEN_C2 (PF10409)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam08416    pfam10409    pfam00017   
Domain families : Smart (EMBL)PTB (SM00462)  PTEN_C2 (SM01326)  PTPc_motif (SM00404)  SH2 (SM00252)  
Conserved Domain (NCBI)TNS3
SuperfamilyQ68CZ2
AlphaFold pdb e-kbQ68CZ2   
Human Protein Atlas [tissue]ENSG00000136205-TNS3 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q68CZ2
IntAct (EBI)Q68CZ2
BioGRIDTNS3
STRING (EMBL)TNS3
ZODIACTNS3
Ontologies - Pathways
QuickGOQ68CZ2
Ontology : AmiGOprotein binding  cytosol  cytosol  focal adhesion  focal adhesion  
Ontology : EGO-EBIprotein binding  cytosol  cytosol  focal adhesion  focal adhesion  
NDEx NetworkTNS3
Atlas of Cancer Signalling NetworkTNS3
Wikipedia pathwaysTNS3
Orthology - Evolution
OrthoDB64759
GeneTree (enSembl)ENSG00000136205
Phylogenetic Trees/Animal Genes : TreeFamTNS3
Homologs : HomoloGeneTNS3
Homology/Alignments : Family Browser (UCSC)TNS3
Gene fusions - Rearrangements
Fusion : MitelmanHARBI1/TNS3 [11p11.2/7p12.3]  
Fusion : MitelmanMAP3K3/TNS3 [17q23.3/7p12.3]  
Fusion : MitelmanTNS3/ELMO1 [7p12.3/7p14.2]  
Fusion : MitelmanTNS3/FOXI2 [7p12.3/10q26.2]  
Fusion : MitelmanTNS3/HSPA1L [7p12.3/6p21.33]  
Fusion : MitelmanTNS3/MAP3K3 [7p12.3/17q23.3]  
Fusion : MitelmanTNS3/PKD1L1 [7p12.3/7p12.3]  
Fusion : MitelmanTNS3/ZNRF2 [7p12.3/7p14.3]  
Fusion : QuiverTNS3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNS3
dbVarTNS3
ClinVarTNS3
MonarchTNS3
1000_GenomesTNS3 
Exome Variant ServerTNS3
GNOMAD BrowserENSG00000136205
Varsome BrowserTNS3
ACMGTNS3 variants
VarityQ68CZ2
Genomic Variants (DGV)TNS3 [DGVbeta]
DECIPHERTNS3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNS3 
Mutations
ICGC Data PortalTNS3 
TCGA Data PortalTNS3 
Broad Tumor PortalTNS3
OASIS PortalTNS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNS3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNS3
Mutations and Diseases : HGMDTNS3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTNS3
DgiDB (Drug Gene Interaction Database)TNS3
DoCM (Curated mutations)TNS3
CIViC (Clinical Interpretations of Variants in Cancer)TNS3
Cancer3DTNS3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606825   
Orphanet
DisGeNETTNS3
MedgenTNS3
Genetic Testing Registry TNS3
NextProtQ68CZ2 [Medical]
GENETestsTNS3
Target ValidationTNS3
Huge Navigator TNS3 [HugePedia]
ClinGenTNS3
Clinical trials, drugs, therapy
MyCancerGenomeTNS3
Protein Interactions : CTDTNS3
Pharm GKB GenePA134888115
PharosQ68CZ2
Clinical trialTNS3
Miscellaneous
canSAR (ICR)TNS3
HarmonizomeTNS3
DataMed IndexTNS3
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTNS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:52 CEST 2021

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