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TNS3 (tensin 3)

Identity

Alias_namesTENS1
tensin-like SH2 domain-containing 1
Alias_symbol (synonym)TEM6
H_NH0549I23.2
FLJ13732
Other alias
HGNC (Hugo) TNS3
LocusID (NCBI) 64759
Atlas_Id 42518
Location 7p12.3  [Link to chromosome band 7p12]
Location_base_pair Starts at 47275154 and ends at 47582144 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ATP5S (14q21.3) / TNS3 (7p12.3)CSTL1 (20p11.21) / TNS3 (7p12.3)EXOC6B (2p13.2) / TNS3 (7p12.3)
HARBI1 (11p11.2) / TNS3 (7p12.3)MAP3K3 (17q23.3) / TNS3 (7p12.3)TNS3 (7p12.3) / APOOL (Xq21.1)
TNS3 (7p12.3) / EBF1 (5q33.3)TNS3 (7p12.3) / ELMO1 (7p14.2)TNS3 (7p12.3) / FOXI2 (10q26.2)
TNS3 (7p12.3) / HSPA1L (6p21.33)TNS3 (7p12.3) / MAP3K3 (17q23.3)TNS3 (7p12.3) / PAPPA2 (1q25.2)
TNS3 (7p12.3) / PKD1L1 (7p12.3)TNS3 (7p12.3) / VPS16 (20p13)TNS3 (7p12.3) / ZNRF2 (7p14.3)
HARBI1 11p11.2 / TNS3 7p12.3TNS3 7p12.3 / ELMO1 7p14.2TNS3 7p12.3 / FOXI2 10q26.2
TNS3 7p12.3 / HSPA1L 6p21.33TNS3 7p12.3 / ZNRF2 7p14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TNS3   21616
Cards
Entrez_Gene (NCBI)TNS3  64759  tensin 3
AliasesTEM6; TENS1
GeneCards (Weizmann)TNS3
Ensembl hg19 (Hinxton)ENSG00000136205 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136205 [Gene_View]  chr7:47275154-47582144 [Contig_View]  TNS3 [Vega]
ICGC DataPortalENSG00000136205
TCGA cBioPortalTNS3
AceView (NCBI)TNS3
Genatlas (Paris)TNS3
WikiGenes64759
SOURCE (Princeton)TNS3
Genetics Home Reference (NIH)TNS3
Genomic and cartography
GoldenPath hg38 (UCSC)TNS3  -     chr7:47275154-47582144 -  7p12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNS3  -     7p12.3   [Description]    (hg19-Feb_2009)
EnsemblTNS3 - 7p12.3 [CytoView hg19]  TNS3 - 7p12.3 [CytoView hg38]
Mapping of homologs : NCBITNS3 [Mapview hg19]  TNS3 [Mapview hg38]
OMIM606825   
Gene and transcription
Genbank (Entrez)AB062750 AB208995 AF378756 AF417489 AK001539
RefSeq transcript (Entrez)NM_022748
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNS3
Cluster EST : UnigeneHs.520814 [ NCBI ]
CGAP (NCI)Hs.520814
Alternative Splicing GalleryENSG00000136205
Gene ExpressionTNS3 [ NCBI-GEO ]   TNS3 [ EBI - ARRAY_EXPRESS ]   TNS3 [ SEEK ]   TNS3 [ MEM ]
Gene Expression Viewer (FireBrowse)TNS3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64759
GTEX Portal (Tissue expression)TNS3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ68CZ2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ68CZ2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ68CZ2
Splice isoforms : SwissVarQ68CZ2
PhosPhoSitePlusQ68CZ2
Domaine pattern : Prosite (Expaxy)C2_TENSIN (PS51182)    PPASE_TENSIN (PS51181)    SH2 (PS50001)   
Domains : Interpro (EBI)C2_dom    PH_dom-like    Prot-tyrosine_phosphatase-like    PTB    PTB/PI_dom    SH2    Tensin_C2-dom    Tensin_lipid_phosphatase_dom    Tensin_PTB    Tyr_Pase_cat   
Domain families : Pfam (Sanger)PTB (PF08416)    PTEN_C2 (PF10409)    SH2 (PF00017)   
Domain families : Pfam (NCBI)pfam08416    pfam10409    pfam00017   
Domain families : Smart (EMBL)PTB (SM00462)  PTEN_C2 (SM01326)  PTPc_motif (SM00404)  SH2 (SM00252)  
Conserved Domain (NCBI)TNS3
DMDM Disease mutations64759
Blocks (Seattle)TNS3
SuperfamilyQ68CZ2
Human Protein AtlasENSG00000136205
Peptide AtlasQ68CZ2
IPIIPI00658152   IPI00854869   IPI00854817   IPI00925665   IPI01015599   IPI00924727   IPI00854760   IPI00925409   IPI00926989   IPI00926634   
Protein Interaction databases
DIP (DOE-UCLA)Q68CZ2
IntAct (EBI)Q68CZ2
FunCoupENSG00000136205
BioGRIDTNS3
STRING (EMBL)TNS3
ZODIACTNS3
Ontologies - Pathways
QuickGOQ68CZ2
Ontology : AmiGOprotein binding  cytosol  cytosol  focal adhesion  positive regulation of cell proliferation  cell migration  lung alveolus development  
Ontology : EGO-EBIprotein binding  cytosol  cytosol  focal adhesion  positive regulation of cell proliferation  cell migration  lung alveolus development  
NDEx NetworkTNS3
Atlas of Cancer Signalling NetworkTNS3
Wikipedia pathwaysTNS3
Orthology - Evolution
OrthoDB64759
GeneTree (enSembl)ENSG00000136205
Phylogenetic Trees/Animal Genes : TreeFamTNS3
HOVERGENQ68CZ2
HOGENOMQ68CZ2
Homologs : HomoloGeneTNS3
Homology/Alignments : Family Browser (UCSC)TNS3
Gene fusions - Rearrangements
Fusion : MitelmanHARBI1/TNS3 [11p11.2/7p12.3]  [t(7;11)(p12;p11)]  
Fusion : MitelmanMAP3K3/TNS3 [17q23.3/7p12.3]  [t(7;17)(p12;q23)]  
Fusion : MitelmanTNS3/ELMO1 [7p12.3/7p14.2]  [t(7;7)(p12;p14)]  
Fusion : MitelmanTNS3/FOXI2 [7p12.3/10q26.2]  [t(7;10)(p12;q26)]  
Fusion : MitelmanTNS3/HSPA1L [7p12.3/6p21.33]  [t(6;7)(p21;p12)]  
Fusion : MitelmanTNS3/MAP3K3 [7p12.3/17q23.3]  [t(7;17)(p12;q23)]  
Fusion : MitelmanTNS3/PKD1L1 [7p12.3/7p12.3]  [t(7;7)(p12;p12)]  
Fusion : MitelmanTNS3/ZNRF2 [7p12.3/7p14.3]  [t(7;7)(p12;p14)]  
Fusion: TCGAHARBI1 11p11.2 TNS3 7p12.3 LGG
Fusion: TCGATNS3 7p12.3 ELMO1 7p14.2 LUAD
Fusion: TCGATNS3 7p12.3 FOXI2 10q26.2 BRCA
Fusion: TCGATNS3 7p12.3 HSPA1L 6p21.33 BRCA
Fusion: TCGATNS3 7p12.3 ZNRF2 7p14.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNS3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNS3
dbVarTNS3
ClinVarTNS3
1000_GenomesTNS3 
Exome Variant ServerTNS3
ExAC (Exome Aggregation Consortium)TNS3 (select the gene name)
Genetic variants : HAPMAP64759
Genomic Variants (DGV)TNS3 [DGVbeta]
DECIPHERTNS3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNS3 
Mutations
ICGC Data PortalTNS3 
TCGA Data PortalTNS3 
Broad Tumor PortalTNS3
OASIS PortalTNS3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNS3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTNS3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNS3
DgiDB (Drug Gene Interaction Database)TNS3
DoCM (Curated mutations)TNS3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNS3 (select a term)
intoGenTNS3
Cancer3DTNS3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606825   
Orphanet
MedgenTNS3
Genetic Testing Registry TNS3
NextProtQ68CZ2 [Medical]
TSGene64759
GENETestsTNS3
Target ValidationTNS3
Huge Navigator TNS3 [HugePedia]
snp3D : Map Gene to Disease64759
BioCentury BCIQTNS3
ClinGenTNS3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64759
Chemical/Pharm GKB GenePA134888115
Clinical trialTNS3
Miscellaneous
canSAR (ICR)TNS3 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTNS3
EVEXTNS3
GoPubMedTNS3
iHOPTNS3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:00:13 CEST 2017

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