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TOB1 (transducer of ERBB2, 1)

Identity

Alias_namesTROB1
Alias_symbol (synonym)TOB
TROB
APRO5
Other aliasAPRO6
PIG49
HGNC (Hugo) TOB1
LocusID (NCBI) 10140
Atlas_Id 42651
Location 17q21.33  [Link to chromosome band 17q21]
Location_base_pair Starts at 50862226 and ends at 50867978 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TAOK3 (12q24.23) / TOB1 (17q21.33)TOB1 (17q21.33) / CHMP4B (20q11.22)TOB1 (17q21.33) / FBXO34 (14q22.3)
TOB1 (17q21.33) / SYNRG (17q12)TOB1 (17q21.33) / TTLL6 (17q21.32)TOB1 17q21.33 / TTLL6 17q21.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TOB1   11979
Cards
Entrez_Gene (NCBI)TOB1  10140  transducer of ERBB2, 1
AliasesAPRO5; APRO6; PIG49; TOB; 
TROB; TROB1
GeneCards (Weizmann)TOB1
Ensembl hg19 (Hinxton)ENSG00000141232 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141232 [Gene_View]  chr17:50862226-50867978 [Contig_View]  TOB1 [Vega]
ICGC DataPortalENSG00000141232
TCGA cBioPortalTOB1
AceView (NCBI)TOB1
Genatlas (Paris)TOB1
WikiGenes10140
SOURCE (Princeton)TOB1
Genetics Home Reference (NIH)TOB1
Genomic and cartography
GoldenPath hg38 (UCSC)TOB1  -     chr17:50862226-50867978 -  17q21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TOB1  -     17q21.33   [Description]    (hg19-Feb_2009)
EnsemblTOB1 - 17q21.33 [CytoView hg19]  TOB1 - 17q21.33 [CytoView hg38]
Mapping of homologs : NCBITOB1 [Mapview hg19]  TOB1 [Mapview hg38]
OMIM605523   
Gene and transcription
Genbank (Entrez)AA675891 AK313904 AY524047 BC031406 BC070493
RefSeq transcript (Entrez)NM_001243877 NM_001243885 NM_005749
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TOB1
Cluster EST : UnigeneHs.744946 [ NCBI ]
CGAP (NCI)Hs.744946
Alternative Splicing GalleryENSG00000141232
Gene ExpressionTOB1 [ NCBI-GEO ]   TOB1 [ EBI - ARRAY_EXPRESS ]   TOB1 [ SEEK ]   TOB1 [ MEM ]
Gene Expression Viewer (FireBrowse)TOB1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10140
GTEX Portal (Tissue expression)TOB1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50616   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP50616  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP50616
Splice isoforms : SwissVarP50616
PhosPhoSitePlusP50616
Domaine pattern : Prosite (Expaxy)BTG_1 (PS00960)    BTG_2 (PS01203)   
Domains : Interpro (EBI)Anti_prolifrtn    Tob1    Tob1/2   
Domain families : Pfam (Sanger)BTG (PF07742)   
Domain families : Pfam (NCBI)pfam07742   
Domain families : Smart (EMBL)btg1 (SM00099)  
Conserved Domain (NCBI)TOB1
DMDM Disease mutations10140
Blocks (Seattle)TOB1
PDB (SRS)2D5R    2Z15    5CI8    5CI9   
PDB (PDBSum)2D5R    2Z15    5CI8    5CI9   
PDB (IMB)2D5R    2Z15    5CI8    5CI9   
PDB (RSDB)2D5R    2Z15    5CI8    5CI9   
Structural Biology KnowledgeBase2D5R    2Z15    5CI8    5CI9   
SCOP (Structural Classification of Proteins)2D5R    2Z15    5CI8    5CI9   
CATH (Classification of proteins structures)2D5R    2Z15    5CI8    5CI9   
SuperfamilyP50616
Human Protein AtlasENSG00000141232
Peptide AtlasP50616
HPRD09273
IPIIPI00000687   IPI00744267   
Protein Interaction databases
DIP (DOE-UCLA)P50616
IntAct (EBI)P50616
FunCoupENSG00000141232
BioGRIDTOB1
STRING (EMBL)TOB1
ZODIACTOB1
Ontologies - Pathways
QuickGOP50616
Ontology : AmiGOtranscription corepressor activity  SH3/SH2 adaptor activity  protein binding  nucleus  cytoplasm  SMAD protein import into nucleus  negative regulation of cell proliferation  positive regulation of signal transduction  negative regulation of translation  CCR4-NOT complex  BMP signaling pathway  negative regulation of BMP signaling pathway  receptor tyrosine kinase binding  negative regulation of osteoblast differentiation  SMAD binding  negative regulation of nuclear-transcribed mRNA poly(A) tail shortening  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  negative regulation of nucleic acid-templated transcription  
Ontology : EGO-EBItranscription corepressor activity  SH3/SH2 adaptor activity  protein binding  nucleus  cytoplasm  SMAD protein import into nucleus  negative regulation of cell proliferation  positive regulation of signal transduction  negative regulation of translation  CCR4-NOT complex  BMP signaling pathway  negative regulation of BMP signaling pathway  receptor tyrosine kinase binding  negative regulation of osteoblast differentiation  SMAD binding  negative regulation of nuclear-transcribed mRNA poly(A) tail shortening  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  negative regulation of nucleic acid-templated transcription  
Pathways : BIOCARTARole of Tob in T-cell activation [Genes]   
Pathways : KEGGRNA degradation   
NDEx NetworkTOB1
Atlas of Cancer Signalling NetworkTOB1
Wikipedia pathwaysTOB1
Orthology - Evolution
OrthoDB10140
GeneTree (enSembl)ENSG00000141232
Phylogenetic Trees/Animal Genes : TreeFamTOB1
HOVERGENP50616
HOGENOMP50616
Homologs : HomoloGeneTOB1
Homology/Alignments : Family Browser (UCSC)TOB1
Gene fusions - Rearrangements
Fusion : MitelmanTOB1/SYNRG [17q21.33/17q12]  
Fusion : MitelmanTOB1/TTLL6 [17q21.33/17q21.32]  [t(17;17)(q21;q21)]  
Fusion: TCGATOB1 17q21.33 TTLL6 17q21.32 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOB1
dbVarTOB1
ClinVarTOB1
1000_GenomesTOB1 
Exome Variant ServerTOB1
ExAC (Exome Aggregation Consortium)TOB1 (select the gene name)
Genetic variants : HAPMAP10140
Genomic Variants (DGV)TOB1 [DGVbeta]
DECIPHERTOB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTOB1 
Mutations
ICGC Data PortalTOB1 
TCGA Data PortalTOB1 
Broad Tumor PortalTOB1
OASIS PortalTOB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOB1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTOB1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TOB1
DgiDB (Drug Gene Interaction Database)TOB1
DoCM (Curated mutations)TOB1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TOB1 (select a term)
intoGenTOB1
Cancer3DTOB1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605523   
Orphanet
MedgenTOB1
Genetic Testing Registry TOB1
NextProtP50616 [Medical]
TSGene10140
GENETestsTOB1
Huge Navigator TOB1 [HugePedia]
snp3D : Map Gene to Disease10140
BioCentury BCIQTOB1
ClinGenTOB1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10140
Chemical/Pharm GKB GenePA36663
Clinical trialTOB1
Miscellaneous
canSAR (ICR)TOB1 (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTOB1
EVEXTOB1
GoPubMedTOB1
iHOPTOB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:41:45 CEST 2017

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