TOB1 (transducer of ERBB2, 1)

2003-02-01  

Identity

HGNC
TOB1
LOCATION
17q21.33
LOCUSID
10140
ALIAS
APRO5,APRO6,PIG49,TOB,TROB,TROB1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10140
MIM: 605523
HGNC: 11979
Ensembl: ENSG00000141232

Variants:

dbSNP: 10140
ClinVar: 10140
TCGA: ENSG00000141232
COSMIC: TOB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141232ENST00000268957P50616
ENSG00000141232ENST00000499247P50616

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
177854422007Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation.69
250433102015MicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1 and correlates with poor survival.65
156760262005Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control.33
213362572011Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase.27
215770132011Progression-free survival in ovarian cancer is reflected in epigenetic DNA methylation profiles.25
146430282003Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer.22
121355002002Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system.21
169511592006Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination.21
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
121513962002Identification of the Anti-proliferative protein Tob as a MAPK substrate.19

Citation

Dessen P

TOB1 (transducer of ERBB2, 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42651/tob1