Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TOB1 (transducer of ERBB2, 1)

Identity

Alias (NCBI)APRO5
APRO6
PIG49
TOB
TROB
TROB1
HGNC (Hugo) TOB1
HGNC Alias symbTOB
TROB
APRO5
HGNC Previous nameTROB1
LocusID (NCBI) 10140
Atlas_Id 42651
Location 17q21.33  [Link to chromosome band 17q21]
Location_base_pair Starts at 50862226 and ends at 50866354 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TAOK3 (12q24.23) / TOB1 (17q21.33)TOB1 (17q21.33) / CHMP4B (20q11.22)TOB1 (17q21.33) / FBXO34 (14q22.3)
TOB1 (17q21.33) / SYNRG (17q12)TOB1 (17q21.33) / TTLL6 (17q21.32)TOB1 17q21.33 / TTLL6 17q21.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TOB1   11979
Cards
Entrez_Gene (NCBI)TOB1    transducer of ERBB2, 1
AliasesAPRO5; APRO6; PIG49; TOB; 
TROB; TROB1
GeneCards (Weizmann)TOB1
Ensembl hg19 (Hinxton)ENSG00000141232 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141232 [Gene_View]  ENSG00000141232 [Sequence]  chr17:50862226-50866354 [Contig_View]  TOB1 [Vega]
ICGC DataPortalENSG00000141232
TCGA cBioPortalTOB1
AceView (NCBI)TOB1
Genatlas (Paris)TOB1
SOURCE (Princeton)TOB1
Genetics Home Reference (NIH)TOB1
Genomic and cartography
GoldenPath hg38 (UCSC)TOB1  -     chr17:50862226-50866354 -  17q21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TOB1  -     17q21.33   [Description]    (hg19-Feb_2009)
GoldenPathTOB1 - 17q21.33 [CytoView hg19]  TOB1 - 17q21.33 [CytoView hg38]
ImmunoBaseENSG00000141232
Genome Data Viewer NCBITOB1 [Mapview hg19]  
OMIM605523   
Gene and transcription
Genbank (Entrez)AA675891 AK313904 AY524047 BC031406 BC070493
RefSeq transcript (Entrez)NM_001243877 NM_001243885 NM_005749
Consensus coding sequences : CCDS (NCBI)TOB1
Gene ExpressionTOB1 [ NCBI-GEO ]   TOB1 [ EBI - ARRAY_EXPRESS ]   TOB1 [ SEEK ]   TOB1 [ MEM ]
Gene Expression Viewer (FireBrowse)TOB1 [ Firebrowse - Broad ]
GenevisibleExpression of TOB1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10140
GTEX Portal (Tissue expression)TOB1
Human Protein AtlasENSG00000141232-TOB1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50616   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP50616  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP50616
PhosPhoSitePlusP50616
Domaine pattern : Prosite (Expaxy)BTG_1 (PS00960)    BTG_2 (PS01203)   
Domains : Interpro (EBI)Anti_prolifrtn    BTG-like_sf    Tob1    Tob1/2   
Domain families : Pfam (Sanger)BTG (PF07742)   
Domain families : Pfam (NCBI)pfam07742   
Domain families : Smart (EMBL)btg1 (SM00099)  
Conserved Domain (NCBI)TOB1
PDB (RSDB)2D5R    2Z15    5CI8    5CI9   
PDB Europe2D5R    2Z15    5CI8    5CI9   
PDB (PDBSum)2D5R    2Z15    5CI8    5CI9   
PDB (IMB)2D5R    2Z15    5CI8    5CI9   
Structural Biology KnowledgeBase2D5R    2Z15    5CI8    5CI9   
SCOP (Structural Classification of Proteins)2D5R    2Z15    5CI8    5CI9   
CATH (Classification of proteins structures)2D5R    2Z15    5CI8    5CI9   
SuperfamilyP50616
AlphaFold pdb e-kbP50616   
Human Protein Atlas [tissue]ENSG00000141232-TOB1 [tissue]
HPRD09273
Protein Interaction databases
DIP (DOE-UCLA)P50616
IntAct (EBI)P50616
BioGRIDTOB1
STRING (EMBL)TOB1
ZODIACTOB1
Ontologies - Pathways
QuickGOP50616
Ontology : AmiGOtranscription corepressor activity  protein binding  nucleus  cytoplasm  negative regulation of cell population proliferation  regulation of gene expression  negative regulation of translation  CCR4-NOT complex  negative regulation of BMP signaling pathway  receptor tyrosine kinase binding  negative regulation of osteoblast differentiation  negative regulation of transcription, DNA-templated  SMAD binding  negative regulation of nuclear-transcribed mRNA poly(A) tail shortening  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  regulation of SMAD protein signal transduction  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
Ontology : EGO-EBItranscription corepressor activity  protein binding  nucleus  cytoplasm  negative regulation of cell population proliferation  regulation of gene expression  negative regulation of translation  CCR4-NOT complex  negative regulation of BMP signaling pathway  receptor tyrosine kinase binding  negative regulation of osteoblast differentiation  negative regulation of transcription, DNA-templated  SMAD binding  negative regulation of nuclear-transcribed mRNA poly(A) tail shortening  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  regulation of SMAD protein signal transduction  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
Pathways : BIOCARTARole of Tob in T-cell activation [Genes]   
Pathways : KEGGRNA degradation   
NDEx NetworkTOB1
Atlas of Cancer Signalling NetworkTOB1
Wikipedia pathwaysTOB1
Orthology - Evolution
OrthoDB10140
GeneTree (enSembl)ENSG00000141232
Phylogenetic Trees/Animal Genes : TreeFamTOB1
Homologs : HomoloGeneTOB1
Homology/Alignments : Family Browser (UCSC)TOB1
Gene fusions - Rearrangements
Fusion : MitelmanTOB1/SYNRG [17q21.33/17q12]  
Fusion : MitelmanTOB1/TTLL6 [17q21.33/17q21.32]  
Fusion : QuiverTOB1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOB1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOB1
dbVarTOB1
ClinVarTOB1
MonarchTOB1
1000_GenomesTOB1 
Exome Variant ServerTOB1
GNOMAD BrowserENSG00000141232
Varsome BrowserTOB1
ACMGTOB1 variants
VarityP50616
Genomic Variants (DGV)TOB1 [DGVbeta]
DECIPHERTOB1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTOB1 
Mutations
ICGC Data PortalTOB1 
TCGA Data PortalTOB1 
Broad Tumor PortalTOB1
OASIS PortalTOB1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOB1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTOB1
Mutations and Diseases : HGMDTOB1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTOB1
DgiDB (Drug Gene Interaction Database)TOB1
DoCM (Curated mutations)TOB1
CIViC (Clinical Interpretations of Variants in Cancer)TOB1
Cancer3DTOB1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605523   
Orphanet
DisGeNETTOB1
MedgenTOB1
Genetic Testing Registry TOB1
NextProtP50616 [Medical]
GENETestsTOB1
Target ValidationTOB1
Huge Navigator TOB1 [HugePedia]
ClinGenTOB1
Clinical trials, drugs, therapy
MyCancerGenomeTOB1
Protein Interactions : CTDTOB1
Pharm GKB GenePA36663
PharosP50616
Clinical trialTOB1
Miscellaneous
canSAR (ICR)TOB1
HarmonizomeTOB1
DataMed IndexTOB1
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTOB1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:35:52 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.