Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TOB2 (transducer of ERBB2, 2)

Identity

Alias_namesTROB2
Alias_symbol (synonym)TOBL
TOB4
bK223H9
APRO5
Other alias
HGNC (Hugo) TOB2
LocusID (NCBI) 10766
Atlas_Id 42652
Location 22q13.2  [Link to chromosome band 22q13]
Location_base_pair Starts at 41433488 and ends at 41447023 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TOB2 (22q13.2) / ACO2 (22q13.2)TOB2 (22q13.2) / HNRNPAB (5q35.3)TOB2 (22q13.2) / SLC35D1 (1p31.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TOB2   11980
Cards
Entrez_Gene (NCBI)TOB2  10766  transducer of ERBB2, 2
AliasesAPRO5; TOB4; TOBL; TROB2
GeneCards (Weizmann)TOB2
Ensembl hg19 (Hinxton)ENSG00000183864 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183864 [Gene_View]  ENSG00000183864 [Sequence]  chr22:41433488-41447023 [Contig_View]  TOB2 [Vega]
ICGC DataPortalENSG00000183864
TCGA cBioPortalTOB2
AceView (NCBI)TOB2
Genatlas (Paris)TOB2
WikiGenes10766
SOURCE (Princeton)TOB2
Genetics Home Reference (NIH)TOB2
Genomic and cartography
GoldenPath hg38 (UCSC)TOB2  -     chr22:41433488-41447023 -  22q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TOB2  -     22q13.2   [Description]    (hg19-Feb_2009)
EnsemblTOB2 - 22q13.2 [CytoView hg19]  TOB2 - 22q13.2 [CytoView hg38]
Mapping of homologs : NCBITOB2 [Mapview hg19]  TOB2 [Mapview hg38]
OMIM607396   
Gene and transcription
Genbank (Entrez)AB035207 AB051450 AI362988 AL133080 BC028919
RefSeq transcript (Entrez)NM_016272
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TOB2
Cluster EST : UnigeneHs.474978 [ NCBI ]
CGAP (NCI)Hs.474978
Alternative Splicing GalleryENSG00000183864
Gene ExpressionTOB2 [ NCBI-GEO ]   TOB2 [ EBI - ARRAY_EXPRESS ]   TOB2 [ SEEK ]   TOB2 [ MEM ]
Gene Expression Viewer (FireBrowse)TOB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10766
GTEX Portal (Tissue expression)TOB2
Human Protein AtlasENSG00000183864-TOB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14106   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14106  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14106
Splice isoforms : SwissVarQ14106
PhosPhoSitePlusQ14106
Domaine pattern : Prosite (Expaxy)BTG_1 (PS00960)    BTG_2 (PS01203)   
Domains : Interpro (EBI)Anti_prolifrtn    Ataxin-2_C    BTG-like_sf    Tob1/2    Tob2   
Domain families : Pfam (Sanger)BTG (PF07742)    PAM2 (PF07145)   
Domain families : Pfam (NCBI)pfam07742    pfam07145   
Domain families : Smart (EMBL)btg1 (SM00099)  
Conserved Domain (NCBI)TOB2
DMDM Disease mutations10766
Blocks (Seattle)TOB2
SuperfamilyQ14106
Human Protein Atlas [tissue]ENSG00000183864-TOB2 [tissue]
Peptide AtlasQ14106
HPRD09583
IPIIPI00028889   IPI00879738   
Protein Interaction databases
DIP (DOE-UCLA)Q14106
IntAct (EBI)Q14106
FunCoupENSG00000183864
BioGRIDTOB2
STRING (EMBL)TOB2
ZODIACTOB2
Ontologies - Pathways
QuickGOQ14106
Ontology : AmiGOtranscription corepressor activity  protein binding  nucleus  nucleus  cytoplasm  cytosol  female gamete generation  negative regulation of cell proliferation  regulation of gene expression  vitamin D receptor binding  negative regulation of osteoclast differentiation  positive regulation of ossification  negative regulation of nucleic acid-templated transcription  
Ontology : EGO-EBItranscription corepressor activity  protein binding  nucleus  nucleus  cytoplasm  cytosol  female gamete generation  negative regulation of cell proliferation  regulation of gene expression  vitamin D receptor binding  negative regulation of osteoclast differentiation  positive regulation of ossification  negative regulation of nucleic acid-templated transcription  
Pathways : KEGGRNA degradation   
NDEx NetworkTOB2
Atlas of Cancer Signalling NetworkTOB2
Wikipedia pathwaysTOB2
Orthology - Evolution
OrthoDB10766
GeneTree (enSembl)ENSG00000183864
Phylogenetic Trees/Animal Genes : TreeFamTOB2
HOGENOMQ14106
Homologs : HomoloGeneTOB2
Homology/Alignments : Family Browser (UCSC)TOB2
Gene fusions - Rearrangements
Fusion : QuiverTOB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOB2
dbVarTOB2
ClinVarTOB2
1000_GenomesTOB2 
Exome Variant ServerTOB2
ExAC (Exome Aggregation Consortium)ENSG00000183864
GNOMAD BrowserENSG00000183864
Varsome BrowserTOB2
Genetic variants : HAPMAP10766
Genomic Variants (DGV)TOB2 [DGVbeta]
DECIPHERTOB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTOB2 
Mutations
ICGC Data PortalTOB2 
TCGA Data PortalTOB2 
Broad Tumor PortalTOB2
OASIS PortalTOB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTOB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TOB2
DgiDB (Drug Gene Interaction Database)TOB2
DoCM (Curated mutations)TOB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TOB2 (select a term)
intoGenTOB2
Cancer3DTOB2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607396   
Orphanet
DisGeNETTOB2
MedgenTOB2
Genetic Testing Registry TOB2
NextProtQ14106 [Medical]
TSGene10766
GENETestsTOB2
Target ValidationTOB2
Huge Navigator TOB2 [HugePedia]
snp3D : Map Gene to Disease10766
BioCentury BCIQTOB2
ClinGenTOB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10766
Chemical/Pharm GKB GenePA36664
Clinical trialTOB2
Miscellaneous
canSAR (ICR)TOB2 (select the gene name)
DataMed IndexTOB2
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTOB2
EVEXTOB2
GoPubMedTOB2
iHOPTOB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Feb 14 17:02:47 CET 2019
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