TOB2 (transducer of ERBB2, 2)

2003-02-01  

Identity

HGNC
LOCATION
22q13.2
LOCUSID
ALIAS
APRO5,TOB4,TOBL,TROB2
FUSION GENES

Other Information

Locus ID:

NCBI: 10766
MIM: 607396
HGNC: 11980
Ensembl: ENSG00000183864

Variants:

dbSNP: 10766
ClinVar: 10766
TCGA: ENSG00000183864
COSMIC: TOB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183864ENST00000327492Q14106
ENSG00000183864ENST00000434408B0QXZ4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
212429602011Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation.33
121355002002Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system.21
197605022010Transactivation of ErbB-2 induced by tumor necrosis factor alpha promotes NF-kappaB activation and breast cancer cell proliferation.16
222523182012Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities.16
256493272015Upregulation of miR-362-3p Modulates Proliferation and Anchorage-Independent Growth by Directly Targeting Tob2 in Hepatocellular Carcinoma.16
199408622010Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy.0

Citation

Dessen P

TOB2 (transducer of ERBB2, 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42652/tob2