TOE1 (target of EGR1, exonuclease)

2014-11-01  

Identity

HGNC
TOE1
LOCATION
1p34.1
LOCUSID
114034
ALIAS
PCH7,TOE-1,hCaf1z
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 114034
MIM: 613931
HGNC: 15954
Ensembl: ENSG00000132773

Variants:

dbSNP: 114034
ClinVar: 114034
TCGA: ENSG00000132773
COSMIC: TOE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132773ENST00000372090Q96GM8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
296692922018PARN and TOE1 Constitute a 3' End Maturation Module for Nuclear Non-coding RNAs.17
280926842017Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing.16
125627642003In vivo cloning and characterization of a new growth suppressor protein TOE1 as a direct target gene of Egr1.9
303718862019TOE1 acts as a 3' exonuclease for telomerase RNA and regulates telomere maintenance.9
260562592015TOE1 is an inhibitor of HIV-1 replication with cell-penetrating capability.5

Citation

Dessen P

TOE1 (target of EGR1, exonuclease)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75047/toe1