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TOLLIP (toll interacting protein)

Identity

Alias_symbol (synonym)IL-1RAcPIP
Other alias
HGNC (Hugo) TOLLIP
LocusID (NCBI) 54472
Atlas_Id 55714
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 1295598 and ends at 1330892 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AP2A1 (19q13.33) / TOLLIP (11p15.5)HIPK3 (11p13) / TOLLIP (11p15.5)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TOLLIP   16476
Cards
Entrez_Gene (NCBI)TOLLIP  54472  toll interacting protein
AliasesIL-1RAcPIP
GeneCards (Weizmann)TOLLIP
Ensembl hg19 (Hinxton)ENSG00000078902 [Gene_View]  chr11:1295598-1330892 [Contig_View]  TOLLIP [Vega]
Ensembl hg38 (Hinxton)ENSG00000078902 [Gene_View]  chr11:1295598-1330892 [Contig_View]  TOLLIP [Vega]
ICGC DataPortalENSG00000078902
TCGA cBioPortalTOLLIP
AceView (NCBI)TOLLIP
Genatlas (Paris)TOLLIP
WikiGenes54472
SOURCE (Princeton)TOLLIP
Genetics Home Reference (NIH)TOLLIP
Genomic and cartography
GoldenPath hg19 (UCSC)TOLLIP  -     chr11:1295598-1330892 -  11p15.5   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TOLLIP  -     11p15.5   [Description]    (hg38-Dec_2013)
EnsemblTOLLIP - 11p15.5 [CytoView hg19]  TOLLIP - 11p15.5 [CytoView hg38]
Mapping of homologs : NCBITOLLIP [Mapview hg19]  TOLLIP [Mapview hg38]
OMIM606277   
Gene and transcription
Genbank (Entrez)AA861717 AB209541 AJ242972 AK022871 AK090850
RefSeq transcript (Entrez)NM_001318512 NM_001318514 NM_001318515 NM_001318516 NM_019009
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_009237 NW_004929378
Consensus coding sequences : CCDS (NCBI)TOLLIP
Cluster EST : UnigeneHs.368527 [ NCBI ]
CGAP (NCI)Hs.368527
Alternative Splicing GalleryENSG00000078902
Gene ExpressionTOLLIP [ NCBI-GEO ]   TOLLIP [ EBI - ARRAY_EXPRESS ]   TOLLIP [ SEEK ]   TOLLIP [ MEM ]
Gene Expression Viewer (FireBrowse)TOLLIP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54472
GTEX Portal (Tissue expression)TOLLIP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H0E2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H0E2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H0E2
Splice isoforms : SwissVarQ9H0E2
PhosPhoSitePlusQ9H0E2
Domaine pattern : Prosite (Expaxy)CUE (PS51140)   
Domains : Interpro (EBI)C2_dom    CUE    UBA-like   
Domain families : Pfam (Sanger)C2 (PF00168)    CUE (PF02845)   
Domain families : Pfam (NCBI)pfam00168    pfam02845   
Domain families : Smart (EMBL)C2 (SM00239)  CUE (SM00546)  
Conserved Domain (NCBI)TOLLIP
DMDM Disease mutations54472
Blocks (Seattle)TOLLIP
PDB (SRS)1WGL    2N31   
PDB (PDBSum)1WGL    2N31   
PDB (IMB)1WGL    2N31   
PDB (RSDB)1WGL    2N31   
Structural Biology KnowledgeBase1WGL    2N31   
SCOP (Structural Classification of Proteins)1WGL    2N31   
CATH (Classification of proteins structures)1WGL    2N31   
SuperfamilyQ9H0E2
Human Protein AtlasENSG00000078902
Peptide AtlasQ9H0E2
HPRD05887
IPIIPI00100154   IPI00973828   IPI00654582   IPI00979964   IPI00167490   IPI01014950   IPI00979862   IPI00979274   
Protein Interaction databases
DIP (DOE-UCLA)Q9H0E2
IntAct (EBI)Q9H0E2
FunCoupENSG00000078902
BioGRIDTOLLIP
STRING (EMBL)TOLLIP
ZODIACTOLLIP
Ontologies - Pathways
QuickGOQ9H0E2
Ontology : AmiGOsignal transducer activity  interleukin-1, Type I receptor binding  protein binding  cytoplasm  cytosol  autophagy  inflammatory response  signal transduction  cell-cell signaling  phosphorylation  nuclear body  kinase binding  epithelial cell differentiation  ubiquitin conjugating enzyme binding  ubiquitin protein ligase binding  SUMO binding  positive regulation of protein sumoylation  Toll-like receptor binding  intracellular signal transduction  protein localization to endosome  innate immune response  interleukin-18 receptor complex  leukocyte activation  interleukin-1 receptor complex  perinuclear region of cytoplasm  extracellular exosome  
Ontology : EGO-EBIsignal transducer activity  interleukin-1, Type I receptor binding  protein binding  cytoplasm  cytosol  autophagy  inflammatory response  signal transduction  cell-cell signaling  phosphorylation  nuclear body  kinase binding  epithelial cell differentiation  ubiquitin conjugating enzyme binding  ubiquitin protein ligase binding  SUMO binding  positive regulation of protein sumoylation  Toll-like receptor binding  intracellular signal transduction  protein localization to endosome  innate immune response  interleukin-18 receptor complex  leukocyte activation  interleukin-1 receptor complex  perinuclear region of cytoplasm  extracellular exosome  
Pathways : KEGGToll-like receptor signaling pathway   
NDEx NetworkTOLLIP
Atlas of Cancer Signalling NetworkTOLLIP
Wikipedia pathwaysTOLLIP
Orthology - Evolution
OrthoDB54472
GeneTree (enSembl)ENSG00000078902
Phylogenetic Trees/Animal Genes : TreeFamTOLLIP
HOVERGENQ9H0E2
HOGENOMQ9H0E2
Homologs : HomoloGeneTOLLIP
Homology/Alignments : Family Browser (UCSC)TOLLIP
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOLLIP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOLLIP
dbVarTOLLIP
ClinVarTOLLIP
1000_GenomesTOLLIP 
Exome Variant ServerTOLLIP
ExAC (Exome Aggregation Consortium)TOLLIP (select the gene name)
Genetic variants : HAPMAP54472
Genomic Variants (DGV)TOLLIP [DGVbeta]
DECIPHER (Syndromes)11:1295598-1330892  ENSG00000078902
CONAN: Copy Number AnalysisTOLLIP 
Mutations
ICGC Data PortalTOLLIP 
TCGA Data PortalTOLLIP 
Broad Tumor PortalTOLLIP
OASIS PortalTOLLIP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOLLIP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTOLLIP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TOLLIP
DgiDB (Drug Gene Interaction Database)TOLLIP
DoCM (Curated mutations)TOLLIP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TOLLIP (select a term)
intoGenTOLLIP
Cancer3DTOLLIP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606277   
Orphanet
MedgenTOLLIP
Genetic Testing Registry TOLLIP
NextProtQ9H0E2 [Medical]
TSGene54472
GENETestsTOLLIP
Huge Navigator TOLLIP [HugePedia]
snp3D : Map Gene to Disease54472
BioCentury BCIQTOLLIP
ClinGenTOLLIP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54472
Chemical/Pharm GKB GenePA134876213
Clinical trialTOLLIP
Miscellaneous
canSAR (ICR)TOLLIP (select the gene name)
Probes
Litterature
PubMed78 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTOLLIP
EVEXTOLLIP
GoPubMedTOLLIP
iHOPTOLLIP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 13:31:50 CET 2017

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