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TOM1 (target of myb1 membrane trafficking protein)

Identity

Alias_namestarget of myb1 (chicken) homolog
target of myb1 (chicken)
Other alias-
HGNC (Hugo) TOM1
LocusID (NCBI) 10043
Atlas_Id 42654
Location 22q12.3  [Link to chromosome band 22q12]
Location_base_pair Starts at 35299275 and ends at 35347994 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BCR (22q11.23) / TOM1 (22q12.3)MCM5 (22q12.3) / TOM1 (22q12.3)TOM1 (22q12.3) / HMGXB4 (22q12.3)
TOM1 (22q12.3) / PITPNB (22q12.1)TOM1 (22q12.3) / TOM1 (22q12.3)BCR 22q11.23 / TOM1 22q12.3
MCM5 22q12.3 / TOM1 22q12.3TOM1 22q12.3 / HMGXB4 22q12.3TOM1 22q12.3 / PITPNB 22q12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)TOM1   11982
Cards
Entrez_Gene (NCBI)TOM1  10043  target of myb1 membrane trafficking protein
Aliases
GeneCards (Weizmann)TOM1
Ensembl hg19 (Hinxton)ENSG00000100284 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100284 [Gene_View]  chr22:35299275-35347994 [Contig_View]  TOM1 [Vega]
ICGC DataPortalENSG00000100284
TCGA cBioPortalTOM1
AceView (NCBI)TOM1
Genatlas (Paris)TOM1
WikiGenes10043
SOURCE (Princeton)TOM1
Genetics Home Reference (NIH)TOM1
Genomic and cartography
GoldenPath hg38 (UCSC)TOM1  -     chr22:35299275-35347994 +  22q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TOM1  -     22q12.3   [Description]    (hg19-Feb_2009)
EnsemblTOM1 - 22q12.3 [CytoView hg19]  TOM1 - 22q12.3 [CytoView hg38]
Mapping of homologs : NCBITOM1 [Mapview hg19]  TOM1 [Mapview hg38]
OMIM604700   
Gene and transcription
Genbank (Entrez)AF040251 AJ006973 AK026576 AK090723 AK091958
RefSeq transcript (Entrez)NM_001135729 NM_001135730 NM_001135732 NM_005488
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TOM1
Cluster EST : UnigeneHs.474705 [ NCBI ]
CGAP (NCI)Hs.474705
Alternative Splicing GalleryENSG00000100284
Gene ExpressionTOM1 [ NCBI-GEO ]   TOM1 [ EBI - ARRAY_EXPRESS ]   TOM1 [ SEEK ]   TOM1 [ MEM ]
Gene Expression Viewer (FireBrowse)TOM1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10043
GTEX Portal (Tissue expression)TOM1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60784   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60784  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60784
Splice isoforms : SwissVarO60784
PhosPhoSitePlusO60784
Domaine pattern : Prosite (Expaxy)GAT (PS50909)    VHS (PS50179)   
Domains : Interpro (EBI)ENTH_VHS    GAT_dom    TOM1    VHS_dom   
Domain families : Pfam (Sanger)GAT (PF03127)    VHS (PF00790)   
Domain families : Pfam (NCBI)pfam03127    pfam00790   
Domain families : Smart (EMBL)VHS (SM00288)  
Conserved Domain (NCBI)TOM1
DMDM Disease mutations10043
Blocks (Seattle)TOM1
PDB (SRS)1ELK    1WRD    2N2N    2N9D   
PDB (PDBSum)1ELK    1WRD    2N2N    2N9D   
PDB (IMB)1ELK    1WRD    2N2N    2N9D   
PDB (RSDB)1ELK    1WRD    2N2N    2N9D   
Structural Biology KnowledgeBase1ELK    1WRD    2N2N    2N9D   
SCOP (Structural Classification of Proteins)1ELK    1WRD    2N2N    2N9D   
CATH (Classification of proteins structures)1ELK    1WRD    2N2N    2N9D   
SuperfamilyO60784
Human Protein AtlasENSG00000100284
Peptide AtlasO60784
HPRD05265
IPIIPI00913835   IPI00941588   IPI00913911   IPI00879680   IPI00903336   IPI00910932   IPI00023191   IPI01012252   IPI00386851   IPI00942537   IPI00879083   IPI00878599   IPI00879406   IPI00879576   IPI00879554   IPI00879858   IPI00879987   
Protein Interaction databases
DIP (DOE-UCLA)O60784
IntAct (EBI)O60784
FunCoupENSG00000100284
BioGRIDTOM1
STRING (EMBL)TOM1
ZODIACTOM1
Ontologies - Pathways
QuickGOO60784
Ontology : AmiGOprotein binding  cytoplasm  endosome  early endosome  cytosol  plasma membrane  intracellular protein transport  endocytosis  protein transport  membrane  endosomal transport  endosomal transport  clathrin binding  azurophil granule membrane  specific granule membrane  neutrophil degranulation  extracellular exosome  
Ontology : EGO-EBIprotein binding  cytoplasm  endosome  early endosome  cytosol  plasma membrane  intracellular protein transport  endocytosis  protein transport  membrane  endosomal transport  endosomal transport  clathrin binding  azurophil granule membrane  specific granule membrane  neutrophil degranulation  extracellular exosome  
NDEx NetworkTOM1
Atlas of Cancer Signalling NetworkTOM1
Wikipedia pathwaysTOM1
Orthology - Evolution
OrthoDB10043
GeneTree (enSembl)ENSG00000100284
Phylogenetic Trees/Animal Genes : TreeFamTOM1
HOVERGENO60784
HOGENOMO60784
Homologs : HomoloGeneTOM1
Homology/Alignments : Family Browser (UCSC)TOM1
Gene fusions - Rearrangements
Fusion : MitelmanBCR/TOM1 [22q11.23/22q12.3]  [t(22;22)(q11;q12)]  
Fusion : MitelmanMCM5/TOM1 [22q12.3/22q12.3]  [t(22;22)(q12;q12)]  
Fusion : MitelmanTOM1/HMGXB4 [22q12.3/22q12.3]  [t(22;22)(q12;q12)]  
Fusion : MitelmanTOM1/PITPNB [22q12.3/22q12.1]  [t(22;22)(q12;q12)]  
Fusion: TCGABCR 22q11.23 TOM1 22q12.3 HNSC
Fusion: TCGAMCM5 22q12.3 TOM1 22q12.3 BRCA
Fusion: TCGATOM1 22q12.3 HMGXB4 22q12.3 BRCA
Fusion: TCGATOM1 22q12.3 PITPNB 22q12.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOM1
dbVarTOM1
ClinVarTOM1
1000_GenomesTOM1 
Exome Variant ServerTOM1
ExAC (Exome Aggregation Consortium)TOM1 (select the gene name)
Genetic variants : HAPMAP10043
Genomic Variants (DGV)TOM1 [DGVbeta]
DECIPHERTOM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTOM1 
Mutations
ICGC Data PortalTOM1 
TCGA Data PortalTOM1 
Broad Tumor PortalTOM1
OASIS PortalTOM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOM1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTOM1
intOGen PortalTOM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TOM1
DgiDB (Drug Gene Interaction Database)TOM1
DoCM (Curated mutations)TOM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TOM1 (select a term)
intoGenTOM1
Cancer3DTOM1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604700   
Orphanet
MedgenTOM1
Genetic Testing Registry TOM1
NextProtO60784 [Medical]
TSGene10043
GENETestsTOM1
Target ValidationTOM1
Huge Navigator TOM1 [HugePedia]
snp3D : Map Gene to Disease10043
BioCentury BCIQTOM1
ClinGenTOM1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10043
Chemical/Pharm GKB GenePA36666
Clinical trialTOM1
Miscellaneous
canSAR (ICR)TOM1 (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTOM1
EVEXTOM1
GoPubMedTOM1
iHOPTOM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:10:12 CEST 2017

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