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TOM1 (target of myb1 membrane trafficking protein)

Identity

Alias (NCBI)-
HGNC (Hugo) TOM1
HGNC Previous nametarget of myb1 (chicken) homolog
 target of myb1 (chicken)
LocusID (NCBI) 10043
Atlas_Id 42654
Location 22q12.3  [Link to chromosome band 22q12]
Location_base_pair Starts at 35299894 and ends at 35347973 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCR (22q11.23) / TOM1 (22q12.3)MCM5 (22q12.3) / TOM1 (22q12.3)TOM1 (22q12.3) / HMGXB4 (22q12.3)
TOM1 (22q12.3) / PITPNB (22q12.1)TOM1 (22q12.3) / TOM1 (22q12.3)BCR 22q11.23 / TOM1 22q12.3
MCM5 22q12.3 / TOM1 22q12.3TOM1 22q12.3 / HMGXB4 22q12.3TOM1 22q12.3 / PITPNB 22q12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TOM1   11982
Cards
Entrez_Gene (NCBI)TOM1    target of myb1 membrane trafficking protein
Aliases
GeneCards (Weizmann)TOM1
Ensembl hg19 (Hinxton)ENSG00000100284 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100284 [Gene_View]  ENSG00000100284 [Sequence]  chr22:35299894-35347973 [Contig_View]  TOM1 [Vega]
ICGC DataPortalENSG00000100284
TCGA cBioPortalTOM1
AceView (NCBI)TOM1
Genatlas (Paris)TOM1
SOURCE (Princeton)TOM1
Genetics Home Reference (NIH)TOM1
Genomic and cartography
GoldenPath hg38 (UCSC)TOM1  -     chr22:35299894-35347973 +  22q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TOM1  -     22q12.3   [Description]    (hg19-Feb_2009)
GoldenPathTOM1 - 22q12.3 [CytoView hg19]  TOM1 - 22q12.3 [CytoView hg38]
ImmunoBaseENSG00000100284
Genome Data Viewer NCBITOM1 [Mapview hg19]  
OMIM604700   
Gene and transcription
Genbank (Entrez)AF040251 AJ006973 AK026576 AK090723 AK091958
RefSeq transcript (Entrez)NM_001135729 NM_001135730 NM_001135732 NM_005488
Consensus coding sequences : CCDS (NCBI)TOM1
Gene ExpressionTOM1 [ NCBI-GEO ]   TOM1 [ EBI - ARRAY_EXPRESS ]   TOM1 [ SEEK ]   TOM1 [ MEM ]
Gene Expression Viewer (FireBrowse)TOM1 [ Firebrowse - Broad ]
GenevisibleExpression of TOM1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10043
GTEX Portal (Tissue expression)TOM1
Human Protein AtlasENSG00000100284-TOM1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60784   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60784  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60784
PhosPhoSitePlusO60784
Domaine pattern : Prosite (Expaxy)GAT (PS50909)    VHS (PS50179)   
Domains : Interpro (EBI)ENTH_VHS    GAT_dom    GAT_sf    TOM1    VHS_dom   
Domain families : Pfam (Sanger)GAT (PF03127)    VHS (PF00790)   
Domain families : Pfam (NCBI)pfam03127    pfam00790   
Domain families : Smart (EMBL)VHS (SM00288)  
Conserved Domain (NCBI)TOM1
PDB (RSDB)1ELK    1WRD    2N2N    2N9D    6J56   
PDB Europe1ELK    1WRD    2N2N    2N9D    6J56   
PDB (PDBSum)1ELK    1WRD    2N2N    2N9D    6J56   
PDB (IMB)1ELK    1WRD    2N2N    2N9D    6J56   
Structural Biology KnowledgeBase1ELK    1WRD    2N2N    2N9D    6J56   
SCOP (Structural Classification of Proteins)1ELK    1WRD    2N2N    2N9D    6J56   
CATH (Classification of proteins structures)1ELK    1WRD    2N2N    2N9D    6J56   
SuperfamilyO60784
AlphaFold pdb e-kbO60784   
Human Protein Atlas [tissue]ENSG00000100284-TOM1 [tissue]
HPRD05265
Protein Interaction databases
DIP (DOE-UCLA)O60784
IntAct (EBI)O60784
BioGRIDTOM1
STRING (EMBL)TOM1
ZODIACTOM1
Ontologies - Pathways
QuickGOO60784
Ontology : AmiGOprotein binding  cytoplasm  endosome  endosome  early endosome  cytosol  plasma membrane  endocytosis  signal transduction  protein transport  membrane  membrane  endosomal transport  endosomal transport  clathrin binding  clathrin binding  phosphatidylinositol binding  azurophil granule membrane  specific granule membrane  ubiquitin binding  neutrophil degranulation  extracellular exosome  
Ontology : EGO-EBIprotein binding  cytoplasm  endosome  endosome  early endosome  cytosol  plasma membrane  endocytosis  signal transduction  protein transport  membrane  membrane  endosomal transport  endosomal transport  clathrin binding  clathrin binding  phosphatidylinositol binding  azurophil granule membrane  specific granule membrane  ubiquitin binding  neutrophil degranulation  extracellular exosome  
NDEx NetworkTOM1
Atlas of Cancer Signalling NetworkTOM1
Wikipedia pathwaysTOM1
Orthology - Evolution
OrthoDB10043
GeneTree (enSembl)ENSG00000100284
Phylogenetic Trees/Animal Genes : TreeFamTOM1
Homologs : HomoloGeneTOM1
Homology/Alignments : Family Browser (UCSC)TOM1
Gene fusions - Rearrangements
Fusion : MitelmanBCR/TOM1 [22q11.23/22q12.3]  
Fusion : MitelmanMCM5/TOM1 [22q12.3/22q12.3]  
Fusion : MitelmanTOM1/HMGXB4 [22q12.3/22q12.3]  
Fusion : MitelmanTOM1/PITPNB [22q12.3/22q12.1]  
Fusion : QuiverTOM1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOM1
dbVarTOM1
ClinVarTOM1
MonarchTOM1
1000_GenomesTOM1 
Exome Variant ServerTOM1
GNOMAD BrowserENSG00000100284
Varsome BrowserTOM1
ACMGTOM1 variants
VarityO60784
Genomic Variants (DGV)TOM1 [DGVbeta]
DECIPHERTOM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTOM1 
Mutations
ICGC Data PortalTOM1 
TCGA Data PortalTOM1 
Broad Tumor PortalTOM1
OASIS PortalTOM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOM1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTOM1
Mutations and Diseases : HGMDTOM1
intOGen PortalTOM1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTOM1
DgiDB (Drug Gene Interaction Database)TOM1
DoCM (Curated mutations)TOM1
CIViC (Clinical Interpretations of Variants in Cancer)TOM1
Cancer3DTOM1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604700   
Orphanet
DisGeNETTOM1
MedgenTOM1
Genetic Testing Registry TOM1
NextProtO60784 [Medical]
GENETestsTOM1
Target ValidationTOM1
Huge Navigator TOM1 [HugePedia]
ClinGenTOM1
Clinical trials, drugs, therapy
MyCancerGenomeTOM1
Protein Interactions : CTDTOM1
Pharm GKB GenePA36666
PharosO60784
Clinical trialTOM1
Miscellaneous
canSAR (ICR)TOM1
HarmonizomeTOM1
DataMed IndexTOM1
Probes
Litterature
PubMed74 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTOM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:53 CEST 2021

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