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TOM1L1 (target of myb1 like 1 membrane trafficking protein)

Identity

Alias (NCBI)SRCASM
HGNC (Hugo) TOM1L1
HGNC Alias symbSRCASM
HGNC Previous nametarget of myb1 (chicken) homolog-like 1
 target of myb1 (chicken)-like 1
LocusID (NCBI) 10040
Atlas_Id 50873
Location 17q22  [Link to chromosome band 17q22]
Location_base_pair Starts at 54900852 and ends at 54961956 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SMIM11A (21q22.11) / TOM1L1 (17q22)TOM1L1 (17q22) / MSX2 (5q35.2)TOM1L1 (17q22) / RPA2 (1p35.3)
TUBD1 (17q23.1) / TOM1L1 (17q22)TUBD1 17q23.1 / TOM1L1 17q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TOM1L1   11983
Cards
Entrez_Gene (NCBI)TOM1L1    target of myb1 like 1 membrane trafficking protein
AliasesSRCASM
GeneCards (Weizmann)TOM1L1
Ensembl hg19 (Hinxton)ENSG00000141198 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141198 [Gene_View]  ENSG00000141198 [Sequence]  chr17:54900852-54961956 [Contig_View]  TOM1L1 [Vega]
ICGC DataPortalENSG00000141198
TCGA cBioPortalTOM1L1
AceView (NCBI)TOM1L1
Genatlas (Paris)TOM1L1
SOURCE (Princeton)TOM1L1
Genetics Home Reference (NIH)TOM1L1
Genomic and cartography
GoldenPath hg38 (UCSC)TOM1L1  -     chr17:54900852-54961956 +  17q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TOM1L1  -     17q22   [Description]    (hg19-Feb_2009)
GoldenPathTOM1L1 - 17q22 [CytoView hg19]  TOM1L1 - 17q22 [CytoView hg38]
ImmunoBaseENSG00000141198
Genome Data Viewer NCBITOM1L1 [Mapview hg19]  
OMIM604701   
Gene and transcription
Genbank (Entrez)AB065085 AJ010071 AK001893 AK223125 AK225351
RefSeq transcript (Entrez)NM_001321173 NM_001321174 NM_001321175 NM_001321176 NM_005486
Consensus coding sequences : CCDS (NCBI)TOM1L1
Gene ExpressionTOM1L1 [ NCBI-GEO ]   TOM1L1 [ EBI - ARRAY_EXPRESS ]   TOM1L1 [ SEEK ]   TOM1L1 [ MEM ]
Gene Expression Viewer (FireBrowse)TOM1L1 [ Firebrowse - Broad ]
GenevisibleExpression of TOM1L1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10040
GTEX Portal (Tissue expression)TOM1L1
Human Protein AtlasENSG00000141198-TOM1L1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75674   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75674  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75674
PhosPhoSitePlusO75674
Domaine pattern : Prosite (Expaxy)GAT (PS50909)    VHS (PS50179)   
Domains : Interpro (EBI)ENTH_VHS    GAT_dom    GAT_sf    TOM1    TOM1L1    VHS_dom   
Domain families : Pfam (Sanger)GAT (PF03127)    VHS (PF00790)   
Domain families : Pfam (NCBI)pfam03127    pfam00790   
Domain families : Smart (EMBL)VHS (SM00288)  
Conserved Domain (NCBI)TOM1L1
PDB (RSDB)3RRU   
PDB Europe3RRU   
PDB (PDBSum)3RRU   
PDB (IMB)3RRU   
Structural Biology KnowledgeBase3RRU   
SCOP (Structural Classification of Proteins)3RRU   
CATH (Classification of proteins structures)3RRU   
SuperfamilyO75674
AlphaFold pdb e-kbO75674   
Human Protein Atlas [tissue]ENSG00000141198-TOM1L1 [tissue]
HPRD05266
Protein Interaction databases
DIP (DOE-UCLA)O75674
IntAct (EBI)O75674
BioGRIDTOM1L1
STRING (EMBL)TOM1L1
ZODIACTOM1L1
Ontologies - Pathways
QuickGOO75674
Ontology : AmiGOprotein binding  cytoplasm  lysosome  endosome  endosome  Golgi stack  cytosol  signal transduction  signal transduction  endosome membrane  protein transport  membrane  SH3 domain binding  protein kinase binding  clathrin binding  clathrin binding  protein kinase activator activity  positive regulation of protein autophosphorylation  activation of protein kinase activity  phosphatidylinositol binding  ubiquitin binding  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  negative regulation of mitotic nuclear division  extracellular exosome  regulation of DNA biosynthetic process  
Ontology : EGO-EBIprotein binding  cytoplasm  lysosome  endosome  endosome  Golgi stack  cytosol  signal transduction  signal transduction  endosome membrane  protein transport  membrane  SH3 domain binding  protein kinase binding  clathrin binding  clathrin binding  protein kinase activator activity  positive regulation of protein autophosphorylation  activation of protein kinase activity  phosphatidylinositol binding  ubiquitin binding  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  negative regulation of mitotic nuclear division  extracellular exosome  regulation of DNA biosynthetic process  
NDEx NetworkTOM1L1
Atlas of Cancer Signalling NetworkTOM1L1
Wikipedia pathwaysTOM1L1
Orthology - Evolution
OrthoDB10040
GeneTree (enSembl)ENSG00000141198
Phylogenetic Trees/Animal Genes : TreeFamTOM1L1
Homologs : HomoloGeneTOM1L1
Homology/Alignments : Family Browser (UCSC)TOM1L1
Gene fusions - Rearrangements
Fusion : MitelmanTUBD1/TOM1L1 [17q23.1/17q22]  
Fusion : QuiverTOM1L1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOM1L1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOM1L1
dbVarTOM1L1
ClinVarTOM1L1
MonarchTOM1L1
1000_GenomesTOM1L1 
Exome Variant ServerTOM1L1
GNOMAD BrowserENSG00000141198
Varsome BrowserTOM1L1
ACMGTOM1L1 variants
VarityO75674
Genomic Variants (DGV)TOM1L1 [DGVbeta]
DECIPHERTOM1L1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTOM1L1 
Mutations
ICGC Data PortalTOM1L1 
TCGA Data PortalTOM1L1 
Broad Tumor PortalTOM1L1
OASIS PortalTOM1L1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOM1L1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTOM1L1
Mutations and Diseases : HGMDTOM1L1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTOM1L1
DgiDB (Drug Gene Interaction Database)TOM1L1
DoCM (Curated mutations)TOM1L1
CIViC (Clinical Interpretations of Variants in Cancer)TOM1L1
Cancer3DTOM1L1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604701   
Orphanet
DisGeNETTOM1L1
MedgenTOM1L1
Genetic Testing Registry TOM1L1
NextProtO75674 [Medical]
GENETestsTOM1L1
Target ValidationTOM1L1
Huge Navigator TOM1L1 [HugePedia]
ClinGenTOM1L1
Clinical trials, drugs, therapy
MyCancerGenomeTOM1L1
Protein Interactions : CTDTOM1L1
Pharm GKB GenePA36667
PharosO75674
Clinical trialTOM1L1
Miscellaneous
canSAR (ICR)TOM1L1
HarmonizomeTOM1L1
DataMed IndexTOM1L1
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTOM1L1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:35:53 CEST 2021

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