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TOM1L1 (target of myb1 like 1 membrane trafficking protein)

Identity

Alias_namestarget of myb1 (chicken) homolog-like 1
target of myb1 (chicken)-like 1
Alias_symbol (synonym)SRCASM
Other alias
HGNC (Hugo) TOM1L1
LocusID (NCBI) 10040
Atlas_Id 50873
Location 17q22  [Link to chromosome band 17q22]
Location_base_pair Starts at 52978052 and ends at 53039328 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
SMIM11A (21q22.11) / TOM1L1 (17q22)TOM1L1 (17q22) / MSX2 (5q35.2)TOM1L1 (17q22) / RPA2 (1p35.3)
TUBD1 (17q23.1) / TOM1L1 (17q22)TUBD1 17q23.1 / TOM1L1 17q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TOM1L1   11983
Cards
Entrez_Gene (NCBI)TOM1L1  10040  target of myb1 like 1 membrane trafficking protein
AliasesSRCASM
GeneCards (Weizmann)TOM1L1
Ensembl hg19 (Hinxton)ENSG00000141198 [Gene_View]  chr17:52978052-53039328 [Contig_View]  TOM1L1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000141198 [Gene_View]  chr17:52978052-53039328 [Contig_View]  TOM1L1 [Vega]
ICGC DataPortalENSG00000141198
TCGA cBioPortalTOM1L1
AceView (NCBI)TOM1L1
Genatlas (Paris)TOM1L1
WikiGenes10040
SOURCE (Princeton)TOM1L1
Genetics Home Reference (NIH)TOM1L1
Genomic and cartography
GoldenPath hg19 (UCSC)TOM1L1  -     chr17:52978052-53039328 +  17q22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TOM1L1  -     17q22   [Description]    (hg38-Dec_2013)
EnsemblTOM1L1 - 17q22 [CytoView hg19]  TOM1L1 - 17q22 [CytoView hg38]
Mapping of homologs : NCBITOM1L1 [Mapview hg19]  TOM1L1 [Mapview hg38]
OMIM604701   
Gene and transcription
Genbank (Entrez)AB065085 AJ010071 AK001893 AK223125 AK225351
RefSeq transcript (Entrez)NM_001321173 NM_001321174 NM_001321175 NM_001321176 NM_005486
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)TOM1L1
Cluster EST : UnigeneHs.153504 [ NCBI ]
CGAP (NCI)Hs.153504
Alternative Splicing GalleryENSG00000141198
Gene ExpressionTOM1L1 [ NCBI-GEO ]   TOM1L1 [ EBI - ARRAY_EXPRESS ]   TOM1L1 [ SEEK ]   TOM1L1 [ MEM ]
Gene Expression Viewer (FireBrowse)TOM1L1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10040
GTEX Portal (Tissue expression)TOM1L1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75674   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75674  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75674
Splice isoforms : SwissVarO75674
PhosPhoSitePlusO75674
Domaine pattern : Prosite (Expaxy)GAT (PS50909)    VHS (PS50179)   
Domains : Interpro (EBI)ENTH_VHS    GAT_dom    TOM1    TOM1L1    VHS_dom    VHS_subgr   
Domain families : Pfam (Sanger)GAT (PF03127)    VHS (PF00790)   
Domain families : Pfam (NCBI)pfam03127    pfam00790   
Domain families : Smart (EMBL)VHS (SM00288)  
Conserved Domain (NCBI)TOM1L1
DMDM Disease mutations10040
Blocks (Seattle)TOM1L1
PDB (SRS)3RRU   
PDB (PDBSum)3RRU   
PDB (IMB)3RRU   
PDB (RSDB)3RRU   
Structural Biology KnowledgeBase3RRU   
SCOP (Structural Classification of Proteins)3RRU   
CATH (Classification of proteins structures)3RRU   
SuperfamilyO75674
Human Protein AtlasENSG00000141198
Peptide AtlasO75674
HPRD05266
IPIIPI00023186   IPI00910373   IPI01014237   IPI00386446   
Protein Interaction databases
DIP (DOE-UCLA)O75674
IntAct (EBI)O75674
FunCoupENSG00000141198
BioGRIDTOM1L1
STRING (EMBL)TOM1L1
ZODIACTOM1L1
Ontologies - Pathways
QuickGOO75674
Ontology : AmiGOprotein binding  cytoplasm  lysosome  endosome  Golgi stack  cytosol  intracellular protein transport  signal transduction  endosome membrane  SH3 domain binding  protein kinase binding  clathrin binding  protein kinase activator activity  positive regulation of protein autophosphorylation  activation of protein kinase activity  ubiquitin binding  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  negative regulation of mitotic nuclear division  extracellular exosome  regulation of DNA biosynthetic process  
Ontology : EGO-EBIprotein binding  cytoplasm  lysosome  endosome  Golgi stack  cytosol  intracellular protein transport  signal transduction  endosome membrane  SH3 domain binding  protein kinase binding  clathrin binding  protein kinase activator activity  positive regulation of protein autophosphorylation  activation of protein kinase activity  ubiquitin binding  ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  negative regulation of mitotic nuclear division  extracellular exosome  regulation of DNA biosynthetic process  
NDEx NetworkTOM1L1
Atlas of Cancer Signalling NetworkTOM1L1
Wikipedia pathwaysTOM1L1
Orthology - Evolution
OrthoDB10040
GeneTree (enSembl)ENSG00000141198
Phylogenetic Trees/Animal Genes : TreeFamTOM1L1
HOVERGENO75674
HOGENOMO75674
Homologs : HomoloGeneTOM1L1
Homology/Alignments : Family Browser (UCSC)TOM1L1
Gene fusions - Rearrangements
Fusion : MitelmanTUBD1/TOM1L1 [17q23.1/17q22]  [t(17;17)(q22;q23)]  
Fusion: TCGATUBD1 17q23.1 TOM1L1 17q22 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOM1L1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOM1L1
dbVarTOM1L1
ClinVarTOM1L1
1000_GenomesTOM1L1 
Exome Variant ServerTOM1L1
ExAC (Exome Aggregation Consortium)TOM1L1 (select the gene name)
Genetic variants : HAPMAP10040
Genomic Variants (DGV)TOM1L1 [DGVbeta]
DECIPHER (Syndromes)17:52978052-53039328  ENSG00000141198
CONAN: Copy Number AnalysisTOM1L1 
Mutations
ICGC Data PortalTOM1L1 
TCGA Data PortalTOM1L1 
Broad Tumor PortalTOM1L1
OASIS PortalTOM1L1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOM1L1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTOM1L1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TOM1L1
DgiDB (Drug Gene Interaction Database)TOM1L1
DoCM (Curated mutations)TOM1L1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TOM1L1 (select a term)
intoGenTOM1L1
Cancer3DTOM1L1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604701   
Orphanet
MedgenTOM1L1
Genetic Testing Registry TOM1L1
NextProtO75674 [Medical]
TSGene10040
GENETestsTOM1L1
Huge Navigator TOM1L1 [HugePedia]
snp3D : Map Gene to Disease10040
BioCentury BCIQTOM1L1
ClinGenTOM1L1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10040
Chemical/Pharm GKB GenePA36667
Clinical trialTOM1L1
Miscellaneous
canSAR (ICR)TOM1L1 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTOM1L1
EVEXTOM1L1
GoPubMedTOM1L1
iHOPTOM1L1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:23:04 CEST 2017

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