TOMM34 (translocase of outer mitochondrial membrane 34)

2003-06-01  

Identity

HGNC
LOCATION
20q13.12
LOCUSID
ALIAS
HTOM34P,TOM34,URCC3
FUSION GENES

Other Information

Locus ID:

NCBI: 10953
MIM: 616049
HGNC: 15746
Ensembl: ENSG00000025772

Variants:

dbSNP: 10953
ClinVar: 10953
TCGA: ENSG00000025772
COSMIC: TOMM34

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000025772ENST00000372813Q15785

Expression (GTEx)

0
50
100
150
200
250
300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
168208802006Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target.19
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
221781332012Tom34: a cytosolic cochaperone of the Hsp90/Hsp70 protein complex involved in mitochondrial protein import.17
245673322014The assembly and intermolecular properties of the Hsp70-Tomm34-Hsp90 molecular chaperone complex.14
183647452008NRF-1 is the major transcription factor regulating the expression of the human TOMM34 gene.13
230536442012TOMM34 expression in early invasive breast cancer: a biomarker associated with poor outcome.8
119139752002Tom34 unlike Tom20 does not interact with the leader sequences of mitochondrial precursor proteins.6
119139762002Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol.6
269443422016Novel Entropically Driven Conformation-specific Interactions with Tomm34 Protein Modulate Hsp70 Protein Folding and ATPase Activities.5
309178582019Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage.1

Citation

Dessen P

TOMM34 (translocase of outer mitochondrial membrane 34)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42657/tomm34