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TOMM70 (translocase of outer mitochondrial membrane 70)

Identity

Alias (NCBI)TOMM70A
Tom70
HGNC (Hugo) TOMM70
HGNC Alias symbKIAA0719
Tom70
HGNC Previous nameTOMM70A
HGNC Previous nametranslocase of outer mitochondrial membrane 70 (yeast) homolog A
 translocase of outer mitochondrial membrane 70 homolog A (yeast)
 translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
LocusID (NCBI) 9868
Atlas_Id 78309
Location 3q12.2  [Link to chromosome band 3q12]
Location_base_pair Starts at 100363431 and ends at 100401089 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TOMM70   11985
Cards
Entrez_Gene (NCBI)TOMM70    translocase of outer mitochondrial membrane 70
AliasesTOMM70A; Tom70
GeneCards (Weizmann)TOMM70
Ensembl hg19 (Hinxton)ENSG00000154174 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154174 [Gene_View]  ENSG00000154174 [Sequence]  chr3:100363431-100401089 [Contig_View]  TOMM70 [Vega]
ICGC DataPortalENSG00000154174
TCGA cBioPortalTOMM70
AceView (NCBI)TOMM70
Genatlas (Paris)TOMM70
SOURCE (Princeton)TOMM70
Genetics Home Reference (NIH)TOMM70
Genomic and cartography
GoldenPath hg38 (UCSC)TOMM70  -     chr3:100363431-100401089 -  3q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TOMM70  -     3q12.2   [Description]    (hg19-Feb_2009)
GoldenPathTOMM70 - 3q12.2 [CytoView hg19]  TOMM70 - 3q12.2 [CytoView hg38]
ImmunoBaseENSG00000154174
Genome Data Viewer NCBITOMM70 [Mapview hg19]  
OMIM606081   
Gene and transcription
Genbank (Entrez)AB018262 AK074951 AK075080 AK075102 AK302796
RefSeq transcript (Entrez)NM_014820
Consensus coding sequences : CCDS (NCBI)TOMM70
Gene ExpressionTOMM70 [ NCBI-GEO ]   TOMM70 [ EBI - ARRAY_EXPRESS ]   TOMM70 [ SEEK ]   TOMM70 [ MEM ]
Gene Expression Viewer (FireBrowse)TOMM70 [ Firebrowse - Broad ]
GenevisibleExpression of TOMM70 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9868
GTEX Portal (Tissue expression)TOMM70
Human Protein AtlasENSG00000154174-TOMM70 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94826   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94826  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94826
PhosPhoSitePlusO94826
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)TPR-contain_dom    TPR-like_helical_dom_sf    TPR_1    TPR_repeat   
Domain families : Pfam (Sanger)TPR_1 (PF00515)    TPR_8 (PF13181)   
Domain families : Pfam (NCBI)pfam00515    pfam13181   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)TOMM70
PDB (RSDB)7KDT   
PDB Europe7KDT   
PDB (PDBSum)7KDT   
PDB (IMB)7KDT   
Structural Biology KnowledgeBase7KDT   
SCOP (Structural Classification of Proteins)7KDT   
CATH (Classification of proteins structures)7KDT   
SuperfamilyO94826
AlphaFold pdb e-kbO94826   
Human Protein Atlas [tissue]ENSG00000154174-TOMM70 [tissue]
HPRD16194
Protein Interaction databases
DIP (DOE-UCLA)O94826
IntAct (EBI)O94826
BioGRIDTOMM70
STRING (EMBL)TOMM70
ZODIACTOMM70
Ontologies - Pathways
QuickGOO94826
Ontology : AmiGOactivation of innate immune response  positive regulation of defense response to virus by host  protein binding  mitochondrion  mitochondrial outer membrane  mitochondrial outer membrane translocase complex  mitochondrial outer membrane translocase complex  protein targeting to mitochondrion  protein targeting to mitochondrion  protein transmembrane transporter activity  protein transmembrane transporter activity  membrane  integral component of membrane  macroautophagy  protein import into mitochondrial matrix  mitochondrion targeting sequence binding  positive regulation of interferon-beta production  regulation of apoptotic process  protein insertion into mitochondrial inner membrane  extracellular exosome  cellular response to virus  
Ontology : EGO-EBIactivation of innate immune response  positive regulation of defense response to virus by host  protein binding  mitochondrion  mitochondrial outer membrane  mitochondrial outer membrane translocase complex  mitochondrial outer membrane translocase complex  protein targeting to mitochondrion  protein targeting to mitochondrion  protein transmembrane transporter activity  protein transmembrane transporter activity  membrane  integral component of membrane  macroautophagy  protein import into mitochondrial matrix  mitochondrion targeting sequence binding  positive regulation of interferon-beta production  regulation of apoptotic process  protein insertion into mitochondrial inner membrane  extracellular exosome  cellular response to virus  
NDEx NetworkTOMM70
Atlas of Cancer Signalling NetworkTOMM70
Wikipedia pathwaysTOMM70
Orthology - Evolution
OrthoDB9868
GeneTree (enSembl)ENSG00000154174
Phylogenetic Trees/Animal Genes : TreeFamTOMM70
Homologs : HomoloGeneTOMM70
Homology/Alignments : Family Browser (UCSC)TOMM70
Gene fusions - Rearrangements
Fusion : QuiverTOMM70
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTOMM70 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TOMM70
dbVarTOMM70
ClinVarTOMM70
MonarchTOMM70
1000_GenomesTOMM70 
Exome Variant ServerTOMM70
GNOMAD BrowserENSG00000154174
Varsome BrowserTOMM70
ACMGTOMM70 variants
VarityO94826
Genomic Variants (DGV)TOMM70 [DGVbeta]
DECIPHERTOMM70 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTOMM70 
Mutations
ICGC Data PortalTOMM70 
TCGA Data PortalTOMM70 
Broad Tumor PortalTOMM70
OASIS PortalTOMM70 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTOMM70  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTOMM70
Mutations and Diseases : HGMDTOMM70
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTOMM70
DgiDB (Drug Gene Interaction Database)TOMM70
DoCM (Curated mutations)TOMM70
CIViC (Clinical Interpretations of Variants in Cancer)TOMM70
Cancer3DTOMM70
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606081   
Orphanet
DisGeNETTOMM70
MedgenTOMM70
Genetic Testing Registry TOMM70
NextProtO94826 [Medical]
GENETestsTOMM70
Target ValidationTOMM70
Huge Navigator TOMM70 [HugePedia]
ClinGenTOMM70
Clinical trials, drugs, therapy
MyCancerGenomeTOMM70
Protein Interactions : CTDTOMM70
Pharm GKB GenePA36669
PharosO94826
Clinical trialTOMM70
Miscellaneous
canSAR (ICR)TOMM70
HarmonizomeTOMM70
DataMed IndexTOMM70
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTOMM70
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:26:33 CEST 2021

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