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TONSL (tonsoku like, DNA repair protein)

Identity

Alias (NCBI)IKBR
NFKBIL2
SEMDSP
HGNC (Hugo) TONSL
HGNC Alias symbIKBR
HGNC Previous nameNFKBIL2
HGNC Previous namenuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2
LocusID (NCBI) 4796
Atlas_Id 51776
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 144428775 and ends at 144444440 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FN1 (2q35) / TONSL (8q24.3)RPS7 (2p25.3) / TONSL (8q24.3)TONSL (8q24.3) / FLJ22184 ()
TONSL (8q24.3) / STMN3 (20q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TONSL   7801
Cards
Entrez_Gene (NCBI)TONSL    tonsoku like, DNA repair protein
AliasesIKBR; NFKBIL2; SEMDSP
GeneCards (Weizmann)TONSL
Ensembl hg19 (Hinxton)ENSG00000160949 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160949 [Gene_View]  ENSG00000160949 [Sequence]  chr8:144428775-144444440 [Contig_View]  TONSL [Vega]
ICGC DataPortalENSG00000160949
TCGA cBioPortalTONSL
AceView (NCBI)TONSL
Genatlas (Paris)TONSL
SOURCE (Princeton)TONSL
Genetics Home Reference (NIH)TONSL
Genomic and cartography
GoldenPath hg38 (UCSC)TONSL  -     chr8:144428775-144444440 -  8q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TONSL  -     8q24.3   [Description]    (hg19-Feb_2009)
GoldenPathTONSL - 8q24.3 [CytoView hg19]  TONSL - 8q24.3 [CytoView hg38]
ImmunoBaseENSG00000160949
Genome Data Viewer NCBITONSL [Mapview hg19]  
OMIM271510   604546   
Gene and transcription
Genbank (Entrez)AB209126 AK097406 BC008782 BF475381 CN366457
RefSeq transcript (Entrez)NM_013432
Consensus coding sequences : CCDS (NCBI)TONSL
Gene ExpressionTONSL [ NCBI-GEO ]   TONSL [ EBI - ARRAY_EXPRESS ]   TONSL [ SEEK ]   TONSL [ MEM ]
Gene Expression Viewer (FireBrowse)TONSL [ Firebrowse - Broad ]
GenevisibleExpression of TONSL in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4796
GTEX Portal (Tissue expression)TONSL
Human Protein AtlasENSG00000160949-TONSL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96HA7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96HA7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96HA7
PhosPhoSitePlusQ96HA7
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    Ankyrin_rpt-contain_sf    Leu-rich_rpt    LRR_dom_sf    TPR-contain_dom    TPR-like_helical_dom_sf    TPR_repeat   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    LRR_6 (PF13516)    TPR_8 (PF13181)   
Domain families : Pfam (NCBI)pfam12796    pfam13516    pfam13181   
Domain families : Smart (EMBL)ANK (SM00248)  TPR (SM00028)  
Conserved Domain (NCBI)TONSL
PDB (RSDB)5JA4   
PDB Europe5JA4   
PDB (PDBSum)5JA4   
PDB (IMB)5JA4   
Structural Biology KnowledgeBase5JA4   
SCOP (Structural Classification of Proteins)5JA4   
CATH (Classification of proteins structures)5JA4   
SuperfamilyQ96HA7
AlphaFold pdb e-kbQ96HA7   
Human Protein Atlas [tissue]ENSG00000160949-TONSL [tissue]
HPRD05180
Protein Interaction databases
DIP (DOE-UCLA)Q96HA7
IntAct (EBI)Q96HA7
BioGRIDTONSL
STRING (EMBL)TONSL
ZODIACTONSL
Ontologies - Pathways
QuickGOQ96HA7
Ontology : AmiGOdouble-strand break repair via homologous recombination  protein binding  nucleoplasm  cytoplasm  nuclear body  replication fork processing  histone binding  nuclear replication fork  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  protein binding  nucleoplasm  cytoplasm  nuclear body  replication fork processing  histone binding  nuclear replication fork  
NDEx NetworkTONSL
Atlas of Cancer Signalling NetworkTONSL
Wikipedia pathwaysTONSL
Orthology - Evolution
OrthoDB4796
GeneTree (enSembl)ENSG00000160949
Phylogenetic Trees/Animal Genes : TreeFamTONSL
Homologs : HomoloGeneTONSL
Homology/Alignments : Family Browser (UCSC)TONSL
Gene fusions - Rearrangements
Fusion Cancer (Beijing)FN1 [2q35]  -  TONSL [8q24.3]  [FUSC002153]
Fusion : QuiverTONSL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTONSL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TONSL
dbVarTONSL
ClinVarTONSL
MonarchTONSL
1000_GenomesTONSL 
Exome Variant ServerTONSL
GNOMAD BrowserENSG00000160949
Varsome BrowserTONSL
ACMGTONSL variants
VarityQ96HA7
Genomic Variants (DGV)TONSL [DGVbeta]
DECIPHERTONSL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTONSL 
Mutations
ICGC Data PortalTONSL 
TCGA Data PortalTONSL 
Broad Tumor PortalTONSL
OASIS PortalTONSL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTONSL  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTONSL
Mutations and Diseases : HGMDTONSL
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTONSL
DgiDB (Drug Gene Interaction Database)TONSL
DoCM (Curated mutations)TONSL
CIViC (Clinical Interpretations of Variants in Cancer)TONSL
Cancer3DTONSL
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM271510    604546   
Orphanet
DisGeNETTONSL
MedgenTONSL
Genetic Testing Registry TONSL
NextProtQ96HA7 [Medical]
GENETestsTONSL
Target ValidationTONSL
Huge Navigator TONSL [HugePedia]
ClinGenTONSL
Clinical trials, drugs, therapy
MyCancerGenomeTONSL
Protein Interactions : CTDTONSL
Pharm GKB GenePA31605
PharosQ96HA7
Clinical trialTONSL
Miscellaneous
canSAR (ICR)TONSL
HarmonizomeTONSL
DataMed IndexTONSL
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTONSL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:35:54 CEST 2021

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