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TONSL (tonsoku-like, DNA repair protein)

Identity

Alias_namesNFKBIL2
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2
Alias_symbol (synonym)IKBR
Other alias
HGNC (Hugo) TONSL
LocusID (NCBI) 4796
Atlas_Id 51776
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 145654163 and ends at 145669812 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
FN1 (2q35) / TONSL (8q24.3)RPS7 (2p25.3) / TONSL (8q24.3)TONSL (8q24.3) / FLJ22184 ()
TONSL (8q24.3) / STMN3 (20q13.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TONSL   7801
Cards
Entrez_Gene (NCBI)TONSL  4796  tonsoku-like, DNA repair protein
AliasesIKBR; NFKBIL2
GeneCards (Weizmann)TONSL
Ensembl hg19 (Hinxton)ENSG00000160949 [Gene_View]  chr8:145654163-145669812 [Contig_View]  TONSL [Vega]
Ensembl hg38 (Hinxton)ENSG00000160949 [Gene_View]  chr8:145654163-145669812 [Contig_View]  TONSL [Vega]
ICGC DataPortalENSG00000160949
TCGA cBioPortalTONSL
AceView (NCBI)TONSL
Genatlas (Paris)TONSL
WikiGenes4796
SOURCE (Princeton)TONSL
Genetics Home Reference (NIH)TONSL
Genomic and cartography
GoldenPath hg19 (UCSC)TONSL  -     chr8:145654163-145669812 -  8q24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TONSL  -     8q24.3   [Description]    (hg38-Dec_2013)
EnsemblTONSL - 8q24.3 [CytoView hg19]  TONSL - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBITONSL [Mapview hg19]  TONSL [Mapview hg38]
OMIM604546   
Gene and transcription
Genbank (Entrez)AB209126 AK097406 BC008782 BF475381 CN366457
RefSeq transcript (Entrez)NM_013432
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_008046 NW_004929341
Consensus coding sequences : CCDS (NCBI)TONSL
Cluster EST : UnigeneHs.675285 [ NCBI ]
CGAP (NCI)Hs.675285
Alternative Splicing GalleryENSG00000160949
Gene ExpressionTONSL [ NCBI-GEO ]   TONSL [ EBI - ARRAY_EXPRESS ]   TONSL [ SEEK ]   TONSL [ MEM ]
Gene Expression Viewer (FireBrowse)TONSL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4796
GTEX Portal (Tissue expression)TONSL
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96HA7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96HA7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96HA7
Splice isoforms : SwissVarQ96HA7
PhosPhoSitePlusQ96HA7
Domaine pattern : Prosite (Expaxy)ANK_REP_REGION (PS50297)    ANK_REPEAT (PS50088)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)Ankyrin_rpt    Ankyrin_rpt-contain_dom    L_dom-like    TPR-contain_dom    TPR-like_helical_dom    TPR_repeat   
Domain families : Pfam (Sanger)Ank_2 (PF12796)    TPR_7 (PF13176)    TPR_8 (PF13181)   
Domain families : Pfam (NCBI)pfam12796    pfam13176    pfam13181   
Domain families : Smart (EMBL)ANK (SM00248)  TPR (SM00028)  
Conserved Domain (NCBI)TONSL
DMDM Disease mutations4796
Blocks (Seattle)TONSL
SuperfamilyQ96HA7
Human Protein AtlasENSG00000160949
Peptide AtlasQ96HA7
HPRD05180
IPIIPI00783999   IPI00889713   IPI00555582   
Protein Interaction databases
DIP (DOE-UCLA)Q96HA7
IntAct (EBI)Q96HA7
FunCoupENSG00000160949
BioGRIDTONSL
STRING (EMBL)TONSL
ZODIACTONSL
Ontologies - Pathways
QuickGOQ96HA7
Ontology : AmiGOdouble-strand break repair via homologous recombination  transcription corepressor activity  protein binding  nucleoplasm  DNA replication factor A complex  cytoplasm  replication fork processing  FACT complex  histone binding  MCM complex  cytoplasmic sequestering of transcription factor  nuclear replication fork  negative regulation of nucleic acid-templated transcription  
Ontology : EGO-EBIdouble-strand break repair via homologous recombination  transcription corepressor activity  protein binding  nucleoplasm  DNA replication factor A complex  cytoplasm  replication fork processing  FACT complex  histone binding  MCM complex  cytoplasmic sequestering of transcription factor  nuclear replication fork  negative regulation of nucleic acid-templated transcription  
NDEx NetworkTONSL
Atlas of Cancer Signalling NetworkTONSL
Wikipedia pathwaysTONSL
Orthology - Evolution
OrthoDB4796
GeneTree (enSembl)ENSG00000160949
Phylogenetic Trees/Animal Genes : TreeFamTONSL
HOVERGENQ96HA7
HOGENOMQ96HA7
Homologs : HomoloGeneTONSL
Homology/Alignments : Family Browser (UCSC)TONSL
Gene fusions - Rearrangements
Fusion Cancer (Beijing)FN1 [2q35]  -  TONSL [8q24.3]  [FUSC002153]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTONSL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TONSL
dbVarTONSL
ClinVarTONSL
1000_GenomesTONSL 
Exome Variant ServerTONSL
ExAC (Exome Aggregation Consortium)TONSL (select the gene name)
Genetic variants : HAPMAP4796
Genomic Variants (DGV)TONSL [DGVbeta]
DECIPHER (Syndromes)8:145654163-145669812  ENSG00000160949
CONAN: Copy Number AnalysisTONSL 
Mutations
ICGC Data PortalTONSL 
TCGA Data PortalTONSL 
Broad Tumor PortalTONSL
OASIS PortalTONSL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTONSL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTONSL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TONSL
DgiDB (Drug Gene Interaction Database)TONSL
DoCM (Curated mutations)TONSL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TONSL (select a term)
intoGenTONSL
Cancer3DTONSL(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604546   
Orphanet
MedgenTONSL
Genetic Testing Registry TONSL
NextProtQ96HA7 [Medical]
TSGene4796
GENETestsTONSL
Huge Navigator TONSL [HugePedia]
snp3D : Map Gene to Disease4796
BioCentury BCIQTONSL
ClinGenTONSL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4796
Chemical/Pharm GKB GenePA31605
Clinical trialTONSL
Miscellaneous
canSAR (ICR)TONSL (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTONSL
EVEXTONSL
GoPubMedTONSL
iHOPTONSL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:23:05 CEST 2017

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