| Nomenclature |
|---|
| HGNC (Hugo) | TOP2A 11989 |
| Cards |
|---|
| Entrez_Gene (NCBI) | TOP2A DNA topoisomerase II alpha |
| Aliases | TOP2; TP2A |
| GeneCards (Weizmann) | TOP2A |
| Ensembl hg19 (Hinxton) | ENSG00000131747 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000131747 [Gene_View] ENSG00000131747 [Sequence] chr17:40388525-40417896 [Contig_View] TOP2A [Vega] |
| ICGC DataPortal | ENSG00000131747 |
| TCGA cBioPortal | TOP2A |
| AceView (NCBI) | TOP2A |
| Genatlas (Paris) | TOP2A |
| SOURCE (Princeton) | TOP2A |
| Genetics Home Reference (NIH) | TOP2A |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | TOP2A - chr17:40388525-40417896 - 17q21.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | TOP2A - 17q21.2 [Description] (hg19-Feb_2009) |
| GoldenPath | TOP2A - 17q21.2 [CytoView hg19] TOP2A - 17q21.2 [CytoView hg38] |
| ImmunoBase | ENSG00000131747 |
| genome Data Viewer NCBI | TOP2A [Mapview hg19] |
| OMIM | 126430 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF285157 AF285158 AF285159 AK024080 BC013429 |
| RefSeq transcript (Entrez) | NM_001067 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | TOP2A |
| Alternative Splicing Gallery | ENSG00000131747 |
| Gene Expression | TOP2A [ NCBI-GEO ] TOP2A [ EBI - ARRAY_EXPRESS ]
TOP2A [ SEEK ] TOP2A [ MEM ] |
| Gene Expression Viewer (FireBrowse) | TOP2A [ Firebrowse - Broad ] |
| Genevisible | Expression of TOP2A in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 7153 |
| GTEX Portal (Tissue expression) | TOP2A |
| Human Protein Atlas | ENSG00000131747-TOP2A [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P11388 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P11388 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P11388 |
| Splice isoforms : SwissVar | P11388 |
| PhosPhoSitePlus | P11388 |
| Domaine pattern : Prosite (Expaxy) | TOPOISOMERASE_II (PS00177) TOPRIM (PS50880) |
| Domains : Interpro (EBI) | DTHCT HATPase_C HATPase_C_sf Ribosomal_S5_D2-typ_fold Ribosomal_S5_D2-typ_fold_subgr Topo_IIA Topo_IIA-like_dom_sf Topo_IIA_A/C Topo_IIA_A/C_ab Topo_IIA_B_C Topo_IIA_bsu_dom2 TopoIIA_CS TOPRIM_C TOPRIM_domain TOPRIM_TopoII |
| Domain families : Pfam (Sanger) | DNA_gyraseB (PF00204) DNA_topoisoIV (PF00521) DTHCT (PF08070) HATPase_c (PF02518) Toprim (PF01751) TOPRIM_C (PF16898) |
| Domain families : Pfam (NCBI) | pfam00204 pfam00521 pfam08070 pfam02518 pfam01751 pfam16898 |
| Domain families : Smart (EMBL) | TOP2c (SM00433) TOP4c (SM00434) |
| Conserved Domain (NCBI) | TOP2A |
| Blocks (Seattle) | TOP2A |
| PDB (RSDB) | 1LWZ 1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE |
| PDB Europe | 1LWZ 1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE |
| PDB (PDBSum) | 1LWZ 1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE |
| PDB (IMB) | 1LWZ 1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE |
| Structural Biology KnowledgeBase | 1LWZ 1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE |
| SCOP (Structural Classification of Proteins) | 1LWZ 1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE |
| CATH (Classification of proteins structures) | 1LWZ 1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE |
| Superfamily | P11388 |
| Human Protein Atlas [tissue] | ENSG00000131747-TOP2A [tissue] |
| Peptide Atlas | P11388 |
| HPRD | 00536 |
| IPI | IPI01011132 IPI00414101 IPI00879004 IPI00953043 IPI00478232 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P11388 |
| IntAct (EBI) | P11388 |
| BioGRID | TOP2A |
| STRING (EMBL) | TOP2A |
| ZODIAC | TOP2A |
| Ontologies - Pathways |
|---|
| QuickGO | P11388 |
| Ontology : AmiGO | nuclear chromosome magnesium ion binding resolution of meiotic recombination intermediates chromosome, centromeric region condensed chromosome sister chromatid segregation hematopoietic progenitor cell differentiation DNA binding chromatin binding RNA binding DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity protein kinase C binding protein binding ATP binding nucleus nucleus nucleoplasm nucleoplasm nucleolus nucleolus cytoplasm centriole DNA topological change DNA topological change DNA ligation cellular response to DNA damage stimulus chromosome segregation female meiotic nuclear division protein C-terminus binding DNA-dependent ATPase activity DNA binding, bending DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex enzyme binding apoptotic chromosome condensation apoptotic chromosome condensation protein-containing complex embryonic cleavage regulation of circadian rhythm protein homodimerization activity histone deacetylase binding positive regulation of apoptotic process ubiquitin binding positive regulation of single stranded viral RNA replication via double stranded DNA intermediate positive regulation of transcription by RNA polymerase II protein heterodimerization activity rhythmic process negative regulation of DNA duplex unwinding ribonucleoprotein complex |
| Ontology : EGO-EBI | nuclear chromosome magnesium ion binding resolution of meiotic recombination intermediates chromosome, centromeric region condensed chromosome sister chromatid segregation hematopoietic progenitor cell differentiation DNA binding chromatin binding RNA binding DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity protein kinase C binding protein binding ATP binding nucleus nucleus nucleoplasm nucleoplasm nucleolus nucleolus cytoplasm centriole DNA topological change DNA topological change DNA ligation cellular response to DNA damage stimulus chromosome segregation female meiotic nuclear division protein C-terminus binding DNA-dependent ATPase activity DNA binding, bending DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex enzyme binding apoptotic chromosome condensation apoptotic chromosome condensation protein-containing complex embryonic cleavage regulation of circadian rhythm protein homodimerization activity histone deacetylase binding positive regulation of apoptotic process ubiquitin binding positive regulation of single stranded viral RNA replication via double stranded DNA intermediate positive regulation of transcription by RNA polymerase II protein heterodimerization activity rhythmic process negative regulation of DNA duplex unwinding ribonucleoprotein complex |
| Pathways : BIOCARTA | Apoptotic DNA fragmentation and tissue homeostasis [Genes] |
| NDEx Network | TOP2A |
| Atlas of Cancer Signalling Network | TOP2A |
| Wikipedia pathways | TOP2A |
| Orthology - Evolution |
|---|
| OrthoDB | 7153 |
| GeneTree (enSembl) | ENSG00000131747 |
| Phylogenetic Trees/Animal Genes : TreeFam | TOP2A |
| HOGENOM | P11388 |
| Homologs : HomoloGene | TOP2A |
| Homology/Alignments : Family Browser (UCSC) | TOP2A |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | C17orf75/TOP2A [17q11.2/17q21.2] |
| Fusion : Mitelman | EZH1/TOP2A [17q21.2/17q21.2] |
| Fusion Portal | C17orf75 17q11.2 TOP2A 17q21.2 BRCA |
| Fusion Portal | EZH1 17q21.2 TOP2A 17q21.2 BRCA |
| Fusion : Quiver | TOP2A |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | TOP2A [hg38] |
| dbVar | TOP2A |
| ClinVar | TOP2A |
| Monarch | TOP2A |
| 1000_Genomes | TOP2A |
| Exome Variant Server | TOP2A |
| GNOMAD Browser | ENSG00000131747 |
| Varsome Browser | TOP2A |
| Genomic Variants (DGV) | TOP2A [DGVbeta] |
| DECIPHER | TOP2A [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | TOP2A |
| Mutations |
|---|
| ICGC Data Portal | TOP2A |
| TCGA Data Portal | TOP2A |
| Broad Tumor Portal | TOP2A |
| OASIS Portal | TOP2A [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | TOP2A [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | TOP2A |
| Mutations and Diseases : HGMD | TOP2A |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search TOP2A |
| DgiDB (Drug Gene Interaction Database) | TOP2A |
| DoCM (Curated mutations) | TOP2A (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | TOP2A (select a term) |
| intoGen | TOP2A |
| Cancer3D | TOP2A(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 126430 |
| Orphanet | 548 |
| DisGeNET | TOP2A |
| Medgen | TOP2A |
| Genetic Testing Registry | TOP2A
|
| NextProt | P11388 [Medical] |
| GENETests | TOP2A |
| Target Validation | TOP2A |
| Huge Navigator |
TOP2A [HugePedia] |
| ClinGen | TOP2A |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | TOP2A |
| Protein Interactions : CTD | |
| Pharm GKB Gene | PA354 |
| Pharm GKB Pathways | PA165292163 PA2025 |
| Pharos | P11388 |
| Clinical trial | TOP2A |
| Miscellaneous |
|---|
| canSAR (ICR) | TOP2A (select the gene name) |
| Harmonizome | TOP2A |
| DataMed Index | TOP2A |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 499 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | TOP2A |
