TOP2A (DNA topoisomerase II alpha)

2003-02-01  

Identity

HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
TOP2,TOP2alpha,TOPIIA,TP2A
FUSION GENES

Other Information

Locus ID:

NCBI: 7153
MIM: 126430
HGNC: 11989
Ensembl: ENSG00000131747

Variants:

dbSNP: 7153
ClinVar: 7153
TCGA: ENSG00000131747
COSMIC: TOP2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131747ENST00000423485P11388
ENSG00000131747ENST00000577541J3QR57
ENSG00000131747ENST00000581055J3KTB7

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G0 and Early G1REACTOMER-HSA-1538133
SUMOylation of DNA replication proteinsREACTOMER-HSA-4615885
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotation, VariantAnnotationassociatedPD
PA443560Breast NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationambiguousPD29938344
PA445113NeutropeniaDiseaseClinicalAnnotation, VariantAnnotationassociatedPD
PA449165cyclophosphamideChemicalClinicalAnnotation, VariantAnnotationambiguousPD29938344
PA449412doxorubicinChemicalVariantAnnotationnot associatedPD29938344
PA449476epirubicinChemicalClinicalAnnotation, VariantAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
236983692013BAF complexes facilitate decatenation of DNA by topoisomerase IIα.93
206554662010TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage.78
161888922005Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks.74
119276022002Dynamics of human DNA topoisomerases IIalpha and IIbeta in living cells.69
162345142005retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group.66
154569042004Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell line.64
211893952011Alteration of topoisomerase II-alpha gene in human breast cancer: association with responsiveness to anthracycline-based chemotherapy.64
223750142012Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs DNA damage induced by topoisomerases I and II and base alkylation in vertebrate cells.62
190039832009TOP2A overexpression in hepatocellular carcinoma correlates with early age onset, shorter patients survival and chemoresistance.61
228419792012The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage.56

Citation

Dessen P

TOP2A (DNA topoisomerase II alpha)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42659/top2a